ES2080899T3 - Acilacion enzimatica enantiomericamente selectiva de una 3-amino-azetidinona racemica. - Google Patents

Acilacion enzimatica enantiomericamente selectiva de una 3-amino-azetidinona racemica.

Info

Publication number
ES2080899T3
ES2080899T3 ES91305110T ES91305110T ES2080899T3 ES 2080899 T3 ES2080899 T3 ES 2080899T3 ES 91305110 T ES91305110 T ES 91305110T ES 91305110 T ES91305110 T ES 91305110T ES 2080899 T3 ES2080899 T3 ES 2080899T3
Authority
ES
Spain
Prior art keywords
racemic
amino
acilation
azetidinone
selective enzymatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91305110T
Other languages
English (en)
Inventor
Jeffrey Neal Levy
Milton Joseph Zmijewski Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2080899T3 publication Critical patent/ES2080899T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONA UN PROCESO SELECTIVO ENANTIOMETICAMENTE PARA ACILAR INTERMEDIOS DE RACEMIC 3-AMINO AZETIDINONA UTILIZANDO LA PENICILINA G AMIDASA (ACILASA) COMO BIOCATALIZADOR.
ES91305110T 1990-06-08 1991-06-06 Acilacion enzimatica enantiomericamente selectiva de una 3-amino-azetidinona racemica. Expired - Lifetime ES2080899T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53508690A 1990-06-08 1990-06-08
US07/591,586 US5057607A (en) 1990-06-08 1990-10-02 Enantiomerically selective biocatalyzed acylation

Publications (1)

Publication Number Publication Date
ES2080899T3 true ES2080899T3 (es) 1996-02-16

Family

ID=27064707

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91305110T Expired - Lifetime ES2080899T3 (es) 1990-06-08 1991-06-06 Acilacion enzimatica enantiomericamente selectiva de una 3-amino-azetidinona racemica.

Country Status (13)

Country Link
US (1) US5057607A (es)
EP (1) EP0460949B1 (es)
JP (1) JP2971621B2 (es)
KR (1) KR0169995B1 (es)
AT (1) ATE130039T1 (es)
CA (1) CA2043763C (es)
DE (1) DE69114363T2 (es)
DK (1) DK0460949T3 (es)
ES (1) ES2080899T3 (es)
GR (1) GR3018170T3 (es)
HU (1) HU211034B (es)
IE (1) IE69754B1 (es)
IL (1) IL98351A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
DE4332738A1 (de) * 1993-09-25 1995-03-30 Basf Ag Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
US6214608B1 (en) 1995-02-03 2001-04-10 Basf Aktiengesellschaft Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation
AU7359198A (en) * 1997-05-01 1998-11-27 G.D. Searle & Co. Method and apparatus for preparation of chiral beta amino acids
DE19727517A1 (de) * 1997-06-30 1999-01-07 Basf Ag Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
NL1009814C2 (nl) * 1998-08-06 2000-02-08 Dsm Nv Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
DE19904207A1 (de) 1999-02-03 2000-08-10 Basf Ag Verfahren zur Herstellung von Estern
AU6049000A (en) * 1999-07-23 2001-02-13 Eli Lilly And Company Enantioselective acylation of cis racemic azetidinones
DE19956786A1 (de) 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
KR20020087500A (ko) * 2000-12-23 2002-11-23 주식회사대웅제약 3-치환 아제티디논의 제조방법
JP4457660B2 (ja) * 2003-12-12 2010-04-28 パナソニック株式会社 画像分類装置、画像分類システム、画像分類に関するプログラム、およびそのプログラムを記録したコンピュータ読み取り可能な記録媒体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150059A (en) * 1962-12-26 1964-09-22 Lilly Co Eli Penicillin deacylation via actinoplanaceae fermentation
GB1369462A (en) * 1971-11-23 1974-10-09 Beecham Group Ltd Enzymic resolution of racemic n-acyl-dl-amino acids
US4316958A (en) * 1979-02-10 1982-02-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing optically active cephalosporin analogs
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
US4332896A (en) * 1979-04-14 1982-06-01 Kyowa Hakko Kogyo Co., Ltd. Process for producing cephalosporin analogs
DE3048612C2 (de) * 1980-12-23 1982-12-02 Hoechst Ag, 6000 Frankfurt "Verfahren zur enzymatischen Trennung von L-2-Ami no-4-methylphosphinobuttersäure"
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
GB8728121D0 (en) * 1987-12-01 1988-01-06 Ciba Geigy Ag Resolution process
US4931556A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-(2-furyl)eth-1-yl)-methoxycarbonylmethyl-azetidin-2-one and malic acid salts thereof

Also Published As

Publication number Publication date
KR0169995B1 (ko) 1999-02-01
IE911958A1 (en) 1991-12-18
JP2971621B2 (ja) 1999-11-08
EP0460949A2 (en) 1991-12-11
IL98351A (en) 1996-07-23
JPH04341196A (ja) 1992-11-27
GR3018170T3 (en) 1996-02-29
DK0460949T3 (da) 1995-12-11
DE69114363T2 (de) 1996-04-25
CA2043763C (en) 2001-05-15
DE69114363D1 (de) 1995-12-14
HUT61604A (en) 1993-01-28
HU911918D0 (en) 1991-12-30
EP0460949B1 (en) 1995-11-08
KR920000942A (ko) 1992-01-29
ATE130039T1 (de) 1995-11-15
US5057607A (en) 1991-10-15
IL98351A0 (en) 1992-07-15
CA2043763A1 (en) 1991-12-09
EP0460949A3 (en) 1992-10-21
HU211034B (en) 1995-09-28
IE69754B1 (en) 1996-10-02

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