DK0877252T3 - Fremgangsmåde og apparat til luminescensassays - Google Patents
Fremgangsmåde og apparat til luminescensassaysInfo
- Publication number
- DK0877252T3 DK0877252T3 DK98200764T DK98200764T DK0877252T3 DK 0877252 T3 DK0877252 T3 DK 0877252T3 DK 98200764 T DK98200764 T DK 98200764T DK 98200764 T DK98200764 T DK 98200764T DK 0877252 T3 DK0877252 T3 DK 0877252T3
- Authority
- DK
- Denmark
- Prior art keywords
- electrochemiluminescence
- working electrode
- analyte
- interest
- electrode surface
- Prior art date
Links
- 238000007422 luminescence assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plasma & Fusion (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65242791A | 1991-02-06 | 1991-02-06 | |
| US82726992A | 1992-02-03 | 1992-02-03 | |
| US82727092A | 1992-02-03 | 1992-02-03 | |
| EP92906820A EP0570518B1 (en) | 1991-02-06 | 1992-02-05 | Methods and apparatus for improved electrochemi-luminescence assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0877252T3 true DK0877252T3 (da) | 2007-05-07 |
Family
ID=27417877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98200764T DK0877252T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåde og apparat til luminescensassays |
| DK92906820T DK0570518T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92906820T DK0570518T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP0877252B1 (es) |
| JP (2) | JP3061416B2 (es) |
| KR (1) | KR100226231B1 (es) |
| CN (2) | CN1495425A (es) |
| AT (2) | ATE368224T1 (es) |
| AU (1) | AU668085B2 (es) |
| CA (1) | CA2103674C (es) |
| DE (3) | DE69233675T2 (es) |
| DK (2) | DK0877252T3 (es) |
| ES (3) | ES2126591T3 (es) |
| GR (1) | GR3029446T3 (es) |
| IE (1) | IE69060B1 (es) |
| IL (1) | IL100867A (es) |
| NZ (1) | NZ241537A (es) |
| TW (1) | TW316291B (es) |
| WO (1) | WO1992014139A1 (es) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100212178B1 (ko) * | 1991-07-10 | 1999-08-02 | 리차드 제이 마세이 | 입자농도 및 화학발광 검출을 이용한 개선된 발광 검정 장치 및 방법 |
| ZA929351B (en) * | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| US5466416A (en) * | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| ATE187732T1 (de) * | 1994-07-25 | 2000-01-15 | Roche Diagnostics Gmbh | Hydrophile metallkomplexe |
| US5744367A (en) * | 1994-11-10 | 1998-04-28 | Igen International, Inc. | Magnetic particle based electrochemiluminescent detection apparatus and method |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| KR100449615B1 (ko) * | 1995-03-10 | 2004-12-08 | 메소 스케일 테크놀러지즈, 엘엘시 | 다-배열,다-특이적전기화학발광시험법 |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US7314711B2 (en) | 1997-05-23 | 2008-01-01 | Bioveris Corporation | Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers |
| JP3366842B2 (ja) * | 1997-08-29 | 2003-01-14 | エーザイ株式会社 | 電気化学発光測定用セル |
| US6200531B1 (en) | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
| US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
| US6136268A (en) * | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
| US7063946B2 (en) * | 2001-09-10 | 2006-06-20 | Meso Scale Technologies, Llc. | Methods, reagents, kits and apparatus for protein function analysis |
| US20030180814A1 (en) * | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
| AU2003249350A1 (en) | 2002-06-20 | 2004-01-06 | Igen International, Inc | Electrochemiluminescence flow cell and flow cell components |
| JP4732755B2 (ja) | 2002-11-07 | 2011-07-27 | 三菱化学メディエンス株式会社 | 磁性粒子捕集用磁力体及びその利用 |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| KR101076578B1 (ko) | 2004-06-23 | 2011-10-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물 |
| WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20060275841A1 (en) * | 2004-12-20 | 2006-12-07 | Martin Blankfard | Assay method and apparatus with reduced sample matrix effects |
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| JP5590796B2 (ja) | 2005-06-03 | 2014-09-17 | ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | 電気化学および単一ファラデー電極による電気化学発光 |
| JPWO2007148762A1 (ja) * | 2006-06-22 | 2009-11-19 | 雅彦 黒田 | ヒトパピローマウイルス（ｈｐｖ）の検出方法、それに用いるプライマーセットおよび検出キット |
| JP5490095B2 (ja) | 2008-04-11 | 2014-05-14 | ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | ナノ粒子による電気化学発光の増幅方法および増幅装置 |
| WO2009137002A2 (en) | 2008-05-08 | 2009-11-12 | Board Of Regents Of The University Of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
| AU2009296526B2 (en) | 2008-09-24 | 2015-11-19 | First Light Diagnostics, Inc. | Method for detecting analytes |
| US20100261292A1 (en) | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
| CN103608116B (zh) * | 2011-06-15 | 2017-05-24 | 皇家飞利浦有限公司 | 对生物样本组分的处理 |
| CN104067123B (zh) * | 2011-12-28 | 2016-02-17 | 株式会社日立高新技术 | 试样分析装置以及试样分析方法 |
| BR112018001956A2 (pt) | 2015-08-20 | 2018-09-11 | Hoffmann La Roche | ?método de medição de analitos e kit? |
