DK0836619T3 - Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering - Google Patents

Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering

Info

Publication number
DK0836619T3
DK0836619T3 DK96923922T DK96923922T DK0836619T3 DK 0836619 T3 DK0836619 T3 DK 0836619T3 DK 96923922 T DK96923922 T DK 96923922T DK 96923922 T DK96923922 T DK 96923922T DK 0836619 T3 DK0836619 T3 DK 0836619T3
Authority
DK
Denmark
Prior art keywords
pct
isoelectric focusing
purification
sec
pure
Prior art date
Application number
DK96923922T
Other languages
English (en)
Inventor
Pier Giorgio Righetti
Ernesto Riva
Alessandra Maria Bossi
Luigi Franco Zerilli
Original Assignee
Aventis Bulk S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Bulk S P A filed Critical Aventis Bulk S P A
Application granted granted Critical
Publication of DK0836619T3 publication Critical patent/DK0836619T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DK96923922T 1995-07-05 1996-06-25 Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering DK0836619T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95110467 1995-07-05
EP95111583 1995-07-24
EP96923922A EP0836619B1 (en) 1995-07-05 1996-06-25 Purification of dalbaheptide antibiotics by isoelectric focusing

Publications (1)

Publication Number Publication Date
DK0836619T3 true DK0836619T3 (da) 2004-12-06

Family

ID=26138707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96923922T DK0836619T3 (da) 1995-07-05 1996-06-25 Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering

Country Status (13)

Country Link
US (1) US5939523A (da)
EP (1) EP0836619B1 (da)
JP (1) JP4051421B2 (da)
KR (1) KR100430202B1 (da)
AT (1) ATE274524T1 (da)
AU (1) AU701463B2 (da)
CA (1) CA2226142C (da)
DE (1) DE69633234T2 (da)
DK (1) DK0836619T3 (da)
ES (1) ES2224173T3 (da)
IL (1) IL122151A (da)
PT (1) PT836619E (da)
WO (1) WO1997002288A1 (da)

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KR20000010589A (ko) * 1996-04-23 2000-02-15 클라우디오 쿼르타 항생제a40926의아미드유도체의개선된화학적제조방법
AU4054900A (en) * 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
US6713448B2 (en) 2001-04-25 2004-03-30 Wyeth Holdings Corporation Substantially pure glycopeptide antibiotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 and AC-98-5
DE60238481D1 (de) * 2001-04-25 2011-01-13 Wyeth Corp Im wesentlichen reine glycopeptid-antibiotika ac-98-1; ac-98-2; ac-98-3; ac-98-4 und ac-98-5
AU2003294262B2 (en) * 2002-11-18 2007-08-23 Vicuron Pharmaceuticals Inc. Methods of administering dalbavancin for treatment of bacterial infections
US20070105756A1 (en) * 2005-10-31 2007-05-10 May Thomas B Vancomycin formulations having reduced amount of histamine
CN101851277B (zh) * 2009-03-12 2012-10-03 成都雅途生物技术有限公司 一种道古霉素关键中间体a40926 bo组分的纯化制备方法
CN105671110B (zh) * 2015-05-05 2019-02-01 重庆乾泰生物医药有限公司 一种生产达巴万星前体a40926的方法

