|
US6685940B2
(en)
*
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
US5783186A
(en)
*
|
1995-12-05 |
1998-07-21 |
Amgen Inc. |
Antibody-induced apoptosis
|
|
IL126303A
(en)
*
|
1996-03-27 |
2002-05-23 |
Genentech Inc |
ErbB3 ANTIBODIES
|
|
US5968511A
(en)
|
1996-03-27 |
1999-10-19 |
Genentech, Inc. |
ErbB3 antibodies
|
|
US20060159688A1
(en)
*
|
1996-05-15 |
2006-07-20 |
Ragupathy Madiyalakan |
Method for diagnosing efficacy of xenotypic antibody therapy
|
|
US8038994B2
(en)
*
|
1996-05-15 |
2011-10-18 |
Quest Pharmatech Inc. |
Combination therapy for treating disease
|
|
ATE233102T1
(de)
*
|
1996-05-15 |
2003-03-15 |
Altarex Inc |
Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten
|
|
US20080220012A1
(en)
*
|
1996-05-15 |
2008-09-11 |
Ragupathy Madiyalakan |
Therapeutic Compositions that alter the immune response
|
|
CN101412758A
(zh)
*
|
1996-10-18 |
2009-04-22 |
基因技术股份有限公司 |
抗ErbB2抗体
|
|
US7371376B1
(en)
|
1996-10-18 |
2008-05-13 |
Genentech, Inc. |
Anti-ErbB2 antibodies
|
|
US6270980B1
(en)
|
1997-06-05 |
2001-08-07 |
Idun Pharmaceuticals, Inc. |
Rapid methods for identifying modifiers of cellular apoptosis activity
|
|
WO1999012973A1
(en)
*
|
1997-09-11 |
1999-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Monoclonal antibody inducing apoptosis
|
|
ZA9811162B
(en)
*
|
1997-12-12 |
2000-06-07 |
Genentech Inc |
Treatment with anti-ERBB2 antibodies.
|
|
JP2002507404A
(ja)
*
|
1998-03-27 |
2002-03-12 |
ジェネンテク・インコーポレイテッド |
Apo−2リガンド−抗HER−2抗体相乗作用
|
|
FR2780062B1
(fr)
*
|
1998-06-17 |
2000-07-28 |
Rhone Poulenc Rorer Sa |
Anticorps monoclonaux diriges contre la proteine g3bp, et leurs utilisations
|
|
US7393823B1
(en)
|
1999-01-20 |
2008-07-01 |
Oregon Health And Science University |
HER-2 binding antagonists
|
|
US7625859B1
(en)
|
2000-02-16 |
2009-12-01 |
Oregon Health & Science University |
HER-2 binding antagonists
|
|
US7396810B1
(en)
*
|
2000-08-14 |
2008-07-08 |
Oregon Health Sciences University |
Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
|
|
ATE425749T1
(de)
|
1999-01-27 |
2009-04-15 |
Cornell Res Foundation Inc |
Behandlung von mit her-2/neu-uberexprimierung einhergehendem krebs
|
|
ATE397959T1
(de)
*
|
1999-04-06 |
2008-07-15 |
Genentech Inc |
Verwendung von erbb-rezeptorliganden zur behandlung von diabetes
|
|
US20030086924A1
(en)
*
|
1999-06-25 |
2003-05-08 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
EP1191944A2
(en)
|
1999-06-25 |
2002-04-03 |
Genentech, Inc. |
METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
US7041292B1
(en)
*
|
1999-06-25 |
2006-05-09 |
Genentech, Inc. |
Treating prostate cancer with anti-ErbB2 antibodies
|
|
CA2376596C
(en)
|
1999-06-25 |
2009-10-06 |
Genentech, Inc. |
Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
|
|
US20040013667A1
(en)
*
|
1999-06-25 |
2004-01-22 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
IL147017A0
(en)
*
|
1999-06-25 |
2002-08-14 |
Genentech Inc |
TREATING PROSTATE CANCER WITH ANTI-ErbB2 ANTIBODIES
|
|
TR200200472T2
(tr)
|
1999-08-27 |
2002-06-21 |
Genentech, Inc. |
Anti-Erb B2 antikorları ile tedavi için dozajlar
|
|
AU775373B2
(en)
|
1999-10-01 |
2004-07-29 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
US8048416B2
(en)
|
1999-10-08 |
2011-11-01 |
Hoffmann-La Roche Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US8071072B2
(en)
*
|
1999-10-08 |
2011-12-06 |
