IT1270124B - Derivati della colchicina e loro impiego terapeutico - Google Patents

Derivati della colchicina e loro impiego terapeutico

Info

Publication number
IT1270124B
IT1270124B ITMI942026A ITMI942026A IT1270124B IT 1270124 B IT1270124 B IT 1270124B IT MI942026 A ITMI942026 A IT MI942026A IT MI942026 A ITMI942026 A IT MI942026A IT 1270124 B IT1270124 B IT 1270124B
Authority
IT
Italy
Prior art keywords
colchicine
colchicine derivatives
therapeutic use
compounds
new
Prior art date
Application number
ITMI942026A
Other languages
English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI942026A0 publication Critical patent/ITMI942026A0/it
Priority to ITMI942026A priority Critical patent/IT1270124B/it
Priority to ES95935393T priority patent/ES2131863T3/es
Priority to CN95195499A priority patent/CN1075059C/zh
Priority to ES98121484T priority patent/ES2224322T3/es
Priority to CA002201723A priority patent/CA2201723C/en
Priority to AU37432/95A priority patent/AU692624B2/en
Priority to PT98121484T priority patent/PT909763E/pt
Priority to EP95935393A priority patent/EP0784613B1/en
Priority to AT95935393T priority patent/ATE181060T1/de
Priority to DE69510212T priority patent/DE69510212T2/de
Priority to PCT/EP1995/003823 priority patent/WO1996011184A1/en
Priority to EP98121484A priority patent/EP0909763B1/en
Priority to CZ19971015A priority patent/CZ290309B6/cs
Priority to DK95935393T priority patent/DK0784613T3/da
Priority to JP8512296A priority patent/JP2921990B2/ja
Priority to DK98121484T priority patent/DK0909763T3/da
Priority to KR1019970702190A priority patent/KR100255074B1/ko
Priority to DE69533267T priority patent/DE69533267T2/de
Priority to AT98121484T priority patent/ATE271061T1/de
Priority to US08/817,626 priority patent/US5843910A/en
Priority to PL95319455A priority patent/PL182204B1/pl
Priority to SK424-97A priority patent/SK281831B6/sk
Priority to RU97107153A priority patent/RU2145598C1/ru
Priority to HK98100368.7A priority patent/HK1001394B/en
Priority to HU9701700A priority patent/HU223779B1/hu
Publication of ITMI942026A1 publication Critical patent/ITMI942026A1/it
Priority to FI971364A priority patent/FI120452B/fi
Priority to NO971503A priority patent/NO308030B1/no
Application granted granted Critical
Publication of IT1270124B publication Critical patent/IT1270124B/it
Priority to HK99102643.9A priority patent/HK1017361B/en
Priority to AU61958/98A priority patent/AU699789B2/en
Priority to GR990401514T priority patent/GR3030449T3/el
Priority to CN00131989A priority patent/CN1127480C/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invenzione riguarda nuovi derivati della colchicina dotati di attività antiproliferativa, antitumorale ed antiinfiammatoria. I nuovi composti hanno una citotossicità su linee cellulari tumorali umane comparabile con la colchicina ma rispetto a questa sono meno tossici e più selettivi soprattutto su cellule resistenti ai più comuni farmaci. Alcuni composti hanno inoltre una marcata attività sul TNF e Interleuchina 2, e sono pertanto antiinfiammatori di notevole potenza. Essi sono incorporabili in formulazioni farmaceutiche utili per somministrazione parenterale, orale e topica.
ITMI942026A 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico IT1270124B (it)

Priority Applications (31)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico
KR1019970702190A KR100255074B1 (ko) 1994-10-05 1995-09-27 콜히친 유도체 및 그의 치료적 용도
DE69533267T DE69533267T2 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische Verwendung
ES98121484T ES2224322T3 (es) 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico.
CA002201723A CA2201723C (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
AU37432/95A AU692624B2 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
PT98121484T PT909763E (pt) 1994-10-05 1995-09-27 Derivados de colchicina e a sua utilizacao terapeutica
EP95935393A EP0784613B1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
AT95935393T ATE181060T1 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische verwendung
DE69510212T DE69510212T2 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische verwendung
PCT/EP1995/003823 WO1996011184A1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
EP98121484A EP0909763B1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
CZ19971015A CZ290309B6 (cs) 1994-10-05 1995-09-27 Deriváty kolchicinu, způsob výroby a farmaceutický prostředek s jejich obsahem
DK95935393T DK0784613T3 (da) 1994-10-05 1995-09-27 Colchicinderivater og den terapeutiske anvendelse deraf
JP8512296A JP2921990B2 (ja) 1994-10-05 1995-09-27 コルヒチン誘導体及びその治療的利用
DK98121484T DK0909763T3 (da) 1994-10-05 1995-09-27 Colchicin-derivater og terapeutisk anvendelse deraf
ES95935393T ES2131863T3 (es) 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico.
US08/817,626 US5843910A (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
CN95195499A CN1075059C (zh) 1994-10-05 1995-09-27 秋水仙素衍生物及其治疗用途
AT98121484T ATE271061T1 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische verwendung
PL95319455A PL182204B1 (en) 1994-10-05 1995-09-27 Derivatives of colchicine and their tharapeutic application
SK424-97A SK281831B6 (sk) 1994-10-05 1995-09-27 Kolchicínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
RU97107153A RU2145598C1 (ru) 1994-10-05 1995-09-27 Производные колхицина, способ их получения, фармацевтическая композиция
HK98100368.7A HK1001394B (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof
HU9701700A HU223779B1 (hu) 1994-10-05 1995-09-27 Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására
FI971364A FI120452B (fi) 1994-10-05 1997-04-03 Kolkisiinijohdannaiset ja niiden terapeuttinen käyttö
NO971503A NO308030B1 (no) 1994-10-05 1997-04-03 Kolkisinderivater og deres terapeutiske anvendelse
HK99102643.9A HK1017361B (en) 1994-10-05 1998-01-16 Colchicine derivatives and the therapeutical use thereof
AU61958/98A AU699789B2 (en) 1994-10-05 1998-04-16 Colchicine derivatives and the therapeutical use thereof
GR990401514T GR3030449T3 (en) 1994-10-05 1999-06-10 Colchicine derivatives and the therapeutical use thereof
CN00131989A CN1127480C (zh) 1994-10-05 2000-11-02 秋水仙素衍生物及其治疗用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico

