DK0744891T3 - Transgene fibrinogener - Google Patents

Transgene fibrinogener

Info

Publication number: DK0744891T3
Authority: DK; Denmark
Prior art keywords: fibrinogens; animals; modified; transgenic; human
Prior art date: 1994-02-18

Application number

DK95911012T

Other languages

English (en)

Inventor

William H Velander

William N Drohan

Henryk Lubon

Susan T Lord

John L Johnson

Christopher G Russell

Original Assignee

American Nat Red Cross

Virginia Tech Intell Prop

Univ North Carolina

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-18

Filing date

1995-02-17

Publication date

2008-02-04

1995-02-17 Application filed by American Nat Red Cross, Virginia Tech Intell Prop, Univ North Carolina filed Critical American Nat Red Cross

2008-02-04 Application granted granted Critical

2008-02-04 Publication of DK0744891T3 publication Critical patent/DK0744891T3/da

Links

FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title abstract 5
102000008946 Fibrinogen Human genes 0.000 title abstract 4
108010049003 Fibrinogen Proteins 0.000 title abstract 4
230000009261 transgenic effect Effects 0.000 title abstract 2
241001465754 Metazoa Species 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
210000001124 body fluid Anatomy 0.000 abstract 1
239000010839 body fluid Substances 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
210000005075 mammary gland Anatomy 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000003248 secreting effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Toxicology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK95911012T 1994-02-18 1995-02-17 Transgene fibrinogener DK0744891T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19806894A	1994-02-18	1994-02-18
PCT/US1995/001944 WO1995022249A1 (en)	1994-02-18	1995-02-17	Transgenic fibrinogen

Publications (1)

Publication Number	Publication Date
DK0744891T3 true DK0744891T3 (da)	2008-02-04

Family

ID=22731871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95911012T DK0744891T3 (da)	1994-02-18	1995-02-17	Transgene fibrinogener

Country Status (9)

Country	Link
EP (1)	EP0744891B1 (da)
JP (1)	JPH10500003A (da)
AT (1)	ATE374525T1 (da)
CA (1)	CA2183546C (da)
DE (1)	DE69535604T2 (da)
DK (1)	DK0744891T3 (da)
ES (1)	ES2296289T3 (da)
PT (1)	PT744891E (da)
WO (1)	WO1995022249A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998035689A1 (en) *	1997-02-14	1998-08-20	American Red Cross	Expression of active human factor ix in mammary tissue of transgenic animals
US6933366B2 (en)	1996-12-27	2005-08-23	Tripep Ab	Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US6660842B1 (en)	1994-04-28	2003-12-09	Tripep Ab	Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US20020184655A1 (en) *	1997-12-01	2002-12-05	Henryk Lubon	Methods for the degradation and detoxification of organic material using urine produced by transgenic animals and related transgenic animals and proteins
JP2002525047A (ja) *	1998-09-16	2002-08-13	ネクシアバイオテクノロジーズ，インコーポレイテッド	尿における組換え蛋白質の産生
AU6104799A (en) *	1998-09-24	2000-04-10	Ppl Therapeutics (Scotland) Limited	Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography
US7030289B2 (en)	1998-11-19	2006-04-18	Ppl Therapeutics (Scotland) Ltd	Stabilization of milk from transgenic animals
GB9825374D0 (en) *	1998-11-19	1999-01-13	Ppl Therapeutics Scotland Ltd	Method
NZ511299A (en) *	1998-11-19	2003-02-28	Ppl Therapeutics Scotland Ltd	Stabilisation of milk from transgenic animals through expression of a serine proteinase inhibitor and optionally fibrinogen in the mammary gland
JP2004509621A (ja) *	2000-09-19	2004-04-02	トリペップ　アクチ　ボラゲット	病原体上の受容体に対して抗体を再指向させるリガンド／受容体特異性変換体
KR20050099536A (ko)	2003-02-06	2005-10-13	트리펩 아베	글리코실화된 특이성 교환체
US7335359B2 (en)	2003-02-06	2008-02-26	Tripep Ab	Glycosylated specificity exchangers
US8283137B2 (en)	2003-07-29	2012-10-09	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Process for producing recombinant fibrinogen highly producing cell and highly producing cell
EP3225252A1 (en)	2008-05-02	2017-10-04	Laboratoire Français du Fractionnement et des Biotechnologies	Treatment of bleeding with low half-life fibrinogen
US9433700B2 (en)	2009-04-27	2016-09-06	Medibeacon Inc.	Tissue sealant compositions, vascular closure devices, and uses thereof
US9546381B2 (en)	2010-03-17	2017-01-17	Pharming Intellectual Property Bv	Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals
JP5839810B2 (ja) *	2011-03-03	2016-01-06	日本製粉株式会社	フィブリノゲンを産生するトランスジェニックカイコ
EP2556842A1 (en)	2011-08-11	2013-02-13	Bioftalmik, S.L.	Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE211177T1 (de) *	1991-01-11	2002-01-15	American Nat Red Cross	Expression von aktivem menschlichem protein c im milchdrüsengewebe transgener tiere

