ES2158622T3 - Derivados de 1,3,8-triazaespiro(4,5)decan-4-ona-8-sustituidos. - Google Patents

Derivados de 1,3,8-triazaespiro(4,5)decan-4-ona-8-sustituidos.

Info

Publication number
ES2158622T3
ES2158622T3 ES98100970T ES98100970T ES2158622T3 ES 2158622 T3 ES2158622 T3 ES 2158622T3 ES 98100970 T ES98100970 T ES 98100970T ES 98100970 T ES98100970 T ES 98100970T ES 2158622 T3 ES2158622 T3 ES 2158622T3
Authority
ES
Spain
Prior art keywords
short chain
rent
chain rent
phenyll
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98100970T
Other languages
English (en)
Inventor
Geo Adam
Andrea Cesura
Guido Galley
Francois Jenck
Frederick Monsma
Stephan Rover
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2158622T3 publication Critical patent/ES2158622T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCION ESTA RELACIONADA CON COMPUESTOS DE FORMULA DONDE R 1 Y R 2 SON, DE FORMA INDEPENDIENTE ENTRE SI, HIDROGENO, ALQUILO DE CADENA CORTA, ALCOXI DE CADENA CORTA O HALOGENO; R 3 ES FENILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO DE CADENA CORTA, CF 3 , ALCOXI DE CADENA CORTA O HALOGENO; Y R 4 ES HIDROGENO, ALQUILO DE CADENA CORTA, ALQUENILO DE CADENA CORTA, - C(O) - ALQUILO DE CADENA CORTA, C(O) - FENILO, FENIL - C(O) - ALQUILO DE CADENA CORTA, ALQUILENO DE CADENA CORTA - C(O)O - ALQUILO DE CADENA CORTA, ALCANOTRIILO DE CADENA CORTA DI - C(O)O - ALQUILO DE CADENA CORTA, HIDROXI - ALQUILO DE CADENA CORTA, ALQUILO DE CADENA CORTA - O ALQUILO DE CADENA CORTA, ALQUILO DE CADENA CORTA - CH(OH)CF SUB,3 , FENILO O BENCILO, R 5 Y R 6 SON, DE FORMA INDE PENDIENTE ENTRE SI, HIDROGENO, FENILO, ALQUILO DE CADENA CORTA O DI - ALQUILO DE CADENA CORTA O PUEDEN FORMAR JUNTOS UN ANILLO FENILO, Y R 5 Y UNO DE R 1 O R 2 PUEDEN FORMAR JUNTOS UN ANILLO SATURADO O INSATURADO DE 6 MIEMBROS, A ES UN ANILLO SATURADO O INSATURADO DE 4-7 MIEMBROS QUE PUEDE CONTENER UN HETEROATOMO TAL COMO O O S, Y CON SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES DE ELLOS QUE SON AGONISTAS Y/O ANTAGONISTAS DEL RECEPTOR OFQ.
ES98100970T 1997-01-30 1998-01-21 Derivados de 1,3,8-triazaespiro(4,5)decan-4-ona-8-sustituidos. Expired - Lifetime ES2158622T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (1)

Publication Number Publication Date
ES2158622T3 true ES2158622T3 (es) 2001-09-01

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98100970T Expired - Lifetime ES2158622T3 (es) 1997-01-30 1998-01-21 Derivados de 1,3,8-triazaespiro(4,5)decan-4-ona-8-sustituidos.

Country Status (34)