Hoffmann-La Roche Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US20040001789A1
(en)
*
|
1999-10-08 |
2004-01-01 |
Young David S. F. |
Cytotoxicity mediation of cells evidencing surface expression of gp96 or precursors thereof
|
|
US7189397B2
(en)
*
|
1999-10-08 |
2007-03-13 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US6657048B2
(en)
*
|
1999-10-08 |
2003-12-02 |
Arius Research, Inc. |
Individualized anti-cancer antibodies
|
|
US6794494B1
(en)
|
2003-04-14 |
2004-09-21 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
US7252821B2
(en)
*
|
1999-10-08 |
2007-08-07 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US6180357B1
(en)
*
|
1999-10-08 |
2001-01-30 |
Arius Research, Inc. |
Individualized patient-specific anti-cancer antibodies
|
|
US7419792B2
(en)
*
|
1999-10-08 |
2008-09-02 |
Arius Research Inc. |
Laminin Receptor 1 Precursor Protein (37LRP) epitope delineated by an Hepatocellular carcinoma specific antibody
|
|
US7442776B2
(en)
*
|
1999-10-08 |
2008-10-28 |
Young David S F |
Cancerous disease modifying antibodies
|
|
US20090004103A1
(en)
*
|
1999-10-08 |
2009-01-01 |
Young David S F |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US7947496B2
(en)
*
|
1999-10-08 |
2011-05-24 |
Hoffmann-La Roche Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US20080124327A1
(en)
*
|
1999-10-08 |
2008-05-29 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US20050100542A1
(en)
*
|
1999-10-08 |
2005-05-12 |
Young David S. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US20040105816A1
(en)
*
|
1999-10-08 |
2004-06-03 |
Young David S. F. |
Cancerous disease modifying antibodies
|
|
US7256271B2
(en)
|
2003-01-21 |
2007-08-14 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
EP1118334A1
(en)
*
|
2000-01-11 |
2001-07-25 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
|
|
US6632979B2
(en)
|
2000-03-16 |
2003-10-14 |
Genentech, Inc. |
Rodent HER2 tumor model
|
|
US7097840B2
(en)
|
2000-03-16 |
2006-08-29 |
Genentech, Inc. |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
|
|
CN101289511A
(zh)
*
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
多价抗体及其应用
|
|
WO2001083781A2
(en)
*
|
2000-04-28 |
2001-11-08 |
Millennium Pharmaceuticals, Inc. |
14094, a novel human trypsin family member and uses thereof
|
|
KR20130056201A
(ko)
|
2000-05-19 |
2013-05-29 |
제넨테크, 인크. |
ErbB 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석
|
|
CA2420543C
(en)
*
|
2000-08-22 |
2013-04-02 |
Agensys, Inc. |
Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
|
|
US7358353B2
(en)
*
|
2000-08-22 |
2008-04-15 |
Agensys, Inc. |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
|
|
US20060210474A1
(en)
*
|
2000-11-29 |
2006-09-21 |
Young David S |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
US7431923B2
(en)
*
|
2005-01-03 |
2008-10-07 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
US7534429B2
(en)
*
|
2000-11-29 |
2009-05-19 |
Hoffmann-La Roche Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
US7442777B2
(en)
*
|
2000-11-29 |
2008-10-28 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
US7361343B2
(en)
*
|
2003-01-21 |
2008-04-22 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
US7009040B2
(en)
*
|
2003-01-21 |
2006-03-07 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
US20040110177A1
(en)
*
|
2001-02-02 |
2004-06-10 |
Axel Ullrich |
Method for identifying functional nucleic acids
|
|
US20050069549A1
(en)
|
