DK0835258T3 - Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse - Google Patents

Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Info

Publication number: DK0835258T3
Authority: DK; Denmark
Prior art keywords: medicines; preparation; hydroxy; methods; lower alkyl
Prior art date: 1995-06-21

Application number

DK96924010T

Other languages

English (en)

Inventor

Gerard Ulibarri

Dennis Bigg

Jacques Pommier

Olivier Lavergne

Rodas Francesc Pla

Original Assignee

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-21

Filing date

1996-06-21

Publication date

2003-02-03

1995-06-21 Priority claimed from GBGB9512670.2A external-priority patent/GB9512670D0/en

1996-06-21 Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic

2003-02-03 Application granted granted Critical

2003-02-03 Publication of DK0835258T3 publication Critical patent/DK0835258T3/da

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
150000001277 beta hydroxy acids Chemical class 0.000 abstract 2
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
229940127093 camptothecin Drugs 0.000 abstract 1
-1 camptothecin hydroxy lactone Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1
238000007142 ring opening reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cephalosporin Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK96924010T 1995-06-21 1996-06-21 Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse DK0835258T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9512670.2A GB9512670D0 (en)	1995-06-21	1995-06-21	Camptothecin analogues
US61047696A	1996-03-04	1996-03-04
PCT/FR1996/000980 WO1997000876A1 (fr)	1995-06-21	1996-06-21	Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
DK0835258T3 true DK0835258T3 (da)	2003-02-03

Family

ID=26307258

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK96924010T DK0835258T3 (da)	1995-06-21	1996-06-21	Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
DK02077736T DK1251125T3 (da)	1995-06-21	1996-06-21	Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK02077736T DK1251125T3 (da)	1995-06-21	1996-06-21	Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Country Status (23)

