DK0754679T3 - Fremgangsmåde til fremstilling af creatin eller creatin-monohydrat - Google Patents

Fremgangsmåde til fremstilling af creatin eller creatin-monohydrat

Info

Publication number: DK0754679T3
Authority: DK; Denmark
Prior art keywords: creatine; water; pref; monohydrate; cyanamide
Prior art date: 1995-07-18

Application number

DK96111542T

Other languages

English (en)

Inventor

Stefan Dr Weiss

Helmut Krommer

Original Assignee

Sueddeutsche Kalkstickstoff

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-18

Filing date

1996-07-17

Publication date

1999-07-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7767164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0754679(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-07-17 Application filed by Sueddeutsche Kalkstickstoff filed Critical Sueddeutsche Kalkstickstoff

1999-07-12 Application granted granted Critical

1999-07-12 Publication of DK0754679T3 publication Critical patent/DK0754679T3/da

Links

CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title abstract 6
229960003624 creatine Drugs 0.000 title abstract 3
239000006046 creatine Substances 0.000 title abstract 3
MEJYXFHCRXAUIL-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;hydrate Chemical compound O.NC(=N)N(C)CC(O)=O MEJYXFHCRXAUIL-UHFFFAOYSA-N 0.000 title abstract 2
229960004826 creatine monohydrate Drugs 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 3
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
108010077895 Sarcosine Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001912 cyanamides Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
229940043230 sarcosine Drugs 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK96111542T 1995-07-18 1996-07-17 Fremgangsmåde til fremstilling af creatin eller creatin-monohydrat DK0754679T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19526236A DE19526236A1 (de)	1995-07-18	1995-07-18	Verfahren zur Herstellung von Kreatin bzw. Kreatin-monohydrat

Publications (1)

Publication Number	Publication Date
DK0754679T3 true DK0754679T3 (da)	1999-07-12

Family

ID=7767164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96111542T DK0754679T3 (da)	1995-07-18	1996-07-17	Fremgangsmåde til fremstilling af creatin eller creatin-monohydrat

Country Status (16)

