DK0775150T3 - Fremgangsmåde til reduktion eller fjernelse af endotoksiner - Google Patents

Fremgangsmåde til reduktion eller fjernelse af endotoksiner

Info

Publication number
DK0775150T3
DK0775150T3 DK95907641T DK95907641T DK0775150T3 DK 0775150 T3 DK0775150 T3 DK 0775150T3 DK 95907641 T DK95907641 T DK 95907641T DK 95907641 T DK95907641 T DK 95907641T DK 0775150 T3 DK0775150 T3 DK 0775150T3
Authority
DK
Denmark
Prior art keywords
treated
active ingredients
salt solution
natural sources
fractions
Prior art date
Application number
DK95907641T
Other languages
English (en)
Inventor
Metin Colpan
Peter Moritz
Joachim Schorr
Original Assignee
Qiagen Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27435911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0775150(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4432654A external-priority patent/DE4432654C2/de
Application filed by Qiagen Gmbh filed Critical Qiagen Gmbh
Application granted granted Critical
Publication of DK0775150T3 publication Critical patent/DK0775150T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/82—Subcellular parts of microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
DK95907641T 1994-02-07 1995-02-03 Fremgangsmåde til reduktion eller fjernelse af endotoksiner DK0775150T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4403692 1994-02-07
DE4422291 1994-06-25
DE4431125 1994-09-01
DE4432654A DE4432654C2 (de) 1994-09-14 1994-09-14 Verfahren zur Isolierung von Nukleinsäuren aus natürlichen Quellen
PCT/EP1995/000391 WO1995021179A1 (de) 1994-02-07 1995-02-03 Verfahren zur abreicherung oder entfernung von endotoxinen

Publications (1)

Publication Number Publication Date
DK0775150T3 true DK0775150T3 (da) 1999-11-08

Family

ID=27435911

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95907641T DK0775150T3 (da) 1994-02-07 1995-02-03 Fremgangsmåde til reduktion eller fjernelse af endotoksiner
DK95908258T DK0743949T3 (da) 1994-02-07 1995-02-03 Fremgangsmåde til fremstilling af endotoksinfrie eller endotoksinfattige nukleinsyrer og/eller oligonukleotider til gentera

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK95908258T DK0743949T3 (da) 1994-02-07 1995-02-03 Fremgangsmåde til fremstilling af endotoksinfrie eller endotoksinfattige nukleinsyrer og/eller oligonukleotider til gentera

Country Status (9)

Country Link
US (5) US5747663A (da)
EP (2) EP0743949B1 (da)
JP (2) JP3847779B2 (da)
AT (2) ATE187733T1 (da)
AU (2) AU691574B2 (da)
CA (2) CA2182397C (da)
DE (2) DE59505786D1 (da)
DK (2) DK0775150T3 (da)
WO (2) WO1995021177A1 (da)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990301A (en) * 1994-02-07 1999-11-23 Qiagen Gmbh Process for the separation and purification of nucleic acids from biological sources
DK0775150T3 (da) * 1994-02-07 1999-11-08 Qiagen Gmbh Fremgangsmåde til reduktion eller fjernelse af endotoksiner
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
DE59709915D1 (de) 1996-02-06 2003-05-28 Roche Diagnostics Gmbh Verfahren zur herstellung von gereinigter nukleinsäure und deren verwendung
US5981735A (en) * 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
GB9602825D0 (en) * 1996-02-12 1996-04-10 Therexsys Ltd Method of plasmid dna production and purification
FR2746412B1 (fr) * 1996-03-21 1998-06-12 Rhone Poulenc Rorer Sa Purification d'adn plasmidique de qualite pharmaceutique
US7026468B2 (en) 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US7807822B2 (en) * 1996-08-01 2010-10-05 Robert Bridenbaugh Methods for purifying nucleic acids
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
GB2327945A (en) 1997-07-31 1999-02-10 Medeva Europ Ltd Removal of endotoxin from vaccines
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US7569342B2 (en) 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6194562B1 (en) * 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
DE19836559A1 (de) 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
EP0987327A1 (en) 1998-09-14 2000-03-22 QIAGEN GmbH Novel method for purifying covalently closed circular DNA
DE19859703B4 (de) 1998-12-23 2009-10-29 Macherey, Nagel Gmbh & Co. Handelsgesellschaft Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens
US20050136458A1 (en) * 1998-12-31 2005-06-23 Oligos, Etc, Inc. Method for nucleic acid preparation
DE19900681B4 (de) * 1999-01-04 2007-04-12 Sartorius Ag Verwendung von Anionaustauschermembranen zur Entfernung von Endotoxinen aus Nukleinsäure-haltigen Lösungen
DE19903507A1 (de) 1999-01-29 2000-08-10 Roche Diagnostics Gmbh Verfahren zur Herstellung endotoxinfreier oder an Endotoxin abgereicherter Nukleinsäuren und deren Verwendung
US6270970B1 (en) * 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
CA2375215C (en) 1999-05-28 2012-11-20 Bio Science Contract Production Corporation Methods of dna purification and purified dna
US20040215129A1 (en) * 1999-09-16 2004-10-28 Gambro Ab Method and cycler for the administration of a peritoneal dialysis fluid
US6894150B1 (en) * 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
ATE315826T1 (de) * 1999-11-17 2006-02-15 Roche Diagnostics Gmbh Magnetische glasteilchen, herstellungsverfahren und benutzung
DE50008101D1 (de) * 2000-02-16 2004-11-11 Macherey Nagel Gmbh & Co Hg Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens
DE10010342A1 (de) * 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
US6623655B1 (en) 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
KR100356738B1 (ko) 2000-09-07 2002-10-18 주식회사 삼양제넥스 염기성 단백질로부터 엔도톡신을 제거하는 방법
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
SE0003958D0 (sv) 2000-10-31 2000-10-31 Biogaia Fermentation Ab Method for growth of microorganisms
US6602718B1 (en) * 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
GB0127803D0 (en) * 2001-11-20 2002-01-09 Glaxo Group Ltd Processing nucleic acid
JP4647911B2 (ja) * 2001-12-26 2011-03-09 日本メジフィジックス株式会社 エンドトキシン除去用組成物及び除去方法
US6833238B2 (en) * 2002-01-04 2004-12-21 Applera Corporation Petal-array support for use with microplates
US20040016702A1 (en) * 2002-07-26 2004-01-29 Applera Corporation Device and method for purification of nucleic acids
JP2005538717A (ja) * 2002-09-13 2005-12-22 ヴァレンティス，インコーポレイテッド 核酸のプレパラティブスケールの精製のための装置および方法
US9187347B2 (en) * 2002-11-19 2015-11-17 Xogen Technologies Inc. Treatment of a waste stream through production and utilization of oxyhydrogen gas
US7113773B2 (en) * 2003-05-16 2006-09-26 Qualcomm Incorporated Reliable reception of broadcast/multicast content
EP1638990B1 (en) * 2003-06-24 2009-04-08 N.V. Organon Removal of lipopolysaccharides from protein- lipopolysaccharide complexes by nonflammable solvents
US8377715B2 (en) * 2003-07-14 2013-02-19 Phynexus, Inc. Method and device for sample preparation
CA2556169C (en) * 2004-01-29 2011-11-22 Andrew Lees Use of amino-oxy functional groups in the preparation of vaccines
