DK0856514T3 - 8-substituerede 1,3,8-triazaspiro[4,5]decan-4-on-derivater - Google Patents

8-substituerede 1,3,8-triazaspiro[4,5]decan-4-on-derivater

Info

Publication number: DK0856514T3
Authority: DK; Denmark
Prior art keywords: triazaspiro; decan; derivatives; substituted
Prior art date: 1997-01-30

Application number

DK98100970T

Other languages

English (en)

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Frederick Monsma

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-30

Filing date

1998-01-21

Publication date

2001-09-17

1998-01-21 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-09-17 Application granted granted Critical

2001-09-17 Publication of DK0856514T3 publication Critical patent/DK0856514T3/da

Links

-1 8-substituted 1,3,8-triazaspiro [4,5] decan-4-one Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Lubricants (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK98100970T 1997-01-30 1998-01-21 8-substituerede 1,3,8-triazaspiro[4,5]decan-4-on-derivater DK0856514T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97101409		1997-01-30
EP97119311		1997-11-05

Publications (1)

Publication Number	Publication Date
DK0856514T3 true DK0856514T3 (da)	2001-09-17

Family

ID=26145196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98100970T DK0856514T3 (da)	1997-01-30	1998-01-21	8-substituerede 1,3,8-triazaspiro[4,5]decan-4-on-derivater

Country Status (34)

Country	Link
US (1)	US6071925A (da)
EP (1)	EP0856514B1 (da)
JP (1)	JP3292457B2 (da)
KR (1)	KR100274107B1 (da)
CN (1)	CN1113881C (da)
AR (1)	AR011576A1 (da)
AT (1)	ATE202105T1 (da)
AU (1)	AU730147B2 (da)
BR (1)	BR9800524B1 (da)
CA (1)	CA2226058C (da)
CO (1)	CO4920223A1 (da)
CZ (1)	CZ27398A3 (da)
DE (1)	DE69800896T2 (da)
DK (1)	DK0856514T3 (da)
EA (1)	EA001357B1 (da)
ES (1)	ES2158622T3 (da)
GR (1)	GR3036523T3 (da)
HR (1)	HRP980043B1 (da)
HU (1)	HUP9800138A3 (da)
ID (1)	ID19773A (da)
IL (1)	IL123036A (da)
MA (1)	MA26470A1 (da)
NO (1)	NO310026B1 (da)
NZ (1)	NZ329627A (da)
PE (1)	PE59999A1 (da)
PL (1)	PL324571A1 (da)
PT (1)	PT856514E (da)
SG (1)	SG71077A1 (da)
SI (1)	SI0856514T1 (da)
TR (1)	TR199800085A3 (da)
TW (1)	TW457238B (da)
UY (1)	UY24865A1 (da)
YU (1)	YU2098A (da)
ZA (1)	ZA98570B (da)

Families Citing this family (34)

