DK0785198T3 - Fremgangsmåde til fremstilling af optisk aktiv 3-quinuclidinol - Google Patents

Fremgangsmåde til fremstilling af optisk aktiv 3-quinuclidinol

Info

Publication number: DK0785198T3
Authority: DK; Denmark
Prior art keywords: optically active; quinuclidinol; preparation; catalyst; formula
Prior art date: 1996-01-19

Application number

DK96120280T

Other languages

English (en)

Inventor

Walter Dr Brieden

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-19

Filing date

1996-12-17

Publication date

2000-11-13

1996-12-17 Application filed by Lonza Ag filed Critical Lonza Ag

2000-11-13 Application granted granted Critical

2000-11-13 Publication of DK0785198T3 publication Critical patent/DK0785198T3/da

Links

IVLICPVPXWEGCA-UHFFFAOYSA-N 3-quinuclidinol Chemical compound C1C[C@@H]2C(O)C[N@]1CC2 IVLICPVPXWEGCA-UHFFFAOYSA-N 0.000 title abstract 2
239000003054 catalyst Substances 0.000 abstract 2
VURFVHCLMJOLKN-UHFFFAOYSA-N diphosphane Chemical compound PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 abstract 2
ZKMZPXWMMSBLNO-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-one Chemical compound C1CC2C(=O)CN1CC2 ZKMZPXWMMSBLNO-UHFFFAOYSA-N 0.000 abstract 1
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
239000002841 Lewis acid Substances 0.000 abstract 1
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
238000009876 asymmetric hydrogenation reaction Methods 0.000 abstract 1
229910052741 iridium Inorganic materials 0.000 abstract 1
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
229910052707 ruthenium Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005039 triarylmethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK96120280T 1996-01-19 1996-12-17 Fremgangsmåde til fremstilling af optisk aktiv 3-quinuclidinol DK0785198T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH13996		1996-01-19

Publications (1)

Publication Number	Publication Date
DK0785198T3 true DK0785198T3 (da)	2000-11-13

Family

ID=4180140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96120280T DK0785198T3 (da)	1996-01-19	1996-12-17	Fremgangsmåde til fremstilling af optisk aktiv 3-quinuclidinol

Country Status (9)

Country	Link
US (1)	US5744606A (da)
EP (1)	EP0785198B1 (da)
JP (1)	JP4122536B2 (da)
AT (1)	ATE194342T1 (da)
CA (1)	CA2194727C (da)
DE (1)	DE59605542D1 (da)
DK (1)	DK0785198T3 (da)
ES (1)	ES2147889T3 (da)
PT (1)	PT785198E (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9206073A (pt) *	1991-05-31	1994-12-06	Pfizer	Derivados de quinuclidina
CA2423192C (en) *	2000-09-20	2010-11-23	Karolinska Innovations Ab	1-azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors
JP2003230398A (ja)	2001-12-07	2003-08-19	Daicel Chem Ind Ltd	光学活性アルコールの製造方法
JP2003176266A (ja) *	2001-12-13	2003-06-24	Sumitomo Chem Co Ltd	光学活性なアゼチジンアミド配位遷移金属錯体および用途
EP1601635B1 (en) *	2003-03-07	2008-01-09	Kawaken Fine Chemicals Co., Ltd.	Process for producing optically active alcohol in the presence of rhodium, a chiral ferrocenyldiphosphine and an optically active diamine
JP4490211B2 (ja) *	2004-08-27	2010-06-23	高砂香料工業株式会社	光学活性３−キヌクリジノール類の製造方法
EP1867654B1 (en)	2005-03-30	2014-06-11	Nagoya Industrial Science Research Institute	Process for production of optically active quinuclidinol
JP5172124B2 (ja) *	2006-09-29	2013-03-27	関東化学株式会社	２位に置換基を有する光学活性キヌクリジノール類の製造方法
DE102013104418B4 (de)	2013-04-30	2018-09-27	Cambrex Iep Gmbh	Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol
CN112707899B (zh) *	2019-10-24	2023-10-17	东莞市东阳光动物保健药品有限公司	一种奎宁醇的制备方法
CN111454258B (zh) *	2020-05-28	2021-07-20	中山奕安泰医药科技有限公司	索非那新中间体的制备方法
CN114437060B (zh) *	2020-11-03	2023-04-14	凯特立斯（深圳）科技有限公司	一种(r)-和(s)-3-奎宁环醇的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3839385A1 (de)	1988-11-22	1990-05-23	Boehringer Ingelheim Kg	Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung
GB9119705D0 (en)	1991-09-14	1991-10-30	Pfizer Ltd	Therapeutic compounds
EP0564406B1 (de)	1992-04-02	1999-05-06	Novartis AG	Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
US5215918A (en) *	1992-06-19	1993-06-01	Bend Research, Inc.	Enantiomeric enrichment of (R,S)-3-quinuclidinol
CA2099233A1 (en) *	1992-06-29	1993-12-30	Conrad P. Dorn	Morpholine and thiomorpholine tachykinin receptor antagonists
US5536858A (en) *	1994-02-12	1996-07-16	Hoffmann-La Roche Inc.	Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions

1996
- 1996-12-17 ES ES96120280T patent/ES2147889T3/es not_active Expired - Lifetime
- 1996-12-17 EP EP96120280A patent/EP0785198B1/de not_active Expired - Lifetime
- 1996-12-17 PT PT96120280T patent/PT785198E/pt unknown
- 1996-12-17 DK DK96120280T patent/DK0785198T3/da active
- 1996-12-17 DE DE59605542T patent/DE59605542D1/de not_active Expired - Fee Related
- 1996-12-17 AT AT96120280T patent/ATE194342T1/de not_active IP Right Cessation
1997
- 1997-01-09 CA CA002194727A patent/CA2194727C/en not_active Expired - Fee Related
- 1997-01-16 JP JP00562797A patent/JP4122536B2/ja not_active Expired - Fee Related
- 1997-01-16 US US08/783,893 patent/US5744606A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2194727C (en)	2005-04-12
US5744606A (en)	1998-04-28
DE59605542D1 (de)	2000-08-10
EP0785198B1 (de)	2000-07-05
PT785198E (pt)	2000-11-30
CA2194727A1 (en)	1997-07-20
ES2147889T3 (es)	2000-10-01
JPH09194480A (ja)	1997-07-29
EP0785198A1 (de)	1997-07-23
JP4122536B2 (ja)	2008-07-23
ATE194342T1 (de)	2000-07-15

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