PT785208E - Compostos fosfonato nucleotidos - Google Patents

Compostos fosfonato nucleotidos Download PDF

Info

Publication number
PT785208E
PT785208E PT97100652T PT97100652T PT785208E PT 785208 E PT785208 E PT 785208E PT 97100652 T PT97100652 T PT 97100652T PT 97100652 T PT97100652 T PT 97100652T PT 785208 E PT785208 E PT 785208E
Authority
PT
Portugal
Prior art keywords
trifluoroethyl
amino
phosphonylmethoxy
bis
ethyl
Prior art date
Application number
PT97100652T
Other languages
English (en)
Portuguese (pt)
Inventor
Masaru Ubasawa
Sekiya Kouichi
Takashima Hideaki
Ueda Naoko
Yuasa Satoshi
Kamiya Naohiro
Original Assignee
Mitsubishi Chem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp
Publication of PT785208E publication Critical patent/PT785208E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT97100652T 1996-01-18 1997-01-17 Compostos fosfonato nucleotidos PT785208E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP648096 1996-01-18

Publications (1)

Publication Number Publication Date
PT785208E true PT785208E (pt) 2001-06-29

Family

ID=11639647

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97100652T PT785208E (pt) 1996-01-18 1997-01-17 Compostos fosfonato nucleotidos

Country Status (12)

Country Link
US (1) US5840716A (da)
EP (1) EP0785208B1 (da)
KR (1) KR100366727B1 (da)
CN (2) CN1088712C (da)
AT (1) ATE199907T1 (da)
CA (1) CA2195262C (da)
DE (1) DE69704286T2 (da)
DK (1) DK0785208T3 (da)
ES (1) ES2155219T3 (da)
GR (1) GR3035776T3 (da)
PT (1) PT785208E (da)
TW (1) TW369536B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199906T1 (de) * 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
US6194398B1 (en) 1996-08-13 2001-02-27 Mitsubishi Chemical Corporation Phosphonate nucleotide compound
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
CN1426418A (zh) 2000-02-29 2003-06-25 三菱制药株式会社 膦酸酯核苷酸化合物
WO2003028737A1 (en) * 2001-08-30 2003-04-10 Mitsubishi Pharma Corporation Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
US20040023928A1 (en) * 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
JP2005511749A (ja) * 2001-12-07 2005-04-28 三菱ウェルファーマ株式会社 Ｂ型肝炎ウィルス感染症を治療するためのホスホネートヌクレオチド類似体の使用
WO2003051881A1 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
AU2003264417A1 (en) * 2002-09-13 2004-04-30 Mitsubishi Pharma Corporation Crystal of 2-amino-6-(4-methoxyphenylthio)-9-(2-(phosphonomethoxy)ethyl)purine bis(2,2,2-trifluoroethyl) ester
KR20040042896A (ko) * 2002-11-15 2004-05-20 미쯔비시 웰 파마 가부시키가이샤 의약 제제 조성물
TW200413399A (en) * 2002-11-15 2004-08-01 Mitsubishi Pharma Corp Process for producing 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl halide
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN100475825C (zh) * 2004-03-19 2009-04-08 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
CN1827627B (zh) * 2005-03-04 2011-05-11 北京美倍他药物研究有限公司 新的无环核苷膦酸及其酯衍生物及其医药用途
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP2842559A3 (en) * 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
CA2683316A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
CN101293899B (zh) * 2007-04-28 2011-12-07 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
ES2572631T3 (es) * 2008-01-25 2016-06-01 Chimerix, Inc. Métodos de tratamiento de infecciones virales
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
CN102093422B (zh) * 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
EP2846788A1 (en) 2012-05-11 2015-03-18 Akron Molecules AG Use of compounds for the treatment of pain
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020932D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Heterocyclic compounds
US5532225A (en) * 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
EP0618214A1 (en) * 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
ATE199906T1 (de) * 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate

Also Published As

Publication number Publication date
CN1216060C (zh) 2005-08-24
CN1164534A (zh) 1997-11-12
KR100366727B1 (ko) 2003-03-15
US5840716A (en) 1998-11-24
CA2195262C (en) 2005-08-09
DE69704286T2 (de) 2001-10-25
EP0785208A1 (en) 1997-07-23
CN1088712C (zh) 2002-08-07
DE69704286D1 (de) 2001-04-26
ATE199907T1 (de) 2001-04-15
DK0785208T3 (da) 2001-04-23
KR970059181A (ko) 1997-08-12
CA2195262A1 (en) 1997-07-19
ES2155219T3 (es) 2001-05-01
EP0785208B1 (en) 2001-03-21
TW369536B (en) 1999-09-11
GR3035776T3 (en) 2001-07-31
CN1398864A (zh) 2003-02-26

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