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EP0921125B1 (en) *	1997-12-05	2002-01-30	F. Hoffmann-La Roche Ag	1,3,8-Triazaspiro[4,5]decan-4-on derivatives
PT921125E (pt) *	1997-12-05	2002-06-28	Hoffmann La Roche	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
US6166209A (en) *	1997-12-11	2000-12-26	Hoffmann-La Roche Inc.	Piperidine derivatives
US6277991B1 (en)	1998-05-18	2001-08-21	Novo Nordisk A/S	1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
PT963985E (pt)	1998-06-12	2003-06-30	Hoffmann La Roche	Derivados de di- ou triaza-espiro(4,5)decano
ATE222908T1 (de) *	1998-06-12	2002-09-15	Hoffmann La Roche	Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
US6262066B1 (en) *	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) *	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
CO5150201A1 (es) *	1998-09-07	2002-04-29	Hoffmann La Roche	Derivados de piperidina
EP0997464B1 (en) *	1998-10-23	2005-02-16	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
AU1185300A (en) *	1998-11-20	2000-06-13	Banyu Pharmaceutical Co., Ltd.	2-oxoimidazole derivatives
GB9900078D0 (en) *	1999-01-05	1999-02-24	Zeneca Ltd	Chemical compounds
GB9914024D0 (en) *	1999-06-17	1999-08-18	Zeneca Ltd	Chemical compounds
WO2001036418A1 (en) *	1999-11-17	2001-05-25	Novo Nordisk A/S	Novel triazaspirodecanones with high affinity for opioid receptor subtypes
US6686370B2 (en)	1999-12-06	2004-02-03	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
ATE449084T1 (de) *	2000-03-31	2009-12-15	Nippon Shinyaku Co Ltd	Derivate von heterocyclen und arzneistoffe
EP1392687B1 (en) *	2001-04-10	2017-02-01	Janssen Pharmaceuticals, Inc.	1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
EP1406629A1 (en)	2001-07-02	2004-04-14	Omeros Corporation	Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
PT1491212E (pt)	2002-03-29	2012-11-16	Mitsubishi Tanabe Pharma Corp	Medicamento para distúrbios de sono
US6995168B2 (en)	2002-05-31	2006-02-07	Euro-Celtique S.A.	Triazaspiro compounds useful for treating or preventing pain
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2004241134A1 (en) *	2003-05-23	2004-12-02	Zealand Pharma A/S	Triaza-spiro compounds as nociceptin analogues and uses thereof
SA04250305B1 (ar)	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) *	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CN101622254B (zh) *	2006-11-28	2013-05-29	詹森药业有限公司	3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
MX2009009355A (es) *	2007-03-01	2009-09-11	Mitsubishi Tanabe Pharma Corp	Compuesto de bencimidazol y uso farmaceutico del mismo.
MX2009011006A (es) *	2007-04-09	2009-11-02	Janssen Pharmaceutica Nv	Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
EP4455145A3 (en) *	2015-12-02	2025-03-12	Astraea Therapeutics, LLC	Piperidinyl nociceptin receptor compounds
US10112924B2 (en)	2015-12-02	2018-10-30	Astraea Therapeutics, Inc.	Piperdinyl nociceptin receptor compounds
CN106467476A (zh) *	2016-09-04	2017-03-01	王际菊	一种左旋胺基化合物的合成方法
CN106397225A (zh) *	2016-09-04	2017-02-15	王际菊	一种手性化合物的制备方法

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SU1095878A3 (ru) *	1980-10-22	1984-05-30	Жансен Фармасетика Н.В. (Фирма)	Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) *	1982-04-09	1983-02-15	Hoechst-Roussel Pharmaceuticals Inc.	8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
US4707484A (en) *	1986-11-25	1987-11-17	Hoffmann-La Roche Inc.	Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5153225A (en) *	1986-12-10	1992-10-06	Bayer Aktiengesellschaft	Substituted basic 2-aminotetralin in pharmaceuticals
DE3718317A1 (de) *	1986-12-10	1988-06-16	Bayer Ag	Substituierte basische 2-aminotetraline
US5039804A (en) *	1989-12-13	1991-08-13	Glaxo Inc.	Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) *	1991-10-28	1993-04-29	Bayer Ag	Triazaspirodecanon-methylchromane
DE4405178A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

1997
- 1997-12-31 CA CA002226058A patent/CA2226058C/en not_active Expired - Fee Related
1998
- 1998-01-07 SG SG1998000062A patent/SG71077A1/en unknown
- 1998-01-15 YU YU2098A patent/YU2098A/sh unknown
- 1998-01-20 US US09/009,457 patent/US6071925A/en not_active Expired - Fee Related
- 1998-01-20 TR TR1998/00085A patent/TR199800085A3/tr unknown
- 1998-01-21 DE DE69800896T patent/DE69800896T2/de not_active Expired - Lifetime
- 1998-01-21 ES ES98100970T patent/ES2158622T3/es not_active Expired - Lifetime
- 1998-01-21 DK DK98100970T patent/DK0856514T3/da active
- 1998-01-21 EP EP98100970A patent/EP0856514B1/en not_active Expired - Lifetime
- 1998-01-21 PT PT98100970T patent/PT856514E/pt unknown
- 1998-01-21 AT AT98100970T patent/ATE202105T1/de active
- 1998-01-21 SI SI9830035T patent/SI0856514T1/xx unknown
- 1998-01-22 ID IDP980073A patent/ID19773A/id unknown
- 1998-01-23 IL IL12303698A patent/IL123036A/xx not_active IP Right Cessation
- 1998-01-23 ZA ZA98570A patent/ZA98570B/xx unknown
- 1998-01-23 CN CN98103687A patent/CN1113881C/zh not_active Expired - Fee Related
- 1998-01-23 NZ NZ329627A patent/NZ329627A/xx unknown
- 1998-01-26 NO NO980332A patent/NO310026B1/no not_active IP Right Cessation
- 1998-01-26 HU HU9800138A patent/HUP9800138A3/hu unknown
- 1998-01-27 PE PE1998000056A patent/PE59999A1/es not_active Application Discontinuation
- 1998-01-27 JP JP01371198A patent/JP3292457B2/ja not_active Expired - Fee Related
- 1998-01-27 HR HR980043A patent/HRP980043B1/xx not_active IP Right Cessation
- 1998-01-27 AR ARP980100349A patent/AR011576A1/es active IP Right Grant
- 1998-01-28 CO CO98003944A patent/CO4920223A1/es unknown
- 1998-01-28 MA MA24950A patent/MA26470A1/fr unknown
- 1998-01-29 UY UY24865A patent/UY24865A1/es unknown
- 1998-01-29 CZ CZ98273A patent/CZ27398A3/cs unknown
- 1998-01-29 PL PL98324571A patent/PL324571A1/xx unknown
- 1998-01-29 AU AU52809/98A patent/AU730147B2/en not_active Ceased
- 1998-01-30 BR BRPI9800524-3A patent/BR9800524B1/pt not_active IP Right Cessation
- 1998-01-30 KR KR1019980002475A patent/KR100274107B1/ko not_active Expired - Fee Related
- 1998-01-30 EA EA199800108A patent/EA001357B1/ru not_active IP Right Cessation
- 1998-02-04 TW TW087101434A patent/TW457238B/zh not_active IP Right Cessation
2001
- 2001-09-05 GR GR20010401383T patent/GR3036523T3/el unknown

