DK0763131T3 - Assay for tetanus- og botulinumtoksiner - Google Patents
Assay for tetanus- og botulinumtoksinerInfo
- Publication number
- DK0763131T3 DK0763131T3 DK95921033T DK95921033T DK0763131T3 DK 0763131 T3 DK0763131 T3 DK 0763131T3 DK 95921033 T DK95921033 T DK 95921033T DK 95921033 T DK95921033 T DK 95921033T DK 0763131 T3 DK0763131 T3 DK 0763131T3
- Authority
- DK
- Denmark
- Prior art keywords
- assay
- tetanus
- toxin
- substrate
- botulinum toxins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9411138A GB9411138D0 (en) | 1994-06-03 | 1994-06-03 | Toxin assay |
| PCT/GB1995/001279 WO1995033850A1 (en) | 1994-06-03 | 1995-06-02 | Toxin assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0763131T3 true DK0763131T3 (da) | 1999-12-13 |
Family
ID=10756143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95921033T DK0763131T3 (da) | 1994-06-03 | 1995-06-02 | Assay for tetanus- og botulinumtoksiner |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0763131B1 (da) |
| JP (1) | JP4246259B2 (da) |
| AT (1) | ATE183779T1 (da) |
| AU (1) | AU687564B2 (da) |
| CA (1) | CA2191895C (da) |
| DE (1) | DE69511693T2 (da) |
| DK (1) | DK0763131T3 (da) |
| GB (1) | GB9411138D0 (da) |
| WO (1) | WO1995033850A1 (da) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6169074B1 (en) | 1996-03-18 | 2001-01-02 | The Regents Of The University Of California | Peptide inhibitors of neurotransmitter secretion by neuronal cells |
| US7192596B2 (en) | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| US5965699A (en) * | 1996-11-06 | 1999-10-12 | The United States Of America As Represented By The Secretary Of The Army | Assay for the proteolytic activity of serotype a from clostridium botulinum |
| GB9721189D0 (en) | 1997-10-08 | 1997-12-03 | Speywood Lab The Limited | Analgesic conjugates |
| US20040071736A1 (en) | 1998-08-25 | 2004-04-15 | Health Protection Agency | Methods and compounds for the treatment of mucus hypersecretion |
| US8790897B2 (en) | 1998-08-25 | 2014-07-29 | Syntaxin Ltd. | Treatment of mucus hypersecretion |
| GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| AU781608B2 (en) * | 1999-05-14 | 2005-06-02 | U.S. Army Medical Research And Materiel Command | Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins |
| US6143513A (en) * | 1999-06-23 | 2000-11-07 | Biacore Ab | Method and kit for detecting betalactam-containing compounds |
| GB9922554D0 (en) * | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
| FR2809733B1 (fr) | 2000-06-02 | 2004-04-30 | Inst Nat Sante Rech Med | Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants |
| US6762280B2 (en) * | 2000-09-25 | 2004-07-13 | The United States Of America As Represented By The Secretary Of The Army | High throughput assays for the proteotytic activities of clostridial neurotoxins |
| US8022172B2 (en) | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
| US7374896B2 (en) | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
| US7208285B2 (en) | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
| US7332567B2 (en) | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
| US7183066B2 (en) | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
| GB0311961D0 (en) | 2003-05-23 | 2003-06-25 | Health Prot Agency | Mass-based toxin assay and substrates therefor |
| US7399607B2 (en) * | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
| GB0426394D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| KR101604515B1 (ko) | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정 |
