ATE210662T1 - Verfahren zur herstellung von epoxiden - Google Patents

Verfahren zur herstellung von epoxiden

Info

Publication number: ATE210662T1
Authority: AT; Austria
Prior art keywords: epoxies; producing; epoxide; renin; proteases
Prior art date: 1994-03-04

Application number

AT95911105T

Other languages

English (en)

Inventor

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Kai Rossen

Ralph P Volante

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-27

Publication date

2001-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE210662(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE210662T1 publication Critical patent/ATE210662T1/de

Links

239000004593 Epoxy Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
150000002118 epoxides Chemical class 0.000 abstract 2
108010010369 HIV Protease Proteins 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
-1 allyl acetonide Chemical compound 0.000 abstract 1
150000003944 halohydrins Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT95911105T 1994-03-04 1995-02-27 Verfahren zur herstellung von epoxiden ATE210662T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04
PCT/US1995/002347 WO1995023797A1 (en)	1994-03-04	1995-02-27	Process for making an epoxide

Publications (1)

Publication Number	Publication Date
ATE210662T1 true ATE210662T1 (de)	2001-12-15

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95911105T ATE210662T1 (de)	1994-03-04	1995-02-27	Verfahren zur herstellung von epoxiden

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (de)
JP (1)	JP3871705B2 (de)
KR (1)	KR100387741B1 (de)
CN (1)	CN1066728C (de)
AT (1)	ATE210662T1 (de)
AU (1)	AU690231B2 (de)
BR (1)	BR9506977A (de)
CA (1)	CA2183976C (de)
CZ (1)	CZ291816B6 (de)
DE (1)	DE69524578T2 (de)
DK (1)	DK0748319T3 (de)
ES (1)	ES2167419T3 (de)
FI (1)	FI120259B (de)
HR (1)	HRP950096B1 (de)
HU (1)	HU222750B1 (de)
MX (1)	MX9603871A (de)
NZ (1)	NZ281866A (de)
PT (1)	PT748319E (de)
RO (1)	RO117696B1 (de)
RU (1)	RU2137769C1 (de)
SK (1)	SK283067B6 (de)
TW (1)	TW380137B (de)
UA (1)	UA45968C2 (de)
WO (1)	WO1995023797A1 (de)
YU (1)	YU49010B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
JP5436860B2 (ja)	2005-11-09	2014-03-05	オニキスセラピューティクス，インク．	酵素阻害のための化合物
NZ573759A (en)	2006-06-19	2012-03-30	Proteolix Inc	Peptide epoxyketones for proteasome inhibition
EA018973B1 (ru)	2007-10-04	2013-12-30	Оникс Терапьютикс, Инк.	Кристаллические пептидные кето-эпоксидные ингибиторы протеаз и синтез кето-эпоксидов аминокислот
BRPI0919668A2 (pt)	2008-10-21	2018-05-29	Onyx Therapeutics, Inc.	terapia de combinação com epóxi-cetonas de peptídeo
AR075899A1 (es)	2009-03-20	2011-05-04	Onyx Therapeutics Inc	Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
EP2498793B1 (de)	2009-11-13	2019-07-10	Onyx Therapeutics, Inc.	Oprozomib zur verwendung in der metastasensuppression
PH12012501719A1 (en)	2010-03-01	2012-11-12	Onyx Therapeutics Inc	Compounds for immunoproteasome inhibition
EP2899185B1 (de)	2010-04-30	2018-01-31	Indiana University Research and Technology Corporation	Verfahren zur Herstellung von Linezolid
US9309283B2 (en)	2012-07-09	2016-04-12	Onyx Therapeutics, Inc.	Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
CA2081970C (en) *	1991-11-08	1997-07-08	Joseph P. Vacca	Hiv protease inhibitors useful for the treatment of aids