Also Published As

Publication number	Publication date
TR199800085A2 (xx)	1998-08-21
PT856514E (pt)	2001-10-31
CA2226058C (en)	2008-01-29
SI0856514T1 (en)	2001-08-31
CO4920223A1 (es)	2000-05-29
TW457238B (en)	2001-10-01
AR011576A1 (es)	2000-08-30
NO310026B1 (no)	2001-05-07
BR9800524B1 (pt)	2008-11-18
TR199800085A3 (tr)	1998-08-21
EA199800108A1 (ru)	1998-10-29
DE69800896D1 (de)	2001-07-19
ATE202105T1 (de)	2001-06-15
JP3292457B2 (ja)	2002-06-17
HU9800138D0 (en)	1998-03-30
IL123036A0 (en)	1998-09-24
UY24865A1 (es)	2000-12-29
HRP980043B1 (en)	2001-12-31
JPH10212290A (ja)	1998-08-11
EP0856514A1 (en)	1998-08-05
HUP9800138A3 (en)	1999-03-01
HRP980043A2 (en)	1998-12-31
AU5280998A (en)	1998-08-06
KR100274107B1 (ko)	2000-12-15
ZA98570B (en)	1998-07-30
IL123036A (en)	2000-12-06
NZ329627A (en)	1999-11-29
AU730147B2 (en)	2001-03-01
SG71077A1 (en)	2000-03-21
GR3036523T3 (en)	2001-12-31
BR9800524A (pt)	2000-03-14
KR19980070900A (ko)	1998-10-26
NO980332D0 (no)	1998-01-26
DE69800896T2 (de)	2002-03-28
NO980332L (no)	1998-07-31
CZ27398A3 (cs)	1998-08-12
PL324571A1 (en)	1998-08-03
US6071925A (en)	2000-06-06
PE59999A1 (es)	1999-07-01
CA2226058A1 (en)	1998-07-30
MA26470A1 (fr)	2004-12-20
YU2098A (sh)	2001-03-07
HUP9800138A2 (hu)	1998-09-28
ID19773A (id)	1998-07-30
EP0856514B1 (en)	2001-06-13
ES2158622T3 (es)	2001-09-01
CN1113881C (zh)	2003-07-09
EA001357B1 (ru)	2001-02-26
CN1191862A (zh)	1998-09-02

Publication	Publication Date	Title
DE69800896D1 (de)	2001-07-19	8-substituierte-1,3,8-Triazaspiro[4,5]decan-4-onderivate
SI0921125T1 (en)	2002-04-30	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
DE69803653D1 (de)	2002-03-14	1,3,8-Triazaspiro[4,5]decan-4-on-derivate
IS4570A (is)	1997-09-25	Imidazó[1,2-a]pýridín afleiður
IL125589A0 (en)	1999-03-12	Pyrimidin-4-one derivatives as pesticides
IL129502A0 (en)	2000-02-29	Naphthyridine derivatives
IL126951A0 (en)	1999-09-22	Carboline derivatives
HU9801587D0 (en)	1998-09-28	5h-thiazolo[3,2-a]pyrimidine derivatives
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