Country	Link
US (1)	US5719319A (da)
EP (1)	EP0754679B1 (da)
JP (1)	JP3056416B2 (da)
CN (1)	CN1061647C (da)
AT (1)	ATE172715T1 (da)
CA (1)	CA2181026C (da)
CZ (1)	CZ290563B6 (da)
DE (2)	DE19526236A1 (da)
DK (1)	DK0754679T3 (da)
ES (1)	ES2126355T3 (da)
HU (1)	HU218820B (da)
NO (1)	NO305200B1 (da)
PL (1)	PL184404B1 (da)
RU (1)	RU2163233C2 (da)
SI (1)	SI0754679T1 (da)
SK (1)	SK280544B6 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7718798A (en) *	1997-05-30	1998-12-30	Kellogg Company	Creatine containing cereal-based food product, processes for making these, and uses thereof
US6465018B1 (en) *	1997-08-22	2002-10-15	B. David Tuttle	Dietary supplement for increasing energy, strength, and immune function
DE19748695A1 (de) *	1997-11-04	1999-05-06	Basf Ag	Verfahren zur Herstellung von substituierten Guanidinderivaten
DE19748694A1 (de) *	1997-11-04	1999-05-06	Basf Ag	Verfahren zur Herstellung von substituierten Guanidinderivaten
DE19748697A1 (de) *	1997-11-04	1999-05-06	Basf Ag	Verfahren zur Herstellung von substituierten Guanidinderivaten
DE19748696A1 (de) *	1997-11-04	1999-05-06	Basf Ag	Verfahren zur Herstellung von substituierten Guanidinderivaten
CN1097578C (zh) *	1998-06-19	2003-01-01	李森	高纯度肌酸及其一水合物的生产工艺
DE19841525A1 (de) *	1998-09-10	2000-03-16	Basf Ag	Verfahren zur Herstellung von Kreatin oder Kreatin-monohydrat
DE19860048A1 (de) *	1998-12-23	2000-06-29	Basf Ag	Verfahren zur Herstellung von Guanidinderivaten
DE19905711A1 (de) *	1999-02-11	2000-08-17	Basf Ag	Verfahren zur Herstellung von Guanidinderivaten
CN1098251C (zh) *	1999-09-07	2003-01-08	天津天成制药有限公司	制备肌酸或肌酸-水合物的方法
DE19962227A1 (de) *	1999-12-22	2001-06-28	Basf Ag	Verfahren zur Reinigung von Kreatin
AU2003273939A1 (en) *	2002-10-04	2004-04-23	Flexsys B.V.	Process for the synthesis of guanidine derivatives
DE10331481A1 (de) *	2003-07-11	2005-02-24	Degussa Ag	Verfahren zur Reduzierung der Formaldehyd- und Cyanid-Gehalte in Lösungen von Sarkosinsalzen
DE102006016227A1 (de) *	2006-04-06	2007-10-11	Degussa Gmbh	Verfahren zur Herstellung von Kreatin, Kreatin-Monohydrat oder Guanidinoessigsäure
CN101434563B (zh) *	2008-12-15	2011-06-22	太仓市新毛涤纶化工有限公司	肌酸一水物的制备方法
CN102329249A (zh) *	2011-07-22	2012-01-25	周彬	胍基丙酸的化学合成方法
CN104080448B (zh) *	2011-11-10	2018-02-13	西泽广久	肌酸组合物的摄取方法及在该摄取方法中使用的肌酸组合物以及使用所述肌酸组合物制成的含肌酸的药剂及食品
WO2014121648A1 (zh) *	2013-02-05	2014-08-14	江苏远洋药业股份有限公司	一种肌酸的合成方法
CN104086461B (zh) *	2014-07-07	2016-02-24	上海宝穗化工有限公司	一水肌酸的制备方法
CN107721882A (zh) *	2016-08-11	2018-02-23	宁夏天成生化科技有限公司	一种n‑甲基胍基丙酸的制备方法
CN106831495A (zh) *	2016-12-28	2017-06-13	安徽省虹升生物股份有限公司	一种一水肌酸的化工合成方法
CN110596269B (zh) *	2019-09-20	2022-03-04	汤臣倍健股份有限公司	一种同时检测肌酸粉中多种成分的含量测定方法
DK4208436T3 (da) *	2020-09-01	2024-07-22	Evonik Operations Gmbh	Fremgangsmåde til fremstilling af guanidinoeddikesyre
CN115322122A (zh) *	2022-09-14	2022-11-11	宁夏太康药业有限公司	一种肌氨酸螯合钙水溶液制备一水肌酸的方法
CN116041226B (zh) *	2022-12-16	2024-06-11	山东阳谷华泰化工股份有限公司	一种连续合成一水肌酸的方法
EP4455123A1 (en) *	2023-09-20	2024-10-30	Qiangjiang Yongan Pharmaceutical Co., Ltd.	Novel preparation method for sarcosine and derivatives thereof
CN119039182A (zh) *	2024-08-15	2024-11-29	河北博泽化工有限责任公司	一种连续生产高纯度一水肌酸的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE494918C (de) *	1926-10-29	1930-03-31	Schering Kahlbaum Akt Ges	Verfahren zur Darstellung von Guanidinen
US1967400A (en) *	1930-03-27	1934-07-24	Schering Kahlbaum Ag	Production of guanidino fatty acids
US2574510A (en) *	1947-02-04	1951-11-13	American Cyanamid Co	Cationic surface active agents and method of preparation
US2654779A (en) *	1950-12-23	1953-10-06	Int Minerals & Chem Corp	Method of preparation of guanidino fatty acids
US2620354A (en) *	1951-01-12	1952-12-02	Int Minerals & Chem Corp	Production of guanidino fatty acids
CH401989A (fr) *	1958-09-26	1965-11-15	Kuhlmann Ets	Procédé de préparation de la phosphocréatine
FR1210435A (fr) *	1958-09-26	1960-03-08	Cfmc	Procédé de synthèse de la phosphocréatine
JPS59500B2 (ja) *	1978-06-28	1984-01-07	富郎岩井	クレアチンの製造法
SU1708810A1 (ru) *	1989-10-18	1992-01-30	Ленинградский государственный университет	Сол нокислые соли эфиров гуанидинэнантовой кислоты в качестве гидрофобных анионообменников
EP0646573A1 (en) *	1993-09-30	1995-04-05	Hoechst Aktiengesellschaft	Preparation of protected and unprotected guanidino-substituted carboxylic acids

