DK0810883T3 - Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler - Google Patents
Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidlerInfo
- Publication number
- DK0810883T3 DK0810883T3 DK96903881T DK96903881T DK0810883T3 DK 0810883 T3 DK0810883 T3 DK 0810883T3 DK 96903881 T DK96903881 T DK 96903881T DK 96903881 T DK96903881 T DK 96903881T DK 0810883 T3 DK0810883 T3 DK 0810883T3
- Authority
- DK
- Denmark
- Prior art keywords
- albumin
- drugs
- conjugate containing
- individual dosing
- containing dtpa
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title 1
- 108010088751 Albumins Proteins 0.000 title 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19505960A DE19505960A1 (de) | 1995-02-21 | 1995-02-21 | Konjugat zur individuellen Dosierung von Arzneimitteln |
| PCT/DE1996/000267 WO1996025956A2 (de) | 1995-02-21 | 1996-02-21 | Konjugat zur individuellen dosierung von arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0810883T3 true DK0810883T3 (da) | 2002-11-11 |
Family
ID=7754621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96903881T DK0810883T3 (da) | 1995-02-21 | 1996-02-21 | Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6410695B1 (da) |
| EP (1) | EP0810883B1 (da) |
| JP (1) | JPH11500134A (da) |
| AT (1) | ATE221391T1 (da) |
| DE (2) | DE19505960A1 (da) |
| DK (1) | DK0810883T3 (da) |
| ES (1) | ES2180737T3 (da) |
| WO (1) | WO1996025956A2 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL133053A0 (en) * | 1998-03-23 | 2001-03-19 | Conjuchem Inc | Local delivery of long lasting therapeutic agents |
| US6740756B1 (en) | 1998-07-07 | 2004-05-25 | Smithkline Beecham Corporation | Fluorescent lanthanide chelates |
| JP2002519404A (ja) * | 1998-07-07 | 2002-07-02 | スミスクライン・ビーチャム・コーポレイション | 新規蛍光ランタニドキレート |
| DE19847362A1 (de) * | 1998-10-14 | 2000-04-20 | Deutsches Krebsforsch | Makromolekulare Wirkstoffkonjugate und Verfahren zu ihrer Herstellung |
| AUPP856399A0 (en) * | 1999-02-08 | 1999-03-04 | Australian Membrane And Biotechnology Research Institute | Improved compounds for protein binding |
| GB9929801D0 (en) * | 1999-12-16 | 2000-02-09 | Btg Int Ltd | Anti-cancer agents iii |
| WO2006032705A2 (en) * | 2004-09-23 | 2006-03-30 | Guerbet | Contrast agents encapsulating systems for cest imaging |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US8926945B2 (en) * | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
| FR3061713B1 (fr) | 2017-01-11 | 2020-02-14 | Universite D'orleans | Complexes de lanthanides a base de derives d'acide triethylenetetramine-n,n,n',n'',n''',n'''-hexaacetique |
| WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2551480C3 (de) * | 1975-11-15 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Technetium-99m-markiertes Nierendiagnostikum und Verfahren zu seiner Herstellung |
| US4339426A (en) | 1980-03-18 | 1982-07-13 | Regents Of The University Of California | Bleomycin analog |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| US4663277A (en) * | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
| DE3404443A1 (de) * | 1984-02-08 | 1985-08-08 | Hartmut Prof. Dr. 1000 Berlin Köpf | Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung |
| US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
| US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
| US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| CA1282069C (en) | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| EP0274343A1 (en) * | 1987-01-06 | 1988-07-13 | IntraCel Corporation | A system of reactants involving an apo-enzyme useful in immunological analysis and a method for carrying out immunoassays with this system |
| WO1989000062A1 (en) | 1987-07-07 | 1989-01-12 | The Cancer Institute Board | Radiotherapy |
| WO1989005853A1 (en) | 1987-12-15 | 1989-06-29 | Synthetic Genetics | Nucleic acid chelate conjugate as therapeutic and diagnostic agents |