2002-01-14 |
2005-03-31 |
William Herman |
Targeted ligands
|
|
US20030215849A1
(en)
*
|
2002-03-01 |
2003-11-20 |
Marcia Belvin |
PDPK1s as modifiers of the p53 pathway and methods of use
|
|
US7435797B2
(en)
|
2002-04-10 |
2008-10-14 |
Genentech, Inc. |
Anti-HER2 antibody variants
|
|
JP2005522483A
(ja)
*
|
2002-04-11 |
2005-07-28 |
アルタレックス メディカル コーポレーション |
結合剤及び腫瘍細胞をターゲティングする際のそれらの使用
|
|
ES2392525T3
(es)
|
2002-07-15 |
2012-12-11 |
F. Hoffmann-La Roche Ag |
Tratamiento del cáncer con el anticuerpo dirigido contra ErbB2 rhuMAb 2C4
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
NZ537277A
(en)
|
2002-07-18 |
2008-04-30 |
Crucell Holland Bv |
Recombinant production of mixtures of antibodies
|
|
JP2006516117A
(ja)
*
|
2002-11-21 |
2006-06-22 |
ジェネンテック・インコーポレーテッド |
抗ErbB2抗体を用いた非悪性疾病または疾患の治療
|
|
US7175846B2
(en)
*
|
2003-01-21 |
2007-02-13 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US7361342B2
(en)
*
|
2003-01-21 |
2008-04-22 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US7488475B2
(en)
|
2003-01-21 |
2009-02-10 |
Arius Research, Inc. |
Antibody therapy of tumors
|
|
US7468254B2
(en)
*
|
2003-01-21 |
2008-12-23 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of MCSP
|
|
US7393531B2
(en)
*
|
2003-01-21 |
2008-07-01 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of MCSP
|
|
US20080213169A1
(en)
*
|
2003-04-14 |
2008-09-04 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD59
|
|
US7399835B2
(en)
*
|
2004-02-26 |
2008-07-15 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US7195764B2
(en)
|
2003-04-14 |
2007-03-27 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US20080025977A1
(en)
*
|
2003-04-14 |
2008-01-31 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD59
|
|
US20060140963A1
(en)
*
|
2003-04-14 |
2006-06-29 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD59
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
ES2408582T3
(es)
*
|
2003-05-30 |
2013-06-21 |
Merus B.V. |
Biblioteca de Fab para la preparación de una mezcla de anticuerpos
|
|
US20050008649A1
(en)
*
|
2003-06-02 |
2005-01-13 |
University Of Miami |
Chimeric molecules and methods of use
|
|
US20050232931A1
(en)
*
|
2003-06-13 |
2005-10-20 |
Oncomax Acquisition Corp. |
Preparation and application of anti-tumor bifunctional fusion proteins
|
|
US20040254108A1
(en)
*
|
2003-06-13 |
2004-12-16 |
Jing Ma |
Preparation and application of anti-tumor bifunctional fusion proteins
|
|
KR101254371B1
(ko)
|
2003-07-18 |
2013-05-02 |
암젠 프레몬트 인코포레이티드 |
간세포 성장인자에 결합하는 분리된 항체
|
|
US20050027106A1
(en)
*
|
2003-07-28 |
2005-02-03 |
Young David S. F. |
Cancerous disease modifying antibodies
|
|
US20050079184A1
(en)
*
|
2003-08-08 |
2005-04-14 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
DK1737971T3
(da)
|
2004-01-20 |
2017-11-13 |
Merus Nv |
Blandinger af bindingsproteiner
|
|
US7348413B2
(en)
*
|
2004-02-26 |
2008-03-25 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US20050255041A1
(en)
*
|
2004-05-13 |
2005-11-17 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
SV2006002143A
(es)
*
|
2004-06-16 |
2006-01-26 |
Genentech Inc |
Uso de un anticuerpo para el tratamiento del cancer resistente al platino
|
|
KR101699142B1
(ko)
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
KR20140032004A
(ko)
|
2004-07-22 |
2014-03-13 |
제넨테크, 인크. |
Her2 항체 조성물
|
|
KR20070057839A
(ko)
*
|
2004-08-19 |
2007-06-07 |
제넨테크, 인크. |
