DK0801571T3 - Opløselige 2'-chlor-2'-deoxyadenosion-formuleringer - Google Patents

Opløselige 2'-chlor-2'-deoxyadenosion-formuleringer

Info

Publication number: DK0801571T3
Authority: DK; Denmark
Prior art keywords: formulations; deoxyadenosion; chloro; soluble; cda
Prior art date: 1994-12-22

Application number

DK95943134T

Other languages

English (en)

Inventor

Michael Bornstein

Rosemary Rozman

Kevin Francis Long

George Kaon Wong

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-12-15

Publication date

2003-01-06

1995-12-15 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

2003-01-06 Application granted granted Critical

2003-01-06 Publication of DK0801571T3 publication Critical patent/DK0801571T3/da

Links

238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

DK95943134T 1994-12-22 1995-12-15 Opløselige 2'-chlor-2'-deoxyadenosion-formuleringer DK0801571T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36208394A	1994-12-22	1994-12-22
PCT/US1995/016418 WO1996019230A1 (en)	1994-12-22	1995-12-15	Soluble 2-chloro-2'-deoxyadenosine formulations

Publications (1)

Publication Number	Publication Date
DK0801571T3 true DK0801571T3 (da)	2003-01-06

Family

ID=23424634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95943134T DK0801571T3 (da)	1994-12-22	1995-12-15	Opløselige 2'-chlor-2'-deoxyadenosion-formuleringer

Country Status (15)

Country	Link
US (1)	US5681822A (da)
EP (1)	EP0801571B1 (da)
JP (1)	JPH10512549A (da)
AT (1)	ATE223221T1 (da)
CA (1)	CA2208484C (da)
CZ (1)	CZ194297A3 (da)
DE (1)	DE69528080T2 (da)
DK (1)	DK0801571T3 (da)
ES (1)	ES2182920T3 (da)
HU (1)	HUT77928A (da)
IL (1)	IL116469A0 (da)
PL (1)	PL321431A1 (da)
PT (1)	PT801571E (da)
WO (1)	WO1996019230A1 (da)
ZA (1)	ZA9510924B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030166525A1 (en) *	1998-07-23	2003-09-04	Hoffmann James Arthur	FSH Formulation
US6194395B1 (en) *	1999-02-25	2001-02-27	Orthro-Mcneil Pharmaceutical, Inc.	Cyclodextrin cladribine formulations
WO2004087213A1 (en) *	2003-04-02	2004-10-14	Ares Trading S.A.	Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
WO2004112826A1 (en) *	2003-06-20	2004-12-29	Ares Trading Sa	Freeze-dried fsh / lh formulations
FR2873695A1 (fr) *	2004-07-30	2006-02-03	Palumed Sa	Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
PL2805723T3 (pl)	2004-12-22	2018-04-30	Merck Serono Sa	Schemat dawkowania kladrybiny dla leczenia stwardnienia rozsianego
MX2008014971A (es)	2006-05-24	2008-12-05	Serono Lab	Regimen de cladribine para tratar esclerosis multiple.
EP2343074A1 (en)	2009-12-23	2011-07-13	Merck Serono S.A.	Use of purine analogues for treating airway diseases
AR113906A1 (es)	2017-11-24	2020-06-24	Merck Patent Ges Mit Beschraenkter Haftung	Régimen con cladribina para tratar formas progresivas de la esclerosis múltiple
IL301246A (en)	2020-09-10	2023-05-01	Merck Patent Gmbh	Treatment regimen with cladribine
JP2024508151A (ja)	2021-03-03	2024-02-22	アレストレーディングソシエテアノニム	自己免疫疾患治療のためのｄｍｄを使用する改善された治療法、並びに該治療法を予測及び／又は最適化するためのバイオマーカー

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826823A (en) *	1985-02-05	1989-05-02	Warner-Lambert Company	Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts
US4719295A (en) *	1985-12-31	1988-01-12	Warner-Lambert Company	Compound 2-iodo-2'-deoxyadenosine
US5310732A (en) *	1986-02-03	1994-05-10	The Scripps Research Institute	2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US4908441A (en) *	1988-07-19	1990-03-13	Warner-Lambert Company	Deoxyadenosine compounds and methods of making and using the same
US5208327A (en) *	1991-12-18	1993-05-04	Ortho Pharmaceutical Corporation	Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
EP0642347A4 (en) *	1992-05-19	1997-06-18	Scripps Research Inst	USE OF 2-HALO-ADENINE DERIVATIVES AS THERAPEUTIC ACTIVE AGENTS AGAINST CHRONIC-MYELOIC LEUKEMIA.

