ATE245189T1 - Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren - Google Patents

Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren

Info

Publication number
ATE245189T1
ATE245189T1 AT95920689T AT95920689T ATE245189T1 AT E245189 T1 ATE245189 T1 AT E245189T1 AT 95920689 T AT95920689 T AT 95920689T AT 95920689 T AT95920689 T AT 95920689T AT E245189 T1 ATE245189 T1 AT E245189T1
Authority
AT
Austria
Prior art keywords
peptide
transcriptional activation
fusion protein
protein
host cell
Prior art date
Application number
AT95920689T
Other languages
English (en)
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE245189T1 publication Critical patent/ATE245189T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95920689T 1994-06-14 1995-05-31 Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren ATE245189T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs
PCT/US1995/006895 WO1995034646A1 (en) 1994-06-14 1995-05-31 Novel cell systems having specific interaction of peptide binding pairs

Publications (1)

Publication Number Publication Date
ATE245189T1 true ATE245189T1 (de) 2003-08-15

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920689T ATE245189T1 (de) 1994-06-14 1995-05-31 Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren

Country Status (18)

Country Link
US (3) US5989808A (de)
EP (1) EP0765389B1 (de)
AT (1) ATE245189T1 (de)
AU (1) AU706173B2 (de)
CA (1) CA2195083A1 (de)
DE (1) DE69531302T2 (de)
DK (1) DK0765389T3 (de)
ES (1) ES2202366T3 (de)
GE (1) GEP20022619B (de)
IL (1) IL114118A0 (de)
LT (1) LT4230B (de)
LV (1) LV11906B (de)
NZ (1) NZ287372A (de)
PT (1) PT765389E (de)
RU (1) RU2208646C2 (de)
SI (1) SI9520073B (de)
WO (1) WO1995034646A1 (de)
ZA (1) ZA954892B (de)

Families Citing this family (44)

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US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
ATE352638T1 (de) * 1995-04-11 2007-02-15 Gen Hospital Corp REVERSE ßTWO-HYBRIDß-SYSTEME
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
ES2183166T3 (es) * 1996-04-26 2003-03-16 Massachusetts Inst Technology Ensayo de cribado por triple hibrido.
EP1241265A3 (de) * 1996-04-26 2004-02-18 Massachusetts Institute Of Technology Screening-Verfahren für kleine Liganden
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
WO1997049808A1 (en) * 1996-06-27 1997-12-31 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
ES2181197T3 (es) 1997-04-25 2003-02-16 Wyeth Corp Isoformas de mort1 neuronal.
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
EP1149920A1 (de) * 1997-10-15 2001-10-31 Diversa, Inc. Screening fÜr neue Verbindungen, die biologische Interaktionen regulieren
US6846627B2 (en) 1997-10-15 2005-01-25 Diversa Corporation Screening for novel compounds which regulate biological interactions
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
CA2309763A1 (en) * 1997-11-14 1999-05-27 Roche Diagnostics Corporation Variable region fusion peptides that form effector complexes in the presence of antigen
WO1999035282A1 (en) 1998-01-09 1999-07-15 Tvw Telethon Institute For Child Health Research Peptide detection method
EP0974649A1 (de) * 1998-06-22 2000-01-26 Universität Zürich Screening-System
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
JP2002541863A (ja) * 1999-04-21 2002-12-10 ワイス Ｎ−型イオンチャンネル不活性化のモジュレーターを同定する方法
AU2001257157A1 (en) * 2000-04-24 2001-11-07 Wyeth Novel cell systems having specific interaction of peptide binding pairs
EP1349946B1 (de) 2000-08-25 2011-01-26 BASF Plant Science GmbH Polynukleotide, die für prenylproteasen aus pflanzen kodieren
AU2002220275A1 (en) * 2000-12-08 2002-06-18 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
PT1534819E (pt) 2002-08-21 2010-03-11 Revivicor Inc Animais porcinos carecendo de qualquer expressão de alfa 1,3-galactosiltransferase funcional
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US7285269B2 (en) 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
WO2005049804A2 (en) * 2003-11-17 2005-06-02 Georgia Tech Research Corporation Engineering enzymes through genetic selection
EP1544307A1 (de) * 2003-12-18 2005-06-22 AXXAM S.r.l. Chimärer LAC9 Rezeptor und dessen Verwendungen
EP2412816B1 (de) 2004-07-26 2014-12-03 Pfenex Inc. Verfahren zur verbesserten Proteinexpression durch Strain-Engineering
CA2909775A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
BRPI0707514A2 (pt) * 2006-02-07 2011-05-10 Wyeth Corp mÉtodo de identificaÇço de um agente que module ossos ou um lipÍdio; mÉtodo de identificaÇço de um agente que module a atividade de norrin-frizzled4; kit para identificar um agente que module a atividade de lrp5-norrin-frizzled4; cÉlula ou linhagem celular desprovida de norrin nativo e que expresse uma lrp5 nço nativa e uma frizzled4 nço nativa
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (de) 2007-04-27 2013-07-17 Pfenex Inc. Schnellscreeningverfahren für Bakterienwirte zur Identifizierung bestimmter Stämme mit verbessertem Ertrag und/oder verbesserter Qualität bei der Expression heterologer Proteine
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
WO2016154452A2 (en) 2015-03-24 2016-09-29 Osiris Therapeutics, Inc. Compositions comprising meniscal tissues and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
DE69333969T2 (de) * 1992-10-30 2006-09-14 The General Hospital Corp., Boston Wechselwirkendes Fallensystem zur Isolierung von Proteinen
US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
EP0743520A3 (de) * 1993-12-30 1999-11-10 The Salk Institute For Biological Studies Neue Verwendungen von Gal4-Rezeptor-Konstruktionen
JP3468523B2 (ja) * 1994-01-21 2003-11-17 イコス コーポレイション ガゼインキナーゼ▲ｉ▼と相互作用するタンパク質に関連する方法および物質
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Also Published As

Publication number Publication date
PT765389E (pt) 2003-11-28
SI9520073A (sl) 1998-02-28
LT97004A (en) 1997-07-25
EP0765389B1 (de) 2003-07-16
EP0765389A1 (de) 1997-04-02
US5989808A (en) 1999-11-23
DK0765389T3 (da) 2003-10-27
DE69531302D1 (de) 2003-08-21
ZA954892B (en) 1996-01-30
LV11906A (lv) 1997-12-20
CA2195083A1 (en) 1995-12-21
IL114118A0 (en) 1995-10-31
RU2208646C2 (ru) 2003-07-20
LT4230B (en) 1997-10-27
LV11906B (en) 1998-06-20
GEP20022619B (en) 2002-01-25
SI9520073B (sl) 2004-06-30
ES2202366T3 (es) 2004-04-01
DE69531302T2 (de) 2004-04-22
AU2606695A (en) 1996-01-05
US6251602B1 (en) 2001-06-26
WO1995034646A1 (en) 1995-12-21
NZ287372A (en) 1997-11-24
US6284519B1 (en) 2001-09-04
AU706173B2 (en) 1999-06-10

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