DK0835257T3 - Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser - Google Patents

Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser

Info

Publication number: DK0835257T3
Authority: DK; Denmark
Prior art keywords: intermediates; cpt; pct; related compounds; camptothecin derivatives
Prior art date: 1995-04-07

Application number

DK96912468T

Other languages

English (en)

Inventor

John C Sih

Kevin E Henegar

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-07

Filing date

1996-04-01

Publication date

2003-02-03

1996-04-01 Application filed by Upjohn Co filed Critical Upjohn Co

2003-02-03 Application granted granted Critical

2003-02-03 Publication of DK0835257T3 publication Critical patent/DK0835257T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 2
WSXJPXFVULHYMX-KRWDZBQOSA-N 7-[(1s)-1-hydroxypropyl]-8-methyl-11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)[C@@H](O)CC)C4=NC2=C1 WSXJPXFVULHYMX-KRWDZBQOSA-N 0.000 abstract 1
WSXJPXFVULHYMX-UHFFFAOYSA-N S-Mappicine Natural products C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(O)CC)C4=NC2=C1 WSXJPXFVULHYMX-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
229960004768 irinotecan Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Paper (AREA)
Steroid Compounds (AREA)
Lubricants (AREA)

DK96912468T 1995-04-07 1996-04-01 Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser DK0835257T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41964395A	1995-04-07	1995-04-07
PCT/US1996/004163 WO1996031513A1 (en)	1995-04-07	1996-04-01	Novel intermediates and process for the manufacture of camptothecin derivatives (cpt-11) and related compounds

Publications (1)

Publication Number	Publication Date
DK0835257T3 true DK0835257T3 (da)	2003-02-03

Family

ID=23663114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96912468T DK0835257T3 (da)	1995-04-07	1996-04-01	Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser

Country Status (25)

Country	Link
US (3)	US6121451A (da)
EP (1)	EP0835257B1 (da)
JP (2)	JP4281075B2 (da)
KR (1)	KR100423627B1 (da)
CN (5)	CN1241926C (da)
AT (1)	ATE224899T1 (da)
AU (1)	AU717179B2 (da)
CA (1)	CA2214793C (da)
CZ (1)	CZ297862B6 (da)
DE (1)	DE69623960T2 (da)
DK (1)	DK0835257T3 (da)
ES (1)	ES2183943T3 (da)
HK (2)	HK1054234B (da)
HU (1)	HUP9801436A3 (da)
IL (1)	IL117684A (da)
MX (1)	MX9707706A (da)
NO (2)	NO320482B1 (da)
NZ (1)	NZ306664A (da)
PL (2)	PL186446B1 (da)
PT (1)	PT835257E (da)
RU (1)	RU2164917C2 (da)
SI (1)	SI0835257T1 (da)
TW (1)	TW438775B (da)
WO (1)	WO1996031513A1 (da)
ZA (1)	ZA962747B (da)

