ATE417100T1 - Eine verbesserte immobilisierte penicillin g acylase - Google Patents

Eine verbesserte immobilisierte penicillin g acylase

Info

Publication number
ATE417100T1
ATE417100T1 AT96926389T AT96926389T ATE417100T1 AT E417100 T1 ATE417100 T1 AT E417100T1 AT 96926389 T AT96926389 T AT 96926389T AT 96926389 T AT96926389 T AT 96926389T AT E417100 T1 ATE417100 T1 AT E417100T1
Authority
AT
Austria
Prior art keywords
acylase
immobilized penicillin
improved immobilized
beta
lactam
Prior art date
Application number
AT96926389T
Other languages
English (en)
Inventor
Vroom Erik De
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE417100T1 publication Critical patent/ATE417100T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96926389T 1995-07-18 1996-07-16 Eine verbesserte immobilisierte penicillin g acylase ATE417100T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US147795P 1995-07-18 1995-07-18
EP95201979 1995-07-18

Publications (1)

Publication Number Publication Date
ATE417100T1 true ATE417100T1 (de) 2008-12-15

Family

ID=26139505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96926389T ATE417100T1 (de) 1995-07-18 1996-07-16 Eine verbesserte immobilisierte penicillin g acylase

Country Status (9)

Country Link
EP (1) EP0839192B1 (de)
JP (1) JP2001527381A (de)
CN (2) CN1572873A (de)
AT (1) ATE417100T1 (de)
AU (1) AU6659296A (de)
DE (1) DE69637771D1 (de)
DK (1) DK0839192T3 (de)
ES (1) ES2318851T3 (de)
WO (1) WO1997004086A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8021398A (en) * 1997-06-10 1998-12-30 Gist-Brocades B.V. Application of reducing sulphur compounds during enzymatic preparation of beta-lactam compounds
NL1009814C2 (nl) * 1998-08-06 2000-02-08 Dsm Nv Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
CN1109746C (zh) * 1998-11-10 2003-05-28 同济医科大学 一种固定化酶载体
DE10256656A1 (de) * 2002-12-03 2004-06-17 Röhm GmbH & Co. KG Verfahren zur Herstellung von Cephalexin
ITMI20030042A1 (it) * 2003-01-14 2004-07-15 Univ Degli Studi Trieste Processo di sintesi enzimatica di antibiotici b lattamici.
US7588913B2 (en) 2003-07-03 2009-09-15 Dsm Ip Assets B.V. Process for the preparation of cephradine
EP1974029A2 (de) 2005-12-28 2008-10-01 DSMIP Assets B.V. Mutante acylasen
CZ200782A3 (cs) 2007-01-31 2009-05-27 Mikrobiologický ústav AV CR, v.v.i. Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci
BRPI0808685A2 (pt) * 2007-03-09 2014-08-19 Dsm Ip Assets Bv Processo para a preparação de derivados semissintéticos de beta-lactama.
CN102264904B (zh) 2008-12-23 2013-10-23 中化帝斯曼制药有限公司荷兰公司 突变体青霉素g酰基转移酶
WO2011073166A2 (en) 2009-12-14 2011-06-23 Dsm Ip Assets B.V. Production process for cephradine
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters
EP2614066B1 (de) 2010-09-07 2017-11-29 DSM Sinochem Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von cephalosporinen
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
EP2723882B1 (de) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase
WO2013057197A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the formylation of cefamandole
WO2013057196A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of cefamandole nafate
CN102645503B (zh) * 2012-05-04 2014-04-02 联邦制药(内蒙古)有限公司 一种酶法制备阿莫西林中残留蛋白质的检测方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
WO2017186864A1 (en) 2016-04-27 2017-11-02 Sandoz Ag Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum
CN110343734B (zh) * 2019-06-14 2021-03-23 浙江工业大学 一种l-草铵膦化学酶法生产方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8301373A (nl) * 1983-04-19 1984-11-16 Tno Geimmobiliseerde biokatalysatoren.
GB2149816B (en) * 1983-11-14 1987-06-10 Kansai Paint Co Ltd Process for producing granular fixed enzymes or/microorganism strains
DK336987D0 (da) * 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
PT83746B (pt) * 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
CZ148593A3 (en) * 1991-01-25 1994-01-19 Novo Nordisk As Process of separating a non-dissolved catalyst from one or a plurality of other non-dissolved components comprised in the same reaction mixture
AU3345193A (en) * 1991-12-19 1993-07-19 Novo Nordisk A/S An improved method for the preparation of certain beta-lactam antibiotics

Also Published As

Publication number Publication date
DK0839192T3 (da) 2009-04-06
ES2318851T3 (es) 2009-05-01
CN1165616C (zh) 2004-09-08
AU6659296A (en) 1997-02-18
CN1190990A (zh) 1998-08-19
MX9800406A (es) 1998-09-30
WO1997004086A1 (en) 1997-02-06
CN1572873A (zh) 2005-02-02
EP0839192B1 (de) 2008-12-10
DE69637771D1 (de) 2009-01-22
EP0839192A1 (de) 1998-05-06
JP2001527381A (ja) 2001-12-25

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