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US2951766A (en) * 1957-07-15 1960-09-06 Le Roy A White Antiseptic plastic
US4322343A (en) * 1980-12-18 1982-03-30 Eli Lilly And Company Pseudo-aglycone of actaplanin
US4521335A (en) * 1983-07-13 1985-06-04 Smithkline Beckman Corporation Aglycone and pseudo-aglycones of the AAD 216 antibiotics
US4563442A (en) * 1983-10-21 1986-01-07 Eli Lilly And Company Glycopeptide bioconversion products
US4504467A (en) * 1983-10-21 1985-03-12 Eli Lilly And Company Glycopeptide derivatives
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
DE3572178D1 (en) * 1984-04-16 1989-09-14 Lilly Co Eli Improvements in and relating to antibiotics m43a, m43b, m43c and m43d
GB8415092D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Ester derivatives
GB8425685D0 (en) * 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
IL78597A0 (en) * 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8531846D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
JP2516202B2 (ja) * 1986-07-10 1996-07-24 三共株式会社 グリコペプチド系抗生物質
GB8618445D0 (en) * 1986-07-29 1986-09-03 Lepetit Spa Antibiotic a 42867
US4742045A (en) * 1986-07-30 1988-05-03 Smithkline Beckman Corporation Glycopeptide antibiotics
DK363587A (da) * 1986-07-30 1988-01-31 Smithkline Beckman Corp Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GR871488B (en) * 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
GB8624806D0 (en) * 1986-10-16 1986-11-19 Pfizer Ltd Glycopeptide antibiotic
EP0273727A3 (en) * 1986-12-30 1990-01-17 Smithkline Beecham Corporation Glycosylated glycopeptides
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
EP0287513B1 (en) * 1987-04-11 1992-12-02 Ciba-Geigy Ag An isoelectric focusing process and a means for carrying out said process
GB8711066D0 (en) * 1987-05-11 1987-06-17 Lepetit Spa Teicoplanin derivatives
GB8715735D0 (en) * 1987-07-03 1987-08-12 Lepetit Spa De-mannosyl teicoplanin derivatives
US4882313A (en) * 1987-07-31 1989-11-21 Smithkline Beckman Corporation Carboxamide derivatives of glycopeptides
WO1989002441A1 (en) * 1987-09-19 1989-03-23 Beecham Group Plc Antibiotic compounds
GB8802211D0 (en) * 1988-02-02 1988-03-02 Lepetit Spa Teicoplanin hydrazides
WO1989007612A1 (en) * 1988-02-10 1989-08-24 Beecham Group Plc Novel antibiotic compounds
DK203089A (da) * 1988-04-28 1989-10-29 Beecham Group Plc Metaboliter
GB8817053D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
GB8817052D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15-alkyl derivatives of teicoplanin compounds
GB8817397D0 (en) * 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
GB8817736D0 (en) * 1988-07-26 1988-09-01 Lepetit Spa New teicoplanin antibiotics
IN167068B (da) * 1988-08-27 1990-08-25 Hoechst India
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
GB8827202D0 (en) * 1988-11-22 1988-12-29 Lepetit Spa Process for preparing 63-carboxyamides of teicoplanin antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
IE64155B1 (en) * 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
DK0448940T3 (da) * 1990-03-28 1997-11-03 Lepetit Spa Fremgangsmåde til fremstilling af mannosylteicoplaninderivater og mannosylteicoplaninaglycon
WO1992010516A1 (en) * 1990-12-05 1992-06-25 Gruppo Lepetit S.P.A. 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them
EP0505735A1 (en) * 1991-03-27 1992-09-30 GRUPPO LEPETIT S.p.A. Antibiotic A 40926 ester derivatives
CZ285703B6 (cs) * 1991-07-29 1999-10-13 Biosearch Italia S. P. A. Amidové deriváty antibiotika A 40926

Also Published As

Publication number Publication date
CA2226142C (en) 2007-11-13
JP4051421B2 (ja) 2008-02-27
DE69633234D1 (de) 2004-09-30
EP0836619A1 (en) 1998-04-22
ES2224173T3 (es) 2005-03-01
US5939523A (en) 1999-08-17
KR19990028712A (ko) 1999-04-15
EP0836619B1 (en) 2004-08-25
PT836619E (pt) 2004-11-30
AU6416196A (en) 1997-02-05
AU701463B2 (en) 1999-01-28
JPH11508572A (ja) 1999-07-27
ATE274524T1 (de) 2004-09-15
WO1997002288A1 (en) 1997-01-23
IL122151A0 (en) 1998-04-05
DE69633234T2 (de) 2005-09-15
IL122151A (en) 2001-08-26
KR100430202B1 (ko) 2004-09-18
CA2226142A1 (en) 1997-01-23

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