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WO2000020405A1 (en) *	1998-10-07	2000-04-13	Mitsubishi Chemical Corporation	Mixtures of optical isomers of 1,2-disubstituted-2,3-epoxypropanes, process for producing the same, pesticides containing the same as the active ingredient and intermediates thereof
FR2794123B1 (fr)	1999-05-28	2001-07-27	Aventis Pharma Sa	Preparation de derives de la camptothecine et de la nothapodytine
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
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TWI245768B (en)	2001-02-21	2005-12-21	Yakult Honsha Kk	Process for synthesizing camptothecin related compound(s)
US6723853B2 (en) *	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
JP3839813B2 (ja) *	2002-04-17	2006-11-01	ファルマシアコーポレイション	カンプトテシン誘導体の調製に有用な化合物
US7151179B2 (en)	2003-05-12	2006-12-19	Scinopharm Taiwan, Ltd.	Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
CZ299329B6 (cs)	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CN1852740B (zh) *	2003-09-17	2011-05-11	耐科塔医药公司	多支链聚合物的药物前体
US8394365B2 (en)	2003-09-17	2013-03-12	Nektar Therapeutics	Multi-arm polymer prodrugs
CZ299593B6 (cs)	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050197355A1 (en) *	2004-03-02	2005-09-08	Henegar Kevin E.	Compounds useful in preparing camptothecin derivatives
US20050267141A1 (en) *	2004-05-28	2005-12-01	Phytogen Life Sciences Inc.	Process to prepare camptothecin derivatives
US20050272757A1 (en) *	2004-06-04	2005-12-08	Phytogen Life Sciences Inc.	Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
WO2006016203A1 (en) *	2004-08-09	2006-02-16	Shilpa Medicare Limited	An improved process for the preparation of irinotecan hydrochloride trihydrate
US20060046993A1 (en) *	2004-09-01	2006-03-02	Pharmacia Italia S.P.A.	Crystalline polymorphic form of irinotecan hydrochloride
ATE446299T1 (de)	2005-02-07	2009-11-15	Fermion Oy	Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
EP1928883B1 (en)	2005-02-08	2013-10-30	Fermion Oy	Process for the preparation of irinotecan hydrochloride
ES2430375T3 (es)	2005-02-08	2013-11-20	Fermion Oy	Procedimiento para la producción de cloruro de [1,4']bipiperidinil-1'-carbonilo o su clorhidrato
TWI375678B (en) *	2005-06-09	2012-11-01	Yakult Honsha Kk	A method of preparation of a tricyclic ketone
EP1803725A1 (en) *	2005-12-13	2007-07-04	W.C. Heraeus GmbH	Methods for preparing irinotecan
US7462627B2 (en) *	2006-02-09	2008-12-09	Enzon Pharmaceuticals, Inc.	Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) *	2006-02-09	2010-03-02	Enzon Pharmaceuticals, Inc.	Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
WO2008066902A2 (en)	2006-11-30	2008-06-05	Nektar Therapeutics Al, Corporation	Method for preparing a polymer conjugate
KR20090108082A (ko) *	2007-02-09	2009-10-14	엔존 파마슈티컬즈, 인코포레이티드	7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
EP2664632A1 (en) *	2008-07-31	2013-11-20	The Lubrizol Corporation	Novel copolymers and lubricating compositions thereof
US8637466B2 (en)	2008-08-11	2014-01-28	Nektar Therapeutics	Multi-arm polymeric alkanoate conjugates
WO2010025337A1 (en) *	2008-08-29	2010-03-04	Enzon Pharmaceuticals, Inc.	Method of treating ras associated cancer
JP2012503602A (ja)	2008-09-23	2012-02-09	ネクターセラピューティックス	対象において持続的治療薬濃度を実現するための組成物及び方法
US20100098654A1 (en) *	2008-10-21	2010-04-22	Fabio Pastorino	Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
WO2012032531A1 (en) *	2010-09-06	2012-03-15	Avra Laboratories Pvt. Ltd.	Process for the manufacture of irinotecan hydrochloride by total synthesis
US10894087B2 (en)	2010-12-22	2021-01-19	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en)	2010-12-22	2013-12-12	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
JO3283B1 (ar)	2011-04-26	2018-09-16	Sanofi Sa	تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
WO2016008975A1 (en)	2014-07-18	2016-01-21	Sanofi	Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
EP3371192B1 (en)	2015-10-27	2020-06-03	California Pacific Medical Center	Podophyllotoxin derivatives and their use
US10087194B2 (en) *	2015-10-27	2018-10-02	California Pacific Medical Center	Podophyllotoxin derivatives and their use
ES3057783T3 (en)	2016-03-15	2026-03-04	Oryzon Genomics Sa	Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
CN105965710B (zh) *	2016-06-28	2019-03-22	常州大学	一种硅棒金钢线切割树脂板的制备方法及应用
US11434196B2 (en)	2019-01-15	2022-09-06	Laurus Labs Limited	Process for preparation of 2-Amino-5-hydroxy propiophenone
CN112300184B (zh) *	2019-08-02	2022-12-06	华东师范大学	一种三元环化合物的制备方法

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GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin

1996
- 1996-03-27 TW TW085103680A patent/TW438775B/zh not_active IP Right Cessation
- 1996-03-27 IL IL11768496A patent/IL117684A/en not_active IP Right Cessation
- 1996-04-01 ES ES96912468T patent/ES2183943T3/es not_active Expired - Lifetime
- 1996-04-01 US US09/230,245 patent/US6121451A/en not_active Expired - Fee Related
- 1996-04-01 AU AU55278/96A patent/AU717179B2/en not_active Ceased
- 1996-04-01 NZ NZ306664A patent/NZ306664A/xx not_active IP Right Cessation
- 1996-04-01 SI SI9630551T patent/SI0835257T1/xx unknown
- 1996-04-01 HU HU9801436A patent/HUP9801436A3/hu unknown
- 1996-04-01 CA CA002214793A patent/CA2214793C/en not_active Expired - Fee Related
- 1996-04-01 EP EP96912468A patent/EP0835257B1/en not_active Expired - Lifetime
- 1996-04-01 PL PL96322651A patent/PL186446B1/pl not_active IP Right Cessation
- 1996-04-01 CN CNB031030998A patent/CN1241926C/zh not_active Expired - Fee Related
- 1996-04-01 RU RU97118673/04A patent/RU2164917C2/ru not_active IP Right Cessation
- 1996-04-01 DE DE69623960T patent/DE69623960T2/de not_active Expired - Lifetime
- 1996-04-01 CN CNB031030971A patent/CN100396682C/zh not_active Expired - Fee Related
- 1996-04-01 PT PT96912468T patent/PT835257E/pt unknown
- 1996-04-01 JP JP53035696A patent/JP4281075B2/ja not_active Expired - Fee Related
- 1996-04-01 WO PCT/US1996/004163 patent/WO1996031513A1/en not_active Ceased
- 1996-04-01 CN CN03103098XA patent/CN1434043B/zh not_active Expired - Fee Related
- 1996-04-01 CN CNB031031005A patent/CN100537538C/zh not_active Expired - Fee Related
- 1996-04-01 CN CN96193138A patent/CN1100058C/zh not_active Expired - Fee Related
- 1996-04-01 KR KR1019970707091A patent/KR100423627B1/ko not_active Expired - Fee Related
- 1996-04-01 PL PL96355318A patent/PL186564B1/pl not_active IP Right Cessation
- 1996-04-01 DK DK96912468T patent/DK0835257T3/da active
- 1996-04-01 MX MX9707706A patent/MX9707706A/es not_active IP Right Cessation
- 1996-04-01 CZ CZ0311097A patent/CZ297862B6/cs not_active IP Right Cessation
- 1996-04-01 AT AT96912468T patent/ATE224899T1/de active
- 1996-04-04 ZA ZA9602747A patent/ZA962747B/xx unknown
1997
- 1997-10-06 NO NO19974608A patent/NO320482B1/no not_active IP Right Cessation
2000
- 2000-02-22 US US09/511,006 patent/US6235907B1/en not_active Expired - Fee Related
- 2000-10-13 US US09/687,227 patent/US6444820B1/en not_active Expired - Fee Related
2003
- 2003-09-11 HK HK03106488.3A patent/HK1054234B/zh not_active IP Right Cessation
- 2003-09-11 HK HK03106509.8A patent/HK1054236B/zh not_active IP Right Cessation
2005
- 2005-01-25 NO NO20050408A patent/NO329776B1/no not_active IP Right Cessation
2007
- 2007-10-25 JP JP2007277903A patent/JP2008069170A/ja active Pending

Also Published As

Publication number	Publication date
CN100537538C (zh)	2009-09-09
CN1241926C (zh)	2006-02-15
AU717179B2 (en)	2000-03-16
CN1181083A (zh)	1998-05-06
NO20050408L (no)	1997-12-08
IL117684A (en)	2002-02-10
PT835257E (pt)	2003-01-31
US6444820B1 (en)	2002-09-03
CN1434046A (zh)	2003-08-06
ES2183943T3 (es)	2003-04-01
CA2214793C (en)	2009-10-20
CN1434043B (zh)	2010-04-28
CZ311097A3 (cs)	1998-03-18
HK1054236B (zh)	2010-02-05
HUP9801436A2 (hu)	1998-10-28
CN1434037A (zh)	2003-08-06
PL322651A1 (en)	1998-02-16
ATE224899T1 (de)	2002-10-15
SI0835257T1 (en)	2003-04-30
PL186564B1 (pl)	2004-01-30
HK1054236A1 (zh)	2003-11-21
NO974608D0 (no)	1997-10-06
DE69623960D1 (de)	2002-10-31
CN1434043A (zh)	2003-08-06
IL117684A0 (en)	1996-07-23
WO1996031513A1 (en)	1996-10-10
HK1054234A1 (zh)	2003-11-21
NO974608L (no)	1997-12-08
NZ306664A (en)	1999-11-29
NO329776B1 (no)	2010-12-13
NO320482B1 (no)	2005-12-12
US6235907B1 (en)	2001-05-22
DE69623960T2 (de)	2003-06-05
CN100396682C (zh)	2008-06-25
AU5527896A (en)	1996-10-23
TW438775B (en)	2001-06-07
JP2008069170A (ja)	2008-03-27
PL186446B1 (pl)	2004-01-30
KR19980703691A (ko)	1998-12-05
KR100423627B1 (ko)	2004-07-27
HK1009448A1 (en)	1999-09-10
EP0835257B1 (en)	2002-09-25
CA2214793A1 (en)	1996-10-10
CN1100058C (zh)	2003-01-29
US6121451A (en)	2000-09-19
HK1054234B (zh)	2010-12-24
MX9707706A (es)	1997-12-31
CN1434044A (zh)	2003-08-06
ZA962747B (en)	1998-04-06
HK1055118A1 (zh)	2003-12-24
HK1055119A1 (en)	2003-12-24
CZ297862B6 (cs)	2007-04-18
HUP9801436A3 (en)	1998-11-30
JP4281075B2 (ja)	2009-06-17
JPH11503156A (ja)	1999-03-23
EP0835257A1 (en)	1998-04-15
RU2164917C2 (ru)	2001-04-10

