DK0824512T3 - Syntese af optisk aktivt aminoindanol - Google Patents
Syntese af optisk aktivt aminoindanolInfo
- Publication number
- DK0824512T3 DK0824512T3 DK96915021T DK96915021T DK0824512T3 DK 0824512 T3 DK0824512 T3 DK 0824512T3 DK 96915021 T DK96915021 T DK 96915021T DK 96915021 T DK96915021 T DK 96915021T DK 0824512 T3 DK0824512 T3 DK 0824512T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- enantiomerically pure
- amide
- racemic
- hydroxyindane
- Prior art date
Links
- HDXFCPZKMFTOLH-UHFFFAOYSA-N 1-amino-2,3-dihydroinden-1-ol Chemical compound C1=CC=C2C(N)(O)CCC2=C1 HDXFCPZKMFTOLH-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 4
- 239000013078 crystal Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 238000007796 conventional method Methods 0.000 abstract 2
- LOPKSXMQWBYUOI-RKDXNWHRSA-N (1r,2r)-1-amino-2,3-dihydro-1h-inden-2-ol Chemical compound C1=CC=C2[C@@H](N)[C@H](O)CC2=C1 LOPKSXMQWBYUOI-RKDXNWHRSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
- 238000010956 selective crystallization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19517421A DE19517421A1 (de) | 1995-05-12 | 1995-05-12 | Synthese von optisch aktivem Aminoindanol |
| PCT/EP1996/001884 WO1996035660A1 (de) | 1995-05-12 | 1996-05-07 | Synthese von optisch aktivem aminoindanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0824512T3 true DK0824512T3 (da) | 2001-02-19 |
Family
ID=7761725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96915021T DK0824512T3 (da) | 1995-05-12 | 1996-05-07 | Syntese af optisk aktivt aminoindanol |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5872296A (da) |
| EP (1) | EP0824512B1 (da) |
| JP (1) | JPH11504929A (da) |
| KR (1) | KR100395717B1 (da) |
| CN (1) | CN1083829C (da) |
| AT (1) | ATE198189T1 (da) |
| CA (1) | CA2217880C (da) |
| DE (2) | DE19517421A1 (da) |
| DK (1) | DK0824512T3 (da) |
| ES (1) | ES2153578T3 (da) |
| PT (1) | PT824512E (da) |
| WO (1) | WO1996035660A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106478429B (zh) * | 2016-10-11 | 2018-02-13 | 上海瀚鸿科技股份有限公司 | 一种合成手性反式茚胺醇的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599985A (en) * | 1993-09-14 | 1997-02-04 | Sepracor, Inc. | Optically pure 1-amido-2-indanols |
| DE4332738A1 (de) * | 1993-09-25 | 1995-03-30 | Basf Ag | Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung |
-
1995
- 1995-05-12 DE DE19517421A patent/DE19517421A1/de not_active Withdrawn
-
1996
- 1996-05-07 CN CN96193873A patent/CN1083829C/zh not_active Expired - Fee Related
- 1996-05-07 CA CA002217880A patent/CA2217880C/en not_active Expired - Fee Related
- 1996-05-07 EP EP96915021A patent/EP0824512B1/de not_active Expired - Lifetime
- 1996-05-07 AT AT96915021T patent/ATE198189T1/de not_active IP Right Cessation
- 1996-05-07 DK DK96915021T patent/DK0824512T3/da active
- 1996-05-07 PT PT96915021T patent/PT824512E/pt unknown
- 1996-05-07 KR KR1019970708088A patent/KR100395717B1/ko not_active Expired - Fee Related
- 1996-05-07 WO PCT/EP1996/001884 patent/WO1996035660A1/de not_active Ceased
- 1996-05-07 ES ES96915021T patent/ES2153578T3/es not_active Expired - Lifetime
- 1996-05-07 US US08/945,531 patent/US5872296A/en not_active Expired - Fee Related
- 1996-05-07 JP JP8533732A patent/JPH11504929A/ja not_active Ceased
- 1996-05-07 DE DE59606235T patent/DE59606235D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100395717B1 (ko) | 2003-10-17 |
| CA2217880C (en) | 2004-02-24 |
| WO1996035660A1 (de) | 1996-11-14 |
| DE19517421A1 (de) | 1996-11-14 |
| PT824512E (pt) | 2001-04-30 |
| ES2153578T3 (es) | 2001-03-01 |
| US5872296A (en) | 1999-02-16 |
| EP0824512A1 (de) | 1998-02-25 |
| CA2217880A1 (en) | 1996-11-14 |
| CN1184464A (zh) | 1998-06-10 |
| JPH11504929A (ja) | 1999-05-11 |
| ATE198189T1 (de) | 2001-01-15 |
| EP0824512B1 (de) | 2000-12-20 |
| KR19990014746A (ko) | 1999-02-25 |
| DE59606235D1 (de) | 2001-01-25 |
| CN1083829C (zh) | 2002-05-01 |
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