| IL89222A (en) * | 1988-02-09 | 1995-03-30 | Mallinckrodt Inc | Preparation of metal-radionuclide-labelled proteins, certain novel compounds used therein and radiopharmaceutical compositions containing the labelled proteins |
| CA1340527C (en) * | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
| US5094950A (en) * | 1988-06-07 | 1992-03-10 | Nihon Medi-Physics Co., Ltd. | Diethylenetriamine pentaacetic acid derivatives |
| EP0353450B1 (en) * | 1988-06-24 | 1995-03-29 | The Dow Chemical Company | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
| US5101041A (en) * | 1989-04-26 | 1992-03-31 | The Curators Of The University Of Missouri | Triamines and their derivatives as bifunctional chelating agents |
| ATE120374T1 (de) | 1989-07-20 | 1995-04-15 | Sandoz Ag | Markierte polypeptidderivate. |
| US5124471A (en) | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
| US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5439829A (en) * | 1991-01-30 | 1995-08-08 | Eli Lilly And Company | Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion |
| US5310539A (en) * | 1991-04-15 | 1994-05-10 | Board Of Regents, The University Of Texas System | Melanin-based agents for image enhancement |
| JPH0616561A (ja) * | 1991-07-09 | 1994-01-25 | Tsumura & Co | 抗レトロウイルス剤 |
| JPH06509116A (ja) | 1991-07-15 | 1994-10-13 | レプリゲン コーポレーション | 修正されたｐｆ４組成物及び使用方法 |
| EP0596011A1 (en) * | 1991-07-19 | 1994-05-11 | Hybritech Incorporated | Trifunctional compounds having specificity for multi-drug resistant cells |
| DE4134158C2 (de) * | 1991-10-11 | 1997-02-13 | Max Delbrueck Centrum | Verwendung von Carboplatin in lyotrophen Mesophasen zur Überwindung einer durch Zytostatika ausgelösten Leukopenie |
| US5326778A (en) * | 1992-03-03 | 1994-07-05 | Research Corporation Technologies, Inc. | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy |
| DE69329145D1 (de) | 1992-03-11 | 2000-09-07 | Kenneth Francis Prendergast | Anti-virale Fusionspeptide |
| US5292938A (en) * | 1992-04-13 | 1994-03-08 | Associated Universities, Inc. | Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
| ATE203168T1 (de) * | 1992-05-07 | 2001-08-15 | Nycomed Imaging As | Komplexbildnermittel und zielimmunoreagenzien |
| GB2268494B (en) * | 1992-07-08 | 1996-08-21 | Kenneth Francis Prendergast | Imaging compositions |
| AU5355094A (en) | 1992-10-14 | 1994-05-09 | Sterling Winthrop Inc. | Therapeutic and diagnostic imaging compositions and methods |
| JP3664727B2 (ja) * | 1994-01-24 | 2005-06-29 | ネオルクス コーポレイション | 放射標識したアネキシン |
| AU2284595A (en) | 1994-04-29 | 1995-11-29 | Center For Molecular Medicine And Immunology | Composition for delivery of toxic radioisotopes to the cell nucleus and use |
| DE4435087A1 (de) * | 1994-09-30 | 1996-04-04 | Deutsches Krebsforsch | Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen |
-
1995
- 1995-02-21 DE DE19505960A patent/DE19505960A1/de not_active Withdrawn
-
1996
- 1996-02-21 US US08/913,217 patent/US6410695B1/en not_active Expired - Fee Related
- 1996-02-21 DE DE59609508T patent/DE59609508D1/de not_active Expired - Fee Related
- 1996-02-21 AT AT96903881T patent/ATE221391T1/de not_active IP Right Cessation
- 1996-02-21 WO PCT/DE1996/000267 patent/WO1996025956A2/de not_active Ceased
- 1996-02-21 ES ES96903881T patent/ES2180737T3/es not_active Expired - Lifetime
- 1996-02-21 DK DK96903881T patent/DK0810883T3/da active
- 1996-02-21 EP EP96903881A patent/EP0810883B1/de not_active Expired - Lifetime
- 1996-02-21 JP JP8525299A patent/JPH11500134A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996025956A2 (de) | 1996-08-29 |
| DE59609508D1 (de) | 2002-09-05 |
| JPH11500134A (ja) | 1999-01-06 |
| US6410695B1 (en) | 2002-06-25 |
| ATE221391T1 (de) | 2002-08-15 |
| ES2180737T3 (es) | 2003-02-16 |
| EP0810883B1 (de) | 2002-07-31 |
| EP0810883A2 (de) | 1997-12-10 |
| WO1996025956A3 (de) | 1996-12-27 |
| DE19505960A1 (de) | 1996-08-22 |
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