변경된 이펙터 기능을 갖는 폴리펩티드 변이체
|
|
US7394210B2
(en)
*
|
2004-09-29 |
2008-07-01 |
Tir Technology Lp |
System and method for controlling luminaires
|
|
WO2006042002A2
(en)
*
|
2004-10-05 |
2006-04-20 |
Oregon Health And Science University |
Compositions and methods for treating disease
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
JP2008523073A
(ja)
*
|
2004-12-07 |
2008-07-03 |
ジェネンテック・インコーポレーテッド |
Her阻害剤を用いた治療のための患者の選択
|
|
CN103555733A
(zh)
|
2005-01-05 |
2014-02-05 |
F-星生物技术研究与开发有限公司 |
分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
|
|
CA2592177A1
(en)
|
2005-01-21 |
2006-07-27 |
Genentech, Inc. |
Fixed dosing of her antibodies
|
|
RU2007133660A
(ru)
*
|
2005-02-09 |
2009-03-20 |
Дженентек, Инк. (Us) |
Ингибирование шеддинга her2 антагонистами матриксной металлопротеиназы
|
|
EP1850874B1
(en)
|
2005-02-23 |
2013-10-16 |
Genentech, Inc. |
Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
|
|
WO2006096861A2
(en)
*
|
2005-03-08 |
2006-09-14 |
Genentech, Inc. |
METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs)
|
|
JP2006316040A
(ja)
|
2005-05-13 |
2006-11-24 |
Genentech Inc |
Herceptin(登録商標)補助療法
|
|
US7411046B2
(en)
|
2005-08-02 |
2008-08-12 |
Arius Research Inc |
Cancerous disease modifying antibodies
|
|
US7452979B2
(en)
|
2005-08-02 |
2008-11-18 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
US7494648B2
(en)
*
|
2005-08-02 |
2009-02-24 |
Hoffmann-La Roche Inc. |
Cancerous disease modifying antibodies
|
|
US7456258B2
(en)
|
2005-08-02 |
2008-11-25 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
US7452978B2
(en)
*
|
2005-08-02 |
2008-11-18 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
US7456259B2
(en)
|
2005-08-02 |
2008-11-25 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
FR2895086B1
(fr)
*
|
2005-12-16 |
2012-10-05 |
Lab Francais Du Fractionnement |
Potentialisation de l'apoptose par des anticorps monoclonaux
|
|
JP2009528993A
(ja)
|
2006-02-24 |
2009-08-13 |
アリアス リサーチ、インコーポレイテッド |
癌様疾患修飾性抗体141205−02
|
|
US20080213267A1
(en)
*
|
2006-02-24 |
2008-09-04 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of TROP-2
|
|
US7420040B2
(en)
*
|
2006-02-24 |
2008-09-02 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of TROP-2
|
|
US7456016B2
(en)
*
|
2006-02-24 |
2008-11-25 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US20080305104A1
(en)
*
|
2006-02-24 |
2008-12-11 |
Young David S F |
Cytotoxicity mediation of cells evidencing surface expression of TROP-2
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
US20080089891A1
(en)
*
|
2006-07-26 |
2008-04-17 |
Arius Research, Inc. |
Cancerous disease modifying antibodies
|
|
EP2054444B1
(en)
|
2006-08-04 |
2016-11-02 |
MedImmune Limited |
Antibodies to erbb2
|
|
AU2007321664A1
(en)
*
|
2006-11-13 |
2008-05-22 |
F. Hoffmann-La Roche Ag |
Cancerous disease modifying antibodies
|
|
EP2092058A1
(en)
*
|
2006-11-13 |
2009-08-26 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
CA2668484A1
(en)
*
|
2006-11-13 |
2008-05-22 |
F. Hoffmann-La Roche Ag |
Cancerous disease modifying antibodies 180706-02
|
|
US8003761B2
(en)
|
2007-01-23 |
2011-08-23 |
Hoffmann-La Roche Inc. |
Cancerous disease modifying antibodies
|
|
US20080206133A1
(en)
*
|
2007-01-23 |
2008-08-28 |
Young David S F |
Cancerous Disease Modifying Antibodies
|
|
MX2009008981A
(es)
|
2007-03-02 |
2009-09-02 |
Genentech Inc |
Prediccion de respuesta a un inhibidor her.