Country	Link
EP (2)	EP1251125B1 (da)
JP (2)	JP3576171B2 (da)
KR (1)	KR100440838B1 (da)
CN (1)	CN1114608C (da)
AT (2)	ATE224900T1 (da)
AU (1)	AU716377B2 (da)
BR (1)	BR9608639A (da)
CA (1)	CA2225528C (da)
CL (1)	CL2004001168A1 (da)
CZ (1)	CZ296156B6 (da)
DE (2)	DE69635560T2 (da)
DK (2)	DK0835258T3 (da)
ES (2)	ES2254600T3 (da)
IL (2)	IL122635A (da)
MX (1)	MX9710228A (da)
NO (1)	NO316749B1 (da)
NZ (1)	NZ312715A (da)
PL (1)	PL185354B1 (da)
PT (1)	PT835258E (da)
RO (1)	RO117918B1 (da)
RU (1)	RU2164515C2 (da)
TW (1)	TW457234B (da)
WO (1)	WO1997000876A1 (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2757515B1 (fr) *	1996-12-20	2000-05-05	Sod Conseils Rech Applic	Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2790261B1 (fr) *	1999-02-26	2004-09-10	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
FR2768431B1 (fr) *	1997-08-29	2000-03-24	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
FR2757514B1 (fr) *	1996-12-20	1999-02-12	Sod Conseils Rech Applic	Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6559309B2 (en) *	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
UA57757C2 (uk) *	1996-12-20	2003-07-15	Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.)	Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
FR2772763B1 (fr) *	1997-12-24	2004-01-23	Sod Conseils Rech Applic	Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE19826499A1 (de) *	1998-06-13	1999-12-16	Beiersdorf Ag	Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
US6207832B1 (en) *	1999-04-09	2001-03-27	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
MXPA02002032A (es) *	1999-08-27	2003-05-19	Ligand Pharm Inc	Compuestos moduladores del receptor de androgeno y metodos.
US6667313B1 (en)	1999-08-27	2003-12-23	Ligand Pharmaceuticals Inc.	8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US6566372B1 (en)	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
PE20010647A1 (es)	1999-09-14	2001-06-23	Lilly Co Eli	Moduladores de receptores de retinoide x (rxr) con perfil farmacologico mejorado
FR2801309B1 (fr) *	1999-11-18	2002-01-04	Adir	Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE60124387T2 (de)	2000-02-28	2007-10-11	Pfizer Enterprises Sarl.	Synergistische pharmazeutische Zusammensetzungen zur Behandlung von kolorektalem Krebs
US6486320B2 (en)	2000-09-15	2002-11-26	Aventis Pharma S.A.	Preparation of camptothecin and of its derivatives
AU1602902A (en)	2000-10-27	2002-05-06	Aventis Pharma Sa	A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6372906B1 (en)	2001-04-12	2002-04-16	University Of Pittsburgh	Synthesis of silyl camptothecins and silyl homocamptothecins
FR2825278A1 (fr) *	2001-05-30	2002-12-06	Sod Conseils Rech Applic	Produit comprenant du mikanolide, du dihydromikanolide ou un analogue de ceux-ci en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer
US6723853B2 (en)	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003225642A1 (en) *	2002-03-01	2003-09-16	Fluorous Techonologies Inc	Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20020305A1 (it) *	2002-05-31	2003-12-01	Sigma Tau Ind Farmaceuti	Camptotecine con anello lattonico modificato.
ITRM20030344A1 (it) *	2003-07-14	2005-01-15	Ist Naz Stud Cura Dei Tumori	7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN100408582C (zh) *	2004-02-12	2008-08-06	中国人民解放军第二军医大学	高喜树碱类化合物及其制备方法和用途
ITRM20040288A1 (it) *	2004-06-11	2004-09-11	Sigma Tau Ind Farmaceuti	Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
US20090104254A1 (en)	2004-12-22	2009-04-23	Rutgers, The State University Of New Jersey	Controlled Release Hydrogels
CN100339377C (zh) *	2005-09-05	2007-09-26	合肥中科大生物技术有限公司	喜树碱衍生物及其制备
CN1319971C (zh) *	2005-09-09	2007-06-06	合肥中科大生物技术有限公司	喜树碱衍生物及其用途
CN100465175C (zh) *	2005-11-29	2009-03-04	中国人民解放军第二军医大学	7-位取代高喜树碱类化合物及作为药物的用途
CN1319970C (zh) *	2005-12-30	2007-06-06	合肥中科大生物技术有限公司	一种用作抗肿瘤剂的喜树碱衍生物及其制备方法
WO2007113687A2 (en)	2006-03-30	2007-10-11	Diatos S.A.	Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
JP5232770B2 (ja) *	2006-04-19	2013-07-10	バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド	新規な「反転した」ラクトン安定なｅ−環を有するカンプトテシン類似体並びにその製造及び使用方法
CN101220037B (zh) *	2008-01-31	2011-02-16	中国人民解放军第二军医大学	10-位取代高喜树碱类化合物及其用途
CN100592871C (zh) *	2008-03-14	2010-03-03	浙江林学院	一种杀虫剂组合物及其加工方法
CN101979392A (zh) *	2010-09-26	2011-02-23	中国人民解放军第二军医大学	7-芳乙烯基取代高喜树碱类化合物及其作为药物的用途
US20140086975A1 (en)	2010-10-15	2014-03-27	Rutgers, The State University Of New Jersey	Hydrogel formulation for dermal and ocular delivery
CN102746314B (zh) *	2011-04-18	2016-07-06	华东师范大学	含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN105601641B (zh) *	2015-12-22	2018-01-16	兰州大学	7‑位哌嗪磺酰胺喜树碱类化合物、制备方法及用途
CN106478648B (zh) *	2016-09-21	2018-11-06	桑迪亚医药技术（上海）有限责任公司	一种高喜树碱化合物及其合成方法
CN111777608B (zh) *	2020-07-08	2021-08-03	湖北精瑜材料有限公司	一种新型植物改性喹啉季铵盐化合物和制备方法及应用
KR20250119655A (ko) *	2021-02-05	2025-08-07	쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드	캄프토테신 화합물, 그의 제조방법 및 그의 응용
WO2023232145A1 (zh) *	2022-06-02	2023-12-07	华东师范大学	一种高喜树碱类小分子及其应用
CN121399135A (zh) *	2023-10-10	2026-01-23	上海翊维康医药有限责任公司	新的i型拓扑异构酶抑制剂及其制备方法和用途
CN120058721A (zh) *	2024-01-08	2025-05-30	杭州爱科瑞思生物医药有限公司	7-氟烷基取代的喜树碱衍生物的制备及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5162532A (en) *	1990-12-20	1992-11-10	North Carolina State University	Intermediates and method of making camptothecin and camptothecin analogs
US5391745A (en) *	1992-07-23	1995-02-21	Sloan-Kettering Institute For Cancer Research	Methods of preparation of camptothecin analogs