Publications (3)

Publication Number Publication Date
ITMI942026A0 ITMI942026A0 (it) 1994-10-05
ITMI942026A1 ITMI942026A1 (it) 1996-04-05
IT1270124B true IT1270124B (it) 1997-04-28

Family

ID=11369650

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico

Country Status (22)

Country Link
US (1) US5843910A (it)
EP (2) EP0784613B1 (it)
JP (1) JP2921990B2 (it)
KR (1) KR100255074B1 (it)
CN (2) CN1075059C (it)
AT (2) ATE181060T1 (it)
AU (1) AU692624B2 (it)
CA (1) CA2201723C (it)
CZ (1) CZ290309B6 (it)
DE (2) DE69533267T2 (it)
DK (2) DK0909763T3 (it)
ES (2) ES2131863T3 (it)
FI (1) FI120452B (it)
GR (1) GR3030449T3 (it)
HU (1) HU223779B1 (it)
IT (1) IT1270124B (it)
NO (1) NO308030B1 (it)
PL (1) PL182204B1 (it)
PT (1) PT909763E (it)
RU (1) RU2145598C1 (it)
SK (1) SK281831B6 (it)
WO (1) WO1996011184A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
WO2000035865A2 (en) * 1998-12-17 2000-06-22 Tularik Inc. Tubulin-binding agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
BR0112224A (pt) * 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
US6720323B2 (en) 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
EP1646608B1 (en) * 2003-06-25 2011-03-02 JE IL Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
ES2356494T3 (es) * 2008-05-28 2011-04-08 Indena S.P.A. Procedimiento para la glucosidación de colchicina y tiocolchicina.
DK2470499T3 (da) * 2009-08-26 2019-09-23 Alberta Health Services Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf
CA2964437C (en) 2014-10-14 2023-09-19 Council Of Scientific & Industrial Research 10-substituted colchicinoids as potent anticancer agents
KR20250172901A (ko) 2018-06-29 2025-12-09 알버타 헬스 서비시즈 콜히친 유도체의 방법 및 용도
CN116082182A (zh) * 2021-11-08 2023-05-09 天津市昕晨投资发展有限公司 秋水仙碱衍生物的制备方法及其用途
CN114656429A (zh) * 2021-11-18 2022-06-24 江苏新元素医药科技有限公司 一类抗炎镇痛化合物及其用途
CN114907228B (zh) * 2022-06-27 2023-11-28 深圳市锦泰医药科技合伙企业(有限合伙) 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513119A (de) * 1968-02-23 1971-09-30 Merck Patent Gmbh Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) * 1972-05-05 1974-02-06 Roussel Uclaf Thiocolchicine derivatives
ATE113273T1 (de) * 1988-08-24 1994-11-15 Advance Biofactures Corp 3-demethylthiocolchicincarbonate und n- acylanaloge.

Also Published As

Publication number Publication date
DE69533267D1 (de) 2004-08-19
KR100255074B1 (ko) 2000-05-01
RU2145598C1 (ru) 2000-02-20
AU692624B2 (en) 1998-06-11
HUT77223A (hu) 1998-03-02
DE69510212T2 (de) 1999-11-11
FI971364L (fi) 1997-05-30
DE69533267T2 (de) 2005-08-04
DE69510212D1 (de) 1999-07-15
HK1017361A1 (en) 1999-11-19
HK1001394A1 (en) 1998-06-19
CN1127480C (zh) 2003-11-12
NO308030B1 (no) 2000-07-10
CN1159801A (zh) 1997-09-17
CZ101597A3 (en) 1997-10-15
JP2921990B2 (ja) 1999-07-19
SK42497A3 (en) 1997-11-05
SK281831B6 (sk) 2001-08-06
ATE181060T1 (de) 1999-06-15
PT909763E (pt) 2004-10-29
ATE271061T1 (de) 2004-07-15
FI971364A0 (fi) 1997-04-03
EP0784613B1 (en) 1999-06-09
ES2131863T3 (es) 1999-08-01
EP0784613A1 (en) 1997-07-23
ITMI942026A0 (it) 1994-10-05
CA2201723C (en) 2003-03-25
AU3743295A (en) 1996-05-02
ES2224322T3 (es) 2005-03-01
EP0909763A3 (en) 2003-01-22
US5843910A (en) 1998-12-01
PL319455A1 (en) 1997-08-04
EP0909763A2 (en) 1999-04-21
CA2201723A1 (en) 1996-04-18
GR3030449T3 (en) 1999-09-30
DK0784613T3 (da) 1999-11-15
FI120452B (fi) 2009-10-30
JPH10507169A (ja) 1998-07-14
EP0909763B1 (en) 2004-07-14
ITMI942026A1 (it) 1996-04-05
CN1075059C (zh) 2001-11-21
NO971503L (no) 1997-05-14
WO1996011184A1 (en) 1996-04-18
HU223779B1 (hu) 2005-01-28
CN1308059A (zh) 2001-08-15
NO971503D0 (no) 1997-04-03
DK0909763T3 (da) 2004-11-22
CZ290309B6 (cs) 2002-07-17
PL182204B1 (en) 2001-11-30

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