|
|
JP2010523479A
(ja)
*
|
2007-03-26 |
2010-07-15 |
エフ.ホフマン−ラ ロシュ アーゲー |
ハイブリドーマ細胞系列ar51a630.3により産生される癌性疾患修飾性抗体010207−01
|
|
KR20100002275A
(ko)
*
|
2007-05-07 |
2010-01-06 |
에프. 호프만-라 로슈 아게 |
암 질환 조절 항체
|
|
US20090258005A1
(en)
*
|
2007-05-29 |
2009-10-15 |
Trubion Pharmaceuticals Inc. |
Therapeutic compositions and methods
|
|
US20090304590A1
(en)
*
|
2007-05-29 |
2009-12-10 |
Wyeth |
Therapeutic compositions and methods
|
|
US9551033B2
(en)
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
|
EP2171090B1
(en)
|
2007-06-08 |
2013-04-03 |
Genentech, Inc. |
Gene expression markers of tumor resistance to her2 inhibitor treatment
|
|
EP3241842B1
(en)
|
2007-06-26 |
2024-01-31 |
F-star Therapeutics Limited |
Display of binding agents
|
|
KR20190140090A
(ko)
|
2007-07-09 |
2019-12-18 |
제넨테크, 인크. |
폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
|
|
NZ583318A
(en)
|
2007-07-16 |
2012-07-27 |
Genentech Inc |
Humanized anti-cd79b antibodies and immunoconjugates and methods of use
|
|
DK2474557T3
(da)
|
2007-07-16 |
2014-11-10 |
Genentech Inc |
Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
|
|
NZ586544A
(en)
*
|
2007-12-26 |
2012-07-27 |
Vaccinex Inc |
Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods
|
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
|
CA2711256C
(en)
|
2008-01-03 |
2019-01-15 |
The Scripps Research Institute |
Antibody targeting through a modular recognition domain
|
|
US20090191197A1
(en)
*
|
2008-01-28 |
2009-07-30 |
Young David S F |
Cancerous disease modifying antibodies
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
SG187517A1
(en)
|
2008-01-31 |
2013-02-28 |
Genentech Inc |
Anti-cd79b antibodies and immunoconjugates and methods of use
|
|
NZ602675A
(en)
|
2008-03-18 |
2014-03-28 |
Genentech Inc |
Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
|
|
US20090285751A1
(en)
*
|
2008-04-10 |
2009-11-19 |
Young David S F |
Cancerous disease modifying antibodies
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
EP2113255A1
(en)
|
2008-05-02 |
2009-11-04 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Cytotoxic immunoglobulin
|
|
JP2011520923A
(ja)
*
|
2008-05-19 |
2011-07-21 |
武田薬品工業株式会社 |
細胞傷害性抗癌モノクローナル抗体
|
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
|
JP2011528010A
(ja)
*
|
2008-07-17 |
2011-11-10 |
武田薬品工業株式会社 |
癌性疾患修飾抗体
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
AU2009308707A1
(en)
*
|
2008-10-31 |
2010-05-06 |
Biogen Idec Ma Inc. |
LIGHT targeting molecules and uses thereof
|
|
EP3912643B8
(en)
|
2009-02-13 |
2023-08-23 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
CN104447995A
(zh)
|
2009-03-20 |
2015-03-25 |
霍夫曼-拉罗奇有限公司 |
双特异性抗-her抗体
|
|
EP2435071A1
(en)
|
2009-05-29 |
2012-04-04 |
F. Hoffmann-La Roche AG |
Modulators for her2 signaling in her2 expressing patients with gastric cancer
|
|
WO2011004899A1
(en)
|
2009-07-06 |
2011-01-13 |
Takeda Pharmaceutical Company Limited |
Cancerous disease modifying antibodies
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
CN104059955A
(zh)
|
2009-08-11 |
2014-09-24 |
弗·哈夫曼-拉罗切有限公司 |
在无谷氨酰胺的细胞培养基中的蛋白质生产
|
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
|
EP3009455A1
(en)
|
2009-09-16 |
2016-04-20 |
Immunomedics Inc. |
Class i anti-cea antibodies and uses thereof
|
|
ES2978177T3
(es)
|
2009-12-02 |
2024-09-06 |
Immunomedics Inc |
Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
|
|
DK2536748T3
(da)
|
2010-02-18 |
2014-10-13 |
Genentech Inc |
Neuregulin-antagonister og anvendelse deraf ved behandling af kræft
|
|
KR20130108069A
(ko)
|
2010-04-15 |
2013-10-02 |
알퍼 바이오테크, 엘엘씨 |
Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도
|
|
US9328024B2
(en)
|
2010-04-29 |
2016-05-03 |