1995
- 1995-12-15 PL PL95321431A patent/PL321431A1/xx unknown
- 1995-12-15 HU HU9801007A patent/HUT77928A/hu unknown
- 1995-12-15 DE DE69528080T patent/DE69528080T2/de not_active Expired - Lifetime
- 1995-12-15 JP JP8519914A patent/JPH10512549A/ja active Pending
- 1995-12-15 WO PCT/US1995/016418 patent/WO1996019230A1/en not_active Ceased
- 1995-12-15 PT PT95943134T patent/PT801571E/pt unknown
- 1995-12-15 ES ES95943134T patent/ES2182920T3/es not_active Expired - Lifetime
- 1995-12-15 CA CA002208484A patent/CA2208484C/en not_active Expired - Lifetime
- 1995-12-15 CZ CZ971942A patent/CZ194297A3/cs unknown
- 1995-12-15 AT AT95943134T patent/ATE223221T1/de active
- 1995-12-15 EP EP95943134A patent/EP0801571B1/en not_active Expired - Lifetime
- 1995-12-15 DK DK95943134T patent/DK0801571T3/da active
- 1995-12-20 IL IL11646995A patent/IL116469A0/xx unknown
- 1995-12-21 ZA ZA9510924A patent/ZA9510924B/xx unknown
1997
- 1997-01-10 US US08/781,438 patent/US5681822A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2208484A1 (en)	1996-06-27
EP0801571B1 (en)	2002-09-04
IL116469A0 (en)	1996-03-31
PL321431A1 (en)	1997-12-08
WO1996019230A1 (en)	1996-06-27
US5681822A (en)	1997-10-28
DE69528080D1 (de)	2002-10-10
CZ194297A3 (en)	1997-10-15
HUT77928A (hu)	1998-11-30
ES2182920T3 (es)	2003-03-16
ZA9510924B (en)	1997-06-23
JPH10512549A (ja)	1998-12-02
DE69528080T2 (de)	2003-06-05
ATE223221T1 (de)	2002-09-15
EP0801571A1 (en)	1997-10-22
CA2208484C (en)	2008-09-23
PT801571E (pt)	2002-12-31

Publication	Publication Date	Title
DK0839026T3 (da)	2002-01-21	Micellære polyether-blokcopolymerkompositioner til målretning af biologiske midler
ZA9510865B (en)	1997-06-20	Stable 2-chloro-2'-deoxyadenosine formulations
TR199700358A2 (xx)	1997-12-21	�nterferon birle�imler.
ITRM920476A0 (it)	1992-06-23	Formulazioni galeniche contenenti ciclosporina.
MY131095A (en)	2007-07-31	Polyethylene protein conjugates.
ATE257014T1 (de)	2004-01-15	Lichtbilderzeugungskontrastmitteln
FI972514L (fi)	1997-08-12	Kasvainspesifisten sytotoksisten T-solujen in vivo aktivointi
IL106750A0 (en)	1993-12-08	Peg interferon conjugates
ATE244015T1 (de)	2003-07-15	Formulierungen fuer faktor ix
PT932397E (pt)	2006-07-31	Formulacoes em aerossol medicinais compreendendo budesonida
FI921142L (fi)	1992-03-17	Gelformulationer.
NO993028L (no)	1999-06-18	Vannbaserte alkoholhydroksykarboksylperoksid-sammensetninger, fremstilling og anvendelse herav
PT801571E (pt)	2002-12-31	Formulacoes soluveis de 2-cloro-2'-desoxiadenosina
DZ1926A1 (fr)	2002-02-17	Formulations pharmaceutiques.
FR2688137B1 (fr)	1994-07-08	Composition cosmetique contre les agressions atmospheriques.
JO1907B1 (en)	1997-01-15	Dissolved compounds of 2-chloro-2-dioxin adenosine
EP0923366A4 (en)	2000-06-07	SUN PROTECTOR CONTAINING DAMAGED RNS FRAGMENTS
JO1908B1 (en)	1997-01-15	Static compounds of 2-chloro-2-dioxin adenosine
IT1254452B (it)	1995-09-25	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
RU96103721A (ru)	1998-05-10	Антгельминтное средство
CA2208241A1 (en)	1996-06-27	Stable solutions of 2-chloro-2'-deoxyadenosine formulations
MA22854A1 (fr)	1993-12-31	Conjugues de proteine et de polyethylene glycol .
IT1288577B1 (it)	1998-09-23	Struttura di supporto, in particolare composita da attacchi per monosci
ES1036308Y (es)	1998-01-01	Telefono movil integrado en el frontal extraible del auto-radio.
KR970008143U (ko)	1997-03-27	여성의 질기능 강화기.