DK0865435T3 - Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid - Google Patents

Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid

Info

Publication number: DK0865435T3
Authority: DK; Denmark
Prior art keywords: amino; preparation; benzofurazan; oxide; benzotriazine
Prior art date: 1995-12-04

Application number

DK96941445T

Other languages

English (en)

Inventor

Richard E Philion

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-04

Filing date

1996-11-21

Publication date

2002-05-27

1996-11-21 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2002-05-27 Application granted granted Critical

2002-05-27 Publication of DK0865435T3 publication Critical patent/DK0865435T3/da

Links

238000000034 method Methods 0.000 title abstract 3
BHHRGAKNBXQGIO-UHFFFAOYSA-N 1,2,4-benzotriazin-3-amine Chemical compound C1=CC=CC2=NC(N)=NN=C21 BHHRGAKNBXQGIO-UHFFFAOYSA-N 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
OKEAMBAZBICIFP-UHFFFAOYSA-N 3-oxido-2,1,3-benzoxadiazol-3-ium Chemical compound C1=CC=CC2=[N+]([O-])ON=C21 OKEAMBAZBICIFP-UHFFFAOYSA-N 0.000 abstract 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
239000008366 buffered solution Substances 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
FFNKZSVHHUBFHT-UHFFFAOYSA-N cyanamide;sodium Chemical compound [Na].[Na].NC#N FFNKZSVHHUBFHT-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
ORYDPOVDJJZGHQ-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=CC2=[N+]([O-])C(N)=N[N+]([O-])=C21 ORYDPOVDJJZGHQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK96941445T 1995-12-04 1996-11-21 Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid DK0865435T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/566,979 US5672702A (en)	1995-12-04	1995-12-04	Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
PCT/US1996/018761 WO1997020828A1 (en)	1995-12-04	1996-11-21	Process for preparing 3-amino-1,2,4-benzotriazine dioxide

Publications (1)

Publication Number	Publication Date
DK0865435T3 true DK0865435T3 (da)	2002-05-27

Family

ID=24265255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96941445T DK0865435T3 (da)	1995-12-04	1996-11-21	Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid

Country Status (18)

Country	Link
US (1)	US5672702A (da)
EP (1)	EP0865435B1 (da)
JP (1)	JP2000501705A (da)
KR (1)	KR100502041B1 (da)
CN (1)	CN1068595C (da)
AT (1)	ATE213234T1 (da)
AU (1)	AU721627B2 (da)
BR (1)	BR9611864A (da)
CZ (1)	CZ292732B6 (da)
DE (1)	DE69619267T2 (da)
DK (1)	DK0865435T3 (da)
ES (1)	ES2172696T3 (da)
MX (1)	MX9804421A (da)
NO (1)	NO311216B1 (da)
NZ (1)	NZ323602A (da)
PT (1)	PT865435E (da)
RU (1)	RU2178413C2 (da)
WO (1)	WO1997020828A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003042192A1 (en) *	2001-11-13	2003-05-22	Sanofi-Synthelabo	Preparation of 3-amino-1,2,4-benzotriazine dioxide
EP1931769A2 (en) *	2005-10-03	2008-06-18	Genetix Pharmaceuticals Inc.	Method for selectively depleting hypoxic cells
CN101683319B (zh) *	2008-09-24	2012-09-05	杭州民生药业有限公司	一种替拉扎明非肠道给药含水制剂及其制备方法
JP2015500295A (ja) *	2011-12-07	2015-01-05	エスアールアイインターナショナルＳＲＩＩｎｔｅｒｎａｔｉｏｎａｌ	ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
WO2014062856A1 (en)	2012-10-16	2014-04-24	Halozyme, Inc.	Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3980779A (en) *	1972-02-01	1976-09-14	Bayer Aktiengesellschaft	3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same
BE794742A (fr) *	1972-02-01	1973-07-30	Bayer Ag	Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
DE2255947A1 (de) *	1972-11-15	1974-05-22	Bayer Ag	Substituierte 3-amino-benzo-1,2,4triazin-di-n-oxide (1,4), verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel
DE2255946A1 (de) *	1972-11-15	1974-05-22	Bayer Ag	Verfahren zur herstellung von neuen eckige klammer auf 3-benzo-1,2,4-triazinyldioxid (1,4) eckige klammer zu -harnstoffen, sowie ihre verwendung als arzneimittel und futterzusatzmittel
US3991189A (en) *	1972-11-15	1976-11-09	Bayer Aktiengesellschaft	Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
US3957779A (en) *	1972-11-15	1976-05-18	Bayer Aktiengesellschaft	Benzo-1,2,4-triazines
CH576231A5 (en) *	1973-02-02	1976-06-15	Ciba Geigy Ag	1,2,4,-benztriazine-1,4-di-N-oxide derivs. - used in veterinary medicine against pathogenic micro-organisms or to promote growth
WO1988002366A1 (en) *	1986-09-25	1988-04-07	Sri International	1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US5175287A (en) *	1986-09-25	1992-12-29	S R I International	Process for preparing 1,2,4-benzotriazine oxides
HU225965B1 (en) *	1989-09-18	2008-01-28	Stanford Res Inst Int	Process for producing medicaments containing 1,2,4-benzotriazine oxides as radiation sensitizers and/or selective cytotoxic agents
US5484612A (en) *	1993-09-22	1996-01-16	The Board Of Trustees Of The Leland Stanford Junior University	Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