EP1559783A1 (de) * 2004-01-29 2005-08-03 Qiagen GmbH Verfahren zur chromatographischen Trennung eines Nukleinsäuregemisches
US20050181378A1 (en) * 2004-02-18 2005-08-18 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
US20060160122A1 (en) * 2004-02-18 2006-07-20 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
US20050196856A1 (en) * 2004-02-18 2005-09-08 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
US7531308B2 (en) * 2004-04-23 2009-05-12 Sigma-Aldrich Co. Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography
US8569477B2 (en) * 2005-02-11 2013-10-29 Life Technologies As Method for isolating nucleic acids comprising the use of ethylene glycol multimers
CA2613094A1 (en) * 2005-07-01 2007-01-11 Promega Corporation Network of buoyant particles for biomolecule purification
DE102005059315A1 (de) * 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
WO2007115046A1 (en) * 2006-03-31 2007-10-11 Invitrogen Corporation Low-endotoxin nucleic acid preparations
GB2445441B (en) * 2006-09-26 2010-06-30 Ge Healthcare Bio Sciences Nucleic acid purification method
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
ES2375314T3 (es) 2007-02-28 2012-02-28 Lipoxen Technologies Limited Reducción de endotoxina en ácidos polisiálicos.
US8686129B2 (en) * 2007-03-20 2014-04-01 Agilent Technologies, Inc. Methods for the separation of biological molecules using sulfolane
US20100331534A1 (en) * 2007-07-27 2010-12-30 Ge Healthcare Bio-Sciences Corp. nucleic acid purification method
EP2479187A1 (en) * 2007-11-23 2012-07-25 Shanghai Zerun Biotechnology Co., Ltd. Genes encoding major capsid protein L1 of human papilloma viruses
US8969068B2 (en) * 2008-04-30 2015-03-03 Gradalis, Inc. Processes for the preparation of highly pure plasmid compositions by enzymatic digestion of colanic acid
DE102008026058A1 (de) 2008-05-30 2009-12-03 Qiagen Gmbh Lyse, Binde- und/oder Waschreagenz verwendbar zur Isolierung und/oder Reinigung von Nukleinsäuren
US11235323B2 (en) 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
JP5492207B2 (ja) 2008-08-27 2014-05-14 ライフ テクノロジーズ コーポレーション 生物学的サンプルの処理装置および処理方法
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
US8647621B2 (en) 2009-07-27 2014-02-11 Fina Biosolutions, Llc Method of producing protein-carbohydrate vaccines reduced in free carbohydrate
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
CA2836140C (en) 2009-12-17 2016-06-21 Fina Biosolutions, Llc Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
US8383783B2 (en) 2010-04-23 2013-02-26 Serum Institute Of India, Ltd. Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
GB2502195B (en) 2010-09-30 2015-02-11 Phynexus Inc Purification of nucleic acids
US20150045232A1 (en) * 2010-12-28 2015-02-12 Bexmart Integrated and versatile methods for systems diagnosis of diseases
US9200251B1 (en) 2011-03-31 2015-12-01 David Gordon Bermudes Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith
JP6253059B2 (ja) 2012-05-30 2017-12-27 国立大学法人 熊本大学 エンドトキシン吸着材
WO2015050191A1 (ja) * 2013-10-03 2015-04-09 協和発酵バイオ株式会社 二重鎖リボ核酸の精製方法
CN104370997B (zh) * 2014-09-24 2018-07-31 陈辉 去除生物制品中细菌内毒素的试剂盒、方法及其生物制品的制备方法
CN108148831A (zh) * 2018-01-15 2018-06-12 南京驯鹿医疗技术有限公司 一种无内毒素质粒大量制备工艺
CN111902129A (zh) * 2018-03-08 2020-11-06 康特伦英国斯温顿捷迪斯有限公司 减少明胶中内毒素的方法
US12473379B2 (en) 2019-09-06 2025-11-18 Serum Institute Of India Private Limited Method for obtaining purified bacterial polysaccharides
US11994528B2 (en) 2019-12-18 2024-05-28 Life Technologies Corporation Systems, methods, and devices for automated nucleic acid and protein isolation
EP3906982B2 (de) 2020-05-08 2025-08-13 AXAGARIUS GmbH & Co. KG Verfahren zur plasmidreinigung unter gleichzeitiger abreicherung von endotoxinen
ES2967202T3 (es) 2021-07-02 2024-04-29 Axagarius Gmbh & Co Kg Mezcla de etoxilatos de alcoholes secundarios ramificados para la eliminación de endotoxinas en cromatografía de intercambio aniónico
CA3227947A1 (en) 2021-08-05 2023-02-09 Anja HEINEN-KREUZIG Method for reducing endotoxin levels in nucleic acid purification
WO2023170028A1 (en) 2022-03-10 2023-09-14 Merck Patent Gmbh Method for reducing endotoxin levels in nucleic acid purification
EP4361130A1 (en) * 2022-10-31 2024-05-01 Illinois Tool Works Inc. Method of treating a chemical product
WO2025262273A1 (en) * 2024-06-21 2025-12-26 Qiagen Gmbh Process for purifying a biological sample containing nucleic acids
CN118620885B (zh) * 2024-08-06 2024-12-03 苏州左旋星生物科技有限公司 一种低拷贝去内毒素质粒的制备方法及试剂盒

