DK0748319T3 - Fremgangsmåde til fremstilling af et epoxid - Google Patents

Fremgangsmåde til fremstilling af et epoxid

Info

Publication number: DK0748319T3
Authority: DK; Denmark
Prior art keywords: epoxide; preparing; renin; proteases; synthesizing
Prior art date: 1994-03-04

Application number

DK95911105T

Other languages

Danish (da)

English (en)

Inventor

Ralph P Volante

Kai Rossen

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-27

Publication date

2002-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0748319(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-03-18 Application granted granted Critical

2002-03-18 Publication of DK0748319T3 publication Critical patent/DK0748319T3/da

Links

150000002118 epoxides Chemical class 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
108010010369 HIV Protease Proteins 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
-1 allyl acetonide Chemical compound 0.000 abstract 1
150000003944 halohydrins Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK95911105T 1994-03-04 1995-02-27 Fremgangsmåde til fremstilling af et epoxid DK0748319T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04
PCT/US1995/002347 WO1995023797A1 (en)	1994-03-04	1995-02-27	Process for making an epoxide

Publications (1)

Publication Number	Publication Date
DK0748319T3 true DK0748319T3 (da)	2002-03-18

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95911105T DK0748319T3 (da)	1994-03-04	1995-02-27	Fremgangsmåde til fremstilling af et epoxid

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (de)
JP (1)	JP3871705B2 (de)
KR (1)	KR100387741B1 (de)
CN (1)	CN1066728C (de)
AT (1)	ATE210662T1 (de)
AU (1)	AU690231B2 (de)
BR (1)	BR9506977A (de)
CA (1)	CA2183976C (de)
CZ (1)	CZ291816B6 (de)
DE (1)	DE69524578T2 (de)
DK (1)	DK0748319T3 (de)
ES (1)	ES2167419T3 (de)
FI (1)	FI120259B (de)
HR (1)	HRP950096B1 (de)
HU (1)	HU222750B1 (de)
MX (1)	MX9603871A (de)
NZ (1)	NZ281866A (de)
PT (1)	PT748319E (de)
RO (1)	RO117696B1 (de)
RU (1)	RU2137769C1 (de)
SK (1)	SK283067B6 (de)
TW (1)	TW380137B (de)
UA (1)	UA45968C2 (de)
WO (1)	WO1995023797A1 (de)
YU (1)	YU49010B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
RU2453556C2 (ru)	2005-11-09	2012-06-20	Протеоликс, Инк.	Соединения для ингибирования фермента
RU2450016C2 (ru)	2006-06-19	2012-05-10	Протеоликс, Инк.	Пептидные эпоксикетоны для ингибирования протеасомы
KR20170040374A (ko) *	2007-10-04	2017-04-12	오닉스 세라퓨틱스, 인크.	결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
AU2009308516B2 (en)	2008-10-21	2016-08-25	Onyx Therapeutics, Inc.	Combination therapy with peptide epoxyketones
AR075899A1 (es)	2009-03-20	2011-05-04	Onyx Therapeutics Inc	Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
JP5919196B2 (ja)	2009-11-13	2016-05-18	オニキスセラピューティクス，インク．ＯｎｙｘＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	転移抑制のためのペプチドエポキシケトンの使用
CA2791651C (en)	2010-03-01	2019-08-20	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
JP5865898B2 (ja) *	2010-04-30	2016-02-17	インディアナユニバーシティーリサーチアンドテクノロジーコーポレーションＩｎｄｉａｎａＵｎｉｖｅｒｓｉｔｙＲｅｓｅａｒｃｈＡｎｄＴｅｃｈｎｏｌｏｇｙＣｏｒｐｏｒａｔｉｏｎ	リネゾリドを調製するためのプロセス
JP2015524394A (ja)	2012-07-09	2015-08-24	オニキスセラピューティクス，インク．ＯｎｙｘＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
ATE163926T1 (de) *	1991-11-08	1998-03-15	Merck & Co Inc	Hiv-protease-inhibitoren verwendbar in der aids- behandlung

