ATE79633T1 - Verfahren zur herstellung des alpha-1-proteinase- inhibitors. - Google Patents

Verfahren zur herstellung des alpha-1-proteinase- inhibitors.

Info

Publication number: ATE79633T1
Authority: AT; Austria
Prior art keywords: alpha; proteinase inhibitor; resin; manufacture; aqueous solution
Prior art date: 1985-11-01

Application number

AT86114461T

Other languages

English (en)

Inventor

Michael H Coan

Original Assignee

Miles Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-11-01

Filing date

1986-10-18

Publication date

1992-09-15

1986-10-18 Application filed by Miles Inc filed Critical Miles Inc

1992-09-15 Application granted granted Critical

1992-09-15 Publication of ATE79633T1 publication Critical patent/ATE79633T1/de

Links

238000000034 method Methods 0.000 title abstract 3
102000015395 alpha 1-Antitrypsin Human genes 0.000 title 1
108010050122 alpha 1-Antitrypsin Proteins 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 4
102000004506 Blood Proteins Human genes 0.000 abstract 2
108010017384 Blood Proteins Proteins 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 2
239000011347 resin Substances 0.000 abstract 2
229920005989 resin Polymers 0.000 abstract 2
101710081722 Antitrypsin Proteins 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
230000001475 anti-trypsic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
239000002753 trypsin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/902—Materials removed
- Y10S210/903—Nitrogenous
- Y10S210/905—Protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT86114461T 1985-11-01 1986-10-18 Verfahren zur herstellung des alpha-1-proteinase- inhibitors. ATE79633T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/793,807 US4697003A (en)	1985-11-01	1985-11-01	Method of preparing alpha-1-proteinase inhibitor
EP86114461A EP0221426B1 (de)	1985-11-01	1986-10-18	Verfahren zur Herstellung des alpha-1-Proteinase-Inhibitors

Publications (1)

Publication Number	Publication Date
ATE79633T1 true ATE79633T1 (de)	1992-09-15

Family

ID=25160853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86114461T ATE79633T1 (de)	1985-11-01	1986-10-18	Verfahren zur herstellung des alpha-1-proteinase- inhibitors.

Country Status (8)

Country	Link
US (1)	US4697003A (de)
EP (1)	EP0221426B1 (de)
JP (1)	JPH0764750B2 (de)
AT (1)	ATE79633T1 (de)
AU (1)	AU591397B2 (de)
CA (1)	CA1286848C (de)
DE (1)	DE3686470T2 (de)
ES (1)	ES2051684T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4629567A (en) *	1986-03-07	1986-12-16	Smithkline-Rit	Alpha-1-antiprotease purification
DE3612137A1 (de) *	1986-04-10	1987-10-15	Biotest Pharma Gmbh	Steriles plasmaaustauschmittel
US4808314A (en) *	1987-09-18	1989-02-28	Scripps Clinic And Research Foundation	Method for reducing bacterial endotoxin contamination in solutions of macromolecules
US5139943A (en) *	1989-06-13	1992-08-18	Genencor International, Inc.	Processes for the recovery of microbially produced chymosin
US5151358A (en) *	1989-06-13	1992-09-29	Genencor International, Inc.	Processes for the recovery of naturally produced chymosin
CA2093422C (en) *	1990-10-05	2001-04-03	Genencor International, Inc.	DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS
US5328841A (en) *	1990-10-05	1994-07-12	Genencor International, Inc.	Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol
US5290474A (en) *	1990-10-05	1994-03-01	Genencor International, Inc.	Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp
DE4407837C1 (de) *	1994-03-09	1995-08-17	Octapharma Ag	Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US5616693A (en) *	1996-07-01	1997-04-01	Alpha Therapeutic Corporation	Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
GB2318732A (en)	1996-11-01	1998-05-06	Johnson & Johnson Medical	Wound healing compositions containing alpha-1-antitrypsin
AT407114B (de) *	1997-06-10	2000-12-27	Immuno Ag	Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US6093804A (en) *	1998-09-24	2000-07-25	American National Red Cross	Method for purification of alpha-1 proteinase inhibitor
US6887678B2 (en) *	1998-12-02	2005-05-03	Cindy L. Bristow	Method for the quantitative determination of proteinase inhibitors
US6462180B1 (en)	1999-11-24	2002-10-08	Bayer Corporation	Method of preparing α-1 proteinase inhibitor
ES2543829T5 (es)	2000-12-14	2023-07-13	Grifols Therapeutics Inc	Procedimiento para la preparación del inhibidor de proteinasa alfa 1
US7777006B2 (en) *	2002-12-31	2010-08-17	Csl Behring L.L.C.	Method for purification of alpha-1-antitrypsin
PL1664123T5 (pl) *	2003-09-22	2012-04-30	Kamada Ltd	Wytwarzanie w dużej skali inhibitora proteinazy alfa-1 i jego zastosowanie
GB0524432D0 (en) *	2005-11-30	2006-01-11	Nhs Blood & Transplant	Method
EP1981572B1 (de) *	2006-02-09	2012-11-21	Kamada Ltd.	Pulmonale abgabe von alpha-i proteinase-hemmer
JP5600061B2 (ja)	2007-08-17	2014-10-01	ツェーエスエルベーリンクゲゼルシャフトミットベシュレンクテルハフツング	α−１−抗トリプシンおよびアポリポタンパク質Ａ−Ｉを精製する方法
CN102180966B (zh) *	2011-01-28	2013-04-03	哈尔滨派斯菲科生物制药股份有限公司	一种规模化生产人α1-抗胰蛋白酶的方法
CN107596359A (zh)	2011-12-30	2018-01-19	基立福有限公司	用于延迟肺部症状加重的发作或进展的α1‑蛋白酶抑制剂
EP3362464B1 (de)	2015-10-15	2021-04-28	Plasma Technologies LLC	Verfahren zur extraktion von proteinen aus blutplasma
AU2017214678B2 (en)	2016-02-03	2024-02-01	Plasma Technologies, Llc	Methods for extracting proteins from a blood-based material
US10815270B1 (en)	2019-09-20	2020-10-27	Plasma Technologies, Llc	Compositions and methods for high efficiency protein precipitation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL286954A (de) *	1962-01-03
US3869436A (en) *	1971-06-01	1975-03-04	Statens Bakteriologiska Lab	Method for fractionating plasma proteins using peg and ion-exchangers
US4100149A (en) *	1975-08-28	1978-07-11	Rhone-Poulenc Industries	Method of separating proteins by ion exchange
US4379087A (en) *	1982-06-17	1983-04-05	Cutter Laboratories, Inc.	Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) *	1985-12-02	1987-04-07	Miles Laboratories, Inc.	Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) *	1986-03-07	1986-12-16	Smithkline-Rit	Alpha-1-antiprotease purification

