DK0804200T3 - Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr - Google Patents

Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr

Info

Publication number: DK0804200T3
Authority: DK; Denmark
Prior art keywords: noribogain; mammals; derivatives; treatment; chemical dependence
Prior art date: 1994-07-25

Application number

DK95927295T

Other languages

English (en)

Inventor

Deborah Mash

Juan University Sanchez-Ramos

W Lee Hearn

Original Assignee

Nda Int Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-25

Filing date

1995-07-25

Publication date

2006-09-11

1995-07-25 Application filed by Nda Int Inc filed Critical Nda Int Inc

2006-09-11 Application granted granted Critical

2006-09-11 Publication of DK0804200T3 publication Critical patent/DK0804200T3/da

Links

241000124008 Mammalia Species 0.000 title 1
206010013663 drug dependence Diseases 0.000 title 1
208000011117 substance-related disease Diseases 0.000 title 1
RAUCDOKTMDOIPF-UHFFFAOYSA-N hydroxyibogamine Natural products CCC1CC(C2)CC3C1N2CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-UHFFFAOYSA-N 0.000 abstract 3
-1 noribogaine compound Chemical class 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
RAUCDOKTMDOIPF-RYRUWHOVSA-N noribogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-RYRUWHOVSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Addiction (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK95927295T 1994-07-25 1995-07-25 Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr DK0804200T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28018794A	1994-07-25	1994-07-25

Publications (1)

Publication Number	Publication Date
DK0804200T3 true DK0804200T3 (da)	2006-09-11

Family

ID=23072046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95927295T DK0804200T3 (da)	1994-07-25	1995-07-25	Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr

Country Status (11)

Country	Link
US (1)	US6348456B1 (da)
EP (1)	EP0804200B1 (da)
AT (1)	ATE324897T1 (da)
AU (1)	AU4613296A (da)
DE (1)	DE69534975T2 (da)
DK (1)	DK0804200T3 (da)
ES (1)	ES2264562T3 (da)
IL (1)	IL114726A (da)
MX (1)	MX9701430A (da)
PT (1)	PT804200E (da)
WO (1)	WO1996003127A1 (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US7220737B1 (en)	1997-09-04	2007-05-22	Novoneuron, Inc	Noribogaine in the treatment of pain and drug addiction
ATE265213T1 (de) *	1997-09-04	2004-05-15	Novoneuron Inc	Noribogain zur behandlung von schmerzen und drogenabhängigkeit
AU2003200404B2 (en) *	1997-09-04	2006-06-29	Demerx, Inc.	Noribogaine in the treatment of pain and drug addiction
BR0106261A (pt) *	2001-12-26	2003-09-02	Fundacao Oswaldo Cruz	Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids
US20030153552A1 (en) *	2002-02-14	2003-08-14	Mash Deborah C.	Method of treating chemical dependency in mammals and a composition therefor
GB2480632A (en)	2010-05-25	2011-11-30	Kythera Biopharmaceuticals Inc	Preparation of 12-keto and 12-alpha-hydroxy steroids
US9394294B2 (en)	2010-05-11	2016-07-19	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en)	2010-05-11	2013-01-29	Demerx, Inc.	Substituted noribogaine
US8765737B1 (en)	2010-05-11	2014-07-01	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8802832B2 (en)	2010-06-22	2014-08-12	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
US8741891B1 (en)	2010-06-22	2014-06-03	Demerx, Inc.	N-substituted noribogaine prodrugs
US8637648B1 (en)	2010-06-22	2014-01-28	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
CA2806232A1 (en)	2010-07-23	2012-01-26	Demerx, Inc.	Noribogaine compositions
AU2012202509B2 (en) *	2010-07-23	2014-02-13	Demerx, Inc.	Noribogaine compositions
EP2481740B1 (en)	2011-01-26	2015-11-04	DemeRx, Inc.	Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en)	2011-08-26	2017-04-11	Demerx, Inc.	Synthetic noribogaine
US9040520B2 (en)	2011-09-15	2015-05-26	Demerx, Inc.	Noribogaine salt ansolvates
IN2014CN04160A (da)	2011-12-08	2015-07-17	Demerx Inc
CA2855994A1 (en)	2011-12-09	2013-06-13	Demerx, Inc.	Phosphate esters of noribogaine
EP2788356A4 (en) *	2011-12-09	2015-10-21	Demerx Inc	SULFATESTER FROM NORIBOGAIN
CA2858820C (en)	2012-01-25	2021-08-17	Demerx, Inc.	Synthetic voacangine
WO2013112163A1 (en) *	2012-01-25	2013-08-01	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US9150584B2 (en)	2012-01-25	2015-10-06	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US9045481B2 (en)	2012-12-20	2015-06-02	Demerx, Inc.	Substituted noribogaine
US8940728B2 (en)	2012-12-20	2015-01-27	Demerx, Inc.	Substituted noribogaine
CA2896133A1 (en) *	2012-12-20	2014-06-26	Demerx, Inc.	Substituted noribogaine
CA2942638C (en)	2013-03-15	2026-03-10	Demerx, Inc.	Method for noribogaine treatment of addiction in patients on methadone
AU2014379612A1 (en) *	2014-01-24	2016-08-11	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9561232B2 (en)	2014-02-18	2017-02-07	Demerx, Inc.	Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
CN106413718A (zh) *	2014-02-18	2017-02-15	德莫科斯公司	采用降伊菠加因和相关化合物的治疗方法
WO2015126434A1 (en)	2014-02-18	2015-08-27	Demerx, Inc.	Methods for acute and long-term treatment of drug addiction
US9345711B2 (en)	2014-02-18	2016-05-24	Demerx, Inc.	Methods for acute and long-term treatment of drug addiction
US9591978B2 (en)	2014-03-13	2017-03-14	Demerx, Inc.	Methods and compositions for pre-screening patients for treatment with noribogaine
WO2015195673A2 (en)	2014-06-18	2015-12-23	Demerx, Inc.	Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en)	2014-07-14	2017-01-24	Demerx, Inc.	Methods and compositions for treating migraines using noribogaine
EP4279134A1 (en)	2014-11-26	2023-11-22	DemeRx, Inc.	Methods and compostions for potentiating the action of opioid analgesics using iboga alkaloids
US12459965B2 (en)	2017-10-09	2025-11-04	Compass Pathfinder Limited	Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en)	2017-10-09	2020-05-27	Compass Pathways Ltd	Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12377112B2 (en)	2019-04-17	2025-08-05	Compass Pathfinder Limited	Methods of treating neurocognitive disorders, chronic pain and reducing inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3516989A (en) *	1967-10-02	1970-06-23	American Home Prod	Intermediates for total synthesis of iboga alkaloids and means of preparation
US4499096A (en) *	1983-11-18	1985-02-12	Lotsof Howard S	Rapid method for interrupting the narcotic addiction syndrome
US4587243A (en) *	1985-07-15	1986-05-06	Lotsof Howard S	Rapid method for interrupting the cocaine and amphetamine abuse syndrome
US5152994A (en) *	1990-05-31	1992-10-06	Lotsof Howard S	Rapid method for interrupting or attenuating poly-drug dependency syndromes
US5591738A (en) *	1994-10-14	1997-01-07	Nda International, Inc.	Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof

1995
- 1995-07-25 AT AT95927295T patent/ATE324897T1/de not_active IP Right Cessation
- 1995-07-25 EP EP95927295A patent/EP0804200B1/en not_active Expired - Lifetime
- 1995-07-25 MX MX9701430A patent/MX9701430A/es not_active IP Right Cessation
- 1995-07-25 ES ES95927295T patent/ES2264562T3/es not_active Expired - Lifetime
- 1995-07-25 DE DE69534975T patent/DE69534975T2/de not_active Expired - Lifetime
- 1995-07-25 WO PCT/US1995/009136 patent/WO1996003127A1/en not_active Ceased
- 1995-07-25 AU AU46132/96A patent/AU4613296A/en not_active Abandoned
- 1995-07-25 PT PT95927295T patent/PT804200E/pt unknown
- 1995-07-25 DK DK95927295T patent/DK0804200T3/da active
- 1995-07-25 IL IL11472695A patent/IL114726A/en not_active IP Right Cessation
1996
- 1996-10-08 US US08/727,123 patent/US6348456B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL114726A (en)	2002-04-21
MX9701430A (es)	1997-12-31
EP0804200B1 (en)	2006-05-03
DE69534975T2 (de)	2007-01-11
ATE324897T1 (de)	2006-06-15
EP0804200A4 (en)	1999-06-23
IL114726A0 (en)	1995-11-27
WO1996003127A1 (en)	1996-02-08
ES2264562T3 (es)	2007-01-01
AU4613296A (en)	1996-04-19
DE69534975D1 (de)	2006-06-08
PT804200E (pt)	2006-09-29
EP0804200A1 (en)	1997-11-05
US6348456B1 (en)	2002-02-19

Publication	Publication Date	Title
DK0804200T3 (da)	2006-09-11	Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr
MX154758A (es)	1987-12-10	Procedimiento para preparacion de derivados de succinimida
ID17851A (id)	1998-01-29	Persenyawaan heterosiklis, produksi dan pemakaiannya
TW370450B (en)	1999-09-21	Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
DE3781716D1 (de)	1992-10-22	Mittel zur ortsspezifischen alkylierung.
HUP9903836A2 (hu)	2001-05-28	Új eljárás Cox-2 inhibítor hatású fenil-szubsztituált 2(5H)-furanonok előállítására
NZ503912A (en)	2002-09-27	Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
ATE263771T1 (de)	2004-04-15	Totalsynthese von acylfulvenen mit antitumorwirkung
EP0945764A3 (en)	2000-04-19	Photoresist composition
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
DK1447400T3 (da)	2008-12-08	Bicyklisk forbindelse
SE0003186D0 (sv)	2000-09-07	New process
YU166291A (sh)	1994-04-05	Indenoindol jedinjenja
MY133207A (en)	2007-10-31	Substituted benzolactam compaunds
DE60004669D1 (de)	2003-09-25	Indolocarbazolalkaloide aus einer marinen actinomycete
BR9911402A (pt)	2001-03-20	Uso de corantes amino azóicos, e, compostos
DE60007848D1 (de)	2004-02-26	Herstellung von 2'-substitutierter rns
TR199900922T2 (xx)	1999-07-21	Lipoprotein (A)'n�n plazma seviyesini d��rmek i�in bir y�ntem.
ATE231514T1 (de)	2003-02-15	Substituierte isophosphindoline und ihre verwendung
DE60114889D1 (de)	2005-12-15	Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
TWI256383B (en)	2006-06-11	Anthraquinone compound
EA199800931A1 (ru)	1999-04-29	Способ получения ингибиторов фосфодиэстеразы iv
WO2002100804A3 (en)	2003-05-08	Novel use of sulfamic acids as resolving agent.
DE69903930D1 (de)	2002-12-19	N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen