DK0771792T3 - Fremgangsmåde til fremstilling af (4,5)-trans-oxazolidinderivater - Google Patents

Fremgangsmåde til fremstilling af (4,5)-trans-oxazolidinderivater

Info

Publication number: DK0771792T3
Authority: DK; Denmark
Prior art keywords: alkyl; oxo; trans; oxazolidine; preparation
Prior art date: 1995-11-06

Application number

DK96117478T

Other languages

English (en)

Inventor

Hans Hilpert

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-06

Filing date

1996-10-31

Publication date

1999-11-15

1996-10-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-11-15 Application granted granted Critical

1999-11-15 Publication of DK0771792T3 publication Critical patent/DK0771792T3/da

Links

238000000034 method Methods 0.000 title abstract 2
229940053194 antiepileptics oxazolidine derivative Drugs 0.000 title 1
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001371 alpha-amino acids Chemical group 0.000 abstract 2
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
ZFFBIQMNKOJDJE-UHFFFAOYSA-N 2-bromo-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(Br)C(=O)C1=CC=CC=C1 ZFFBIQMNKOJDJE-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
-1 alkyl lithium compound Chemical class 0.000 abstract 1
150000004791 alkyl magnesium halides Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
125000003944 tolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK96117478T 1995-11-06 1996-10-31 Fremgangsmåde til fremstilling af (4,5)-trans-oxazolidinderivater DK0771792T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH313195		1995-11-06

Publications (1)

Publication Number	Publication Date
DK0771792T3 true DK0771792T3 (da)	1999-11-15

Family

ID=4249292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96117478T DK0771792T3 (da)	1995-11-06	1996-10-31	Fremgangsmåde til fremstilling af (4,5)-trans-oxazolidinderivater

Country Status (9)

Country	Link
US (1)	US5670653A (da)
EP (1)	EP0771792B1 (da)
JP (1)	JP2907781B2 (da)
KR (1)	KR100197459B1 (da)
CN (1)	CN1152570A (da)
AT (1)	ATE180775T1 (da)
DE (1)	DE59602077D1 (da)
DK (1)	DK0771792T3 (da)
ES (1)	ES2133877T3 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2002100841A1 (fr)	2001-05-23	2002-12-19	Kaneka Corporation	Procedes de production d'un derive d'oxazolidinone d'un compose de $g(b)-hydroxyethylamine et de production d'un compose de $g(b)-hydroxyethylamine
KR100686117B1 (ko) *	2005-05-04	2007-02-26	엘지전자 주식회사	식기세척기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5455353A (en) *	1993-03-24	1995-10-03	Hoffmann-La Roche Inc.	4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides

1996
- 1996-10-28 JP JP8284820A patent/JP2907781B2/ja not_active Expired - Lifetime
- 1996-10-30 US US08/739,565 patent/US5670653A/en not_active Expired - Fee Related
- 1996-10-31 AT AT96117478T patent/ATE180775T1/de active
- 1996-10-31 DE DE59602077T patent/DE59602077D1/de not_active Expired - Fee Related
- 1996-10-31 EP EP96117478A patent/EP0771792B1/de not_active Expired - Lifetime
- 1996-10-31 ES ES96117478T patent/ES2133877T3/es not_active Expired - Lifetime
- 1996-10-31 DK DK96117478T patent/DK0771792T3/da active
- 1996-11-04 CN CN96112021A patent/CN1152570A/zh active Pending
- 1996-11-05 KR KR1019960052158A patent/KR100197459B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR970027061A (ko)	1997-06-24
KR100197459B1 (ko)	1999-06-15
JP2907781B2 (ja)	1999-06-21
DE59602077D1 (de)	1999-07-08
ATE180775T1 (de)	1999-06-15
EP0771792B1 (de)	1999-06-02
ES2133877T3 (es)	1999-09-16
US5670653A (en)	1997-09-23
JPH09169744A (ja)	1997-06-30
CN1152570A (zh)	1997-06-25
EP0771792A1 (de)	1997-05-07

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