DK0828704T3 - Fremgangsmåde til fremstilling af (S)-3-(aminomethyl)-5-methylhexansyre - Google Patents
Fremgangsmåde til fremstilling af (S)-3-(aminomethyl)-5-methylhexansyreInfo
- Publication number
- DK0828704T3 DK0828704T3 DK96913186T DK96913186T DK0828704T3 DK 0828704 T3 DK0828704 T3 DK 0828704T3 DK 96913186 T DK96913186 T DK 96913186T DK 96913186 T DK96913186 T DK 96913186T DK 0828704 T3 DK0828704 T3 DK 0828704T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- methylhexanoic acid
- carbamoylmethyl
- aminomethyl
- reacting
- Prior art date
Links
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title abstract 3
- RQEUFEKYXDPUSK-SSDOTTSWSA-N (1R)-1-phenylethanamine Chemical compound C[C@@H](N)C1=CC=CC=C1 RQEUFEKYXDPUSK-SSDOTTSWSA-N 0.000 abstract 2
- NPDKTSLVWGFPQG-SSDOTTSWSA-N (3r)-3-(2-amino-2-oxoethyl)-5-methylhexanoic acid Chemical compound CC(C)C[C@H](CC(N)=O)CC(O)=O NPDKTSLVWGFPQG-SSDOTTSWSA-N 0.000 abstract 2
- NPDKTSLVWGFPQG-UHFFFAOYSA-N 3-(2-amino-2-oxoethyl)-5-methylhexanoic acid Chemical compound CC(C)CC(CC(N)=O)CC(O)=O NPDKTSLVWGFPQG-UHFFFAOYSA-N 0.000 abstract 2
- UATSLDZQNXAKMA-UHFFFAOYSA-N 3-(2-methylpropyl)pentanedioic acid Chemical compound CC(C)CC(CC(O)=O)CC(O)=O UATSLDZQNXAKMA-UHFFFAOYSA-N 0.000 abstract 2
- YGHRJJRRZDOVPD-UHFFFAOYSA-N 3-methylbutanal Chemical compound CC(C)CC=O YGHRJJRRZDOVPD-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 alkyl cyanoacetate Chemical compound 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/458,950 US5616793A (en) | 1995-06-02 | 1995-06-02 | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| PCT/US1996/005831 WO1996038405A1 (en) | 1995-06-02 | 1996-04-26 | Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0828704T3 true DK0828704T3 (da) | 2002-07-01 |
Family
ID=23822760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96913186T DK0828704T3 (da) | 1995-06-02 | 1996-04-26 | Fremgangsmåde til fremstilling af (S)-3-(aminomethyl)-5-methylhexansyre |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5616793A (da) |
| EP (1) | EP0828704B1 (da) |
| JP (1) | JP3965440B2 (da) |
| AT (1) | ATE214361T1 (da) |
| AU (1) | AU699982B2 (da) |
| CZ (1) | CZ297631B6 (da) |
| DE (1) | DE69619809T2 (da) |
| DK (1) | DK0828704T3 (da) |
| EE (1) | EE03964B1 (da) |
| ES (1) | ES2173279T3 (da) |
| HU (1) | HUP9802090A3 (da) |
| NZ (1) | NZ307030A (da) |
| PL (1) | PL185034B1 (da) |
| PT (1) | PT828704E (da) |
| SK (1) | SK283663B6 (da) |
| WO (1) | WO1996038405A1 (da) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001876A (en) | 1996-07-24 | 1999-12-14 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| SI1250311T1 (en) * | 2000-01-27 | 2004-10-31 | Warner-Lambert Company | Asymmetric synthesis of pregabalin |
| EP1543831A1 (en) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Pregabalin composition |
| DE602005002253T2 (de) * | 2004-03-12 | 2008-05-29 | Warner-Lambert Company Llc | C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin |
| AP2466A (en) * | 2004-06-21 | 2012-09-17 | Warner Lambert Co | Preparation of pregabalin and related compounds |
| US7417165B2 (en) * | 2005-04-06 | 2008-08-26 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of pregabalin |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| WO2006110783A2 (en) * | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
| KR100893312B1 (ko) * | 2005-05-10 | 2009-04-15 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린 및 이의 염의 제조 방법 |
| WO2006121557A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| WO2006122259A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
| KR20070067077A (ko) * | 2005-05-10 | 2007-06-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법 |
| CN100410242C (zh) * | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
| WO2007035890A1 (en) | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid |
| NL2000281C2 (nl) * | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Vaste farmaceutische samenstellingen die pregabaline bevatten. |
| WO2007127309A2 (en) * | 2006-04-24 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 3-isobutylglutaric acid |
| WO2007139933A2 (en) * | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
| US20080015385A1 (en) * | 2006-05-31 | 2008-01-17 | Lilach Hedvati | Preparation of (S)-pregabalin-nitrile |
| EP2071032A3 (en) | 2006-05-31 | 2009-07-08 | Teva Pharmaceutical Industries Ltd | The use of enzymatic resolution for the preparation of intermediates of pregabalin |
| ITMI20061297A1 (it) * | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi |
| GB0614133D0 (en) * | 2006-07-15 | 2006-08-23 | Pliva Istrazivanje I Razvoj D | Process for preparing a pharmaceutical compound |
| WO2008118427A2 (en) * | 2007-03-22 | 2008-10-02 | Teva Pharmaceutical Industries Ltd. | Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid |
| WO2008137512A2 (en) * | 2007-05-03 | 2008-11-13 | Dr. Reddy's Laboratories Ltd. | Process for preparing pregabalin via hofmann reaction and crystalline form thereof |
| WO2009004643A2 (en) * | 2007-05-08 | 2009-01-08 | Cadila Healthcare Limited | An improved process for preparation of (s)-pregabalin and intermediates thereof |
| EP1992609A1 (en) * | 2007-05-14 | 2008-11-19 | Dipharma Francis S.r.l. | A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid |
| KR20090101462A (ko) * | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| JP5234901B2 (ja) * | 2007-10-04 | 2013-07-10 | 学校法人東京理科大学 | 不斉触媒マイケル反応生成物の製造方法 |
| PL2225198T3 (pl) * | 2007-11-30 | 2013-04-30 | Laboratorio Chimico Int S P A | Sposoby wytwarzania podstawionego gamma-aminokwasu |
| ITMI20072262A1 (it) * | 2007-12-03 | 2009-06-04 | Dipharma Francis Srl | Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico |
| WO2009087674A2 (en) * | 2007-12-18 | 2009-07-16 | Watson Pharma Private Limited | Improved process for the preparation of (s)-pregabalin |
| US20110144383A1 (en) * | 2008-02-18 | 2011-06-16 | Matrix Laboratories Limited | Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid |
| KR20110025917A (ko) | 2008-05-21 | 2011-03-14 | 산도즈 아게 | ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법 |
| US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| WO2010070593A2 (en) | 2008-12-19 | 2010-06-24 | Pfizer Ireland Pharmaceuticals | Malonate esters |
| EP2213659A1 (en) | 2009-01-29 | 2010-08-04 | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Intermediates in the Enantioselective Synthesis of 3-(Aminomethyl)-5-Methyl-Hexanoic Acid |
| CN101987826A (zh) * | 2009-08-04 | 2011-03-23 | 铜陵凯顺生物科技有限公司 | 一种(3s)-3-氨甲基-5-甲基己酸的合成方法 |
| CN102126979A (zh) * | 2009-12-15 | 2011-07-20 | 中国科学院成都有机化学有限公司 | 一种光学纯的3-(氨甲酰甲基)-5-甲基己酸的制备方法 |
| WO2011077463A1 (en) * | 2009-12-24 | 2011-06-30 | Msn Laboratories Limited | Process for preparing pregabalin and its intermediate |