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 EP EP95911105A patent/EP0748319B1/de not_active Expired - Lifetime
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en not_active Ceased
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0748319A1 (de)	1996-12-18
UA45968C2 (uk)	2002-05-15
FI963452L (fi)	1996-09-03
BR9506977A (pt)	1997-09-02
SK112296A3 (en)	1997-02-05
HRP950096A2 (en)	1997-06-30
EP0748319B1 (de)	2001-12-12
FI120259B (fi)	2009-08-31
YU49010B (sh)	2003-04-30
HUT75611A (en)	1997-05-28
AU1882895A (en)	1995-09-18
YU14595A (sh)	1997-12-05
HU9602412D0 (en)	1996-11-28
SK283067B6 (sk)	2003-02-04
ES2167419T3 (es)	2002-05-16
KR970701714A (ko)	1997-04-12
FI963452A0 (fi)	1996-09-03
WO1995023797A1 (en)	1995-09-08
ATE210662T1 (de)	2001-12-15
CZ291816B6 (cs)	2003-06-18
CZ254396A3 (en)	1997-01-15
HRP950096B1 (en)	2002-06-30
RO117696B1 (ro)	2002-06-28
RU2137769C1 (ru)	1999-09-20
DE69524578T2 (de)	2002-07-18
MX9603871A (es)	1997-07-31
KR100387741B1 (ko)	2003-10-04
CA2183976C (en)	2005-02-01
CA2183976A1 (en)	1995-09-08
HU222750B1 (hu)	2003-09-29
JP3871705B2 (ja)	2007-01-24
JPH09509929A (ja)	1997-10-07
NZ281866A (en)	1998-05-27
DE69524578D1 (de)	2002-01-24
CN1066728C (zh)	2001-06-06
TW380137B (en)	2000-01-21
PT748319E (pt)	2002-05-31
CN1146768A (zh)	1997-04-02
AU690231B2 (en)	1998-04-23

Publication	Publication Date	Title
DK0443449T3 (da)	1997-11-24	Fremgangsmåde til fremstilling af oxetanoner
DK0748319T3 (da)	2002-03-18	Fremgangsmåde til fremstilling af et epoxid
YU27304A (sh)	2006-08-17	Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova
BRPI0013885B8 (pt)	2021-05-25	comprimidos aperfeiçoados
PT931083E (pt)	2003-07-31	Processo para a producao de compostos de ecteinascidina
NO982850L (no)	1998-06-19	Ny syntese
DE122007000045I1 (de)	2007-08-16	Hydroxyethylaminosulfonamide verwendbar als Inhibitoren retroviraler Proteasen
DK0547910T3 (da)	1997-03-24	Fremgangsmåde til fremstilling af 2-chlor-2-deoxyadenosin
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
SG143062A1 (en)	2008-06-27	Synthesis of temozolomide and analogs
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
YU55900A (sh)	2003-02-28	Postupak za sintezu inhibitora hiv proteaze
DE69432176D1 (de)	2003-04-03	Verfahren zur herstellung von hiv protease inhibitoren
EA199900772A1 (ru)	2000-04-24	Способ селективного эпоксидирования для получения лекарственных соединений
DK0912504T3 (da)	2003-01-20	Fremgangsmåde til fremstilling af taxol
DK1105392T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin
NO20032558D0 (no)	2003-06-05	Fremgangsmåte for fremstilling av paklitaxel
DK1280752T3 (da)	2004-11-01	Fremgangsmåde til fremstilling af 2-alkyl-3-chlorphenoler
GB2369356B (en)	2004-02-04	Process
EA199900282A2 (ru)	1999-10-28	Способ получения феноксифенилсульфонилгалогенидов
DE69819504D1 (de)	2003-12-11	Verfahren zur herstellung von 2-alkylthiobenzonitril-derivaten
ATE336493T1 (de)	2006-09-15	Tricyclische epoxide
DK1331218T3 (da)	2007-04-10	Fremgangsmåde til fremstilling af beskyttet 3-amino-1,2-dihydroxypropanacetal og derivater deraf
TW200611691A (en)	2006-04-16	Retroviral protease inhibiting compounds
DK1444244T3 (da)	2005-10-17	Fremgangsmåde til fremstilling af desclarithromycin, samt mellemprodukter