DK0755919T3 - Substituerede kanelsyreguanidider, fremgangsmåde til deres fremstilling, deres anvendelse som hjerte-kredsløbs-medikament e - Google Patents

Substituerede kanelsyreguanidider, fremgangsmåde til deres fremstilling, deres anvendelse som hjerte-kredsløbs-medikament e

Info

Publication number: DK0755919T3
Authority: DK; Denmark
Prior art keywords: preparation; cinnamic acid; cardiovascular drug; substituted cinnamic; guanides
Prior art date: 1995-07-26

Application number

DK96111665T

Other languages

English (en)

Inventor

Jan-Robert Schwark

Joachim Brendel

Heinz-Werner Kleemann

Hans Jochen Lang

Andreas Weichert

Udo Albus

Wolfgang Scholz

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-26

Filing date

1996-07-19

Publication date

2000-04-25

1996-07-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

2000-04-25 Application granted granted Critical

2000-04-25 Publication of DK0755919T3 publication Critical patent/DK0755919T3/da

Links

WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 title 1
239000002327 cardiovascular agent Substances 0.000 title 1
229940125692 cardiovascular agent Drugs 0.000 title 1
229930016911 cinnamic acid Natural products 0.000 title 1
235000013985 cinnamic acid Nutrition 0.000 title 1
150000001851 cinnamic acid derivatives Chemical class 0.000 title 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK96111665T 1995-07-26 1996-07-19 Substituerede kanelsyreguanidider, fremgangsmåde til deres fremstilling, deres anvendelse som hjerte-kredsløbs-medikament e DK0755919T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19527305A DE19527305A1 (de)	1995-07-26	1995-07-26	Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number	Publication Date
DK0755919T3 true DK0755919T3 (da)	2000-04-25

Family

ID=7767840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96111665T DK0755919T3 (da)	1995-07-26	1996-07-19	Substituerede kanelsyreguanidider, fremgangsmåde til deres fremstilling, deres anvendelse som hjerte-kredsløbs-medikament e

Country Status (29)

