DK0868911T3 - Rapamycinpræparater til oral indgivelse - Google Patents

Rapamycinpræparater til oral indgivelse

Info

Publication number: DK0868911T3
Authority: DK; Denmark
Prior art keywords: oral administration; rapamycin; preparations; rapamycin preparations; oral
Prior art date: 1997-03-14

Application number

DK98301716T

Other languages

English (en)

Inventor

Arwinder S Nagi

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-14

Filing date

1998-03-09

Publication date

2003-01-20

1998-03-09 Application filed by Wyeth Corp filed Critical Wyeth Corp

2003-01-20 Application granted granted Critical

2003-01-20 Publication of DK0868911T3 publication Critical patent/DK0868911T3/da

Links

238000002360 preparation method Methods 0.000 title 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
229960002930 sirolimus Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Oncology (AREA)
Hematology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Child & Adolescent Psychology (AREA)
Molecular Biology (AREA)

DK98301716T 1997-03-14 1998-03-09 Rapamycinpræparater til oral indgivelse DK0868911T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81501597A	1997-03-14	1997-03-14

Publications (1)

Publication Number	Publication Date
DK0868911T3 true DK0868911T3 (da)	2003-01-20

Family

ID=25216622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98301716T DK0868911T3 (da)	1997-03-14	1998-03-09	Rapamycinpræparater til oral indgivelse

Country Status (24)

Country	Link
EP (1)	EP0868911B1 (da)
JP (2)	JP4616426B2 (da)
KR (1)	KR100513919B1 (da)
CN (1)	CN1140268C (da)
AR (1)	AR012069A1 (da)
AT (1)	ATE223705T1 (da)
AU (1)	AU723943B2 (da)
BR (1)	BR9801120B1 (da)
CA (1)	CA2230748C (da)
CY (1)	CY2313B1 (da)
CZ (1)	CZ292949B6 (da)
DE (1)	DE69807768T2 (da)
DK (1)	DK0868911T3 (da)
ES (1)	ES2183287T3 (da)
HU (1)	HU224701B1 (da)
IL (1)	IL123525A (da)
NZ (1)	NZ329976A (da)
PT (1)	PT868911E (da)
RU (1)	RU2220714C2 (da)
SG (1)	SG63824A1 (da)
SI (1)	SI0868911T1 (da)
TW (1)	TW550091B (da)
UA (1)	UA56143C2 (da)
ZA (1)	ZA982112B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
TR199903065T2 (xx) *	1997-06-13	2000-09-21	American Home Products Corporation	Oral uygulamaya y�nelik rapamisin form�lasyonlar�.
JP4969747B2 (ja) *	2001-01-19	2012-07-04	武田薬品工業株式会社	錠剤フィルムコーティング用組成物
UA81265C2 (en) *	2002-09-17	2007-12-25	Wyeth Corp	Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof
BRPI0608573A2 (pt) *	2005-03-08	2017-07-25	Lifecycle Pharma As	Composição farmacêutica, e, método para a preparação de uma composição farmacêutica.
RU2487703C2 (ru) *	2006-09-26	2013-07-20	Новартис Аг	Фармацевтические композиции, включающие модулятор s1р
AU2007316458A1 (en) *	2006-11-07	2008-05-15	Wyeth	Sugar coatings and methods therefor
EP1938800A1 (en) *	2006-12-06	2008-07-02	Ranbaxy Laboratories Limited	Sirolimus nanodispersion
EP1952807A1 (en) *	2007-01-24	2008-08-06	LEK Pharmaceuticals D.D.	Sirolimus formulation
FR2943539B1 (fr)	2009-03-31	2011-07-22	Ethypharm Sa	Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
US8912215B2 (en) *	2011-12-13	2014-12-16	Everon Biosciences, Inc.	Rapamycin composition
HUP1400075A2 (hu)	2014-02-14	2015-08-28	Druggability Technologies Ip Holdco Jersey Ltd	Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
US10576076B2 (en)	2015-05-20	2020-03-03	Novartis Ag	Pharmaceutical combination of everolimus with dactolisib
JP2020500930A (ja)	2016-11-23	2020-01-16	ノバルティスアーゲー	エベロリムス、ダクトリシブまたは両方で免疫応答を増強する方法
WO2019157516A1 (en)	2018-02-12	2019-08-15	resTORbio, Inc.	Combination therapies
CN110585159B (zh) *	2019-09-12	2021-11-02	杭州华东医药集团新药研究院有限公司	一种含有西罗莫司的片剂
WO2026053150A1 (en) *	2024-09-06	2026-03-12	Intrepid Labs Inc.	Pharmaceutical compositions for enhanced solubility and bioavailability of hydrophobic drugs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04234812A (ja) *	1990-03-16	1992-08-24	Yamanouchi Pharmaceut Co Ltd	持続性製剤用顆粒
US5145684A (en) *	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
US5223268A (en) *	1991-05-16	1993-06-29	Sterling Drug, Inc.	Low solubility drug-coated bead compositions
DE69209183T2 (de) *	1991-06-18	1996-08-08	American Home Prod	Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen
CH686761A5 (de) *	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
GB2278780B (en) *	1993-05-27	1998-10-14	Sandoz Ltd	Macrolide formulations
US5352783A (en) *	1993-06-09	1994-10-04	Merck & Co., Inc.	Microbial transformation product having immunosuppressive activity
IL111004A (en) *	1993-09-30	1998-06-15	American Home Prod	Oral formulations of rapamycin
SE9402422D0 (sv) *	1994-07-08	1994-07-08	Astra Ab	New beads for controlled release and a pharmaceutical preparation containing the same
RU2065299C1 (ru) *	1994-07-15	1996-08-20	Акционерное общество закрытого типа "Олвик"	Ноотропное и транквилизирующее средство
GB9421836D0 (en) *	1994-10-28	1994-12-14	Scherer Corp R P	Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
US5547948A (en) *	1995-01-17	1996-08-20	American Home Products Corporation	Controlled release of steroids from sugar coatings
FR2736550B1 (fr) *	1995-07-14	1998-07-24	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule

1998
- 1998-03-02 CA CA2230748A patent/CA2230748C/en not_active Expired - Lifetime
- 1998-03-03 IL IL12352598A patent/IL123525A/en not_active IP Right Cessation
- 1998-03-03 TW TW087103043A patent/TW550091B/zh not_active IP Right Cessation
- 1998-03-09 PT PT98301716T patent/PT868911E/pt unknown
- 1998-03-09 ES ES98301716T patent/ES2183287T3/es not_active Expired - Lifetime
- 1998-03-09 EP EP98301716A patent/EP0868911B1/en not_active Expired - Lifetime
- 1998-03-09 DK DK98301716T patent/DK0868911T3/da active
- 1998-03-09 SI SI9830250T patent/SI0868911T1/xx unknown
- 1998-03-09 AT AT98301716T patent/ATE223705T1/de active
- 1998-03-09 DE DE69807768T patent/DE69807768T2/de not_active Expired - Lifetime
- 1998-03-12 SG SG1998000512A patent/SG63824A1/en unknown
- 1998-03-12 ZA ZA9802112A patent/ZA982112B/xx unknown
- 1998-03-13 CZ CZ1998771A patent/CZ292949B6/cs not_active IP Right Cessation
- 1998-03-13 BR BRPI9801120-0A patent/BR9801120B1/pt not_active IP Right Cessation
- 1998-03-13 KR KR1019980008439A patent/KR100513919B1/ko not_active Expired - Lifetime
- 1998-03-13 UA UA98031295A patent/UA56143C2/uk unknown
- 1998-03-13 RU RU98104946/15A patent/RU2220714C2/ru active
- 1998-03-13 CN CNB981082440A patent/CN1140268C/zh not_active Expired - Lifetime
- 1998-03-13 AR ARP980101154A patent/AR012069A1/es active IP Right Grant
- 1998-03-13 AU AU58383/98A patent/AU723943B2/en not_active Expired
- 1998-03-13 JP JP06288598A patent/JP4616426B2/ja not_active Expired - Lifetime
- 1998-03-13 HU HU9800573A patent/HU224701B1/hu active IP Right Grant
- 1998-03-17 NZ NZ329976A patent/NZ329976A/en not_active IP Right Cessation
2003
- 2003-01-27 CY CY0300006A patent/CY2313B1/xx unknown
2009
- 2009-10-02 JP JP2009230289A patent/JP2009298823A/ja active Pending

Also Published As

Publication number	Publication date
EP0868911B1 (en)	2002-09-11
HU9800573D0 (en)	1998-05-28
SI0868911T1 (en)	2002-12-31
AU5838398A (en)	1998-09-17
CZ292949B6 (cs)	2004-01-14
ZA982112B (en)	1999-09-13
AR012069A1 (es)	2000-09-27
HK1015677A1 (en)	1999-10-22
CN1197639A (zh)	1998-11-04
PT868911E (pt)	2002-12-31
KR100513919B1 (ko)	2006-02-28
CA2230748C (en)	2010-08-03
NZ329976A (en)	1999-10-28
HUP9800573A2 (hu)	1999-06-28
CY2313B1 (en)	2003-11-14
ATE223705T1 (de)	2002-09-15
KR19980080222A (ko)	1998-11-25
RU2220714C2 (ru)	2004-01-10
EP0868911A2 (en)	1998-10-07
JP4616426B2 (ja)	2011-01-19
IL123525A0 (en)	1998-10-30
UA56143C2 (uk)	2003-05-15
DE69807768D1 (de)	2002-10-17
CZ77198A3 (cs)	1998-09-16
DE69807768T2 (de)	2003-02-06
TW550091B (en)	2003-09-01
BR9801120A (pt)	2000-01-11
IL123525A (en)	2002-03-10
BR9801120B1 (pt)	2009-12-01
JP2009298823A (ja)	2009-12-24
AU723943B2 (en)	2000-09-07
HU224701B1 (en)	2006-01-30
EP0868911A3 (en)	2000-12-06
JPH10259131A (ja)	1998-09-29
SG63824A1 (en)	1999-03-30
CA2230748A1 (en)	1998-09-14
HUP9800573A3 (en)	2000-01-28
ES2183287T3 (es)	2003-03-16
CN1140268C (zh)	2004-03-03

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ID23531A (id)	2000-04-27	Komposisi farmasi
NO20003284D0 (no)	2000-06-22	Farmasøytisk preparat for oral administrering
FI3862U1 (fi)	1999-03-18	Geelimuotoinen farmaseuttinen valmiste
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