DK0815245T3 - Bioaktive IL 12 fusionsproteiner - Google Patents

Bioaktive IL 12 fusionsproteiner

Info

Publication number
DK0815245T3
DK0815245T3 DK96905439T DK96905439T DK0815245T3 DK 0815245 T3 DK0815245 T3 DK 0815245T3 DK 96905439 T DK96905439 T DK 96905439T DK 96905439 T DK96905439 T DK 96905439T DK 0815245 T3 DK0815245 T3 DK 0815245T3
Authority
DK
Denmark
Prior art keywords
bioactive
fusion proteins
polypeptide
chains
joined
Prior art date
Application number
DK96905439T
Other languages
English (en)
Inventor
Richard C Mulligan
Graham J Lieschke
Original Assignee
Whitehead Biomedical Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst filed Critical Whitehead Biomedical Inst
Application granted granted Critical
Publication of DK0815245T3 publication Critical patent/DK0815245T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK96905439T 1995-02-08 1996-02-07 Bioaktive IL 12 fusionsproteiner DK0815245T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/385,335 US5891680A (en) 1995-02-08 1995-02-08 Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
PCT/US1996/001787 WO1996024676A1 (en) 1995-02-08 1996-02-07 Bioactive fusion proteins and pre-existing tumor therapy

Publications (1)

Publication Number Publication Date
DK0815245T3 true DK0815245T3 (da) 2008-07-21

Family

ID=23520989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96905439T DK0815245T3 (da) 1995-02-08 1996-02-07 Bioaktive IL 12 fusionsproteiner

Country Status (11)

Country Link
US (1) US5891680A (da)
EP (1) EP0815245B1 (da)
JP (2) JP3919220B2 (da)
AT (1) ATE391181T1 (da)
AU (1) AU701918B2 (da)
DE (1) DE69637480T2 (da)
DK (1) DK0815245T3 (da)
ES (1) ES2302565T3 (da)
MX (1) MX9706050A (da)
PT (1) PT815245E (da)
WO (1) WO1996024676A1 (da)

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US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
ATE329622T1 (de) * 1998-04-15 2006-07-15 Lexigen Pharm Corp Steigerung der antikörper-zytokin- fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor
WO2000014257A1 (en) * 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
DE19919148A1 (de) * 1999-04-27 2000-11-16 Wieser Raimund J Von Interleukin 12 abgeleitete Peptid-Homodimere und Peptid-Heterodimere
WO2001004310A1 (en) * 1999-07-13 2001-01-18 Heska Corporation Fc EPSILON RECEPTOR-LUMINESCENCE INDUCING PROTEIN CHIMERIC NUCLEIC ACID MOLECULES, FUSION PROTEINS AND USES THEREOF
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
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EP3184637A1 (en) 1999-09-09 2017-06-28 Merck Sharp & Dohme Corp. Mammalian interleukin-12 p40 and interleukin b30 complexes, antibodies, uses in pharmaceutical compositions
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US20210139601A1 (en) * 2017-05-25 2021-05-13 The Broad Institute, Inc. Lymphocyte antigen cd5-like (cd5l) monomer, homodimer, and interleukin 12b (p40) heterodimer agonists and methods of use thereof
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Also Published As

Publication number Publication date
PT815245E (pt) 2008-07-09
JP2006314332A (ja) 2006-11-24
EP0815245A1 (en) 1998-01-07
MX9706050A (es) 1997-11-29
WO1996024676A1 (en) 1996-08-15
AU4919896A (en) 1996-08-27
AU701918B2 (en) 1999-02-11
DE69637480T2 (de) 2009-04-09
ES2302565T3 (es) 2008-07-16
DE69637480D1 (de) 2008-05-15
US5891680A (en) 1999-04-06
EP0815245B1 (en) 2008-04-02
JP3919220B2 (ja) 2007-05-23
JPH10513362A (ja) 1998-12-22
ATE391181T1 (de) 2008-04-15

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