DK0951474T3 - Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf - Google Patents

Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf

Info

Publication number: DK0951474T3
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical preparations; cyclosporin derivatives; new cyclosporin; new
Prior art date: 1996-12-24

Application number

DK97952999T

Other languages

English (en)

Inventor

Jean-Claude Barriere

Georges Bashiardes

Jean-Christophe Carry

Michel Evers

Bruno Filoche

Serge Mignani

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-24

Filing date

1997-12-23

Publication date

2002-09-16

1997-12-23 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK0951474T3 publication Critical patent/DK0951474T3/da

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK97952999T 1996-12-24 1997-12-23 Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf DK0951474T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615955A FR2757521B1 (fr)	1996-12-24	1996-12-24	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002406 WO1998028330A1 (fr)	1996-12-24	1997-12-23	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
DK0951474T3 true DK0951474T3 (da)	2002-09-16

Family

ID=9499088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97952999T DK0951474T3 (da)	1996-12-24	1997-12-23	Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf

Country Status (14)

Country	Link
US (1)	US5994299A (da)
EP (1)	EP0951474B1 (da)
JP (1)	JP4146518B2 (da)
AT (1)	ATE218582T1 (da)
AU (1)	AU5669398A (da)
DE (1)	DE69713152D1 (da)
DK (1)	DK0951474T3 (da)
ES (1)	ES2178038T3 (da)
FR (1)	FR2757521B1 (da)
MA (1)	MA26458A1 (da)
PT (1)	PT951474E (da)
TN (1)	TNSN97212A1 (da)
WO (1)	WO1998028330A1 (da)
ZA (1)	ZA9711607B (da)

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US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
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PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
US6254860B1 (en) *	1999-04-13	2001-07-03	Allergan Sales, Inc.	Ocular treatment using cyclosporin-A derivatives
WO2001013957A2 (en)	1999-08-24	2001-03-01	Cellgate, Inc.	Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
KR100465012B1 (ko) *	2001-05-11	2005-01-13	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
EP1435910B9 (en) *	2001-10-19	2010-02-03	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
US6987090B2 (en) *	2002-05-09	2006-01-17	Lg Household & Health Care Ltd.	Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
CA2518265A1 (en)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
GB0320638D0 (en) *	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US7780973B2 (en) *	2003-12-15	2010-08-24	Ethicon Endo-Surgery, Inc.	Method and device for minimally invasive implantation of biomaterial
US20050142161A1 (en) *	2003-12-30	2005-06-30	Freeman Lynetta J.	Collagen matrix for soft tissue augmentation
BRPI0513370A (pt) *	2004-07-14	2008-05-06	Novartis Ag	uso de uma combinação de ciclosporina e interferonas peguilados para tratamento de hepatite c (hcv)
KR100597309B1 (ko)	2004-09-17	2006-07-05	주식회사 핸슨바이오텍	세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
PT1802650E (pt) *	2004-10-01	2011-12-30	Scynexis Inc	Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7691812B2 (en) *	2004-11-04	2010-04-06	Trustees Of The University Of Pennsylvania	Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine A or other cyclophilin inhibitors
NZ555142A (en) *	2004-12-23	2010-03-26	Novartis Ag	Compounds for flaviviridae treatment
WO2006071619A1 (en) *	2004-12-23	2006-07-06	Novartis Ag	Compositions for hcv treatment
WO2007041632A2 (en) *	2005-09-30	2007-04-12	Scynexis, Inc.	Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
CN101316606B (zh) *	2005-09-30	2015-05-27	西尼克斯公司	治疗和预防丙型肝炎感染的方法和药物组合物
WO2007041631A1 (en)	2005-09-30	2007-04-12	Scynexis, Inc.	ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CA2652662C (en)	2006-05-19	2015-11-03	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
KR20090083902A (ko) *	2006-10-12	2009-08-04	노파르티스 아게	개질된 사이클로스포린의 용도
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
JP5820722B2 (ja) *	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
US8716238B2 (en) *	2008-07-10	2014-05-06	Allergan, Inc.	Cyclosporin derivatives for treating ocular and dermal diseases and conditions
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8536114B2 (en)	2008-12-31	2013-09-17	Scynexis, Inc.	Macrocycles
KR20110116136A (ko) *	2009-01-07	2011-10-25	싸이넥시스, 인크.	Ｈｃｖ 및 ｈｉｖ 감염의 치료에 사용하기 위한 사이클로스포린 유도체
JP2012528163A (ja)	2009-05-27	2012-11-12	アラーガン、インコーポレイテッド	炎症性疾患および状態を処置するためのシクロスポリン誘導体
CA2785978A1 (en)	2009-12-30	2011-07-07	Scynexis, Inc.	Cyclosporine analogues
US9217015B2 (en)	2010-07-16	2015-12-22	S&T Global Inc.	Cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh)	2010-08-12	2017-08-18	美国科技环球有限公司	新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
AU2011316690C1 (en)	2010-10-12	2017-01-19	Allergan, Inc.	Cyclosporin analogs
EP2627663B1 (en) *	2010-10-12	2018-02-21	Allergan, Inc.	Cyclosporin analogs
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
AU2011342284C1 (en)	2010-12-15	2017-07-13	Contravir Pharmaceuticals, Inc.	Cyclosporine analogue molecules modified at amino acid 1 and 3
EP2705856A1 (en)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Compounds for the treatment of neurodegenerative disorders
WO2020037530A1 (en)	2018-08-22	2020-02-27	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Crystalline form of compound and uses thereof in medicine
ES2987605T3 (es) *	2018-12-14	2024-11-15	Waterstone Pharmaceuticals Wuhan Co Ltd	Maleato de SCY-635 y usos del mismo en medicina
WO2020118715A1 (en) *	2018-12-14	2020-06-18	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Salts of scy-635 and uses thereof in medicine
ES3064540T3 (en) *	2021-12-09	2026-04-27	Waterstone Pharmaceuticals Wuhan Co Ltd	Ws635 for promoting wound healing