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en not_active Ceased
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 EP EP95911105A patent/EP0748319B1/de not_active Expired - Lifetime
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3871705B2 (ja)	2007-01-24
UA45968C2 (uk)	2002-05-15
HU9602412D0 (en)	1996-11-28
CZ254396A3 (en)	1997-01-15
CA2183976C (en)	2005-02-01
PT748319E (pt)	2002-05-31
CN1066728C (zh)	2001-06-06
YU49010B (sh)	2003-04-30
TW380137B (en)	2000-01-21
EP0748319A1 (de)	1996-12-18
DK0748319T3 (da)	2002-03-18
HU222750B1 (hu)	2003-09-29
DE69524578D1 (de)	2002-01-24
SK112296A3 (en)	1997-02-05
KR100387741B1 (ko)	2003-10-04
HRP950096A2 (en)	1997-06-30
SK283067B6 (sk)	2003-02-04
EP0748319B1 (de)	2001-12-12
RO117696B1 (ro)	2002-06-28
CA2183976A1 (en)	1995-09-08
YU14595A (sh)	1997-12-05
RU2137769C1 (ru)	1999-09-20
HUT75611A (en)	1997-05-28
CN1146768A (zh)	1997-04-02
AU690231B2 (en)	1998-04-23
FI963452A0 (fi)	1996-09-03
NZ281866A (en)	1998-05-27
ES2167419T3 (es)	2002-05-16
WO1995023797A1 (en)	1995-09-08
MX9603871A (es)	1997-07-31
FI963452L (fi)	1996-09-03
CZ291816B6 (cs)	2003-06-18
HRP950096B1 (en)	2002-06-30
KR970701714A (ko)	1997-04-12
FI120259B (fi)	2009-08-31
AU1882895A (en)	1995-09-18
BR9506977A (pt)	1997-09-02
DE69524578T2 (de)	2002-07-18
JPH09509929A (ja)	1997-10-07

Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2011-12-15	EEFA	Change of the company name

Publication	Publication Date	Title
UA50730C2 (uk)	2002-11-15	Спосіб одержання 1-(тіометил)циклопропаноцтової кислоти та проміжних сполук для її одержання
NO910712D0 (no)	1991-02-22	Fremgangsmaate ved fremstilling av oksetanoner.
NO303574B1 (no)	1998-08-03	Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner
DE69524578D1 (de)	2002-01-24	Verfahren zur herstellung von epoxiden
EP0641333A1 (de)	1995-03-08	Verfahren zur herstellung von intermediaten in der synthese von retroviralen protease inhibitoren.
YU27304A (sh)	2006-08-17	Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
DE60100238D1 (de)	2003-06-12	Synthese von 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-2H-Pyran-2-one
ATE277915T1 (de)	2004-10-15	Verfahren sowie neue zwischenprodukte zur herstellung von isoxazolin-3-yl-acylbenzolen
EA199800034A1 (ru)	1998-08-27	Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
DE60103759D1 (de)	2004-07-15	Kontinuierliches verfahren zur herstellung von oxiranen
DE69432176D1 (de)	2003-04-03	Verfahren zur herstellung von hiv protease inhibitoren
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
ATE281434T1 (de)	2004-11-15	Verfahren zur herstellung von benzoperhydroisoindolen
EA199900772A1 (ru)	2000-04-24	Способ селективного эпоксидирования для получения лекарственных соединений
ATE191907T1 (de)	2000-05-15	Verfahren zur herstellung von zwischenprodukten, die für die herstellung von retroviral-protease hemmenden verbindungen verwendbar sind
ATE156819T1 (de)	1997-08-15	Verfahren zur herstellung einer oxazolidincarbon säure nützlich für die herstellung von therapeutischen taxoiden
DE60014330D1 (de)	2004-11-04	Verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan
DE69819504D1 (de)	2003-12-11	Verfahren zur herstellung von 2-alkylthiobenzonitril-derivaten
DE60102483D1 (de)	2004-04-29	Verfahren zur herstellung optisch-aktiver epoxide
ATE299147T1 (de)	2005-07-15	Verfahren zur herstellung von 3-amino-1,5- benzodiazepinderivaten
DE69620244D1 (de)	2002-05-02	Verfahren zur herstellung von prostaglandin e1