DK0842143T3 - 2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater - Google Patents

2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater

Info

Publication number
DK0842143T3
DK0842143T3 DK96924888T DK96924888T DK0842143T3 DK 0842143 T3 DK0842143 T3 DK 0842143T3 DK 96924888 T DK96924888 T DK 96924888T DK 96924888 T DK96924888 T DK 96924888T DK 0842143 T3 DK0842143 T3 DK 0842143T3
Authority
DK
Denmark
Prior art keywords
benzylamino
substituted
methyl
propanamide derivatives
propanamide
Prior art date
Application number
DK96924888T
Other languages
English (en)
Other versions
DK0842143T5 (da
Inventor
Alberto Bonsignori
Paolo Pevarello
Raffaella Amici
Mario Varasi
Patricia Salvati
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10778352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0842143(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of DK0842143T3 publication Critical patent/DK0842143T3/da
Application granted granted Critical
Publication of DK0842143T5 publication Critical patent/DK0842143T5/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/36Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96924888T 1995-07-27 1996-07-05 2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater DK0842143T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515412.6A GB9515412D0 (en) 1995-07-27 1995-07-27 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
PCT/EP1996/002961 WO1997005102A1 (en) 1995-07-27 1996-07-05 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Publications (2)

Publication Number Publication Date
DK0842143T3 true DK0842143T3 (da) 2001-07-23
DK0842143T5 DK0842143T5 (da) 2009-06-02

Family

ID=10778352

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924888T DK0842143T5 (da) 1995-07-27 1996-07-05 2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater

Country Status (27)

Country Link
US (1) US5945454A (da)
EP (1) EP0842143B3 (da)
JP (1) JP4040089B2 (da)
KR (1) KR100412747B1 (da)
CN (1) CN1085659C (da)
AR (1) AR003469A1 (da)
AT (1) ATE202078T1 (da)
AU (1) AU711309B2 (da)
BR (1) BR9609849B1 (da)
CA (1) CA2226894C (da)
DE (2) DE69613377T4 (da)
DK (1) DK0842143T5 (da)
EA (1) EA001322B1 (da)
ES (1) ES2159749T7 (da)
GB (1) GB9515412D0 (da)
GR (1) GR3036559T3 (da)
HU (1) HU227806B1 (da)
IL (1) IL122705A (da)
MX (1) MX9800718A (da)
NO (1) NO324273B1 (da)
NZ (1) NZ313185A (da)
PL (1) PL184302B1 (da)
PT (1) PT842143E (da)
SI (1) SI0842143T1 (da)
UA (1) UA44331C2 (da)
WO (1) WO1997005102A1 (da)
ZA (1) ZA965998B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
EP1032377B1 (en) 1997-11-21 2010-11-17 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
AU4961001A (en) * 2000-03-31 2001-10-15 Cocensys Inc Aminopyridines and their use as anticonvulsants and sodium channel blockers
DK1423168T3 (da) 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
US6667327B2 (en) 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
AU2004283452A1 (en) 2003-10-23 2005-05-06 F. Hoffmann-La Roche Ag Benzazepine derivatives as MAO-B inhibitors
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
DK1809271T5 (da) * 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer
RU2008120619A (ru) * 2005-10-26 2009-12-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) (гетеро)арилы, обладающие антагонистической активностью по отношению к меланинконцентрирующему гормону
EP1963280B1 (en) 2005-12-22 2015-10-28 Newron Pharmaceuticals S.p.A. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
AU2007278837A1 (en) * 2006-07-28 2008-01-31 Alcon Research, Ltd. Monoamine oxidase inhibitors useful for treating disorders of the outer retina
CA2689561C (en) 2007-06-15 2015-11-17 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
SI2563355T1 (sl) * 2010-04-27 2016-10-28 Newron Pharmaceuticals S.P.A. Postopek za izdelavo metansulfonatnih soli ralfinamida ali njihovih R-enantiomerov
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation

Also Published As

Publication number Publication date
PL324639A1 (en) 1998-06-08
CN1085659C (zh) 2002-05-29
CN1192199A (zh) 1998-09-02
NZ313185A (en) 2000-05-26
BR9609849A (pt) 1999-03-16
IL122705A (en) 2001-01-28
UA44331C2 (uk) 2002-02-15
EP0842143B3 (en) 2009-02-18
EA199800170A1 (ru) 1998-08-27
CA2226894C (en) 2009-03-31
AU711309B2 (en) 1999-10-07
PT842143E (pt) 2001-10-30
DE69613377T2 (de) 2001-09-20
SI0842143T1 (da) 2001-08-31
HUP9900351A3 (en) 1999-11-29
CA2226894A1 (en) 1997-02-13
ES2159749T7 (es) 2009-06-18
HU227806B1 (en) 2012-03-28
DE69613377D1 (de) 2001-07-19
AU711309C (en) 1997-02-26
EP0842143B1 (en) 2001-06-13
DE69613377T4 (de) 2009-08-13
ZA965998B (en) 1997-01-31
JP2000500732A (ja) 2000-01-25
IL122705A0 (en) 1998-08-16
PL184302B1 (pl) 2002-09-30
NO980290D0 (no) 1998-01-22
KR19990035843A (ko) 1999-05-25
MX9800718A (es) 1998-04-30
GR3036559T3 (en) 2001-12-31
BR9609849B1 (pt) 2010-05-18
AU6418796A (en) 1997-02-26
EP0842143A1 (en) 1998-05-20
KR100412747B1 (ko) 2004-04-28
US5945454A (en) 1999-08-31
DK0842143T5 (da) 2009-06-02
NO980290L (no) 1998-01-22
HUP9900351A2 (hu) 1999-06-28
ES2159749T3 (es) 2001-10-16
NO324273B1 (no) 2007-09-17
ATE202078T1 (de) 2001-06-15
AR003469A1 (es) 1998-08-05
EA001322B1 (ru) 2001-02-26
JP4040089B2 (ja) 2008-01-30
GB9515412D0 (en) 1995-09-27
WO1997005102A1 (en) 1997-02-13

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