DK0883611T3 - Azolylpiperazinylphenyloxazolidinoner som antimikrobielle midler - Google Patents

Azolylpiperazinylphenyloxazolidinoner som antimikrobielle midler

Info

Publication number
DK0883611T3
DK0883611T3 DK97907574T DK97907574T DK0883611T3 DK 0883611 T3 DK0883611 T3 DK 0883611T3 DK 97907574 T DK97907574 T DK 97907574T DK 97907574 T DK97907574 T DK 97907574T DK 0883611 T3 DK0883611 T3 DK 0883611T3
Authority
DK
Denmark
Prior art keywords
carbon
nitrogen
image
azolylpiperazinylphenyloxazolidinones
antimicrobial agents
Prior art date
Application number
DK97907574T
Other languages
Danish (da)
English (en)
Inventor
Robert C Gadwood
Michael R Barbachyn
Dana S Toops
Herman W Smith
Valerie A Vaillancourt
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0883611T3 publication Critical patent/DK0883611T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK97907574T 1996-02-26 1997-02-18 Azolylpiperazinylphenyloxazolidinoner som antimikrobielle midler DK0883611T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1231696P 1996-02-26 1996-02-26
PCT/US1997/001970 WO1997030981A1 (fr) 1996-02-26 1997-02-18 Antimicrobiens a base d'azolyl piperazinyl phenyl oxazolidone

Publications (1)

Publication Number Publication Date
DK0883611T3 true DK0883611T3 (da) 2002-12-02

Family

ID=21754387

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97907574T DK0883611T3 (da) 1996-02-26 1997-02-18 Azolylpiperazinylphenyloxazolidinoner som antimikrobielle midler

Country Status (18)

Country Link
US (1) US5736545A (fr)
EP (1) EP0883611B1 (fr)
JP (1) JP2000505084A (fr)
KR (1) KR19990087238A (fr)
CN (1) CN1082952C (fr)
AT (1) ATE221521T1 (fr)
AU (1) AU703831B2 (fr)
DE (1) DE69714418T2 (fr)
DK (1) DK0883611T3 (fr)
ES (1) ES2180945T3 (fr)
ID (1) ID18467A (fr)
MY (1) MY116093A (fr)
NZ (1) NZ331011A (fr)
PE (1) PE55898A1 (fr)
PT (1) PT883611E (fr)
TW (1) TW442460B (fr)
WO (1) WO1997030981A1 (fr)
ZA (1) ZA971287B (fr)