| ES2362913B1 (es) | 2009-12-24 | 2012-05-24 | Moehs Iberica S.L. | Nuevo método para la preparación de (s)-pregabalina. |
| JPWO2011078172A1 (ja) * | 2009-12-25 | 2013-05-09 | 株式会社カネカ | 光学活性３−置換グルタル酸モノアミドの製造法 |
| US8212072B2 (en) | 2010-08-13 | 2012-07-03 | Divi's Laboratories, Ltd. | Process for the preparation of pregabalin |
| WO2012025861A1 (en) | 2010-08-23 | 2012-03-01 | Pfizer Manufacturing Ireland | Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin |
| KR101306585B1 (ko) * | 2011-04-14 | 2013-09-10 | 한국외국어대학교 연구산학협력단 | 프레가발린의 제조방법 |
| EP2700645A4 (en) | 2011-04-20 | 2014-09-24 | Kemphys Ltd | SILICONE-CONTAINING CARBOXYLENE DERIVATIVE |
| CA2856666A1 (en) | 2011-11-24 | 2013-05-30 | Lupin Limited | Novel process for racemization of an optically active (s)-3-carbamoylmethyl-5-methyl-hexanoic acid to corresponding 3-carbamoylmethyl-5-methyl-hexanoic acid racemate |
| CN102863326A (zh) * | 2012-03-20 | 2013-01-09 | 常州制药厂有限公司 | 一种抗癫痫药物中间体的制备方法 |
| US9353134B2 (en) * | 2012-10-18 | 2016-05-31 | Kemphys Ltd. | Silicon-containing carboxylic acid derivative |
| CN102898320A (zh) * | 2012-10-26 | 2013-01-30 | 浙江省天台县奥锐特药业有限公司 | (3r)-(-)-3-(2-乙酰氨基)-5-甲基己酸的制备方法 |
| EP2916832B1 (en) | 2012-11-07 | 2019-01-16 | Hikal Limited | A process for the preparation of pregabalin |
| CN102964263B (zh) * | 2012-11-29 | 2014-12-03 | 太仓市茜泾化工有限公司 | 一种(±)-3-(氨甲酰基)-5-甲基己酸的制备方法 |
| CN103980144B (zh) * | 2014-05-16 | 2018-08-17 | 浙江华海药业股份有限公司 | 一种普瑞巴林中间体母液的套用方法 |
| CN104086439B (zh) * | 2014-06-30 | 2018-11-16 | 浙江华海药业股份有限公司 | 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法 |
| CN104356016B (zh) * | 2014-10-24 | 2019-08-23 | 浙江华海药业股份有限公司 | 一种用回收制备3-异丁基戊二酸单酰胺的方法 |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| CN104496832A (zh) * | 2014-11-21 | 2015-04-08 | 浙江美诺华药物化学有限公司 | 一种普瑞巴林的合成方法 |
| CN104557577B (zh) * | 2014-12-26 | 2016-08-17 | 上海臣邦医药科技有限公司 | 高纯度(+)-普瑞巴林和(-)-普瑞巴林的制备方法 |
| EP3242879B1 (en) * | 2015-01-08 | 2019-12-11 | Lee Pharma Ltd. | Novel process for the preparation of dipeptidyl peptidase-4 (dpp-4) enzyme inhibitor |
| CN104803868B (zh) * | 2015-03-27 | 2020-10-02 | 浙江华海药业股份有限公司 | 一种回收3-异丁基戊二酸单酰胺的方法 |
| CN104803869A (zh) * | 2015-03-27 | 2015-07-29 | 浙江华海药业股份有限公司 | 一种无溶剂反应制备3-异丁基戊二酸单酰胺的方法 |
| CN104803871B (zh) * | 2015-05-12 | 2021-03-05 | 浙江华海药业股份有限公司 | 一种制备普瑞巴林中间体的方法 |
| CN104892441A (zh) * | 2015-05-22 | 2015-09-09 | 浙江华海药业股份有限公司 | 一种制备普瑞巴林异构体r-普瑞巴林的方法 |
| JP2018520112A (ja) | 2015-05-26 | 2018-07-26 | オディディ，イサ | 制御持続放出プレガバリン |
| WO2017019791A1 (en) | 2015-07-27 | 2017-02-02 | Teva Pharmaceuticals International Gmbh | Synthesis of (s)-pregabalin |
| CN105481712A (zh) * | 2015-11-30 | 2016-04-13 | 常州市阳光药业有限公司 | 普瑞巴林中间体拆分母液的消旋回收方法 |
| WO2019193607A1 (en) * | 2018-04-04 | 2019-10-10 | Msn Laboratories Private Limited, R&D Center | An improved process for the preparation of pregabalin |
| CN108912004B (zh) * | 2018-08-01 | 2021-05-07 | 宏冠生物药业有限公司 | 一种普瑞巴林中间体的合成方法 |
| CN109942446B (zh) * | 2019-04-17 | 2021-09-07 | 黄冈鲁班药业股份有限公司 | 一种普瑞巴林的制备方法 |
| CN112062689A (zh) * | 2019-06-11 | 2020-12-11 | 太仓市茜泾化工有限公司 | 一种r-3-（氨甲酰基）-5-甲基己酸的制备方法 |
| CN113045468A (zh) * | 2019-12-26 | 2021-06-29 | 上虞京新药业有限公司 | 一种布瓦西坦中间体的制备方法 |
| EP4103168A4 (en) | 2020-02-14 | 2024-04-24 | Council Of Scientific & Industrial Research | PROCESS FOR PREPARING GAMMA-AMINO-BUTYRIC ACIDS AND THEIR ANALOGS |
