DK0784613T3 - Colchicinderivater og den terapeutiske anvendelse deraf - Google Patents

Colchicinderivater og den terapeutiske anvendelse deraf

Info

Publication number: DK0784613T3
Authority: DK; Denmark
Prior art keywords: colchicine derivatives; therapeutic use; derivatives; colchicine; antitumoral
Prior art date: 1994-10-05

Application number

DK95935393T

Other languages

Danish (da)

English (en)

Inventor

Ezio Bombardelli

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-05

Filing date

1995-09-27

Publication date

1999-11-15

1995-09-27 Application filed by Indena Spa filed Critical Indena Spa

1999-11-15 Application granted granted Critical

1999-11-15 Publication of DK0784613T3 publication Critical patent/DK0784613T3/da

Links

IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 2
229940045695 antineooplastic colchicine derivative Drugs 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011200 topical administration Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK95935393T 1994-10-05 1995-09-27 Colchicinderivater og den terapeutiske anvendelse deraf DK0784613T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942026A IT1270124B (it)	1994-10-05	1994-10-05	Derivati della colchicina e loro impiego terapeutico
PCT/EP1995/003823 WO1996011184A1 (en)	1994-10-05	1995-09-27	Colchicine derivatives and the therapeutical use thereof

Publications (1)

Publication Number	Publication Date
DK0784613T3 true DK0784613T3 (da)	1999-11-15

Family

ID=11369650

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK98121484T DK0909763T3 (da)	1994-10-05	1995-09-27	Colchicin-derivater og terapeutisk anvendelse deraf
DK95935393T DK0784613T3 (da)	1994-10-05	1995-09-27	Colchicinderivater og den terapeutiske anvendelse deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK98121484T DK0909763T3 (da)	1994-10-05	1995-09-27	Colchicin-derivater og terapeutisk anvendelse deraf

Country Status (22)

Country	Link
US (1)	US5843910A (it)
EP (2)	EP0784613B1 (it)
JP (1)	JP2921990B2 (it)
KR (1)	KR100255074B1 (it)
CN (2)	CN1075059C (it)
AT (2)	ATE181060T1 (it)
AU (1)	AU692624B2 (it)
CA (1)	CA2201723C (it)
CZ (1)	CZ290309B6 (it)
DE (2)	DE69533267T2 (it)
DK (2)	DK0909763T3 (it)
ES (2)	ES2131863T3 (it)
FI (1)	FI120452B (it)
GR (1)	GR3030449T3 (it)
HU (1)	HU223779B1 (it)
IT (1)	IT1270124B (it)
NO (1)	NO308030B1 (it)
PL (1)	PL182204B1 (it)
PT (1)	PT909763E (it)
RU (1)	RU2145598C1 (it)
SK (1)	SK281831B6 (it)
WO (1)	WO1996011184A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique
WO2000035865A2 (en) *	1998-12-17	2000-06-22	Tularik Inc.	Tubulin-binding agents
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
US6399093B1 (en)	1999-05-19	2002-06-04	Advanced Medical Instruments	Method and composition to treat musculoskeletal disorders
BR0112224A (pt) *	2000-07-07	2003-06-10	Angiogene Pharm Ltd	Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
US6720323B2 (en)	2000-07-07	2004-04-13	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en)	2000-09-25	2003-09-23	The University Of North Carolina At Chapel Hill	Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) *	2003-06-06	2004-12-07	Indena Spa	Analoghi del colchicoside.
EP1646608B1 (en) *	2003-06-25	2011-03-02	JE IL Pharmaceutical Co., Ltd.	Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
ES2356494T3 (es) *	2008-05-28	2011-04-08	Indena S.P.A.	Procedimiento para la glucosidación de colchicina y tiocolchicina.
DK2470499T3 (da) *	2009-08-26	2019-09-23	Alberta Health Services	Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf
CA2964437C (en)	2014-10-14	2023-09-19	Council Of Scientific & Industrial Research	10-substituted colchicinoids as potent anticancer agents
KR20250172901A (ko)	2018-06-29	2025-12-09	알버타 헬스 서비시즈	콜히친 유도체의 방법 및 용도
CN116082182A (zh) *	2021-11-08	2023-05-09	天津市昕晨投资发展有限公司	秋水仙碱衍生物的制备方法及其用途
CN114656429A (zh) *	2021-11-18	2022-06-24	江苏新元素医药科技有限公司	一类抗炎镇痛化合物及其用途
CN114907228B (zh) *	2022-06-27	2023-11-28	深圳市锦泰医药科技合伙企业(有限合伙)	一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH513119A (de) *	1968-02-23	1971-09-30	Merck Patent Gmbh	Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) *	1972-05-05	1974-02-06	Roussel Uclaf	Thiocolchicine derivatives
ATE113273T1 (de) *	1988-08-24	1994-11-15	Advance Biofactures Corp	3-demethylthiocolchicincarbonate und n- acylanaloge.

