DK0876366T3 - Angiogenese-inhiberende pyridazinaminer - Google Patents
Angiogenese-inhiberende pyridazinaminerInfo
- Publication number
- DK0876366T3 DK0876366T3 DK97901059T DK97901059T DK0876366T3 DK 0876366 T3 DK0876366 T3 DK 0876366T3 DK 97901059 T DK97901059 T DK 97901059T DK 97901059 T DK97901059 T DK 97901059T DK 0876366 T3 DK0876366 T3 DK 0876366T3
- Authority
- DK
- Denmark
- Prior art keywords
- 6alkyl
- alk
- amino
- 6alkyloxy
- hydrogen
- Prior art date
Links
- -1 pyridazine amines Chemical class 0.000 title abstract 5
- 230000033115 angiogenesis Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200085 | 1996-01-15 | ||
| PCT/EP1997/000201 WO1997026258A1 (en) | 1996-01-15 | 1997-01-14 | Angiogenesis inhibiting pyridazinamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0876366T3 true DK0876366T3 (da) | 2001-11-05 |
Family
ID=8223585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97901059T DK0876366T3 (da) | 1996-01-15 | 1997-01-14 | Angiogenese-inhiberende pyridazinaminer |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5985878A (de) |
| EP (1) | EP0876366B1 (de) |
| JP (1) | JP4169368B2 (de) |
| KR (1) | KR100443893B1 (de) |
| CN (1) | CN1104430C (de) |
| AT (1) | ATE203534T1 (de) |
| AU (1) | AU717744B2 (de) |
| CA (1) | CA2237273C (de) |
| DE (1) | DE69705819T2 (de) |
| DK (1) | DK0876366T3 (de) |
| ES (1) | ES2162235T3 (de) |
| GR (1) | GR3036900T3 (de) |
| IL (1) | IL124461A (de) |
| MY (1) | MY117098A (de) |
| NO (1) | NO309653B1 (de) |
| NZ (1) | NZ326354A (de) |
| PT (1) | PT876366E (de) |
| SI (1) | SI0876366T1 (de) |
| TW (1) | TW480256B (de) |
| WO (1) | WO1997026258A1 (de) |
| ZA (1) | ZA97288B (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228871B1 (en) | 1995-07-10 | 2001-05-08 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| DE69829966T2 (de) | 1997-05-14 | 2006-02-09 | Atherogenics, Inc. | Ein monoether von probucol und methoden zur hemmung der vcam-1 expression |
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
| US6833369B2 (en) | 1997-06-24 | 2004-12-21 | Janssen Pharmaceutica, Nv | Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives |
| PL191409B1 (pl) * | 1997-06-24 | 2006-05-31 | Janssen Pharmaceutica Nv | Pochodna tiadiazolilopirydazyny, jej zastosowanie i sposób wytwarzania oraz kompozycja farmaceutyczna |
| KR100523755B1 (ko) | 1997-06-24 | 2005-10-26 | 얀센 파마슈티카 엔.브이. | 혈관형성을 저해하는 티아디아졸릴 피리다진 유도체 |
| JP2002505680A (ja) * | 1997-06-24 | 2002-02-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 血管形成抑制５−置換−１，２，４−チアジアゾリル誘導体 |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| AR013693A1 (es) * | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
| WO1999021834A1 (en) * | 1997-10-27 | 1999-05-06 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors |
| AU1600599A (en) * | 1998-02-27 | 1999-09-15 | Warner-Lambert Company | Heterocyclic substituted aniline calcium channel blockers |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| US6833370B1 (en) | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
| US6887870B1 (en) * | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| NZ519981A (en) | 2000-01-20 | 2005-02-25 | Eisai Co Ltd | Nitrogenous cyclic compounds and pharmaceutical compositions containing the same |
| IT1316986B1 (it) | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| US6881860B2 (en) | 2000-04-11 | 2005-04-19 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
| US7208503B2 (en) | 2000-04-21 | 2007-04-24 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| GB0111078D0 (en) | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| EP2316827B1 (de) | 2003-07-30 | 2016-01-27 | Xenon Pharmaceuticals Inc. | Piperazin derivate und deren anwendung als therapeutische wirkstoffe |
| US7754711B2 (en) * | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| DE102004003812A1 (de) * | 2004-01-25 | 2005-08-11 | Aventis Pharma Deutschland Gmbh | Arylsubstituierte Heterozyklen, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| TW200533356A (en) * | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
| JP5149009B2 (ja) | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体 |
| WO2006034279A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| CN101090724A (zh) * | 2004-09-20 | 2007-12-19 | 泽农医药公司 | 用于抑制人硬脂酰CoA去饱和酶的吡啶衍生物 |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP1807085B1 (de) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| PE20061093A1 (es) * | 2005-02-16 | 2006-11-10 | Schering Corp | Piperazinas sustituidas con heterociclos con actividad antagonista de cxcr3 |
| WO2007046867A2 (en) * | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their uses as therapeutic agents |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| WO2007009236A1 (en) * | 2005-07-20 | 2007-01-25 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2007071023A1 (en) * | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| TW200826936A (en) | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| AR064965A1 (es) | 2007-01-26 | 2009-05-06 | Merck Frosst Canada Inc | Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa |
| WO2008118948A1 (en) | 2007-03-26 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions of derivatives of probucol for the treatment of diabetes |
| US8012956B2 (en) | 2007-10-25 | 2011-09-06 | Exelixis, Inc. | Tropane compounds |
| KR101260116B1 (ko) | 2008-04-29 | 2013-05-02 | 일라이 릴리 앤드 캄파니 | 이치환된 프탈라진 헤지호그 경로 길항제 |
| DK2364185T3 (da) | 2008-11-03 | 2013-06-03 | Lilly Co Eli | Disubstituerede phthalazin-hedgehog-pathway-antagonister |
| PT2358698E (pt) | 2008-11-17 | 2012-10-24 | Lilly Co Eli | Antagonistas da via hedgehog de piridazina tetrasubstituída |
| WO2010056620A1 (en) | 2008-11-17 | 2010-05-20 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| WO2011002067A1 (ja) * | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US9102669B2 (en) | 2011-12-06 | 2015-08-11 | Janssen Pharmaceutica Nv | Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors |
| WO2013085954A1 (en) | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN108912116A (zh) * | 2018-08-15 | 2018-11-30 | 翟学旭 | 一种含氮杂环类衍生物及其在视网膜疾病中的应用 |
| CN116349204A (zh) | 2020-10-13 | 2023-06-27 | 奋进生物医药公司 | 治疗纤维化的方法 |
| EP4395890A1 (de) * | 2021-08-30 | 2024-07-10 | Remix Therapeutics Inc. | Verbindungen und verfahren zur modulation des spleissens |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| TW202506117A (zh) | 2023-06-26 | 2025-02-16 | 英商維羅納製藥Ｐｌｃ公司 | 顆粒組成物 |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| FR2663326B2 (fr) * | 1989-11-17 | 1992-10-16 | Sanofi Sa | Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant. |
| US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
| NZ233526A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Pyridazine derivatives and their pharmaceutical compositions |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| ZA9010357B (en) * | 1989-12-26 | 1992-08-26 | Janssen Pharmaceutica Nv | Antipicornaviral pyridazinamines |
| US5100893A (en) * | 1990-04-18 | 1992-03-31 | Janssen Pharmaceutica N.V. | Antipicornaviral pyridazinamines |
| US5242924A (en) * | 1992-07-02 | 1993-09-07 | Sterling Winthrop Inc. | Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents |
-
1997
- 1997-01-14 SI SI9730191T patent/SI0876366T1/xx unknown
- 1997-01-14 NZ NZ326354A patent/NZ326354A/xx unknown
- 1997-01-14 ZA ZA97288A patent/ZA97288B/xx unknown
- 1997-01-14 DK DK97901059T patent/DK0876366T3/da active
- 1997-01-14 AT AT97901059T patent/ATE203534T1/de not_active IP Right Cessation
- 1997-01-14 CA CA002237273A patent/CA2237273C/en not_active Expired - Lifetime
- 1997-01-14 KR KR10-1998-0703682A patent/KR100443893B1/ko not_active Expired - Fee Related
- 1997-01-14 EP EP97901059A patent/EP0876366B1/de not_active Expired - Lifetime
- 1997-01-14 WO PCT/EP1997/000201 patent/WO1997026258A1/en not_active Ceased
- 1997-01-14 DE DE69705819T patent/DE69705819T2/de not_active Expired - Lifetime
- 1997-01-14 IL IL12446197A patent/IL124461A/xx not_active IP Right Cessation
- 1997-01-14 CN CN97191705A patent/CN1104430C/zh not_active Expired - Lifetime
- 1997-01-14 ES ES97901059T patent/ES2162235T3/es not_active Expired - Lifetime
- 1997-01-14 JP JP52465697A patent/JP4169368B2/ja not_active Expired - Lifetime
- 1997-01-14 PT PT97901059T patent/PT876366E/pt unknown
- 1997-01-14 AU AU14439/97A patent/AU717744B2/en not_active Expired
- 1997-01-14 MY MYPI97000130A patent/MY117098A/en unknown
- 1997-01-23 TW TW086100703A patent/TW480256B/zh not_active IP Right Cessation
-
1998
- 1998-05-05 NO NO982037A patent/NO309653B1/no unknown
- 1998-07-09 US US09/119,075 patent/US5985878A/en not_active Expired - Lifetime
-
2001
- 2001-10-16 GR GR20010401770T patent/GR3036900T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2237273C (en) | 2009-01-13 |
| EP0876366A2 (de) | 1998-11-11 |
| NO982037D0 (no) | 1998-05-05 |
| US5985878A (en) | 1999-11-16 |
| AU717744B2 (en) | 2000-03-30 |
| IL124461A0 (en) | 1998-12-06 |
| IL124461A (en) | 2000-07-26 |
| JP4169368B2 (ja) | 2008-10-22 |
| NZ326354A (en) | 1999-05-28 |
| NO309653B1 (no) | 2001-03-05 |
| KR100443893B1 (ko) | 2004-10-15 |
| MY117098A (en) | 2004-05-31 |
| DE69705819D1 (de) | 2001-08-30 |
| CN1104430C (zh) | 2003-04-02 |
| DE69705819T2 (de) | 2002-04-11 |
| TW480256B (en) | 2002-03-21 |
| PT876366E (pt) | 2002-01-30 |
| EP0876366B1 (de) | 2001-07-25 |
| AU1443997A (en) | 1997-08-11 |
| KR19990067654A (ko) | 1999-08-25 |
| WO1997026258A1 (en) | 1997-07-24 |
| ZA97288B (en) | 1998-07-14 |
| ATE203534T1 (de) | 2001-08-15 |
| CA2237273A1 (en) | 1997-07-24 |
| NO982037L (no) | 1998-09-15 |
| ES2162235T3 (es) | 2001-12-16 |
| GR3036900T3 (en) | 2002-01-31 |
| JP2000503014A (ja) | 2000-03-14 |
| CN1208415A (zh) | 1999-02-17 |
| SI0876366T1 (en) | 2001-12-31 |
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