1995
- 1995-07-18 DE DE19526236A patent/DE19526236A1/de not_active Withdrawn
1996
- 1996-06-26 CZ CZ19961885A patent/CZ290563B6/cs not_active IP Right Cessation
- 1996-06-28 JP JP8169945A patent/JP3056416B2/ja not_active Expired - Fee Related
- 1996-07-09 US US08/677,073 patent/US5719319A/en not_active Expired - Lifetime
- 1996-07-10 CN CN96110631A patent/CN1061647C/zh not_active Expired - Lifetime
- 1996-07-11 CA CA002181026A patent/CA2181026C/en not_active Expired - Lifetime
- 1996-07-17 DE DE59600727T patent/DE59600727D1/de not_active Expired - Lifetime
- 1996-07-17 SI SI9630027T patent/SI0754679T1/xx not_active IP Right Cessation
- 1996-07-17 NO NO962984A patent/NO305200B1/no not_active IP Right Cessation
- 1996-07-17 RU RU96115328/04A patent/RU2163233C2/ru not_active IP Right Cessation
- 1996-07-17 AT AT96111542T patent/ATE172715T1/de active
- 1996-07-17 HU HU9601954A patent/HU218820B/hu not_active IP Right Cessation
- 1996-07-17 ES ES96111542T patent/ES2126355T3/es not_active Expired - Lifetime
- 1996-07-17 PL PL96315319A patent/PL184404B1/pl unknown
- 1996-07-17 EP EP96111542A patent/EP0754679B1/de not_active Expired - Lifetime
- 1996-07-17 DK DK96111542T patent/DK0754679T3/da active
- 1996-07-18 SK SK939-96A patent/SK280544B6/sk not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5719319A (en)	1998-02-17
DE59600727D1 (de)	1998-12-03
JPH0931043A (ja)	1997-02-04
DE19526236A1 (de)	1997-01-23
RU2163233C2 (ru)	2001-02-20
HU218820B (hu)	2000-12-28
ATE172715T1 (de)	1998-11-15
CN1061647C (zh)	2001-02-07
HU9601954D0 (en)	1996-09-30
CA2181026A1 (en)	1997-01-19
HUP9601954A1 (en)	1997-05-28
JP3056416B2 (ja)	2000-06-26
CZ290563B6 (cs)	2002-08-14
NO962984D0 (no)	1996-07-17
NO305200B1 (no)	1999-04-19
PL184404B1 (pl)	2002-10-31
NO962984L (no)	1997-01-20
EP0754679B1 (de)	1998-10-28
SK93996A3 (en)	1997-03-05
EP0754679A1 (de)	1997-01-22
SI0754679T1 (en)	1998-12-31
ES2126355T3 (es)	1999-03-16
PL315319A1 (en)	1997-01-20
HUP9601954A3 (en)	1998-07-28
CZ188596A3 (en)	1997-02-12
CA2181026C (en)	2004-04-27
CN1140707A (zh)	1997-01-22
SK280544B6 (sk)	2000-03-13

Publication	Publication Date	Title
NO962984L (no)	1997-01-20	Fremgangsmåte for fremstilling av kreatin eller kreatinmonohydrat
RU96115328A (ru)	1998-10-20	Способ получения креатина или моногидрата креатина
DK0985661T3 (da)	2002-03-25	Fremgangsmåde til fremstilling af kreatin eller kreatin-monohydrat
KR930019616A (ko)	1993-10-18	구아니딘 유도체의 제조 방법
GB1509950A (en)	1978-05-10	Urea manufacture
JPS54132520A (en)	1979-10-15	Preparation of colorless methionine
JPS5352274A (en)	1978-05-12	Treating method for aqueous solution containing urea, ammonia and carbondioxide
CA2045220A1 (en)	1991-12-28	Process for the production of chlorine dioxide
SU1047903A1 (ru)	1983-10-15	Способ получени 2,2,7,7-тетраметил-5-оксогексагидро-1,4-диазепин-1-оксила
RU2154627C2 (ru)	2000-08-20	Способ получения нитрометана
JPS6479134A (en)	1989-03-24	Production of optically active (r)-2-hydroxy-4-phenyllactic acid
JPS54138556A (en)	1979-10-27	Preparation of hydantoin
JPS6440453A (en)	1989-02-10	Racemization of optically active serine
JPS554349A (en)	1980-01-12	Preparation of creatine
YAMANA et al.	1968	Studies on the stability of drugs. XVII. Stability of benzothiadiazines.(8). Kinetics of acid-base catalysed hydrolysis of chlorothiazide
CA1111444A (en)	1981-10-27	Process for production of beta-chloroalanine
JPS55151554A (en)	1980-11-26	Production of dihydroperoxide
CA2242685A1 (en)	1999-02-01	Nitric acid based chlorine dioxide generation process
JPS61167670A (ja)	1986-07-29	ヒダントイン製造における着色防止法
JPS56125358A (en)	1981-10-01	Preparation of guanidine sulfamate
JPS5772983A (en)	1982-05-07	Preparation of 1,2,3,4,6,7,8,9-octahydrophenazine
KR790001554B1 (ko)	1979-10-30	S-카복시메틸-시스테인의 신규한 제조방법
SU1334658A1 (ru)	1995-10-10	Способ получения м-хлордифенилметилмочевины
SU1744946A1 (ru)	1998-11-10	Способ получения смеси изомеров 9-(2-хлорэтил)-7-нитрозо-l-гомоцитруллина и 9-(2-хлорэтил)-9-нитрозо-l-гомоцитруллина
SU1541218A1 (ru)	1996-05-20	Способ получения производных декстрана