DK0785208T3 - Phosphonat-nukleotid-forbindelser - Google Patents

Phosphonat-nukleotid-forbindelser

Info

Publication number: DK0785208T3
Authority: DK; Denmark
Prior art keywords: halogen; alkyl; substituted; phosphonate nucleotide; alkoxy
Prior art date: 1996-01-18

Application number

DK97100652T

Other languages

English (en)

Inventor

Masaru Ubasawa

Kouichi Sekiya

Hideaki Takashima

Naoko Ueda

Satoshi Yuasa

Naohiro Kamiya

Original Assignee

Mitsubishi Chem Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-18

Filing date

1997-01-17

Publication date

2001-04-23

1997-01-17 Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp

2001-04-23 Application granted granted Critical

2001-04-23 Publication of DK0785208T3 publication Critical patent/DK0785208T3/da

Links

-1 Phosphonate nucleotide compounds Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical class 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK97100652T 1996-01-18 1997-01-17 Phosphonat-nukleotid-forbindelser DK0785208T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP648096		1996-01-18

Publications (1)

Publication Number	Publication Date
DK0785208T3 true DK0785208T3 (da)	2001-04-23

Family

ID=11639647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97100652T DK0785208T3 (da)	1996-01-18	1997-01-17	Phosphonat-nukleotid-forbindelser

Country Status (12)

Country	Link
US (1)	US5840716A (da)
EP (1)	EP0785208B1 (da)
KR (1)	KR100366727B1 (da)
CN (2)	CN1088712C (da)
AT (1)	ATE199907T1 (da)
CA (1)	CA2195262C (da)
DE (1)	DE69704286T2 (da)
DK (1)	DK0785208T3 (da)
ES (1)	ES2155219T3 (da)
GR (1)	GR3035776T3 (da)
PT (1)	PT785208E (da)
TW (1)	TW369536B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE199906T1 (de) *	1993-06-29	2001-04-15	Mitsubishi Chem Corp	Phosphonat-nukleotid ester-derivate
EP0919562B1 (en) *	1996-08-13	2002-11-06	Mitsubishi Chemical Corporation	Phosphonate nucleotide compounds
US7205404B1 (en) *	1999-03-05	2007-04-17	Metabasis Therapeutics, Inc.	Phosphorus-containing prodrugs
US6767900B2 (en)	2000-02-29	2004-07-27	Mitsubishi Pharma Corporation	Phosphonate nucleotide compound
WO2003028737A1 (en) *	2001-08-30	2003-04-10	Mitsubishi Pharma Corporation	Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
US20040023928A1 (en) *	2001-10-31	2004-02-05	Colacino Joseph Matthew	Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
KR20050044587A (ko) *	2001-12-07	2005-05-12	미쯔비시 웰 파마 가부시키가이샤	Ｂ형 간염 바이러스 감염 치료용 포스포네이트뉴클레오타이드 유사체의 용도
WO2003051881A1 (en) *	2001-12-17	2003-06-26	Ribapharm Inc.	Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
WO2004024743A1 (ja) *	2002-09-13	2004-03-25	Mitsubishi Pharma Corporation	２−アミノ−６−（４−メトキシフェニルチオ）−９−[２−（ホスホノメトキシ）エチル]プリンビス（２，２，２−トリフルオロエチル）エステルの結晶
TW200413399A (en) *	2002-11-15	2004-08-01	Mitsubishi Pharma Corp	Process for producing 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl halide
KR20040042896A (ko) *	2002-11-15	2004-05-20	미쯔비시 웰 파마 가부시키가이샤	의약 제제 조성물
WO2005090370A1 (en)	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN100475825C (zh) *	2004-03-19	2009-04-08	中国人民解放军军事医学科学院毒物药物研究所	无环核苷膦酸酯衍生物
ES2401285T3 (es)	2004-12-16	2013-04-18	The Regents Of The University Of California	Fármacos con el pulmón como diana
CN1827627B (zh) *	2005-03-04	2011-05-11	北京美倍他药物研究有限公司	新的无环核苷膦酸及其酯衍生物及其医药用途
JP2008538354A (ja)	2005-04-08	2008-10-23	キメリクス，インコーポレイテッド	ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
US8642577B2 (en)	2005-04-08	2014-02-04	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
KR101519028B1 (ko)	2007-04-13	2015-05-11	써던 리서취 인스티튜트	항혈관형성제 및 사용방법
CN101293899B (zh) *	2007-04-28	2011-12-07	中国人民解放军军事医学科学院毒物药物研究所	无环核苷膦酸酯衍生物及其医药用途
CN101977610B (zh) *	2008-01-25	2012-05-16	奇默里克斯公司	治疗病毒感染的方法
WO2011011519A1 (en)	2009-07-21	2011-01-27	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
US20120164104A1 (en)	2009-08-03	2012-06-28	Chimerix, Inc.	Composition and Methods of Treating Viral Infections and Viral Induced Tumors
CN102093422B (zh) *	2009-12-10	2015-02-25	中国人民解放军军事医学科学院毒物药物研究所	无环核苷膦酸酯衍生物及其医药用途
PT2534150T (pt)	2010-02-12	2017-05-02	Chimerix Inc	Métodos para tratar uma infecção viral
US9278135B2 (en)	2010-04-26	2016-03-08	Chimerix Inc.	Methods of treating retroviral infections and related dosage regimes
CN102286026B (zh) *	2010-06-18	2014-07-02	中国人民解放军军事医学科学院毒物药物研究所	无环核苷酸类似物的盐及其晶型和药物组合物
EP2794624B1 (en)	2011-12-22	2019-05-15	Geron Corporation	Guanine analogs as telomerase substrates and telomere length affectors
EP2846788A1 (en)	2012-05-11	2015-03-18	Akron Molecules AG	Use of compounds for the treatment of pain
SMT201800538T1 (it)	2013-03-15	2019-01-11	Univ California	Diesteri di fosfonato nucleosidico aciclico
US10449210B2 (en)	2014-02-13	2019-10-22	Ligand Pharmaceuticals Inc.	Prodrug compounds and their uses
CN106687118A (zh)	2014-07-02	2017-05-17	配体药物公司	前药化合物及其用途
HRP20220651T1 (hr)	2014-09-15	2022-08-19	The Regents Of The University Of California	Nukleotidni analozi
US10377782B2 (en)	2015-09-15	2019-08-13	The Regents Of The University Of California	Nucleotide analogs
CN111788196A (zh)	2018-01-09	2020-10-16	配体药物公司	缩醛化合物及其治疗用途
JP2025526212A (ja)	2022-07-21	2025-08-13	アンティババイオサイエンシズインコーポレイテッド	Ｈｐｖ感染症及びｈｐｖ誘発性新生物の治療用の組成物及び剤形