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GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
CA2294293A1 (fr) * 1997-07-11 1999-01-21 Pharmacia & Upjohn Company Agents antibacteriens de type phenyloxazolidinones de thiadiazolyle et d'oxadiazolyle
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
CA2318969A1 (fr) * 1998-01-23 1999-07-29 Mikhail F. Gordeev Banques combinatoires d'oxazolidinones, compositions a base de tels composes et procedes de preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1082323A2 (fr) * 1998-06-05 2001-03-14 AstraZeneca UK Limited Composes chimiques
US6689372B1 (en) * 1998-08-04 2004-02-10 Ciba Specialty Chemicals Corporation Microbicidal active substances
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002006278A1 (fr) * 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Derives d'oxazolidinone utilises en tant qu'antimicrobiens
WO2003008389A1 (fr) * 2001-07-16 2003-01-30 Ranbaxy Laboratories Limited Derives d'oxazolidinone utilises comme antimicrobiens potentiels
ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
CA2483600A1 (fr) * 2002-05-15 2003-11-27 Ranbaxy Laboratories Limited Formes polymorphes de derives d'oxazolidinone de phenyle
BR0215921A (pt) * 2002-07-29 2005-09-13 Ranbaxy Lab Ltd Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação
MXPA05001558A (es) 2002-08-12 2005-09-08 Pharmacia & Upjohn Co Llc N-aril-2-oxazolidinonas y sus derivados.
WO2004026848A1 (fr) * 2002-09-20 2004-04-01 Lupin Limited Derives d'oxazolidinone, leur procede de preparation et leur utilisation comme agents antimycobacterients
ATE344036T1 (de) 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
US20070293493A1 (en) * 2003-07-02 2007-12-20 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
CA2529292A1 (fr) * 2003-07-02 2005-01-20 Merck & Co., Inc. Antibiotiques a base d'oxazolidinone et derives
MXPA06000228A (es) * 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
WO2005051933A1 (fr) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Procede ameliore de synthese d'ester test-butylique d'acide 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylique, compose intermediaire cle de la preparation d'agents antimicrobiens a l'oxazolidinone, et composes ainsi prepares
WO2005082899A1 (fr) * 2004-01-28 2005-09-09 Ranbaxy Laboratories Limited Derives d'oxazolidinones utilises en tant qu'antimicrobiens
AU2005247929B2 (en) * 2004-05-24 2010-03-11 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
WO2006035283A1 (fr) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Derives d'oxazolidinone a activite antimicrobienne
WO2006043121A1 (fr) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Derives d'oxazolidinone servant d'antimicrobiens
WO2006051408A1 (fr) * 2004-11-11 2006-05-18 Ranbaxy Laboratories Limited Derives d'oxazolidinone comme antimicrobiens
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
CN100406455C (zh) * 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JP5431305B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
RU2489431C2 (ru) * 2007-04-23 2013-08-10 Янссен Фармацевтика Н.В. Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2
AU2008240727C1 (en) * 2007-04-23 2013-10-03 Janssen Pharmaceutica N.V. Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
CN101965353B (zh) * 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
JP5417439B2 (ja) * 2008-07-03 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
EA019048B1 (ru) * 2008-07-31 2013-12-30 Янссен Фармацевтика Нв Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина
WO2011152442A1 (fr) * 2010-06-03 2011-12-08 塩野義製薬株式会社 Procédé de production de 2‑chloro-6-fluorobenzoxazole
CN102079730B (zh) * 2010-09-06 2013-10-16 贵州大学 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用
CN103450173B (zh) * 2013-09-07 2015-06-03 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途
CN103709119B (zh) * 2013-12-04 2015-05-20 上海应用技术学院 一种制备5-氨基噻唑-4-甲酰胺的方法
CN104202835A (zh) * 2014-09-03 2014-12-10 苏州微站通信科技有限公司 Ue进入静默期时让基站及时释放时频资源的方法
CN112204017B (zh) * 2018-04-27 2024-08-20 国立大学法人大阪大学 苯并异噁唑化合物
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors

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US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
NZ274966A (en) * 1993-11-22 1998-01-26 Upjohn Co Substituted-hydroxyacetyl piperazine phenyl oxazolidinone derivatives, use in pharmaceutical compositions

Also Published As

Publication number Publication date
EP0883611B1 (fr) 2002-07-31
ID18467A (id) 1998-04-09
TW442460B (en) 2001-06-23
HK1017033A1 (en) 1999-11-12
JP2000505084A (ja) 2000-04-25
NZ331011A (en) 2000-04-28
PT883611E (pt) 2002-12-31
AU703831B2 (en) 1999-04-01
ZA971287B (en) 1998-08-14
DE69714418D1 (de) 2002-09-05
ES2180945T3 (es) 2003-02-16
EP0883611A1 (fr) 1998-12-16
DE69714418T2 (de) 2003-01-16
WO1997030981A1 (fr) 1997-08-28
US5736545A (en) 1998-04-07
CN1206410A (zh) 1999-01-27
MY116093A (en) 2003-11-28
AU1954797A (en) 1997-09-10
ATE221521T1 (de) 2002-08-15
CN1082952C (zh) 2002-04-17
PE55898A1 (es) 1998-09-16
KR19990087238A (ko) 1999-12-15

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