| MY155049A (en) * | 2008-03-14 | 2015-08-28 | Allergan Inc | Immuno-based botolinum toxin serotype a activity assay |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| WO2010085473A1 (en) | 2009-01-20 | 2010-07-29 | Trustees Of Tufts College | Methods for the delivery of toxins or enzymatically active portions thereof |
| KR102017327B1 (ko) | 2009-03-13 | 2019-09-03 | 알러간, 인코포레이티드 | 면역 기반 보툴리눔 독소 혈청형 ａ 활성 검정에 유용한 세포 |
| JP5826635B2 (ja) * | 2009-03-13 | 2015-12-02 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 免疫系調節エンドペプチターゼ活性アッセイ |
| WO2010124998A1 (en) * | 2009-04-27 | 2010-11-04 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| WO2011060916A1 (en) * | 2009-11-18 | 2011-05-26 | Merz Pharma Gmbh & Co. Kgaa | Assay for quantifying clostridial neurotoxin |
| LT2761065T (lt) | 2011-09-29 | 2018-01-10 | Cellsnap, Llc | Kompozicijos ir būdai toksigeniškumo testavimui |
| EP2798077A2 (en) | 2011-12-31 | 2014-11-05 | Allergan, Inc. | Highly Sensitive Cell-Based Assay to Detect the Presence of Active Botulinum Neurotoxin Serotype-A |
| MX359480B (es) | 2012-05-30 | 2018-09-28 | President And Fellows Of Harvard College Star | Neurotoxina botulínica diseñada. |
| GB201219024D0 (en) | 2012-10-23 | 2012-12-05 | Syntaxin Ltd | Assay |
| EP2922866B1 (en) | 2012-11-21 | 2019-01-23 | Merz Pharma GmbH & Co. KGaA | Means and methods for determination of botulinum neurotoxin biological activity |
| US11976110B2 (en) | 2013-06-28 | 2024-05-07 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the biological activity of neurotoxin polypeptides in cells |
| CN107001451A (zh) | 2014-07-07 | 2017-08-01 | 阿勒根公司 | 检测组织样品中裂解的snap25的方法 |
| KR102514666B1 (ko) | 2014-12-19 | 2023-03-27 | 메르츠 파마 게엠베하 운트 코. 카가아 | 세포에서 BoNT/E의 생물학적 활성의 결정을 위한 수단 및 방법 |
| RU2746736C2 (ru) | 2015-03-26 | 2021-04-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Сконструированный ботулинический нейротоксин |
| AU2017236163B2 (en) | 2016-03-25 | 2024-07-18 | Ipsen Biopharm Limited | Collecting physical therapy information to enhance treatment efficacy of botulinum toxin |
| UA127310C2 (uk) | 2016-05-16 | 2023-07-19 | Презідент Енд Феллоуз Оф Гарвард Колледж | Спосіб очищення і активації ботулінічного нейротоксину |
| EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
| JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
| EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171662A (en) * | 1990-09-13 | 1992-12-15 | The Upjohn Company | Method of detecting HIV protease activity |
| EP0529719A1 (en) * | 1991-08-26 | 1993-03-03 | Merck & Co. Inc. | Assay for evaluating inhibition of PMN elastase by N-Substituted Azetidinones |
-
1994
- 1994-06-03 GB GB9411138A patent/GB9411138D0/en active Pending
-
1995
- 1995-06-02 AU AU26240/95A patent/AU687564B2/en not_active Expired
- 1995-06-02 EP EP95921033A patent/EP0763131B1/en not_active Expired - Lifetime
- 1995-06-02 WO PCT/GB1995/001279 patent/WO1995033850A1/en not_active Ceased
- 1995-06-02 CA CA002191895A patent/CA2191895C/en not_active Expired - Lifetime
- 1995-06-02 AT AT95921033T patent/ATE183779T1/de active
- 1995-06-02 DK DK95921033T patent/DK0763131T3/da active
- 1995-06-02 JP JP50054496A patent/JP4246259B2/ja not_active Expired - Lifetime
- 1995-06-02 DE DE69511693T patent/DE69511693T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU687564B2 (en) | 1998-02-26 |
| GB9411138D0 (en) | 1994-07-27 |
| CA2191895C (en) | 2009-03-17 |
| JPH10504801A (ja) | 1998-05-12 |
| DE69511693D1 (de) | 1999-09-30 |
| ATE183779T1 (de) | 1999-09-15 |
| EP0763131A1 (en) | 1997-03-19 |
| WO1995033850A1 (en) | 1995-12-14 |
| DE69511693T2 (de) | 2000-03-09 |
| AU2624095A (en) | 1996-01-04 |
| EP0763131B1 (en) | 1999-08-25 |
| CA2191895A1 (en) | 1995-12-14 |
| JP4246259B2 (ja) | 2009-04-02 |
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