1996
- 1996-06-21 ES ES02077736T patent/ES2254600T3/es not_active Expired - Lifetime
- 1996-06-21 WO PCT/FR1996/000980 patent/WO1997000876A1/fr not_active Ceased
- 1996-06-21 IL IL12263596A patent/IL122635A/en not_active IP Right Cessation
- 1996-06-21 AT AT96924010T patent/ATE224900T1/de not_active IP Right Cessation
- 1996-06-21 BR BR9608639A patent/BR9608639A/pt not_active IP Right Cessation
- 1996-06-21 EP EP02077736A patent/EP1251125B1/fr not_active Expired - Lifetime
- 1996-06-21 AU AU64608/96A patent/AU716377B2/en not_active Ceased
- 1996-06-21 DE DE69635560T patent/DE69635560T2/de not_active Expired - Lifetime
- 1996-06-21 CZ CZ0415397A patent/CZ296156B6/cs not_active IP Right Cessation
- 1996-06-21 RO RO97-02400A patent/RO117918B1/ro unknown
- 1996-06-21 JP JP50364497A patent/JP3576171B2/ja not_active Expired - Fee Related
- 1996-06-21 PT PT96924010T patent/PT835258E/pt unknown
- 1996-06-21 DK DK96924010T patent/DK0835258T3/da active
- 1996-06-21 NZ NZ312715A patent/NZ312715A/xx not_active IP Right Cessation
- 1996-06-21 CA CA002225528A patent/CA2225528C/fr not_active Expired - Fee Related
- 1996-06-21 RU RU98101135/04A patent/RU2164515C2/ru not_active IP Right Cessation
- 1996-06-21 ES ES96924010T patent/ES2184882T3/es not_active Expired - Lifetime
- 1996-06-21 EP EP96924010A patent/EP0835258B1/fr not_active Expired - Lifetime
- 1996-06-21 DK DK02077736T patent/DK1251125T3/da active
- 1996-06-21 DE DE69623961T patent/DE69623961T2/de not_active Expired - Lifetime
- 1996-06-21 CN CN96196127A patent/CN1114608C/zh not_active Expired - Fee Related
- 1996-06-21 MX MX9710228A patent/MX9710228A/es unknown
- 1996-06-21 KR KR1019970709577A patent/KR100440838B1/ko not_active Expired - Fee Related
- 1996-06-21 AT AT02077736T patent/ATE312105T1/de not_active IP Right Cessation
- 1996-06-21 PL PL96324339A patent/PL185354B1/pl not_active IP Right Cessation
- 1996-08-08 TW TW085109645A patent/TW457234B/zh not_active IP Right Cessation
1997
- 1997-12-19 NO NO19975988A patent/NO316749B1/no not_active IP Right Cessation
1999
- 1999-01-14 IL IL12804499A patent/IL128044A0/xx unknown
2003
- 2003-11-26 JP JP2003395824A patent/JP2004123756A/ja active Pending
2004
- 2004-05-20 CL CL200401168A patent/CL2004001168A1/es unknown

