ATE113273T1 - 3-demethylthiocolchicincarbonate und n- acylanaloge. - Google Patents

3-demethylthiocolchicincarbonate und n- acylanaloge.

Info

Publication number: ATE113273T1
Authority: AT; Austria
Prior art keywords: demethylthiocolchicine; acylanalogs; carbonates; alkyl; relates
Prior art date: 1988-08-24

Application number

AT89308341T

Other languages

English (en)

Inventor

Arnold Dr Brossi

Original Assignee

Advance Biofactures Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-17

Publication date

1994-11-15

1989-08-17 Application filed by Advance Biofactures Corp filed Critical Advance Biofactures Corp

1994-11-15 Application granted granted Critical

1994-11-15 Publication of ATE113273T1 publication Critical patent/ATE113273T1/de

Links

PKYOHQGXPPVIGD-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound O=C1C(SC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 PKYOHQGXPPVIGD-HNNXBMFYSA-N 0.000 title abstract 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 title 1
-1 alkoxyacetyl Chemical group 0.000 abstract 2
201000005569 Gout Diseases 0.000 abstract 1
206010037660 Pyrexia Diseases 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005179 haloacetyl group Chemical group 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Luminescent Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89308341T 1988-08-24 1989-08-17 3-demethylthiocolchicincarbonate und n- acylanaloge. ATE113273T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23590788A	1988-08-24	1988-08-24

Publications (1)

Publication Number	Publication Date
ATE113273T1 true ATE113273T1 (de)	1994-11-15

Family

ID=22887351

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89308341T ATE113273T1 (de)	1988-08-24	1989-08-17	3-demethylthiocolchicincarbonate und n- acylanaloge.

Country Status (10)

Country	Link
EP (1)	EP0356137B1 (de)
JP (1)	JPH02142765A (de)
AT (1)	ATE113273T1 (de)
AU (1)	AU618395B2 (de)
CA (1)	CA1338432C (de)
DE (1)	DE68919025T2 (de)
DK (1)	DK416289A (de)
ES (1)	ES2062014T3 (de)
FI (1)	FI95461C (de)
ZA (1)	ZA896411B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1291550B1 (it) *	1997-04-11	1999-01-11	Indena Spa	Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
EP2435403A4 (de)	2009-05-27	2015-04-01	Takeda Pharmaceuticals Usa Inc	Thiocolchicinderivate sowie herstellungs- und verwendungsverfahren dafür

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US235907A (en) *		1880-12-28		sqhlimp
US2820029A (en) *	1954-02-10	1958-01-14	U C L A F	New thio-derivatives of colchiceine compounds and a process of making same
FR1099138A (fr) *	1954-02-10	1955-08-30	Roussel Uclaf	Thiodérivés tropoloniques de la colchicine et leur procédé d'obtention

1989
- 1989-08-17 AT AT89308341T patent/ATE113273T1/de active
- 1989-08-17 EP EP89308341A patent/EP0356137B1/de not_active Expired - Lifetime
- 1989-08-17 DE DE68919025T patent/DE68919025T2/de not_active Expired - Fee Related
- 1989-08-17 ES ES89308341T patent/ES2062014T3/es not_active Expired - Lifetime
- 1989-08-22 ZA ZA896411A patent/ZA896411B/xx unknown
- 1989-08-23 DK DK416289A patent/DK416289A/da not_active Application Discontinuation
- 1989-08-23 AU AU40191/89A patent/AU618395B2/en not_active Ceased
- 1989-08-23 FI FI893955A patent/FI95461C/fi not_active IP Right Cessation
- 1989-08-24 CA CA000609341A patent/CA1338432C/en not_active Expired - Fee Related
- 1989-08-24 JP JP1218416A patent/JPH02142765A/ja active Pending

Also Published As

Publication number	Publication date
FI893955A0 (fi)	1989-08-23
EP0356137A3 (en)	1990-11-07
FI95461C (fi)	1996-02-12
DK416289A (da)	1990-02-25
EP0356137B1 (de)	1994-10-26
ZA896411B (en)	1990-05-30
EP0356137A2 (de)	1990-02-28
AU4019189A (en)	1990-03-01
FI893955L (fi)	1990-02-25
AU618395B2 (en)	1991-12-19
CA1338432C (en)	1996-07-02
ES2062014T3 (es)	1994-12-16
FI95461B (fi)	1995-10-31
DK416289D0 (da)	1989-08-23
DE68919025T2 (de)	1995-03-02
JPH02142765A (ja)	1990-05-31
DE68919025D1 (de)	1994-12-01

Publication	Publication Date	Title
PT88603A (pt)	1988-10-01	Immunomodulatory azapiranes
NO873071D0 (no)	1987-07-22	Fremgangsmaate for fremstilling av amid-derivater.
DE69212925D1 (de)	1996-09-26	Polymerisationsinhibitoren für Acrylsäure und Ester
SE8305467D0 (sv)	1983-10-05	1,4-dihydropyridinderivat
DE69033069D1 (de)	1999-05-27	Prostaglandinanaloge
ATE266641T1 (de)	2004-05-15	Picolinsäure-derivate zur behandlung von il-1 und tnf bedingten erkrankungen
FI834702A0 (fi)	1983-12-21	Nya nitroalifatiska foereningar, deras framstaellningsfoerfarande och anvaendning
LV10235A (lv)	1994-10-20	Jauni esteri to iegusanas panemiens farmaceitiska kompozicija arstesanas metode
DE68919025D1 (de)	1994-12-01	3-Demethylthiocolchicincarbonate und N-Acylanaloge.
EP0605474A4 (de)	1994-08-03
IL69881A (en)	1986-10-31	1-pyridinyl(or tetrahydropyridinyl)-3-phenyl indenes,their preparation and pharmaceutical compositions comprising them
DE59912459D1 (de)	2005-09-29	Verwendung von Estern der 12-Hydroxystearinsäure als Solubilisatoren
ATE100077T1 (de)	1994-01-15	2-hydroxy-3-phenoxypropylaminoverbindungen.
FR2396001A1 (fr)	1979-01-26	Derives a-acetyleniques et a-vinyliques d'amino-acides utiles comme medicaments et leur procede de preparation
ATE186719T1 (de)	1999-12-15	Dl-di od. tri hydroxyphenylglycinalkylester zur behandlung entzündlicher und allergischer zustände
AU2742288A (en)	1989-06-29	Novel compound effective as cerebral insufficiency improver
DK0580378T3 (da)	1996-07-29	Substituerede benzoatderivater
JPS5579372A (en)	1980-06-14	Preparation of carbostyril derivative
NO941757L (no)	1994-05-10	1-fenylpyrrolidon-derivater med optisk aktivitet, mellomprodukter for fremstilling derav og fremgangsmåter for deres fremstilling
AU5977980A (en)	1981-01-15	Aminodeoxyclavulanic acids
ATE144257T1 (de)	1996-11-15	Tetrahydro-4-phenylimino-3-thiophenessigsäuren
DE58909563D1 (de)	1996-02-22	3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren