ES2167419T3 - Procedimiento de fabricacion de un epoxido. - Google Patents

Procedimiento de fabricacion de un epoxido.

Info

Publication number
ES2167419T3
ES2167419T3 ES95911105T ES95911105T ES2167419T3 ES 2167419 T3 ES2167419 T3 ES 2167419T3 ES 95911105 T ES95911105 T ES 95911105T ES 95911105 T ES95911105 T ES 95911105T ES 2167419 T3 ES2167419 T3 ES 2167419T3
Authority
ES
Spain
Prior art keywords
epoxide
manufacturing procedure
proteases
rhinine
halohidrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95911105T
Other languages
English (en)
Inventor
David Askin
Kan K Eng
Peter E Maligres
Paul J Reider
Kai Rossen
Ralph P Volante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2167419(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2167419T3 publication Critical patent/ES2167419T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN PROCESO PARA SINTETIZAR EL EPOXIDO DE FORMULA (I) SE COMPONE DE, COMO MINIMO, LA FORMACION DEL REACTIVO ALIL ACETONIDA EN SU FORMA DE HALOHIDRINA, SEGUIDA DE UNA CICLIZACION INDUCIDA DE BASE, EL PRODUCTO EPOXIDO (I) SIENDO UTIL COMO UN INTERMEDIO PARA LA SINTESIS DE LOS INHIBIDORES DE RENINA O PROTEASAS DEL HIV U OTRAS PROTEASAS
ES95911105T 1994-03-04 1995-02-27 Procedimiento de fabricacion de un epoxido. Expired - Lifetime ES2167419T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04

Publications (1)

Publication Number Publication Date
ES2167419T3 true ES2167419T3 (es) 2002-05-16

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95911105T Expired - Lifetime ES2167419T3 (es) 1994-03-04 1995-02-27 Procedimiento de fabricacion de un epoxido.

Country Status (25)

Country Link
EP (1) EP0748319B1 (es)
JP (1) JP3871705B2 (es)
KR (1) KR100387741B1 (es)
CN (1) CN1066728C (es)
AT (1) ATE210662T1 (es)
AU (1) AU690231B2 (es)
BR (1) BR9506977A (es)
CA (1) CA2183976C (es)
CZ (1) CZ291816B6 (es)
DE (1) DE69524578T2 (es)
DK (1) DK0748319T3 (es)
ES (1) ES2167419T3 (es)
FI (1) FI120259B (es)
HR (1) HRP950096B1 (es)
HU (1) HU222750B1 (es)
MX (1) MX9603871A (es)
NZ (1) NZ281866A (es)
PT (1) PT748319E (es)
RO (1) RO117696B1 (es)
RU (1) RU2137769C1 (es)
SK (1) SK283067B6 (es)
TW (1) TW380137B (es)
UA (1) UA45968C2 (es)
WO (1) WO1995023797A1 (es)
YU (1) YU49010B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
JP5436860B2 (ja) 2005-11-09 2014-03-05 オニキス セラピューティクス， インク． 酵素阻害のための化合物
NZ573759A (en) 2006-06-19 2012-03-30 Proteolix Inc Peptide epoxyketones for proteasome inhibition
EA018973B1 (ru) 2007-10-04 2013-12-30 Оникс Терапьютикс, Инк. Кристаллические пептидные кето-эпоксидные ингибиторы протеаз и синтез кето-эпоксидов аминокислот
BRPI0919668A2 (pt) 2008-10-21 2018-05-29 Onyx Therapeutics, Inc. terapia de combinação com epóxi-cetonas de peptídeo
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
PH12012501719A1 (en) 2010-03-01 2012-11-12 Onyx Therapeutics Inc Compounds for immunoproteasome inhibition
EP2899185B1 (en) 2010-04-30 2018-01-31 Indiana University Research and Technology Corporation Processes for preparing linezolid
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids

Also Published As

Publication number Publication date
JP3871705B2 (ja) 2007-01-24
UA45968C2 (uk) 2002-05-15
HU9602412D0 (en) 1996-11-28
ATE210662T1 (de) 2001-12-15
CZ254396A3 (en) 1997-01-15
CA2183976C (en) 2005-02-01
PT748319E (pt) 2002-05-31
CN1066728C (zh) 2001-06-06
YU49010B (sh) 2003-04-30
TW380137B (en) 2000-01-21
EP0748319A1 (en) 1996-12-18
DK0748319T3 (da) 2002-03-18
HU222750B1 (hu) 2003-09-29
DE69524578D1 (de) 2002-01-24
SK112296A3 (en) 1997-02-05
KR100387741B1 (ko) 2003-10-04
HRP950096A2 (en) 1997-06-30
SK283067B6 (sk) 2003-02-04
EP0748319B1 (en) 2001-12-12
RO117696B1 (ro) 2002-06-28
CA2183976A1 (en) 1995-09-08
YU14595A (sh) 1997-12-05
RU2137769C1 (ru) 1999-09-20
HUT75611A (en) 1997-05-28
CN1146768A (zh) 1997-04-02
AU690231B2 (en) 1998-04-23
FI963452A0 (fi) 1996-09-03
NZ281866A (en) 1998-05-27
WO1995023797A1 (en) 1995-09-08
MX9603871A (es) 1997-07-31
FI963452L (fi) 1996-09-03
CZ291816B6 (cs) 2003-06-18
HRP950096B1 (en) 2002-06-30
KR970701714A (ko) 1997-04-12
FI120259B (fi) 2009-08-31
AU1882895A (en) 1995-09-18
BR9506977A (pt) 1997-09-02
DE69524578T2 (de) 2002-07-18
JPH09509929A (ja) 1997-10-07

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