1994
- 1994-10-05 IT ITMI942026A patent/IT1270124B/it active IP Right Grant
1995
- 1995-09-27 AT AT95935393T patent/ATE181060T1/de not_active IP Right Cessation
- 1995-09-27 DK DK98121484T patent/DK0909763T3/da active
- 1995-09-27 KR KR1019970702190A patent/KR100255074B1/ko not_active Expired - Fee Related
- 1995-09-27 CA CA002201723A patent/CA2201723C/en not_active Expired - Fee Related
- 1995-09-27 PT PT98121484T patent/PT909763E/pt unknown
- 1995-09-27 CZ CZ19971015A patent/CZ290309B6/cs not_active IP Right Cessation
- 1995-09-27 DE DE69533267T patent/DE69533267T2/de not_active Expired - Lifetime
- 1995-09-27 AT AT98121484T patent/ATE271061T1/de not_active IP Right Cessation
- 1995-09-27 PL PL95319455A patent/PL182204B1/pl not_active IP Right Cessation
- 1995-09-27 AU AU37432/95A patent/AU692624B2/en not_active Ceased
- 1995-09-27 WO PCT/EP1995/003823 patent/WO1996011184A1/en not_active Ceased
- 1995-09-27 EP EP95935393A patent/EP0784613B1/en not_active Expired - Lifetime
- 1995-09-27 EP EP98121484A patent/EP0909763B1/en not_active Expired - Lifetime
- 1995-09-27 JP JP8512296A patent/JP2921990B2/ja not_active Expired - Lifetime
- 1995-09-27 HU HU9701700A patent/HU223779B1/hu not_active IP Right Cessation
- 1995-09-27 ES ES95935393T patent/ES2131863T3/es not_active Expired - Lifetime
- 1995-09-27 CN CN95195499A patent/CN1075059C/zh not_active Expired - Fee Related
- 1995-09-27 DE DE69510212T patent/DE69510212T2/de not_active Expired - Lifetime
- 1995-09-27 SK SK424-97A patent/SK281831B6/sk not_active IP Right Cessation
- 1995-09-27 ES ES98121484T patent/ES2224322T3/es not_active Expired - Lifetime
- 1995-09-27 DK DK95935393T patent/DK0784613T3/da active
- 1995-09-27 RU RU97107153A patent/RU2145598C1/ru not_active IP Right Cessation
- 1995-09-27 US US08/817,626 patent/US5843910A/en not_active Expired - Fee Related
1997
- 1997-04-03 FI FI971364A patent/FI120452B/fi active IP Right Grant
- 1997-04-03 NO NO971503A patent/NO308030B1/no not_active IP Right Cessation
1999
- 1999-06-10 GR GR990401514T patent/GR3030449T3/el unknown
2000
- 2000-11-02 CN CN00131989A patent/CN1127480C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69533267D1 (de)	2004-08-19
KR100255074B1 (ko)	2000-05-01
RU2145598C1 (ru)	2000-02-20
AU692624B2 (en)	1998-06-11
HUT77223A (hu)	1998-03-02
DE69510212T2 (de)	1999-11-11
FI971364L (fi)	1997-05-30
DE69533267T2 (de)	2005-08-04
DE69510212D1 (de)	1999-07-15
HK1017361A1 (en)	1999-11-19
HK1001394A1 (en)	1998-06-19
CN1127480C (zh)	2003-11-12
NO308030B1 (no)	2000-07-10
CN1159801A (zh)	1997-09-17
CZ101597A3 (en)	1997-10-15
JP2921990B2 (ja)	1999-07-19
SK42497A3 (en)	1997-11-05
SK281831B6 (sk)	2001-08-06
ATE181060T1 (de)	1999-06-15
PT909763E (pt)	2004-10-29
IT1270124B (it)	1997-04-28
ATE271061T1 (de)	2004-07-15
FI971364A0 (fi)	1997-04-03
EP0784613B1 (en)	1999-06-09
ES2131863T3 (es)	1999-08-01
EP0784613A1 (en)	1997-07-23
ITMI942026A0 (it)	1994-10-05
CA2201723C (en)	2003-03-25
AU3743295A (en)	1996-05-02
ES2224322T3 (es)	2005-03-01
EP0909763A3 (en)	2003-01-22
US5843910A (en)	1998-12-01
PL319455A1 (en)	1997-08-04
EP0909763A2 (en)	1999-04-21
CA2201723A1 (en)	1996-04-18
GR3030449T3 (en)	1999-09-30
FI120452B (fi)	2009-10-30
JPH10507169A (ja)	1998-07-14
EP0909763B1 (en)	2004-07-14
ITMI942026A1 (it)	1996-04-05
CN1075059C (zh)	2001-11-21
NO971503L (no)	1997-05-14
WO1996011184A1 (en)	1996-04-18
HU223779B1 (hu)	2005-01-28
CN1308059A (zh)	2001-08-15
NO971503D0 (no)	1997-04-03
DK0909763T3 (da)	2004-11-22
CZ290309B6 (cs)	2002-07-17
PL182204B1 (en)	2001-11-30