Country	Link
US (1)	US5883133A (da)
EP (1)	EP0755919B1 (da)
JP (1)	JP4177466B2 (da)
KR (1)	KR970006281A (da)
CN (1)	CN1062554C (da)
AR (1)	AR003467A1 (da)
AT (1)	ATE186720T1 (da)
AU (1)	AU704461B2 (da)
BR (1)	BR9603179A (da)
CA (1)	CA2182062C (da)
CZ (1)	CZ289327B6 (da)
DE (2)	DE19527305A1 (da)
DK (1)	DK0755919T3 (da)
ES (1)	ES2140765T3 (da)
GR (1)	GR3032363T3 (da)
HR (1)	HRP960356B1 (da)
HU (1)	HUP9602072A3 (da)
IL (1)	IL118925A (da)
MX (1)	MX9603004A (da)
MY (1)	MY115466A (da)
NO (1)	NO306060B1 (da)
NZ (1)	NZ299052A (da)
PL (1)	PL183439B1 (da)
RU (1)	RU2190601C2 (da)
SI (1)	SI0755919T1 (da)
SK (1)	SK282018B6 (da)
TR (1)	TR199600612A2 (da)
TW (1)	TW536531B (da)
ZA (1)	ZA966313B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19527305A1 (de) *	1995-07-26	1997-01-30	Hoechst Ag	Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6867203B2 (en)	1998-12-29	2005-03-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6110922A (en)	1998-12-29	2000-08-29	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6878700B1 (en)	1998-12-29	2005-04-12	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
DE10024319A1 (de) *	2000-05-17	2001-11-22	Merck Patent Gmbh	Bisacylguanidine
GB0015205D0 (en) *	2000-06-21	2000-08-09	Karobio Ab	Bioisosteric thyroid receptor ligands and method
CN1705649A (zh)	2000-06-29	2005-12-07	艾伯特公司	芳基苯基杂环基硫醚衍生物及其作为抑制细胞粘附的抗炎和免疫抑制剂的用途
US6521619B2 (en)	2000-06-29	2003-02-18	Icos Corporation	Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
DE10046993A1 (de) *	2000-09-22	2002-04-11	Aventis Pharma Gmbh	Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
SG165988A1 (en) *	2001-11-29	2010-11-29	Theracos Inc	Compounds for treatment of inflammation, diabetes and related disorders
DE10258168B4 (de) *	2002-12-12	2005-07-07	Infineon Technologies Ag	Integrierter DRAM-Halbleiterspeicher und Verfahren zum Betrieb desselben
BRPI0411900B8 (pt)	2003-06-26	2021-05-25	Biotron Ltd	compostos e composições farmacêuticas compreendendo os mesmos
PT2826770T (pt)	2005-06-24	2018-12-18	Biotron Ltd	Compostos acilguanidinas com atividade antiviral
US20120088737A2 (en) *	2009-10-02	2012-04-12	Ajinomoto Co., Inc	Novel acyl guanidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2734904A (en) *		1956-02-14		Xcxnhxc-nh
US4544670A (en)	1982-08-24	1985-10-01	William H. Rorer, Inc.	Method of treating coccidiosis with acyl guanidines
CN1036267C (zh) *	1992-02-15	1997-10-29	赫彻斯特股份公司	氨基取代的苯甲酰胍的制备方法
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE4325822A1 (de) *	1993-07-31	1995-02-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4327244A1 (de) *	1993-08-13	1995-02-16	Hoechst Ag	Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19527305A1 (de) *	1995-07-26	1997-01-30	Hoechst Ag	Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1995
- 1995-07-26 DE DE19527305A patent/DE19527305A1/de not_active Withdrawn
1996
- 1996-05-16 PL PL96314279A patent/PL183439B1/pl unknown
- 1996-07-19 DE DE59603659T patent/DE59603659D1/de not_active Expired - Lifetime
- 1996-07-19 SI SI9630144T patent/SI0755919T1/xx unknown
- 1996-07-19 EP EP96111665A patent/EP0755919B1/de not_active Expired - Lifetime
- 1996-07-19 ES ES96111665T patent/ES2140765T3/es not_active Expired - Lifetime
- 1996-07-19 AT AT96111665T patent/ATE186720T1/de not_active IP Right Cessation
- 1996-07-19 DK DK96111665T patent/DK0755919T3/da active
- 1996-07-23 CN CN96110200A patent/CN1062554C/zh not_active Expired - Fee Related
- 1996-07-24 CZ CZ19962184A patent/CZ289327B6/cs not_active IP Right Cessation
- 1996-07-24 MY MYPI96003033A patent/MY115466A/en unknown
- 1996-07-24 IL IL11892596A patent/IL118925A/en not_active IP Right Cessation
- 1996-07-24 TR TR96/00612A patent/TR199600612A2/xx unknown
- 1996-07-24 US US08/686,999 patent/US5883133A/en not_active Expired - Lifetime
- 1996-07-24 NZ NZ299052A patent/NZ299052A/en unknown
- 1996-07-24 AR ARP960103724A patent/AR003467A1/es unknown
- 1996-07-24 AU AU60668/96A patent/AU704461B2/en not_active Ceased
- 1996-07-24 SK SK965-96A patent/SK282018B6/sk unknown
- 1996-07-25 MX MX9603004A patent/MX9603004A/es not_active IP Right Cessation
- 1996-07-25 BR BR9603179-4A patent/BR9603179A/pt unknown
- 1996-07-25 HR HR19527305.2 patent/HRP960356B1/xx not_active IP Right Cessation
- 1996-07-25 JP JP19628396A patent/JP4177466B2/ja not_active Expired - Fee Related
- 1996-07-25 NO NO963108A patent/NO306060B1/no unknown
- 1996-07-25 CA CA002182062A patent/CA2182062C/en not_active Expired - Fee Related
- 1996-07-25 RU RU96115333/04A patent/RU2190601C2/ru not_active IP Right Cessation
- 1996-07-25 ZA ZA9606313A patent/ZA966313B/xx unknown
- 1996-07-26 HU HU9602072A patent/HUP9602072A3/hu unknown
- 1996-07-26 KR KR1019960031743A patent/KR970006281A/ko not_active Ceased
- 1996-08-23 TW TW085110279A patent/TW536531B/zh active
2000
- 2000-01-14 GR GR20000400061T patent/GR3032363T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
SI0755919T1 (en)	2000-04-30
HRP960356B1 (en)	2001-02-28
EP0755919A3 (de)	1997-04-09
RU2190601C2 (ru)	2002-10-10
NO306060B1 (no)	1999-09-13
EP0755919B1 (de)	1999-11-17
PL314279A1 (en)	1997-02-03
GR3032363T3 (en)	2000-04-27
HUP9602072A3 (en)	1997-10-28
CA2182062A1 (en)	1997-01-27
NO963108L (no)	1997-01-27
IL118925A0 (en)	1996-10-31
SK96596A3 (en)	1997-03-05
AU6066896A (en)	1997-01-30
SK282018B6 (sk)	2001-10-08
ZA966313B (en)	1997-02-11
JPH0952823A (ja)	1997-02-25
CN1062554C (zh)	2001-02-28
JP4177466B2 (ja)	2008-11-05
NO963108D0 (no)	1996-07-25
CN1145899A (zh)	1997-03-26
DE19527305A1 (de)	1997-01-30
MY115466A (en)	2003-06-30
CZ289327B6 (cs)	2002-01-16
IL118925A (en)	2001-08-08
HRP960356A2 (en)	1998-02-28
NZ299052A (en)	1997-10-24
CA2182062C (en)	2008-12-02
DE59603659D1 (de)	1999-12-23
AR003467A1 (es)	1998-08-05
HU9602072D0 (en)	1996-09-30
HUP9602072A2 (en)	1997-05-28
TW536531B (en)	2003-06-11
PL183439B1 (pl)	2002-06-28
TR199600612A2 (tr)	1997-04-22
AU704461B2 (en)	1999-04-22
ATE186720T1 (de)	1999-12-15
US5883133A (en)	1999-03-16
BR9603179A (pt)	2002-04-09
MX9603004A (es)	1997-01-31
KR970006281A (ko)	1997-02-19
ES2140765T3 (es)	2000-03-01
EP0755919A2 (de)	1997-01-29
CZ218496A3 (en)	1997-02-12

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