Publication	Publication Date	Title
NO974608L (no)	1997-12-08	Nye mellomprodukter og fremgangsmåte for fremstilling av camptothecinderivater (CPT-11) og beslektede forbindelser
IL140419A0 (en)	2002-02-10	Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
DE59606920D1 (de)	2001-06-21	Chirale methylphenyloxazolidinone
BG105009A (en)	2001-11-30	Method for producing 4-carboxyamino-2-substituted 1,2,3,4-tetrahydroquinoline
IS4730A (is)	1998-04-29	Aðferð til að búa til kamptóþesín afleiður
DK0787124T3 (da)	2000-05-08	Fremgangsmåde til fremstilling af substituerede 3-aminobenzonitriler
ATE250057T1 (de)	2003-10-15	Verfahren zur herstellung von 1-(1h)- benzoquinolizin-3-on derivaten
UA29395C2 (uk)	2000-11-15	Похідне прегна-4,9(11),17(20)-трієн-3-она, спосіб його одержання, спосіб одержання 21-ацилоксипрегна-4, 9(11),16-трієн-3,20-діону та проміжні сполуки
DK1089976T3 (da)	2004-01-19	Fremgangsmåde til fremstilling af 5-bromisoquinolin og dets 8-nitroderivat
BR9610175A (pt)	1998-08-11	Composto processo de preparação do composto composição farmacêutica e utilização do composto
DE69812079D1 (de)	2003-04-17	Verfahren zur herstellung eines buthylthuio-isochinolinderivates und zwischenprodukte dafür
CZ20011915A3 (cs)	2001-09-12	Způsob výroby cyklenu
DK0809627T3 (da)	2001-11-26	Hidtil ukendte borneolderivater, fremgangsmåde til deres fremstilling og deres farmaceutiske anvendelse
ATE173259T1 (de)	1998-11-15	Verfahren zur herstellung von indolizinderivaten
DK0808306T3 (da)	2000-03-06	Hidtil ukendte pyridin- eller pyridazinderivater, fremgangsmåder til fremstilling deraf og lægemidler indeholdende disse fo
NO975961L (no)	1998-02-20	Fremgangsmåte for fremstilling av 1-(3-trialkylsilylfenyl)-2,2,2-trifluorometyl-ethanonderivater
ATE188694T1 (de)	2000-01-15	Verfahren zur herstellung von benzopyranderivaten
BG104964A (bg)	2001-07-31	Подобрен метод за получаване на фармацевтично ценни норбензоморфанови производни
DK0796256T3 (da)	2004-05-10	Fremgangsmåde til fremstilling af ranitidin
DK1070082T3 (da)	2004-01-26	Fremgangsmåde til fremstilling af 4,4-dimethyl-5alfa-cholesta-8,14,24-trien-3beta-ol og mellemprodukter i fremgangsmåden (I)
DK1163257T3 (da)	2003-03-03	Fremgangsmåde til fremstilling af 4,4-dimethyl-3beta-hydroxypregna-8,14-dien-21-carboxylsyreestere og mellemprodukter i fremgangsmåden
DE60029493D1 (de)	2006-08-31	Neues verfahren zur herstellung von 1-phenyl-2-(2-pyridyl)ethanamin