1995
- 1995-12-04 US US08/566,979 patent/US5672702A/en not_active Expired - Lifetime
1996
- 1996-11-21 ES ES96941445T patent/ES2172696T3/es not_active Expired - Lifetime
- 1996-11-21 AT AT96941445T patent/ATE213234T1/de not_active IP Right Cessation
- 1996-11-21 BR BR9611864A patent/BR9611864A/pt not_active Application Discontinuation
- 1996-11-21 DK DK96941445T patent/DK0865435T3/da active
- 1996-11-21 WO PCT/US1996/018761 patent/WO1997020828A1/en not_active Ceased
- 1996-11-21 EP EP96941445A patent/EP0865435B1/en not_active Expired - Lifetime
- 1996-11-21 AU AU10588/97A patent/AU721627B2/en not_active Ceased
- 1996-11-21 RU RU98112135/04A patent/RU2178413C2/ru not_active IP Right Cessation
- 1996-11-21 CN CN96199754A patent/CN1068595C/zh not_active Expired - Fee Related
- 1996-11-21 CZ CZ19981723A patent/CZ292732B6/cs not_active IP Right Cessation
- 1996-11-21 DE DE69619267T patent/DE69619267T2/de not_active Expired - Fee Related
- 1996-11-21 JP JP09521313A patent/JP2000501705A/ja not_active Ceased
- 1996-11-21 PT PT96941445T patent/PT865435E/pt unknown
- 1996-11-21 NZ NZ323602A patent/NZ323602A/en unknown
- 1996-11-21 KR KR10-1998-0704200A patent/KR100502041B1/ko not_active Expired - Fee Related
1998
- 1998-05-20 NO NO19982315A patent/NO311216B1/no unknown
- 1998-06-03 MX MX9804421A patent/MX9804421A/es unknown

Also Published As

Publication number	Publication date
AU1058897A (en)	1997-06-27
DE69619267D1 (de)	2002-03-21
HK1017358A1 (en)	1999-11-19
WO1997020828A1 (en)	1997-06-12
NO982315L (no)	1998-05-20
NO982315D0 (no)	1998-05-20
EP0865435A1 (en)	1998-09-23
EP0865435A4 (en)	1998-12-23
CZ292732B6 (cs)	2003-12-17
NZ323602A (en)	1999-10-28
NO311216B1 (no)	2001-10-29
US5672702A (en)	1997-09-30
KR19990071913A (ko)	1999-09-27
ES2172696T3 (es)	2002-10-01
KR100502041B1 (ko)	2005-09-26
DE69619267T2 (de)	2003-12-24
CZ172398A3 (cs)	1998-09-16
JP2000501705A (ja)	2000-02-15
ATE213234T1 (de)	2002-02-15
AU721627B2 (en)	2000-07-13
BR9611864A (pt)	1999-05-18
EP0865435B1 (en)	2002-02-13
CN1068595C (zh)	2001-07-18
PT865435E (pt)	2002-07-31
MX9804421A (es)	1998-09-30
RU2178413C2 (ru)	2002-01-20
CN1207736A (zh)	1999-02-10

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