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
FI111730B (fi) *	1990-11-02	2003-09-15	Novartis Ag	Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
CN1141317C (zh) *	1995-07-17	2004-03-10	碳化学公司	有抗人体免疫缺损病毒作用的环孢菌素衍生物

1996
- 1996-12-24 FR FR9615955A patent/FR2757521B1/fr not_active Expired - Fee Related
1997
- 1997-12-19 MA MA24907A patent/MA26458A1/fr unknown
- 1997-12-23 PT PT97952999T patent/PT951474E/pt unknown
- 1997-12-23 AT AT97952999T patent/ATE218582T1/de not_active IP Right Cessation
- 1997-12-23 DE DE69713152T patent/DE69713152D1/de not_active Expired - Lifetime
- 1997-12-23 WO PCT/FR1997/002406 patent/WO1998028330A1/fr not_active Ceased
- 1997-12-23 DK DK97952999T patent/DK0951474T3/da active
- 1997-12-23 EP EP97952999A patent/EP0951474B1/fr not_active Expired - Lifetime
- 1997-12-23 AU AU56693/98A patent/AU5669398A/en not_active Abandoned
- 1997-12-23 JP JP52849098A patent/JP4146518B2/ja not_active Expired - Lifetime
- 1997-12-23 ZA ZA9711607A patent/ZA9711607B/xx unknown
- 1997-12-23 US US08/997,612 patent/US5994299A/en not_active Expired - Lifetime
- 1997-12-23 ES ES97952999T patent/ES2178038T3/es not_active Expired - Lifetime
- 1997-12-23 TN TNTNSN97212A patent/TNSN97212A1/fr unknown

Also Published As

Publication number	Publication date
EP0951474A1 (fr)	1999-10-27
PT951474E (pt)	2002-11-29
DE69713152D1 (de)	2002-07-11
ZA9711607B (en)	1998-06-24
ES2178038T3 (es)	2002-12-16
MA26458A1 (fr)	2004-12-20
FR2757521B1 (fr)	1999-01-29
US5994299A (en)	1999-11-30
JP2001507347A (ja)	2001-06-05
AU5669398A (en)	1998-07-17
EP0951474B1 (fr)	2002-06-05
WO1998028330A1 (fr)	1998-07-02
JP4146518B2 (ja)	2008-09-10
ATE218582T1 (de)	2002-06-15
TNSN97212A1 (fr)	2005-03-15
FR2757521A1 (fr)	1998-06-26

Publication	Publication Date	Title
ZA9711607B (en)	1998-06-24	Novel cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
ZA9711606B (en)	1998-06-25	Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
DK0951473T3 (da)	2002-09-16	Cyclosporinderivat, fremstilling af dette og farmaceutiske præparater indeholdende dette
ATE290015T1 (de)	2005-03-15	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
BG103945A (bg)	2000-07-31	Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
RU95101048A (ru)	1996-10-27	Производные пролинамида, фармкомпозиция на их основе
DK0750618T3 (da)	2003-06-10	Oxazolidinonderivater og farmaceutiske præparater indeholdende dem
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
RU95106362A (ru)	1996-12-27	Производные липопептида, способ их получения, содержащая их фармацевтическая композиция и способ ее получения
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
ES2196331T3 (es)	2003-12-16	Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.
BG100016A (bg)	1996-04-30	Нiv протеазни инхибитори във фармацевтични комбинации за лечение на спин
ATE254630T1 (de)	2003-12-15	Cyclosporine
NO971625L (no)	1997-05-30	Nye peptider med immunomodulatoriske effekter
DE69430385D1 (de)	2002-05-16	Hiv-proteaseinhibitoren
TR199900732T2 (xx)	1999-08-23	PDE IV inhibe eden 2-siyanoiminoimidazol t�revleri.
DK72289A (da)	1989-08-18	Cephemcarboxylsyreestere, deres fremstilling og anvendelse
NO20020914D0 (no)	2002-02-25	Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
DK0989994T3 (da)	2005-08-22	Streptograminderivater, deres fremstilling og præparater, der indeholder dem
NO20001846L (no)	2000-04-10	Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
ATE243219T1 (de)	2003-07-15	9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
MX9605312A (es)	1998-02-28	Dipsipeptidos ciclicos antifungales.
WO2003004019A8 (en)	2003-08-14	Use of heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin a for the treatment of beta-thalassaemia
ECSP900707A (es)	1992-03-18	Derivados de aminoacidos