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303193A (en) 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
DE3639949A1 (de) * 1986-11-22 1988-06-09 Diagen Inst Molekularbio Verfahren zur trennung von langkettigen nukleinsaeuren
JPH01501939A (ja) 1987-01-28 1989-07-06 オーソ・フアーマシユーチカル・コーポレーシヨン 免疫抑制ペプチドおよび使用法
US5260422A (en) 1988-06-23 1993-11-09 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
CA2001720C (en) 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
US5136026A (en) * 1989-04-10 1992-08-04 Behringwerke Aktiengesellschaft Process for removing toxins from protein solutions
JPH0666B2 (ja) 1989-05-02 1994-01-05 倉敷紡績株式会社 Ｄｎａの単離精製法
US4997932A (en) * 1989-11-13 1991-03-05 Boehringer Mannheim Corporation Method and kit for purifying nucleic acids
DE4021063A1 (de) * 1990-07-03 1992-01-09 Boehringer Mannheim Gmbh Neue ss-galactosidase-substrate fuer den cedia
US5652141A (en) * 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
JPH06501033A (ja) 1991-07-12 1994-01-27 ギスト　ブロカデス　ナムローゼ　フェンノートシャップ 血清アルブミンの精製方法
DE4143639C2 (de) * 1991-12-02 2002-10-24 Qiagen Gmbh Verfahren zur Isolierung und Reinigung von Nukleinsäuren
US5506114A (en) * 1992-02-07 1996-04-09 Osborn Laboratories Methods and kits for detecting the presence or concentration of biological analytes
CH685498A5 (fr) 1992-02-14 1995-07-31 Om Lab Sa Extrait de macromolécules bactériennes, procédé pour sa préparation et composition pharmaceutique contenant cet extrait.
JP3524120B2 (ja) * 1992-05-08 2004-05-10 生化学工業株式会社 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法
US5843707A (en) * 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
FR2713240B1 (fr) * 1993-12-02 1996-03-01 Bio Merieux Milieu nutritif pour la culture de microorganismes.
DK0775150T3 (da) * 1994-02-07 1999-11-08 Qiagen Gmbh Fremgangsmåde til reduktion eller fjernelse af endotoksiner
US5981735A (en) * 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
US5981235A (en) * 1996-07-29 1999-11-09 Promega Corporation Methods for isolating nucleic acids using alkaline protease
US6011148A (en) * 1996-08-01 2000-01-04 Megabios Corporation Methods for purifying nucleic acids
JP5053470B2 (ja) * 1996-08-23 2012-10-17 クック バイオテク インコーポレイティド グラフト・プロテーゼとその材料及び方法
US6194562B1 (en) * 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
US6268492B1 (en) * 1998-08-10 2001-07-31 Chiron Corporation Methods for purifying non-chromosomal nucleic acid molecules from cells
DE19900681B4 (de) * 1999-01-04 2007-04-12 Sartorius Ag Verwendung von Anionaustauschermembranen zur Entfernung von Endotoxinen aus Nukleinsäure-haltigen Lösungen