1995
- 1995-02-17 CA CA002183546A patent/CA2183546C/en not_active Expired - Lifetime
- 1995-02-17 ES ES95911012T patent/ES2296289T3/es not_active Expired - Lifetime
- 1995-02-17 EP EP95911012A patent/EP0744891B1/en not_active Expired - Lifetime
- 1995-02-17 DE DE69535604T patent/DE69535604T2/de not_active Expired - Lifetime
- 1995-02-17 DK DK95911012T patent/DK0744891T3/da active
- 1995-02-17 WO PCT/US1995/001944 patent/WO1995022249A1/en not_active Ceased
- 1995-02-17 PT PT95911012T patent/PT744891E/pt unknown
- 1995-02-17 AT AT95911012T patent/ATE374525T1/de active
- 1995-02-17 JP JP7521903A patent/JPH10500003A/ja active Pending

Also Published As

Publication number	Publication date
CA2183546A1 (en)	1995-08-24
EP0744891B1 (en)	2007-10-03
WO1995022249A1 (en)	1995-08-24
DE69535604T2 (de)	2008-05-21
DE69535604D1 (en)	2007-11-15
JPH10500003A (ja)	1998-01-06
EP0744891A1 (en)	1996-12-04
ATE374525T1 (de)	2007-10-15
ES2296289T3 (es)	2008-04-16
CA2183546C (en)	2001-08-21
PT744891E (pt)	2008-01-14

Publication	Publication Date	Title
ATE374525T1 (de)	2007-10-15	Transgenes fibrinogen
EP0737746A3 (en)	1996-10-23	Production of recombinant polypeptides by bovine species and transgenic methods
DE69534295D1 (de)	2005-08-04	Fibrinogenproduktion in transgenen tieren
ATE391181T1 (de)	2008-04-15	Bioaktive il-12 fusionsproteine
DE3382760D1 (de)	1994-11-17	Herstellung von funktionellen menschlichen Urokinasepolypeptiden.
ATE128625T1 (de)	1995-10-15	Expression von proteinen in milch.
ATE159289T1 (de)	1997-11-15	Herstellung von peptiden
NZ521396A (en)	2004-06-25	Fusion proteins comprising two or more Neisseria polypeptides
DK1218504T3 (da)	2007-11-12	GL50 molekyler og anvendelser deraf
WO1996034966A3 (en)	1996-12-05	Engineering protein posttranslational modification in transgenic organisms
DK0555435T3 (da)	2000-04-25	DNA-sekvens, der koder bovint alfa-lactalbumin, og fremgangsmåder til anvendelse
DK175989A (da)	1989-10-20	Fremgangsmaade til fremstilling af protein
WO2001019846A8 (en)	2001-04-19	Transgenically produced fusion proteins
IL115873A0 (en)	1996-01-31	Transgenic protein production
EP1147184A4 (en)	2002-10-21	REGULATED EXPRESSION OF HETEROLOGOUS PROTEINS IN THE MAMMARY GLAND OF A TRANSGENIC ANIMAL
ATE36348T1 (de)	1988-08-15	Herstellungsverfahren und selektive isolierung von proteinen und polypeptiden, rekombinant und expressionsvektor dazu und schmelzprotein das zum konstanten teil von immoglobulinen binden kann.