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| US2944969A (en) * | 1957-02-06 | 1960-07-12 | Petrolite Corp | Prevention of rust and corrosion |
| US3544467A (en) * | 1966-02-07 | 1970-12-01 | Chevron Res | Acid-amide pour point depressants |
| US3857879A (en) * | 1967-12-04 | 1974-12-31 | W Abramitis | Amine salts of substituted succinamic acids |
| DE2460285A1 (de) * | 1973-12-25 | 1975-07-03 | Ono Pharmaceutical Co | Trans-delta hoch 2-prostaglandinverbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4123438A (en) * | 1975-03-05 | 1978-10-31 | Stamicarbon, B.V. | Process for preparing 2-pyrrolidones |
| US4739114A (en) * | 1982-09-30 | 1988-04-19 | Rhone-Poulenc Agrochimie | Process for the preparation of 3-alkyl-substituted glutaric acids and 2-alkyl-substituted succinic acids |
| US4711671A (en) * | 1985-10-03 | 1987-12-08 | National Starch And Chemical Corporation | Storage stable paper size composition containing ethoxylated lanolin |
| DE4033259A1 (de) * | 1990-10-19 | 1992-04-23 | Basf Ag | Verfahren zur herstellung von 2-pyrrolidinonen |
| RU94046105A (ru) * | 1992-05-20 | 1997-06-20 | Нортвестерн Юниверсити (Us) | АНАЛОГИ γ -АМИНОМАСЛЯНОЙ КИСЛОТЫ И L-ГЛУТАМИНОВОЙ КИСЛОТЫ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
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1995
- 1995-06-02 US US08/458,950 patent/US5616793A/en not_active Expired - Lifetime
-
1996
- 1996-04-26 HU HU9802090A patent/HUP9802090A3/hu unknown
- 1996-04-26 AT AT96913186T patent/ATE214361T1/de not_active IP Right Cessation
- 1996-04-26 PL PL96323563A patent/PL185034B1/pl unknown
- 1996-04-26 WO PCT/US1996/005831 patent/WO1996038405A1/en not_active Ceased
- 1996-04-26 CZ CZ0374297A patent/CZ297631B6/cs not_active IP Right Cessation
- 1996-04-26 DE DE69619809T patent/DE69619809T2/de not_active Expired - Fee Related
- 1996-04-26 EE EE9700311A patent/EE03964B1/xx not_active IP Right Cessation
- 1996-04-26 JP JP53647696A patent/JP3965440B2/ja not_active Expired - Fee Related
- 1996-04-26 DK DK96913186T patent/DK0828704T3/da active
- 1996-04-26 AU AU55778/96A patent/AU699982B2/en not_active Ceased
- 1996-04-26 NZ NZ307030A patent/NZ307030A/xx unknown
- 1996-04-26 ES ES96913186T patent/ES2173279T3/es not_active Expired - Lifetime
- 1996-04-26 SK SK1621-97A patent/SK283663B6/sk not_active IP Right Cessation
- 1996-04-26 EP EP96913186A patent/EP0828704B1/en not_active Expired - Lifetime
- 1996-04-26 PT PT96913186T patent/PT828704E/pt unknown
- 1996-06-28 US US08/672,783 patent/US5629447A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9802090A3 (en) | 1999-08-30 |
| AU699982B2 (en) | 1998-12-17 |
| AU5577896A (en) | 1996-12-18 |
| EE03964B1 (et) | 2003-02-17 |
| NZ307030A (en) | 1999-02-25 |
| SK283663B6 (sk) | 2003-11-04 |
| ES2173279T3 (es) | 2002-10-16 |
| JPH11506098A (ja) | 1999-06-02 |
| DE69619809D1 (de) | 2002-04-18 |
| EP0828704A1 (en) | 1998-03-18 |
| DE69619809T2 (de) | 2002-09-26 |
| EP0828704B1 (en) | 2002-03-13 |
| US5629447A (en) | 1997-05-13 |
| PL323563A1 (en) | 1998-04-14 |
| EE9700311A (et) | 1998-06-15 |
| WO1996038405A1 (en) | 1996-12-05 |
| SK162197A3 (en) | 1998-10-07 |
| JP3965440B2 (ja) | 2007-08-29 |
| PL185034B1 (pl) | 2003-02-28 |
| HUP9802090A2 (hu) | 1998-12-28 |
| CZ297631B6 (cs) | 2007-02-14 |
| PT828704E (pt) | 2002-08-30 |
| US5616793A (en) | 1997-04-01 |
| ATE214361T1 (de) | 2002-03-15 |
| CZ374297A3 (cs) | 1998-10-14 |
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