Country Link
US (1) US6071925A (es)
EP (1) EP0856514B1 (es)
JP (1) JP3292457B2 (es)
KR (1) KR100274107B1 (es)
CN (1) CN1113881C (es)
AR (1) AR011576A1 (es)
AT (1) ATE202105T1 (es)
AU (1) AU730147B2 (es)
BR (1) BR9800524B1 (es)
CA (1) CA2226058C (es)
CO (1) CO4920223A1 (es)
CZ (1) CZ27398A3 (es)
DE (1) DE69800896T2 (es)
DK (1) DK0856514T3 (es)
EA (1) EA001357B1 (es)
ES (1) ES2158622T3 (es)
GR (1) GR3036523T3 (es)
HR (1) HRP980043B1 (es)
HU (1) HUP9800138A3 (es)
ID (1) ID19773A (es)
IL (1) IL123036A (es)
MA (1) MA26470A1 (es)
NO (1) NO310026B1 (es)
NZ (1) NZ329627A (es)
PE (1) PE59999A1 (es)
PL (1) PL324571A1 (es)
PT (1) PT856514E (es)
SG (1) SG71077A1 (es)
SI (1) SI0856514T1 (es)
TR (1) TR199800085A3 (es)
TW (1) TW457238B (es)
UY (1) UY24865A1 (es)
YU (1) YU2098A (es)
ZA (1) ZA98570B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0921125B1 (en) * 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on derivatives
PT921125E (pt) * 1997-12-05 2002-06-28 Hoffmann La Roche Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
PT963985E (pt) 1998-06-12 2003-06-30 Hoffmann La Roche Derivados de di- ou triaza-espiro(4,5)decano
ATE222908T1 (de) * 1998-06-12 2002-09-15 Hoffmann La Roche Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
EP0997464B1 (en) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
WO2001036418A1 (en) * 1999-11-17 2001-05-25 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
US6686370B2 (en) 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
ATE449084T1 (de) * 2000-03-31 2009-12-15 Nippon Shinyaku Co Ltd Derivate von heterocyclen und arzneistoffe
EP1392687B1 (en) * 2001-04-10 2017-02-01 Janssen Pharmaceuticals, Inc. 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
EP1406629A1 (en) 2001-07-02 2004-04-14 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
PT1491212E (pt) 2002-03-29 2012-11-16 Mitsubishi Tanabe Pharma Corp Medicamento para distúrbios de sono
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
AU2003268512A1 (en) * 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2004241134A1 (en) * 2003-05-23 2004-12-02 Zealand Pharma A/S Triaza-spiro compounds as nociceptin analogues and uses thereof
SA04250305B1 (ar) 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CN101622254B (zh) * 2006-11-28 2013-05-29 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
MX2009009355A (es) * 2007-03-01 2009-09-11 Mitsubishi Tanabe Pharma Corp Compuesto de bencimidazol y uso farmaceutico del mismo.
MX2009011006A (es) * 2007-04-09 2009-11-02 Janssen Pharmaceutica Nv Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
EP4455145A3 (en) * 2015-12-02 2025-03-12 Astraea Therapeutics, LLC Piperidinyl nociceptin receptor compounds
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
CN106467476A (zh) * 2016-09-04 2017-03-01 王际菊 一种左旋胺基化合物的合成方法
CN106397225A (zh) * 2016-09-04 2017-02-15 王际菊 一种手性化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488082A (en) * 1892-12-13 Automatic gut-off for gas bxxenees
JPS5212171A (en) * 1975-07-17 1977-01-29 Yoshitomi Pharmaceut Ind Ltd Process for preparation of cyclohexane derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4160836A (en) * 1976-05-17 1979-07-10 Janssen Pharmaceutica N.V. Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives
US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) * 1980-10-22 1984-05-30 Жансен Фармасетика Н.В. (Фирма) Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) * 1984-01-23 1985-04-01 吉富製薬株式会社 脂環式誘導体
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4405178A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

