DK0839192T3 - Et forbedret immobiliseret penicillin G-acylase - Google Patents
Et forbedret immobiliseret penicillin G-acylaseInfo
- Publication number
- DK0839192T3 DK0839192T3 DK96926389T DK96926389T DK0839192T3 DK 0839192 T3 DK0839192 T3 DK 0839192T3 DK 96926389 T DK96926389 T DK 96926389T DK 96926389 T DK96926389 T DK 96926389T DK 0839192 T3 DK0839192 T3 DK 0839192T3
- Authority
- DK
- Denmark
- Prior art keywords
- acylase
- immobilized penicillin
- improved immobilized
- beta
- lactam
- Prior art date
Links
- 108010073038 Penicillin Amidase Proteins 0.000 title abstract 2
- GCBWDZYSLVSRRI-UHFFFAOYSA-N 3-aminoazetidin-2-one Chemical compound NC1CNC1=O GCBWDZYSLVSRRI-UHFFFAOYSA-N 0.000 abstract 1
- 108010093096 Immobilized Enzymes Proteins 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US147795P | 1995-07-18 | 1995-07-18 | |
| EP95201979 | 1995-07-18 | ||
| PCT/EP1996/003253 WO1997004086A1 (en) | 1995-07-18 | 1996-07-16 | An improved immobilized penicillin g acylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0839192T3 true DK0839192T3 (da) | 2009-04-06 |
Family
ID=26139505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96926389T DK0839192T3 (da) | 1995-07-18 | 1996-07-16 | Et forbedret immobiliseret penicillin G-acylase |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0839192B1 (de) |
| JP (1) | JP2001527381A (de) |
| CN (2) | CN1572873A (de) |
| AT (1) | ATE417100T1 (de) |
| AU (1) | AU6659296A (de) |
| DE (1) | DE69637771D1 (de) |
| DK (1) | DK0839192T3 (de) |
| ES (1) | ES2318851T3 (de) |
| WO (1) | WO1997004086A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8021398A (en) * | 1997-06-10 | 1998-12-30 | Gist-Brocades B.V. | Application of reducing sulphur compounds during enzymatic preparation of beta-lactam compounds |
| NL1009814C2 (nl) * | 1998-08-06 | 2000-02-08 | Dsm Nv | Werkwijze voor de bereiding van een N-geacyleerd aminonitril. |
| CN1109746C (zh) * | 1998-11-10 | 2003-05-28 | 同济医科大学 | 一种固定化酶载体 |
| DE10256656A1 (de) * | 2002-12-03 | 2004-06-17 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Cephalexin |
| ITMI20030042A1 (it) * | 2003-01-14 | 2004-07-15 | Univ Degli Studi Trieste | Processo di sintesi enzimatica di antibiotici b lattamici. |
| HUE036242T2 (hu) | 2003-07-03 | 2018-06-28 | Dsm Sinochem Pharm Nl Bv | Eljárás cefradin elõállítására |
| BRPI0621278A2 (pt) | 2005-12-28 | 2011-12-06 | Dsm Ip Assests Bv | acilases mutantes |
| CZ300467B6 (cs) | 2007-01-31 | 2009-05-27 | Mikrobiologický ústav AV CR, v.v.i. | Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci |
| KR101444492B1 (ko) * | 2007-03-09 | 2014-09-24 | 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. | 베타-락탐 화합물의 제조 방법 |
| HUE036302T2 (hu) | 2008-12-23 | 2018-07-30 | Dsm Sinochem Pharm Nl Bv | Mutáns penicillin-G-acilázok |
| CN102656274B (zh) | 2009-12-14 | 2014-10-15 | 中化帝斯曼制药有限公司荷兰公司 | 生产头孢拉定的方法 |
| WO2011113486A1 (en) | 2010-03-17 | 2011-09-22 | Deretil, S.A. | Process for the synthesis of hydroxyphenylglycine esters |
| EP2614066B1 (de) | 2010-09-07 | 2017-11-29 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von cephalosporinen |
| EP2723881A2 (de) | 2011-06-23 | 2014-04-30 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Neues kristallines cefoperazon-zwischenprodukt |
| EP2723882B1 (de) | 2011-06-23 | 2019-05-01 | Centrient Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase |
| WO2013057197A1 (en) | 2011-10-20 | 2013-04-25 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the formylation of cefamandole |
| WO2013057196A1 (en) | 2011-10-20 | 2013-04-25 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the preparation of cefamandole nafate |
| CN102645503B (zh) * | 2012-05-04 | 2014-04-02 | 联邦制药(内蒙古)有限公司 | 一种酶法制备阿莫西林中残留蛋白质的检测方法 |
| CN103805672B (zh) * | 2014-02-25 | 2016-05-25 | 华北制药集团先泰药业有限公司 | 一种酶法制备氨苄西林的工艺 |
| WO2017186864A1 (en) | 2016-04-27 | 2017-11-02 | Sandoz Ag | Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum |
| CN110343734B (zh) * | 2019-06-14 | 2021-03-23 | 浙江工业大学 | 一种l-草铵膦化学酶法生产方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8301373A (nl) * | 1983-04-19 | 1984-11-16 | Tno | Geimmobiliseerde biokatalysatoren. |
| GB2149816B (en) * | 1983-11-14 | 1987-06-10 | Kansai Paint Co Ltd | Process for producing granular fixed enzymes or/microorganism strains |
| DK336987D0 (da) * | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| PT83746B (pt) * | 1985-11-15 | 1988-08-17 | Gist Brocades Nv | Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao |
| DK589389D0 (da) * | 1989-11-23 | 1989-11-23 | Novo Nordisk As | Immobiliseret enzympraeparat |
| MX9200313A (es) * | 1991-01-25 | 1992-10-30 | Novo Nordisk A S Novo Nordisk | Procedimiento para la separacion de dos componentes solidos. |
| ES2059285T1 (es) * | 1991-12-19 | 1994-11-16 | Novo Nordisk As | Un metodo mejorado para la preparacion de ciertos antibioticos beta-lactamicos. |
-
1996
- 1996-07-16 EP EP96926389A patent/EP0839192B1/de not_active Expired - Lifetime
- 1996-07-16 ES ES96926389T patent/ES2318851T3/es not_active Expired - Lifetime
- 1996-07-16 AU AU66592/96A patent/AU6659296A/en not_active Abandoned
- 1996-07-16 DE DE69637771T patent/DE69637771D1/de not_active Expired - Lifetime
- 1996-07-16 JP JP50632697A patent/JP2001527381A/ja active Pending
- 1996-07-16 WO PCT/EP1996/003253 patent/WO1997004086A1/en not_active Ceased
- 1996-07-16 AT AT96926389T patent/ATE417100T1/de active
- 1996-07-16 CN CN200410063362.1A patent/CN1572873A/zh active Pending
- 1996-07-16 CN CNB961955430A patent/CN1165616C/zh not_active Expired - Lifetime
- 1996-07-16 DK DK96926389T patent/DK0839192T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997004086A1 (en) | 1997-02-06 |
| CN1190990A (zh) | 1998-08-19 |
| DE69637771D1 (de) | 2009-01-22 |
| MX9800406A (es) | 1998-09-30 |
| ES2318851T3 (es) | 2009-05-01 |
| EP0839192B1 (de) | 2008-12-10 |
| CN1572873A (zh) | 2005-02-02 |
| EP0839192A1 (de) | 1998-05-06 |
| CN1165616C (zh) | 2004-09-08 |
| ATE417100T1 (de) | 2008-12-15 |
| AU6659296A (en) | 1997-02-18 |
| JP2001527381A (ja) | 2001-12-25 |
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