Also Published As

Publication number	Publication date
EP1251125A3 (fr)	2002-12-11
CZ415397A3 (cs)	1998-08-12
BR9608639A (pt)	1999-06-29
PL324339A1 (en)	1998-05-25
MX9710228A (es)	1998-03-31
RO117918B1 (ro)	2002-09-30
NO975988D0 (no)	1997-12-19
RU2164515C2 (ru)	2001-03-27
CN1114608C (zh)	2003-07-16
ATE312105T1 (de)	2005-12-15
IL128044A0 (en)	1999-11-30
CA2225528C (fr)	2007-06-05
ES2184882T3 (es)	2003-04-16
EP1251125B1 (fr)	2005-12-07
DE69623961D1 (de)	2002-10-31
DE69635560T2 (de)	2006-08-17
HK1015783A1 (en)	1999-10-22
EP1251125A2 (fr)	2002-10-23
IL122635A0 (en)	1998-08-16
PL185354B1 (pl)	2003-04-30
ES2254600T3 (es)	2006-06-16
NO316749B1 (no)	2004-04-26
AU716377B2 (en)	2000-02-24
KR100440838B1 (ko)	2004-12-17
IL122635A (en)	2001-10-31
EP0835258B1 (fr)	2002-09-25
JPH11508249A (ja)	1999-07-21
DK1251125T3 (da)	2006-04-18
JP2004123756A (ja)	2004-04-22
CA2225528A1 (fr)	1997-01-09
NO975988L (no)	1998-02-19
AU6460896A (en)	1997-01-22
CZ296156B6 (cs)	2006-01-11
TW457234B (en)	2001-10-01
WO1997000876A1 (fr)	1997-01-09
NZ312715A (en)	2000-01-28
DE69623961T2 (de)	2003-05-08
PT835258E (pt)	2003-02-28
CN1192740A (zh)	1998-09-09
HK1056726A1 (en)	2004-02-27
KR19990028263A (ko)	1999-04-15
CL2004001168A1 (es)	2005-05-20
EP0835258A1 (fr)	1998-04-15
HK1050686A1 (en)	2003-07-04
ATE224900T1 (de)	2002-10-15
JP3576171B2 (ja)	2004-10-13
DE69635560D1 (de)	2006-01-12

Publication	Publication Date	Title
DK0835258T3 (da)	2003-02-03	Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
NO2011026I2 (no)	2012-06-11	Eribulin eller et farmasøytisk akseptabelt salt derav
MX9305767A (es)	1994-05-31	Procedimiento para la preparacion de derivados de taxano y los derivados de taxano asi obtenidos.
DK8885D0 (da)	1985-01-08	N-heterocyclyl-4-piperidinaminderivater og fremgangsmaade til fremstilling deraf
FI98460B (fi)	1997-03-14	Menetelmä terapeuttisesti käyttökelpoisen 4H-1-bentsopyran-4-onijohdoksen tai sen suolan valmistamiseksi ja menetelmässä käyttökelpoinen välituote
DK551989D0 (da)	1989-11-06	3-piperidinyl-1,2-benzisoxazoler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK0896533T3 (da)	2004-01-26	Pentafluorbenzensulfonamider og analoger
WO1987006226A3 (en)	1988-04-07	Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparations containing the absorption promoters
DK0559079T3 (da)	1998-03-30	Substituerede aminophosphonatderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
DE69621469D1 (de)	2002-07-04	Phenylpiperidin-derivate
AR004688A1 (es)	1999-03-10	Derivados de la 5-0-desosaminil--6-o-metil-eritronolida a, su procedimiento de preparacion, compuestos intermediarios para su exclusivo uso en dichoprocedimiento para la preparacion de productos biologicamente activo
DK0461986T3 (da)	1996-05-28	Hexahydroazepinderivater, en fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
IT1251226B (it)	1995-05-05	Composizioni farmaceutiche contenenti clozapina, loro preparazione e loro impiego
ES8800005A1 (es)	1987-11-01	Procedimiento para preparar derivados de amidas herbicidas y fungicidas
ATE96418T1 (de)	1993-11-15	6-fluorshikiminsaeurederivate.
DK0446921T3 (da)	1999-06-21	Optisk aktive alkylendioxybenzenderivater og deres anvendelse ved terapi
DK0520372T3 (da)	1997-05-12	Inositol-phosphat-analoger som calciumantagonistiske stoffer
FI934303A0 (fi)	1993-09-30	Acylsulfonamido- och sulfonamidopyridin-2-karboxylsyraestrar och deraspyridin-n-oxider, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
ES2130392T3 (es)	1999-07-01	Procedimiento para la preparacion de acido clavulanico.
ES2124757T3 (es)	1999-02-16	Composicion callicida que contiene naoh.
BR8804486A (pt)	1989-03-28	Tinoalcanodifosfonatos de o-alquil-o-(6-metil-2-alquil-pirimidino-4-ilo),processo para sua preparacao,composicoes inseticidas,processo para o combate a atropodes e para a preparacao de artropodicidas
NO943008L (no)	1995-02-17	Renseblanding for galleveiene