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9020932D0 (en) *	1990-09-26	1990-11-07	Wellcome Found	Heterocyclic compounds
US5532225A (en) *	1992-07-31	1996-07-02	Sri International	Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
EP0618214A1 (en) *	1993-04-01	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Unsaturated phosphonate derivatives of purines and pyrimidines
ATE199906T1 (de) *	1993-06-29	2001-04-15	Mitsubishi Chem Corp	Phosphonat-nukleotid ester-derivate

1997
- 1997-01-16 TW TW086100424A patent/TW369536B/zh active
- 1997-01-16 CA CA002195262A patent/CA2195262C/en not_active Expired - Fee Related
- 1997-01-17 ES ES97100652T patent/ES2155219T3/es not_active Expired - Lifetime
- 1997-01-17 DE DE69704286T patent/DE69704286T2/de not_active Expired - Fee Related
- 1997-01-17 EP EP97100652A patent/EP0785208B1/en not_active Expired - Lifetime
- 1997-01-17 AT AT97100652T patent/ATE199907T1/de not_active IP Right Cessation
- 1997-01-17 DK DK97100652T patent/DK0785208T3/da active
- 1997-01-17 US US08/785,606 patent/US5840716A/en not_active Expired - Fee Related
- 1997-01-17 PT PT97100652T patent/PT785208E/pt unknown
- 1997-01-18 KR KR1019970001362A patent/KR100366727B1/ko not_active Expired - Fee Related
- 1997-01-18 CN CN97103169A patent/CN1088712C/zh not_active Expired - Fee Related
2001
- 2001-04-23 GR GR20010400489T patent/GR3035776T3/el not_active IP Right Cessation
2002
- 2002-03-28 CN CN021085013A patent/CN1216060C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR970059181A (ko)	1997-08-12
CN1164534A (zh)	1997-11-12
KR100366727B1 (ko)	2003-03-15
ES2155219T3 (es)	2001-05-01
EP0785208B1 (en)	2001-03-21
CA2195262C (en)	2005-08-09
CA2195262A1 (en)	1997-07-19
DE69704286D1 (de)	2001-04-26
CN1398864A (zh)	2003-02-26
US5840716A (en)	1998-11-24
TW369536B (en)	1999-09-11
ATE199907T1 (de)	2001-04-15
CN1216060C (zh)	2005-08-24
CN1088712C (zh)	2002-08-07
GR3035776T3 (en)	2001-07-31
DE69704286T2 (de)	2001-10-25
EP0785208A1 (en)	1997-07-23
PT785208E (pt)	2001-06-29

Publication	Publication Date	Title
ATE199907T1 (de)	2001-04-15	Phosphonat-nukleotid-verbindungen
TW370450B (en)	1999-09-21	Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
HU9502512D0 (en)	1995-11-28	Anthranilic acid derivative
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
ZA88309B (en)	1988-07-01	3(2h)pyridazinone,process for its preparation and antagonistic agent against srs-a containing it
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
ES2142773A1 (es)	2000-04-16	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
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MX9701949A (es)	1997-06-28	Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.
AU9025601A (en)	2002-04-02	Cephem compounds and esbl-detecting reagents containing the same
DE69612967D1 (en)	2001-06-28	Optisch aktive thiazolidinonderivate
TW356471B (en)	1999-04-21	Novel carbocyclic nucleoside agents useful as selective inhibitor of proinflammatory cytokines
DK0742211T3 (da)	2000-08-14	Pyridazinonderivater
NO972905L (no)	1997-08-18	Tienoksasinon-derivater anvendelige som antivirusmidler
CA2419463A1 (en)	2002-03-07	Primary intermediates for oxidative coloration of hair
AU5660598A (en)	1998-07-17	Use of aminoisothiazoles as microbicides
EG24798A (en)	2010-09-15	Pyrazole compound.
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
BR9305092A (pt)	1994-08-16	Processo para a preparação de derivados de 5-pirazolmercáptan, composto ditiocarbazato de etilideno, processo para a preparação de derivados do mesmo