ATE113273T1 - 3-demethylthiocolchicincarbonate und n- acylanaloge. - Google Patents

3-demethylthiocolchicincarbonate und n- acylanaloge.

Info

Publication number: ATE113273T1
Authority: AT; Austria
Prior art keywords: demethylthiocolchicine; acylanalogs; carbonates; alkyl; relates
Prior art date: 1988-08-24

Application number

AT89308341T

Other languages

English (en)

Inventor

Arnold Dr Brossi

Original Assignee

Advance Biofactures Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-17

Publication date

1994-11-15

1989-08-17 Application filed by Advance Biofactures Corp filed Critical Advance Biofactures Corp

1994-11-15 Application granted granted Critical

1994-11-15 Publication of ATE113273T1 publication Critical patent/ATE113273T1/de

Links

PKYOHQGXPPVIGD-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound O=C1C(SC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 PKYOHQGXPPVIGD-HNNXBMFYSA-N 0.000 title abstract 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 title 1
-1 alkoxyacetyl Chemical group 0.000 abstract 2
201000005569 Gout Diseases 0.000 abstract 1
206010037660 Pyrexia Diseases 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005179 haloacetyl group Chemical group 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Luminescent Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

AT89308341T 1988-08-24 1989-08-17 3-demethylthiocolchicincarbonate und n- acylanaloge. ATE113273T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23590788A	1988-08-24	1988-08-24

Publications (1)

Publication Number	Publication Date
ATE113273T1 true ATE113273T1 (de)	1994-11-15

Family

ID=22887351

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89308341T ATE113273T1 (de)	1988-08-24	1989-08-17	3-demethylthiocolchicincarbonate und n- acylanaloge.

Country Status (10)

Country	Link
EP (1)	EP0356137B1 (de)
JP (1)	JPH02142765A (de)
AT (1)	ATE113273T1 (de)
AU (1)	AU618395B2 (de)
CA (1)	CA1338432C (de)
DE (1)	DE68919025T2 (de)
DK (1)	DK416289A (de)
ES (1)	ES2062014T3 (de)
FI (1)	FI95461C (de)
ZA (1)	ZA896411B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1291550B1 (it) *	1997-04-11	1999-01-11	Indena Spa	Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
US8497290B2 (en)	2009-05-27	2013-07-30	Takeda Pharmaceuticals U.S.A., Inc.	Thiocolchicine derivatives, method of making and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US235907A (en) *		1880-12-28		sqhlimp
US2820029A (en) *	1954-02-10	1958-01-14	U C L A F	New thio-derivatives of colchiceine compounds and a process of making same
FR1099138A (fr) *	1954-02-10	1955-08-30	Roussel Uclaf	Thiodérivés tropoloniques de la colchicine et leur procédé d'obtention

1989
- 1989-08-17 ES ES89308341T patent/ES2062014T3/es not_active Expired - Lifetime
- 1989-08-17 DE DE68919025T patent/DE68919025T2/de not_active Expired - Fee Related
- 1989-08-17 EP EP89308341A patent/EP0356137B1/de not_active Expired - Lifetime
- 1989-08-17 AT AT89308341T patent/ATE113273T1/de active
- 1989-08-22 ZA ZA896411A patent/ZA896411B/xx unknown
- 1989-08-23 FI FI893955A patent/FI95461C/fi not_active IP Right Cessation
- 1989-08-23 DK DK416289A patent/DK416289A/da not_active Application Discontinuation
- 1989-08-23 AU AU40191/89A patent/AU618395B2/en not_active Ceased
- 1989-08-24 CA CA000609341A patent/CA1338432C/en not_active Expired - Fee Related
- 1989-08-24 JP JP1218416A patent/JPH02142765A/ja active Pending

Also Published As

Publication number	Publication date
FI893955A0 (fi)	1989-08-23
FI893955L (fi)	1990-02-25
FI95461C (fi)	1996-02-12
ES2062014T3 (es)	1994-12-16
AU618395B2 (en)	1991-12-19
DE68919025T2 (de)	1995-03-02
ZA896411B (en)	1990-05-30
CA1338432C (en)	1996-07-02
DK416289D0 (da)	1989-08-23
EP0356137A3 (en)	1990-11-07
FI95461B (fi)	1995-10-31
DE68919025D1 (de)	1994-12-01
AU4019189A (en)	1990-03-01
DK416289A (da)	1990-02-25
EP0356137B1 (de)	1994-10-26
EP0356137A2 (de)	1990-02-28
JPH02142765A (ja)	1990-05-31

Publication	Publication Date	Title
DK77090D0 (da)	1990-03-23	Immunmodulerende azaspiraner
FR2430412A1 (fr)	1980-02-01	Derives substitues de propanolamine utiles comme medicaments et procede de leur preparation
ATE46696T1 (de)	1989-10-15	1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons\|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung.
ATE141588T1 (de)	1996-09-15	Polymerisationsinhibitoren für acrylsäure und ester
SE8305467L (sv)	1985-04-06	1,4-dihydropyridinderivat
DE69033069D1 (de)	1999-05-27	Prostaglandinanaloge
ATE266641T1 (de)	2004-05-15	Picolinsäure-derivate zur behandlung von il-1 und tnf bedingten erkrankungen
FI834702A0 (fi)	1983-12-21	Nya nitroalifatiska foereningar, deras framstaellningsfoerfarande och anvaendning
LV10235A (lv)	1994-10-20	Jauni esteri to iegusanas panemiens farmaceitiska kompozicija arstesanas metode
ATE113273T1 (de)	1994-11-15	3-demethylthiocolchicincarbonate und n- acylanaloge.
EP0605474A4 (de)	1994-08-03
IL69881A (en)	1986-10-31	1-pyridinyl(or tetrahydropyridinyl)-3-phenyl indenes,their preparation and pharmaceutical compositions comprising them
ATE302615T1 (de)	2005-09-15	Verwendung von estern der 12-hydroxystearinsäure als solubilisatoren
ATE100077T1 (de)	1994-01-15	2-hydroxy-3-phenoxypropylaminoverbindungen.
NZ219758A (en)	1989-04-26	Heterocyclic ester derivatives of 1,4 dihydropyridin-3,5-dicarboxylic acids intermediates and pharmaceutical compositions
ATE186719T1 (de)	1999-12-15	Dl-di od. tri hydroxyphenylglycinalkylester zur behandlung entzündlicher und allergischer zustände
DK0580378T3 (da)	1996-07-29	Substituerede benzoatderivater
JPS5579372A (en)	1980-06-14	Preparation of carbostyril derivative
NO941757L (no)	1994-05-10	1-fenylpyrrolidon-derivater med optisk aktivitet, mellomprodukter for fremstilling derav og fremgangsmåter for deres fremstilling
AU5977980A (en)	1981-01-15	Aminodeoxyclavulanic acids
ES2095831T3 (es)	1997-03-01	Acidos tetrahidro-4-fenilimino-3-tiofeno-aceticos.
DE58909563D1 (de)	1996-02-22	3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren