MA26470A1 - Derives de 1,3,8-triazaspiro (4,5) decane-4-one substitues en position 8, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation - Google Patents

Derives de 1,3,8-triazaspiro (4,5) decane-4-one substitues en position 8, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Info

Publication number: MA26470A1
Authority: MA; Morocco
Prior art keywords: triazaspiro; decane; substitutes; derivatives; preparation
Prior art date: 1997-01-30

Application number

MA24950A

Other languages

English (en)

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Frederick Monsma

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-30

Filing date

1998-01-28

Publication date

2004-12-20

1998-01-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26470A1 publication Critical patent/MA26470A1/fr

Links

JRKPNHLSQGAUDY-UHFFFAOYSA-N 1,3,8-triazaspiro[4.5]decan-4-one Chemical class O=C1NCNC11CCNCC1 JRKPNHLSQGAUDY-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Lubricants (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MA24950A 1997-01-30 1998-01-28 Derives de 1,3,8-triazaspiro (4,5) decane-4-one substitues en position 8, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation MA26470A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97101409		1997-01-30
EP97119311		1997-11-05

Publications (1)

Publication Number	Publication Date
MA26470A1 true MA26470A1 (fr)	2004-12-20

Family

ID=26145196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24950A MA26470A1 (fr)	1997-01-30	1998-01-28	Derives de 1,3,8-triazaspiro (4,5) decane-4-one substitues en position 8, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Country Status (34)

Country	Link
US (1)	US6071925A (fr)
EP (1)	EP0856514B1 (fr)
JP (1)	JP3292457B2 (fr)
KR (1)	KR100274107B1 (fr)
CN (1)	CN1113881C (fr)
AR (1)	AR011576A1 (fr)
AT (1)	ATE202105T1 (fr)
AU (1)	AU730147B2 (fr)
BR (1)	BR9800524B1 (fr)
CA (1)	CA2226058C (fr)
CO (1)	CO4920223A1 (fr)
CZ (1)	CZ27398A3 (fr)
DE (1)	DE69800896T2 (fr)
DK (1)	DK0856514T3 (fr)
EA (1)	EA001357B1 (fr)
ES (1)	ES2158622T3 (fr)
GR (1)	GR3036523T3 (fr)
HR (1)	HRP980043B1 (fr)
HU (1)	HUP9800138A3 (fr)
ID (1)	ID19773A (fr)
IL (1)	IL123036A (fr)
MA (1)	MA26470A1 (fr)
NO (1)	NO310026B1 (fr)
NZ (1)	NZ329627A (fr)
PE (1)	PE59999A1 (fr)
PL (1)	PL324571A1 (fr)
PT (1)	PT856514E (fr)
SG (1)	SG71077A1 (fr)
SI (1)	SI0856514T1 (fr)
TR (1)	TR199800085A2 (fr)
TW (1)	TW457238B (fr)
UY (1)	UY24865A1 (fr)
YU (1)	YU2098A (fr)
ZA (1)	ZA98570B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI0921125T1 (en) *	1997-12-05	2002-04-30	F. Hoffmann-La Roche Ag	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
DE69803653T2 (de) *	1997-12-05	2002-08-29	F. Hoffmann-La Roche Ag, Basel	1,3,8-Triazaspiro[4,5]decan-4-on-derivate
US6166209A (en) *	1997-12-11	2000-12-26	Hoffmann-La Roche Inc.	Piperidine derivatives
US6277991B1 (en)	1998-05-18	2001-08-21	Novo Nordisk A/S	1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
DE69905798T2 (de)	1998-06-12	2004-02-12	F. Hoffmann-La Roche Ag	Di- oder Triazaspiro[4,5]decanderivate
ES2181336T3 (es) *	1998-06-12	2003-02-16	Hoffmann La Roche	Espiro(piperidin-4,1'-pirrolo(3,4-c)pirrol).
ID29137A (id) *	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en)	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
CO5150201A1 (es) *	1998-09-07	2002-04-29	Hoffmann La Roche	Derivados de piperidina
EP0997464B1 (fr) *	1998-10-23	2005-02-16	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanones utiles comme agonistes du récepteur orl1
AU1185300A (en) *	1998-11-20	2000-06-13	Banyu Pharmaceutical Co., Ltd.	2-oxoimidazole derivatives
GB9900078D0 (en) *	1999-01-05	1999-02-24	Zeneca Ltd	Chemical compounds
GB9914024D0 (en) *	1999-06-17	1999-08-18	Zeneca Ltd	Chemical compounds
AU1382901A (en) *	1999-11-17	2001-05-30	Novo Nordisk A/S	Novel triazaspirodecanones with high affinity for opioid receptor subtypes
JP3989247B2 (ja) *	1999-12-06	2007-10-10	ユーロ−セルティークエス．エイ．	ノシセプチン受容体親和性を有するトリアゾスピロ化合物
CN1242993C (zh)	2000-03-31	2006-02-22	日本新药株式会社	杂环衍生物和药物
MXPA03009239A (es) *	2001-04-10	2004-11-12	Johnson & Johnson	Derivados de 1,3,8-triazapiro[4,5]decan-4-ona utiles para el tratamiento de trastornos mediados por el receptor orl-1.
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
WO2003004034A1 (fr)	2001-07-02	2003-01-16	Omeros Corporation	Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
US7566728B2 (en)	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
US6995168B2 (en)	2002-05-31	2006-02-07	Euro-Celtique S.A.	Triazaspiro compounds useful for treating or preventing pain
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
ZA200510329B (en) *	2003-05-23	2007-04-25	Zealand Pharma As	Triaza-spiro compounds as nociceptin analogues and uses thereof
SA04250305B1 (ar)	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) *	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CN103202840B (zh) *	2006-11-28	2015-02-11	詹森药业有限公司	3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101622241B (zh)	2007-03-01	2013-05-22	田边三菱制药株式会社	苯并咪唑化合物及其医药用途
EP2150552B1 (fr) *	2007-04-09	2013-01-02	Janssen Pharmaceutica NV	Dérivés de 1,3,8-trisubstitué-1,3,8-triaza-spiro[4.5]décan-4-one utilisés comme ligands du récepteur orl-i dans le traitement de l'anxiété et de la dépression
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
US10112924B2 (en)	2015-12-02	2018-10-30	Astraea Therapeutics, Inc.	Piperdinyl nociceptin receptor compounds
CN122562777A (zh) *	2015-12-02	2026-08-14	阿斯特来亚治疗有限责任公司	哌啶基痛敏肽受体化合物
CN106467476A (zh) *	2016-09-04	2017-03-01	王际菊	一种左旋胺基化合物的合成方法
CN106397225A (zh) *	2016-09-04	2017-02-15	王际菊	一种手性化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US488082A (en) *		1892-12-13		Automatic gut-off for gas bxxenees
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4160836A (en) *	1976-05-17	1979-07-10	Janssen Pharmaceutica N.V.	Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) *	1980-10-22	1984-05-30	Жансен Фармасетика Н.В. (Фирма)	Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) *	1982-04-09	1983-02-15	Hoechst-Roussel Pharmaceuticals Inc.	8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
US4707484A (en) *	1986-11-25	1987-11-17	Hoffmann-La Roche Inc.	Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
DE3718317A1 (de) *	1986-12-10	1988-06-16	Bayer Ag	Substituierte basische 2-aminotetraline
US5153225A (en) *	1986-12-10	1992-10-06	Bayer Aktiengesellschaft	Substituted basic 2-aminotetralin in pharmaceuticals
US5039804A (en) *	1989-12-13	1991-08-13	Glaxo Inc.	Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) *	1991-10-28	1993-04-29	Bayer Ag	Triazaspirodecanon-methylchromane
DE4405178A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

1997
- 1997-12-31 CA CA002226058A patent/CA2226058C/fr not_active Expired - Fee Related
1998
- 1998-01-07 SG SG1998000062A patent/SG71077A1/en unknown
- 1998-01-15 YU YU2098A patent/YU2098A/sh unknown
- 1998-01-20 US US09/009,457 patent/US6071925A/en not_active Expired - Fee Related
- 1998-01-20 TR TR1998/00085A patent/TR199800085A2/xx unknown
- 1998-01-21 DK DK98100970T patent/DK0856514T3/da active
- 1998-01-21 ES ES98100970T patent/ES2158622T3/es not_active Expired - Lifetime
- 1998-01-21 DE DE69800896T patent/DE69800896T2/de not_active Expired - Lifetime
- 1998-01-21 EP EP98100970A patent/EP0856514B1/fr not_active Expired - Lifetime
- 1998-01-21 PT PT98100970T patent/PT856514E/pt unknown
- 1998-01-21 SI SI9830035T patent/SI0856514T1/xx unknown
- 1998-01-21 AT AT98100970T patent/ATE202105T1/de active
- 1998-01-22 ID IDP980073A patent/ID19773A/id unknown
- 1998-01-23 IL IL12303698A patent/IL123036A/xx not_active IP Right Cessation
- 1998-01-23 NZ NZ329627A patent/NZ329627A/xx unknown
- 1998-01-23 ZA ZA98570A patent/ZA98570B/xx unknown
- 1998-01-23 CN CN98103687A patent/CN1113881C/zh not_active Expired - Fee Related
- 1998-01-26 NO NO980332A patent/NO310026B1/no not_active IP Right Cessation
- 1998-01-26 HU HU9800138A patent/HUP9800138A3/hu unknown
- 1998-01-27 AR ARP980100349A patent/AR011576A1/es active IP Right Grant
- 1998-01-27 JP JP01371198A patent/JP3292457B2/ja not_active Expired - Fee Related
- 1998-01-27 HR HR980043A patent/HRP980043B1/xx not_active IP Right Cessation
- 1998-01-27 PE PE1998000056A patent/PE59999A1/es not_active Application Discontinuation
- 1998-01-28 MA MA24950A patent/MA26470A1/fr unknown
- 1998-01-28 CO CO98003944A patent/CO4920223A1/es unknown
- 1998-01-29 PL PL98324571A patent/PL324571A1/xx unknown
- 1998-01-29 CZ CZ98273A patent/CZ27398A3/cs unknown
- 1998-01-29 UY UY24865A patent/UY24865A1/es unknown
- 1998-01-29 AU AU52809/98A patent/AU730147B2/en not_active Ceased
- 1998-01-30 BR BRPI9800524-3A patent/BR9800524B1/pt not_active IP Right Cessation
- 1998-01-30 KR KR1019980002475A patent/KR100274107B1/ko not_active Expired - Fee Related
- 1998-01-30 EA EA199800108A patent/EA001357B1/ru not_active IP Right Cessation
- 1998-02-04 TW TW087101434A patent/TW457238B/zh not_active IP Right Cessation
2001
- 2001-09-05 GR GR20010401383T patent/GR3036523T3/el unknown

Also Published As

Publication number	Publication date
YU2098A (sh)	2001-03-07
GR3036523T3 (en)	2001-12-31
IL123036A0 (en)	1998-09-24
NO310026B1 (no)	2001-05-07
HUP9800138A3 (en)	1999-03-01
KR100274107B1 (ko)	2000-12-15
SI0856514T1 (en)	2001-08-31
US6071925A (en)	2000-06-06
CZ27398A3 (cs)	1998-08-12
PT856514E (pt)	2001-10-31
EP0856514B1 (fr)	2001-06-13
DK0856514T3 (da)	2001-09-17
ES2158622T3 (es)	2001-09-01
HUP9800138A2 (hu)	1998-09-28
EA199800108A1 (ru)	1998-10-29
JPH10212290A (ja)	1998-08-11
KR19980070900A (ko)	1998-10-26
IL123036A (en)	2000-12-06
CA2226058C (fr)	2008-01-29
ZA98570B (en)	1998-07-30
CN1113881C (zh)	2003-07-09
BR9800524A (pt)	2000-03-14
NO980332D0 (no)	1998-01-26
CO4920223A1 (es)	2000-05-29
DE69800896T2 (de)	2002-03-28
BR9800524B1 (pt)	2008-11-18
NZ329627A (en)	1999-11-29
HU9800138D0 (en)	1998-03-30
CA2226058A1 (fr)	1998-07-30
EA001357B1 (ru)	2001-02-26
JP3292457B2 (ja)	2002-06-17
HRP980043A2 (en)	1998-12-31
NO980332L (no)	1998-07-31
TR199800085A3 (tr)	1998-08-21
PL324571A1 (en)	1998-08-03
AU730147B2 (en)	2001-03-01
PE59999A1 (es)	1999-07-01
HRP980043B1 (en)	2001-12-31
SG71077A1 (en)	2000-03-21
TR199800085A2 (xx)	1998-08-21
AR011576A1 (es)	2000-08-30
ID19773A (id)	1998-07-30
CN1191862A (zh)	1998-09-02
TW457238B (en)	2001-10-01
ATE202105T1 (de)	2001-06-15
AU5280998A (en)	1998-08-06
EP0856514A1 (fr)	1998-08-05
DE69800896D1 (de)	2001-07-19
UY24865A1 (es)	2000-12-29

Publication	Publication Date	Title
FR2595351B1 (fr)	1990-07-13	Derives d'indole, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26438A1 (fr)	2004-12-20	Derives 6,5-heterobicycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26468A1 (fr)	2004-12-20	Derives de sulfonyluree, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26559A1 (fr)	2004-12-20	Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation
FR2530625B1 (fr)	1986-04-18	Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant
MA26433A1 (fr)	2004-12-20	Derives de pyridylpyrrole, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2740136B1 (fr)	1998-01-09	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
MA26439A1 (fr)	2004-12-20	Derives d'indazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26687A1 (fr)	2004-12-20	4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26526A1 (fr)	2004-12-20	Derives d'indole inhibiteurs de cyclo-oxygenase, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26479A1 (fr)	2004-12-20	Derives de nicotinamide, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26686A1 (fr)	2004-12-20	Derives de 4,4-biarylpiperidine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26571A1 (fr)	2004-12-20	Derives d'acide hydroxamique, compositions pharmaceutiques les contenant et procede pour leur preparation
MA26471A1 (fr)	2004-12-20	Derives d'acide arylsulfonylaminohydroxamique, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26424A1 (fr)	2004-12-20	Derives de 6-phenylpyridyl-2-amine, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26654A1 (fr)	2004-12-20	Pyrrolopyrimidines nouvelles procede pour leur preparation et compositions pharmaceutiques les contenant
MA26443A1 (fr)	2004-12-20	Aralkyl- et aralkylidene-lactames et -imides heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les contenant
MA26415A1 (fr)	2004-12-20	Composes heterocycliques, procede pour la preparation et compositions pharmaceutiques les contenant
FR2735777B1 (fr)	1997-09-12	Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
MA26519A1 (fr)	2004-12-20	Derives d'azetidinylpropylpiperidine, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2636628B1 (fr)	1990-12-28	Derives du thiadiazole-1,3,4, leur procede d'obtention et compositions pharmaceutiques en contenant
MA26501A1 (fr)	2004-12-20	Derives de quinoleine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26417A1 (fr)	2004-12-20	Azetidines, procede pour leur preparation, et compositions pharmaceutiques les contenant
FR2728901B1 (fr)	1997-03-28	Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26552A1 (fr)	2004-12-20	Derives d'isoquinoleine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.