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| WO2017153574A1 (en) | 2016-03-11 | 2017-09-14 | Roche Diagnostics Gmbh | Branched-chain amines in electrochemiluminescence detection |
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| DE102017114537A1 (de) * | 2017-06-29 | 2019-01-03 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensorkappe und optischer Sensor |
| US11072820B2 (en) * | 2017-10-19 | 2021-07-27 | Bio-Rad Laboratories, Inc. | Digital amplification assays with unconventional and/or inverse changes in photoluminescence |
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| CN119804399A (zh) | 2018-04-19 | 2025-04-11 | 曙光诊断学公司 | 靶标检测 |
| CN112639475A (zh) | 2018-08-31 | 2021-04-09 | 豪夫迈·罗氏有限公司 | Dlbcl的预后指数中的胸苷激酶(tk-1) |
| AU2019353145B2 (en) | 2018-10-04 | 2025-12-04 | First Light Diagnostics, Inc. | Microbial analysis without cell purification |
| CN111351781B (zh) * | 2018-12-20 | 2023-11-24 | 麦德龙生物株式会社 | 电化学发光分析装置和使用其分析样品的方法 |
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| WO2021013781A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
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| JP2022542056A (ja) | 2019-07-22 | 2022-09-29 | エフ．ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ６ |
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Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030087A1 (en) * | 1979-11-13 | 1981-06-10 | Technicon Instruments Company Limited | Immunoassay method and apparatus and kit for carrying out the method |
| DE3013765A1 (de) * | 1980-04-10 | 1981-10-15 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie |
| US4652533A (en) * | 1983-04-28 | 1987-03-24 | Pandex Laboratories, Inc. | Method of solid phase immunoassay incorporating a luminescent label |
| US4628037A (en) * | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| AU596946B2 (en) * | 1984-07-10 | 1990-05-24 | F. Hoffmann-La Roche Ltd | Methods of assay |
| FI844027A7 (fi) * | 1984-10-12 | 1986-04-13 | Labsystems Oy | Immunologiskt bestaemningsfoerfarande. |
| GB8507706D0 (en) * | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
| CA1339465C (en) * | 1986-04-30 | 1997-09-16 | Richard J. Massey | Electrochemiluminescent assays |
| EP0247796A1 (en) * | 1986-05-22 | 1987-12-02 | Unilever Plc | Solid phase immunoassay method |
| GB8620893D0 (en) * | 1986-08-29 | 1986-10-08 | Unilever Plc | Assays |
| US5093268A (en) * | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| ZA898290B (en) * | 1988-11-03 | 1991-06-26 | Igen Inc | Electrochemiluminescent assays |
| US5061445A (en) * | 1988-11-03 | 1991-10-29 | Igen, Inc. | Apparatus for conducting measurements of electrochemiluminescent phenomena |
| CA2002083C (en) * | 1988-11-03 | 2001-01-09 | Haresh P. Shah | Enhanced electrochemiluminescence |
| US5068088A (en) * | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
-
1992
- 1992-02-04 IL IL10086792A patent/IL100867A/en not_active IP Right Cessation
- 1992-02-05 DE DE69233675T patent/DE69233675T2/de not_active Expired - Lifetime
- 1992-02-05 KR KR1019930702344A patent/KR100226231B1/ko not_active Expired - Fee Related
- 1992-02-05 AT AT02022214T patent/ATE368224T1/de active
- 1992-02-05 ES ES92906820T patent/ES2126591T3/es not_active Expired - Lifetime
- 1992-02-05 DK DK98200764T patent/DK0877252T3/da active
- 1992-02-05 EP EP98200764A patent/EP0877252B1/en not_active Expired - Lifetime
- 1992-02-05 EP EP92906820A patent/EP0570518B1/en not_active Expired - Lifetime
- 1992-02-05 ES ES98200764T patent/ES2281119T3/es not_active Expired - Lifetime
- 1992-02-05 IE IE920380A patent/IE69060B1/en not_active IP Right Cessation
- 1992-02-05 DE DE69233703T patent/DE69233703T2/de not_active Expired - Lifetime
- 1992-02-05 AT AT92906820T patent/ATE173542T1/de active
- 1992-02-05 DE DE69227624T patent/DE69227624T2/de not_active Expired - Lifetime
- 1992-02-05 EP EP02022214A patent/EP1286164B1/en not_active Expired - Lifetime
- 1992-02-05 ES ES02022214T patent/ES2291407T3/es not_active Expired - Lifetime
- 1992-02-05 NZ NZ241537A patent/NZ241537A/en not_active IP Right Cessation
- 1992-02-05 CA CA002103674A patent/CA2103674C/en not_active Expired - Lifetime
- 1992-02-05 WO PCT/US1992/000992 patent/WO1992014139A1/en not_active Ceased
- 1992-02-05 JP JP4506644A patent/JP3061416B2/ja not_active Expired - Lifetime
- 1992-02-05 AU AU14206/92A patent/AU668085B2/en not_active Ceased
- 1992-02-05 DK DK92906820T patent/DK0570518T3/da active
- 1992-02-07 CN CNA021320268A patent/CN1495425A/zh active Granted
- 1992-02-07 CN CN92102540.8A patent/CN1094593C/zh not_active Expired - Lifetime
- 1992-03-19 TW TW081102075A patent/TW316291B/zh active
-
1998
- 1998-07-15 JP JP20086598A patent/JP3182515B2/ja not_active Expired - Lifetime
-
1999
- 1999-02-18 GR GR990400531T patent/GR3029446T3/el unknown
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