Also Published As

Publication number Publication date
TR199800085A2 (xx) 1998-08-21
PT856514E (pt) 2001-10-31
CA2226058C (en) 2008-01-29
SI0856514T1 (en) 2001-08-31
CO4920223A1 (es) 2000-05-29
TW457238B (en) 2001-10-01
DK0856514T3 (da) 2001-09-17
AR011576A1 (es) 2000-08-30
NO310026B1 (no) 2001-05-07
BR9800524B1 (pt) 2008-11-18
TR199800085A3 (tr) 1998-08-21
EA199800108A1 (ru) 1998-10-29
DE69800896D1 (de) 2001-07-19
ATE202105T1 (de) 2001-06-15
JP3292457B2 (ja) 2002-06-17
HU9800138D0 (en) 1998-03-30
IL123036A0 (en) 1998-09-24
UY24865A1 (es) 2000-12-29
HRP980043B1 (en) 2001-12-31
JPH10212290A (ja) 1998-08-11
EP0856514A1 (en) 1998-08-05
HUP9800138A3 (en) 1999-03-01
HRP980043A2 (en) 1998-12-31
AU5280998A (en) 1998-08-06
KR100274107B1 (ko) 2000-12-15
ZA98570B (en) 1998-07-30
IL123036A (en) 2000-12-06
NZ329627A (en) 1999-11-29
AU730147B2 (en) 2001-03-01
SG71077A1 (en) 2000-03-21
GR3036523T3 (en) 2001-12-31
BR9800524A (pt) 2000-03-14
KR19980070900A (ko) 1998-10-26
NO980332D0 (no) 1998-01-26
DE69800896T2 (de) 2002-03-28
NO980332L (no) 1998-07-31
CZ27398A3 (cs) 1998-08-12
PL324571A1 (en) 1998-08-03
US6071925A (en) 2000-06-06
PE59999A1 (es) 1999-07-01
CA2226058A1 (en) 1998-07-30
MA26470A1 (fr) 2004-12-20
YU2098A (sh) 2001-03-07
HUP9800138A2 (hu) 1998-09-28
ID19773A (id) 1998-07-30
EP0856514B1 (en) 2001-06-13
CN1113881C (zh) 2003-07-09
EA001357B1 (ru) 2001-02-26
CN1191862A (zh) 1998-09-02

Similar Documents

Publication Publication Date Title
AR039489A1 (es) Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas
ES2109796T3 (es) Derivados de pirrolopirimidilo con efecto antiproliferante.
UY28565A1 (es) Nuevos compuestos
PE20010706A1 (es) Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo-3-il-aminas biciclicas, procedimiento para la preparacion de esta biblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos pa
AR011576A1 (es) Compuestos derivados de 1,3,8-triaza-espiro[4,5]decan-4-ona 8-sustituidos; su empleo, un procedimiento para prepararlos y medicamentos que los contienen
ES2157424T3 (es) Esteres de acido 5-aminolevulinico como agentes fotosensibilizantes en fotoquimioterapia.
UY27109A1 (es) Derivados de quinazolona como antagonistas de receptores adrenergicos alfa-1a/b
AU4926301A (en) Lpa receptor agonists and antagonists and methods of use
ATE365740T1 (de) Substituierte pyrazolopyrimidine
ES2032899T3 (es) Agente cosmetico para aplicacion externa y su uso.
AR077414A2 (es) Compuestos de piperazina como antagonistas de taquinina sus sales y solvatos composiciones farmaceuticas que lo contienen su uso y procesos para su preparacion
CO4770964A1 (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos
ES2084816T3 (es) Agentes de recubrimiento.
ES2188957T3 (es) N-(4-(heteroarilmetil)fenil)-heteroarilaminas.
ES8505972A1 (es) Un procedimiento para preparar derivados de pirimidina
UY25300A1 (es) Composiciones conteniendo un antagonista alfa adrenérgico y un compuesto que eleva los niveles de cgmp para el tratamiento de la impotencia
PA8576001A1 (es) "difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion , medicamentos que comprenden estos compuestos y su uso".
ES2052508T3 (es) Empleo de heteroariletilaminas para favorecer el rendimiento en animales, heteroariletilaminas y procedimiento para su obtencion.
ES2123996T3 (es) Analogos de 7-etertaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.
AR240941A2 (es) Procedimiento para preparar compuestos de pirazolopirimidinas
UY28848A1 (es) Antagonistas de cgrp seleccionados, procedimientos para su preparación, y su empleo como medicamentos
ES2026669T3 (es) Procedimiento para la preparacion y el uso terapeutico de los beta-d-fenil tioxilosidos.
PA8572001A1 (es) Derivados de isoquinolina
ES2179352T3 (es) Compuesto de pirazolopiridina y su uso farmaceutico.
UY28139A1 (es) Compuestos quimicos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 856514

Country of ref document: ES