JPS554349A - Preparation of creatine - Google Patents

Preparation of creatine

Info

Publication number
JPS554349A
JPS554349A JP7736478A JP7736478A JPS554349A JP S554349 A JPS554349 A JP S554349A JP 7736478 A JP7736478 A JP 7736478A JP 7736478 A JP7736478 A JP 7736478A JP S554349 A JPS554349 A JP S554349A
Authority
JP
Japan
Prior art keywords
sarcosine
aqueous solution
creatine
maintained
always
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7736478A
Other languages
Japanese (ja)
Other versions
JPS59500B2 (en
Inventor
Tomiro Iwai
Tomiyasu Tsunoda
Ichiro Yamamoto
Masao Kuronuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP7736478A priority Critical patent/JPS59500B2/en
Publication of JPS554349A publication Critical patent/JPS554349A/en
Publication of JPS59500B2 publication Critical patent/JPS59500B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain creatine, a remedy for muscular dystrophy, in high yield and purity, without forming mercaptans, by reacting an 0-alkylisourea with an aqueous solution of sarcosine maintained always alkaline.
CONSTITUTION: An 0-alkyl isourea is reacted with an aqueous solution of sarcosine always maintained at a pH of 10W12 for more than 3W4 hr to give creatine. A commercially available 30W38% aqueous solution of the sodium salt is directly used as the sarcosine. The reaction is carried out at 5°C to ordinary temperature with vigorous stirring.
COPYRIGHT: (C)1980,JPO&Japio
JP7736478A 1978-06-28 1978-06-28 Creatine manufacturing method Expired JPS59500B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7736478A JPS59500B2 (en) 1978-06-28 1978-06-28 Creatine manufacturing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7736478A JPS59500B2 (en) 1978-06-28 1978-06-28 Creatine manufacturing method

Publications (2)

Publication Number Publication Date
JPS554349A true JPS554349A (en) 1980-01-12
JPS59500B2 JPS59500B2 (en) 1984-01-07

Family

ID=13631842

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7736478A Expired JPS59500B2 (en) 1978-06-28 1978-06-28 Creatine manufacturing method

Country Status (1)

Country Link
JP (1) JPS59500B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719319A (en) * 1995-07-18 1998-02-17 Skw Trostberg Aktiengesellschaft Process for the preparation of a creatine or creatine monohydrate
US5969182A (en) * 1997-11-04 1999-10-19 Basf Aktiengesellschaft Preparation of substituted guanidine derivatives
EP0915083A3 (en) * 1997-11-04 1999-12-08 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives
EP1013640A1 (en) * 1998-12-23 2000-06-28 Basf Aktiengesellschaft Synthesis of guanidines from O-alkylisoureas using a crystal seed

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719319A (en) * 1995-07-18 1998-02-17 Skw Trostberg Aktiengesellschaft Process for the preparation of a creatine or creatine monohydrate
CN1061647C (en) * 1995-07-18 2001-02-07 Skw特罗斯特贝格股份公司 Process for preparing creatine or creatine-hydrate
US5969182A (en) * 1997-11-04 1999-10-19 Basf Aktiengesellschaft Preparation of substituted guanidine derivatives
EP0915083A3 (en) * 1997-11-04 1999-12-08 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives
EP0915085A3 (en) * 1997-11-04 1999-12-08 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives
US6093848A (en) * 1997-11-04 2000-07-25 Basf Aktiengesellschaft Preparation of substituted guanidine derivatives
EP1013640A1 (en) * 1998-12-23 2000-06-28 Basf Aktiengesellschaft Synthesis of guanidines from O-alkylisoureas using a crystal seed
US6143929A (en) * 1998-12-23 2000-11-07 Basf Aktiengesellschaft Process for preparing guanidine derivatives

Also Published As

Publication number Publication date
JPS59500B2 (en) 1984-01-07

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