Publication	Publication Date	Title
DK0909763T3 (da)	2004-11-22	Colchicin-derivater og terapeutisk anvendelse deraf
IS1846B (is)	2003-02-07	Setin N-(indól-2-karbónýl)-b-alaninamíð, notkun þeirra og lyfjaefnablöndur
NO307092B1 (no)	2000-02-07	Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding
NO306398B1 (no)	1999-11-01	Substituerte N-(indol-2-karbonyl) glycinamider, anvendelse derav, mellomprodukt og farmasöytisk preparat
ITGE930014A0 (it)	1993-02-26	Spazzolino da denti,antiplacca,motorizzato.
NO972451D0 (no)	1997-05-29	2-heterocyklyloksy og tiometyl-1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og fremgangsmåte for anvendelse derav
FI950458L (fi)	1995-08-04	N-(3-aminopropyyli)-N-fenyyli-5,6,7,8-tetrahydronaftalen-2-karboksamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
IT219016Z2 (it)	1992-11-26	"pinza per saldatura perfezionata ad anidride carbonica"
FI910088L (fi)	1991-07-10	Oral farmaceutisk komposition.
NO972449D0 (no)	1997-05-29	Substituerte 2-arylkarbonyloksymetyl-1,2,5-tiadiazolidin-3-on 1,1 dioksidderivater og preparater og fremgangsmåte for anvendelse derav
DE69312319D1 (de)	1997-08-21	Tachyquinin antagonisten, ihre herstellung und ihre verwendung in pharmazeutischen formulierungen
NO302170B1 (no)	1998-02-02	Enantiomerisk 1-fenyl-2-(2-pyridinyl)etylamin, farmasöytisk formulering og anvendelse derav
ITMI911470A0 (it)	1991-05-29	N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico
FR2779429B1 (fr)	2000-07-13	Derives d'oxindole, leurs preparations et leurs applications en therapeutique
IS6159A (is)	2001-11-13	Fjölgervingar af kristölluðu asabísýkló (2,2,2) oktan-3-amín sítrati og lyfjasamsetningar
EE9600197A (et)	1997-06-16	Uudsed 1,1-bis(heteroasolüül)alkaani derivaadid ja nende kasutamine neuroprotektiivsete ainetena
IS5334A (is)	2000-01-11	Indól og 2,3-díhýdróindól afleiður, framleiðsla þeirra og notkun
FR2672796B1 (fr)	1993-06-11	Arc facial orthodontique perfectionne.
ITMO920074A1 (it)	1993-11-19	Spazzolino da denti perfezionato
DE69111530D1 (de)	1995-08-31	Pyridincarbonsäure-Amid-Derivate und diese enthaltende pharmazeutische Zusammensetzungen.
FR2710832B1 (fr)	1995-12-22	Articulateur dentaire.
IT233870Y1 (it)	2000-02-10	Dispositivo simmetropredeterminatore per la riproduzione del tracciato dell'arcata dentale
ITVI960022V0 (it)	1996-03-08	Dispositivo perfezionato per la depurazione e l'ossigenazione dell'aria ambiente.
IT234739Y1 (it)	2000-03-16	Testiera senza morzo da usare al posto della classica imboccatura per i cavalli
ITMI940711A0 (it)	1994-04-14	Specchio orale da dentista