1985
- 1985-11-01 US US06/793,807 patent/US4697003A/en not_active Expired - Lifetime
1986
- 1986-10-18 AT AT86114461T patent/ATE79633T1/de not_active IP Right Cessation
- 1986-10-18 EP EP86114461A patent/EP0221426B1/de not_active Expired - Lifetime
- 1986-10-18 ES ES86114461T patent/ES2051684T3/es not_active Expired - Lifetime
- 1986-10-18 DE DE8686114461T patent/DE3686470T2/de not_active Expired - Lifetime
- 1986-10-30 CA CA000521806A patent/CA1286848C/en not_active Expired - Lifetime
- 1986-10-31 JP JP61258702A patent/JPH0764750B2/ja not_active Expired - Lifetime
- 1986-10-31 AU AU64624/86A patent/AU591397B2/en not_active Expired

Also Published As

Publication number	Publication date
JPH0764750B2 (ja)	1995-07-12
CA1286848C (en)	1991-07-23
EP0221426A2 (de)	1987-05-13
AU591397B2 (en)	1989-11-30
DE3686470D1 (de)	1992-09-24
US4697003A (en)	1987-09-29
AU6462486A (en)	1987-05-07
EP0221426B1 (de)	1992-08-19
JPS62108821A (ja)	1987-05-20
ES2051684T3 (es)	1994-07-01
EP0221426A3 (en)	1989-02-08
DE3686470T2 (de)	1993-01-21

Legal Events

Date	Code	Title
1993-02-15	UEP	Publication of translation of european patent specification
1996-03-15	EEFA	Change of the company name
2007-01-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE79633T1 (de)	1992-09-15	Verfahren zur herstellung des alpha-1-proteinase- inhibitors.
DE3686475D1 (de)	1992-09-24	Verfahren zur herstellung des alpha-1-proteinase-inhibitors.
ES2155477T3 (es)	2001-05-16	Purificacion cromatografica y procedimiento de separacion de acidos nucleicos.
PT83205B (pt)	1988-07-01	Metodo de purificacao e activacao de proteinas a partir de corpos de inclusao insoluveis
DE3484179D1 (de)	1991-04-04	Verfahren zur reinigung von faktor viii-c.
ATE302216T1 (de)	2005-09-15	Verfahren zur aufreinigung des faktors viii
ATE179717T1 (de)	1999-05-15	Verfahren zur reinigung von menschlichem albumin
ES2068000T3 (es)	1995-04-01	Separacion de metales de peroxiacidos o peroxisales acuosos.
DE69311337D1 (de)	1997-07-10	Verfahren zur Reinigung von Proteinen
ATE30844T1 (de)	1987-12-15	Verfahren zur herstellung der wichtigsten proteine des haemolysierten bluts in einer nichtdenaturierten form.
ATE347564T1 (de)	2006-12-15	Verfahren zur reinigung von hämoglobin
ATE6925T1 (de)	1984-04-15	Verfahren zur reinigung von gallium enthaltenden loesungen.
EP0656419A4 (de)	1996-05-29	Verfahren zur hochreinigung von menschlichem serumalbumin.
ATE146525T1 (de)	1997-01-15	Wiedergewinnungsverfahren von mikrobiell erzeugtem chymosin
SE8501170D0 (sv)	1985-03-08	Forfarande
ATE1865T1 (de)	1982-12-15	Verfahren zur reinigung von iso-alpha-saeuren aus hopfen.
KR930023371A (ko)	1993-12-18	사람의 뇨로부터의 유용 단백질의 생산방법
FR2632302B1 (fr)	1991-02-22	Procede de recuperation d'acide citrique a partir d'une liqueur en contenant
ATE388722T1 (de)	2008-03-15	THERAPEUTISCHE FRAGMENTE DES ßVON WILLEBRANDß FAKTORS
ATE222925T1 (de)	2002-09-15	Verbessertes verfahren zur herstellung von faktor viii
FI1343809T4 (fi)	2023-09-04	Menetelmä alfa-1 proteinaasinestäjän valmistamiseksi
ATE26130T1 (de)	1987-04-15	Verfahren zur reinigung von lactulosesirup.
PT77232A (fr)	1983-09-01	Procede pour la dissolution selective du plomb
DE3764511D1 (de)	1990-10-04	Verfahren zur reinigung von carnitin.
JPS51122952A (en)	1976-10-27	Process for treating a drain water of purified exhaust gas