Also Published As

Publication number Publication date
US7510826B2 (en) 2009-03-31
DK0743949T3 (da) 2000-04-10
EP0743949B1 (de) 1999-12-15
US5747663A (en) 1998-05-05
WO1995021177A1 (de) 1995-08-10
EP0775150B1 (de) 1999-04-28
CA2182397C (en) 2004-04-13
AU1664695A (en) 1995-08-21
ATE179425T1 (de) 1999-05-15
DE59507433D1 (de) 2000-01-20
US20020032324A1 (en) 2002-03-14
US7109322B2 (en) 2006-09-19
US20030036175A1 (en) 2003-02-20
DE59505786D1 (de) 1999-06-02
ATE187733T1 (de) 2000-01-15
JPH09508407A (ja) 1997-08-26
US20060194304A1 (en) 2006-08-31
WO1995021179A1 (de) 1995-08-10
CA2182388A1 (en) 1995-08-10
CA2182388C (en) 2007-08-07
CA2182397A1 (en) 1995-08-10
EP0775150A1 (de) 1997-05-28
AU691574B2 (en) 1998-05-21
EP0743949A1 (de) 1996-11-27
JP4113580B2 (ja) 2008-07-09
US6297371B1 (en) 2001-10-02
AU1577795A (en) 1995-08-21
JPH09508406A (ja) 1997-08-26
AU693511B2 (en) 1998-07-02
JP3847779B2 (ja) 2006-11-22

Similar Documents

Publication Publication Date Title
DE59505786D1 (de) Verfahren zur abreicherung oder entfernung von endotoxinen
KR860008276A (ko) 단백질이 생성된 배양기로 부터 그것을 추출, 정제하는 방법
PT848752E (pt) Processo de purificacao de virus por cromatografia
ATE163043T1 (de) Reinigungsmethode und entsprechende vorrichtung
PT83205B (pt) Metodo de purificacao e activacao de proteinas a partir de corpos de inclusao insoluveis
EP0121976A3 (en) Partially purified osteogenic factor and process for preparing same from demineralized bone or an osteosarcoma
ATE79633T1 (de) Verfahren zur herstellung des alpha-1-proteinase- inhibitors.
SE8402861D0 (sv) Rening av biologiskt material
EP0669342B1 (de) Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
DE3463509D1 (en) Process for the dissolution of peptides and proteins, solutions thereby obtained and their use
DE69902639D1 (de) Verbessertes verfahren zur herstellung von faktor viii
AU697217B2 (en) A process for the preparation of factor IX from biological sources
DK0484464T4 (da) Fremgangsmåde til rensning af proteiner
FI1343809T4 (fi) Menetelmä alfa-1 proteinaasinestäjän valmistamiseksi
ATE141284T1 (de) Verfahren zur herstellung von hochreinem fibrinogen
RU2006123543A (ru) Способ очистки интерферона бета
RU94023134A (ru) Способ выделения и очистки инсулина и его биотехнологических предшественников
RU96110890A (ru) Способ получения с помощью хроматографических методов вирусно-инактивированной фракции, содержащей фактор viii
EP0446850A3 (en) Process for purifying recombinant human beta-interferon
SE7710201L (sv) Medel med antimalign verkan
JPS6391080A (ja) ヒト組織プラスミノゲン活性化因子の精製法
Dengler Ion Exchange Processes for Waste Water Treatment in Surface Treatment Technology
MX9604624A (es) Un pañal de tipo de calzoncillos o calzon sanitario que tiene una parte frontal unida en forma desprendible.
UA8125A1 (uk) Спосіб підготовки води
KR820002452A (ko) 항생물질 네오스라마이신(neothramycin)의 정제방법