The Regents Of The University Of California |
Application of high toughness, low viscosity nano-molecular resin for reinforcing pothole patching materials in asphalt and concrete base pavement
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
EP2407487A1
(en)
|
2010-07-14 |
2012-01-18 |
F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. |
Multispecific modular antibody
|
|
US20120100166A1
(en)
|
2010-07-15 |
2012-04-26 |
Zyngenia, Inc. |
Ang-2 Binding Complexes and Uses Thereof
|
|
US20130245233A1
(en)
|
2010-11-24 |
2013-09-19 |
Ming Lei |
Multispecific Molecules
|
|
TWI812066B
(zh)
|
2010-11-30 |
2023-08-11 |
日商中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
KR101574864B1
(ko)
|
2010-12-21 |
2015-12-11 |
에프. 호프만-라 로슈 아게 |
이소폼이 농축된 항체 제제 및 그의 제조 방법
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
CN112812184A
(zh)
|
2011-02-25 |
2021-05-18 |
中外制药株式会社 |
FcγRIIb特异性Fc抗体
|
|
WO2012122512A1
(en)
|
2011-03-10 |
2012-09-13 |
Hco Antibody, Inc. |
Recombinant production of mixtures of single chain antibodies
|
|
AU2012250924B2
(en)
|
2011-05-02 |
2017-05-25 |
Immunomedics, Inc. |
Ultrafiltration concentration of allotype selected antibodies for small-volume administration
|
|
EP2714738B1
(en)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
EP2546268A1
(en)
|
2011-07-13 |
2013-01-16 |
F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. |
Internalising immunoglobulin
|
|
US20140363438A1
(en)
|
2011-08-17 |
2014-12-11 |
Genentech, Inc. |
Neuregulin antibodies and uses thereof
|
|
SG2014011316A
(en)
|
2011-08-31 |
2014-06-27 |
Genentech Inc |
Diagnostic markers
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
WO2013055874A2
(en)
|
2011-10-14 |
2013-04-18 |
Genentech, Inc. |
Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
|
|
WO2013063229A1
(en)
*
|
2011-10-25 |
2013-05-02 |
The Regents Of The University Of Michigan |
Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells
|
|
RU2014126098A
(ru)
|
2011-11-30 |
2016-01-27 |
Дженентек, Инк. |
МУТАЦИИ ErbB3 ПРИ РАКЕ
|
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
|
RU2014136886A
(ru)
|
2012-03-27 |
2016-05-20 |
Дженентек, Инк. |
Диагностика и виды лечения, связанные с ингибиторами her3
|
|
SI2838917T1
(sl)
|
2012-04-20 |
2019-11-29 |
Merus Nv |
Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul
|
|
AU2013302696B9
(en)
|
2012-08-14 |
2018-08-09 |
Ibc Pharmaceuticals, Inc. |
T-cell redirecting bispecific antibodies for treatment of disease
|
|
EP3494996B1
(en)
|
2012-08-23 |
2026-04-15 |
Agensys, Inc. |
Antibody drug conjugates (adc) that bind to 158p1d7 proteins
|
|
AU2013337926B2
(en)
|
2012-10-30 |
2017-12-21 |
Esperance Pharmaceuticals, Inc. |
Antibody/drug conjugates and methods of use
|
|
KR102291355B1
(ko)
|
2012-11-30 |
2021-08-19 |
에프. 호프만-라 로슈 아게 |
Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
|
|
SI2900277T1
(sl)
|
2012-12-13 |
2022-05-31 |
Immunomedics, Inc. |
Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
|
|
BR112015023752B1
(pt)
|
2013-03-15 |
2023-11-14 |
Zyngenia, Inc. |
Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo
|
|
KR101453462B1
(ko)
|
2013-05-16 |
2014-10-23 |
앱클론(주) |
Her2에 특이적으로 결합하는 항체
|
|
WO2015126548A1
(en)
|
2014-02-21 |
2015-08-27 |
Ibc Pharmaceuticals, Inc. |
Disease therapy by inducing immune response to trop-2 expressing cells
|
|
US9139649B2
(en)
|
2014-02-25 |
2015-09-22 |
Immunomedics, Inc. |
Humanized anti-CD22 antibody
|
|
CA2945320A1
(en)
|
2014-04-10 |
2015-10-15 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Drug regulated transgene expression
|
|
MX2016012830A
(es)
|
2014-04-11 |
2017-01-05 |
Medimmune Llc |
Anticuerpos contra el receptor 2 del factor de crecimiento epidermico humano (her2) biespecificos.
|
|
RU2689145C2
(ru)
|
2014-04-16 |
2019-05-24 |
Биокон Лтд. |
Стабильные белковые препараты, содержащие молярный избыток сорбитола
|
|
WO2015200260A1
(en)
|
2014-06-24 |
2015-12-30 |
Immunomedics, Inc. |
Anti-histone therapy for vascular necrosis in severe glomerulonephritis
|
|
PT3262071T
(pt)
|
2014-09-23 |
2020-06-16 |
H Hoffnabb La Roche Ag |
Métodos de utilização de imunoconjugados anti-cd79b
|
|
CN117138060A
(zh)
|
2014-10-07 |
2023-12-01 |
免疫医疗公司 |
抗体-药物缀合物的新辅助剂用途
|
|
CN107207607B
(zh)
|
2014-12-19 |
2021-05-04 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
KR101860280B1
(ko)
|
2014-12-19 |
2018-05-21 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
CN114773470A
(zh)
|
2015-02-05 |
2022-07-22 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
|
|
JP6130983B2
(ja)
|
2015-02-27 |
2017-05-17 |
中外製薬株式会社 |
Il−6関連疾患治療用組成物
|
|
WO2016172427A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
AU2016271124C1
(en)
|
2015-05-30 |
2020-05-14 |
Molecular Templates, Inc. |
De-immunized, Shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
|
|
CN107787331B
(zh)
|
2015-06-17 |
2022-01-11 |
豪夫迈·罗氏有限公司 |
抗her2抗体和使用方法
|
|
EP4257134A3
(en)
|
2015-06-25 |
2024-01-24 |
Immunomedics, Inc. |
Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
WO2017027291A1
(en)
|
2015-08-07 |
2017-02-16 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Bispecific car t-cells for solid tumor targeting
|
|
US11359009B2
(en)
|
2015-12-25 |
2022-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
WO2017194554A1
(en)
|
2016-05-10 |
2017-11-16 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Combinations therapies for the treatment of cancer
|
|
TWI693940B
(zh)
|
2016-08-05 |
2020-05-21 |
日商中外製藥股份有限公司 |
Il-8相關疾病之治療用或預防用組成物
|
|
CN110291200B
(zh)
|
2016-12-12 |
2024-05-14 |
西雅图儿童医院(Dba西雅图儿童研究所) |
对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体
|
|
WO2018124766A2
(ko)
|
2016-12-28 |
2018-07-05 |
주식회사 녹십자랩셀 |
키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
|
|
SG11201905622VA
(en)
|
2017-01-17 |
2019-08-27 |
Genentech Inc |
Subcutaneous her2 antibody formulations
|
|
JP7191833B2
(ja)
|
2017-01-30 |
2022-12-19 |
中外製薬株式会社 |
抗スクレロスチン抗体およびその使用
|
|
US20210330801A1
(en)
|
2017-03-02 |
2021-10-28 |
Cadila Healthcare Limited |
Novel protein drug conjugate formulation
|
|
US11077189B2
(en)
|
2017-03-02 |
2021-08-03 |
Genentech Inc. |
Adjuvant treatment of HER2-positive breast cancer
|
|
EP3620531A4
(en)
|
2017-05-02 |
2021-03-17 |
National Center of Neurology and Psychiatry |
METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
|
|
US12116417B2
(en)
|
2017-11-14 |
2024-10-15 |
GC Cell Corporation |
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
US11649294B2
(en)
|
2017-11-14 |
2023-05-16 |
GC Cell Corporation |
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
SG10201801219VA
(en)
|
2018-02-13 |
2019-09-27 |
Agency Science Tech & Res |
Anti-HER2 Antibodies
|
|
AU2019257343A1
(en)
|
2018-04-17 |
2020-09-10 |
Molecular Templates, Inc. |
HER2-targeting molecules comprising de-immunized, Shiga toxin A Subunit scaffolds
|
|
EP3560945A1
(en)
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Methods for purification of polypeptides using polysorbates
|
|
AU2020456731A1
(en)
|
2020-06-29 |
2023-01-05 |
F. Hoffmann-La Roche Ag |
Pertuzumab plus trastuzumab fixed dose combination
|
|
JP2023545099A
(ja)
|
2020-10-08 |
2023-10-26 |
アフィメド ゲーエムベーハー |
三重特異性バインダー
|
|
BR112023022439A2
(pt)
|
2021-04-26 |
2023-12-26 |
Celanese Eva Performance Polymers Llc |
Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
|
|
US20250073349A1
(en)
|
2021-05-10 |
2025-03-06 |
Kawasaki Institute Of Industrial Promotion |
Antibody having reduced binding affinity for antigen
|
|
CA3216098A1
(en)
|
2021-07-30 |
2023-02-02 |
Uwe Reusch |
Duplexbodies
|
|
EP4405396A2
(en)
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