DK0951474T3 - Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf - Google Patents

Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf

Info

Publication number: DK0951474T3
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical preparations; cyclosporin derivatives; new cyclosporin; new
Prior art date: 1996-12-24

Application number

DK97952999T

Other languages

English (en)

Inventor

Jean-Claude Barriere

Georges Bashiardes

Jean-Christophe Carry

Michel Evers

Bruno Filoche

Serge Mignani

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-24

Filing date

1997-12-23

Publication date

2002-09-16

1997-12-23 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK0951474T3 publication Critical patent/DK0951474T3/da

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK97952999T 1996-12-24 1997-12-23 Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf DK0951474T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615955A FR2757521B1 (fr)	1996-12-24	1996-12-24	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002406 WO1998028330A1 (fr)	1996-12-24	1997-12-23	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
DK0951474T3 true DK0951474T3 (da)	2002-09-16

Family

ID=9499088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97952999T DK0951474T3 (da)	1996-12-24	1997-12-23	Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf

Country Status (14)

Country	Link
US (1)	US5994299A (da)
EP (1)	EP0951474B1 (da)
JP (1)	JP4146518B2 (da)
AT (1)	ATE218582T1 (da)
AU (1)	AU5669398A (da)
DE (1)	DE69713152D1 (da)
DK (1)	DK0951474T3 (da)
ES (1)	ES2178038T3 (da)
FR (1)	FR2757521B1 (da)
MA (1)	MA26458A1 (da)
PT (1)	PT951474E (da)
TN (1)	TNSN97212A1 (da)
WO (1)	WO1998028330A1 (da)
ZA (1)	ZA9711607B (da)

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US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
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FR2780061B1 (fr) *	1998-06-22	2001-09-07	Rhone Poulenc Rorer Sa	Nouveau procede de preparation de derives de cyclosporine
PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
US6254860B1 (en)	1999-04-13	2001-07-03	Allergan Sales, Inc.	Ocular treatment using cyclosporin-A derivatives
MXPA02001857A (es)	1999-08-24	2003-07-14	Cellgate Inc	Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales.
KR100465012B1 (ko) *	2001-05-11	2005-01-13	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
WO2003033526A2 (en)	2001-10-19	2003-04-24	Isotechnika Inc.	Synthesis of cyclosporin analogs
EP2116228A1 (en) *	2001-10-19	2009-11-11	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
US6987090B2 (en) *	2002-05-09	2006-01-17	Lg Household & Health Care Ltd.	Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
JP2006524232A (ja)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
GB0320638D0 (en) *	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US7780973B2 (en) *	2003-12-15	2010-08-24	Ethicon Endo-Surgery, Inc.	Method and device for minimally invasive implantation of biomaterial
US20050142161A1 (en) *	2003-12-30	2005-06-30	Freeman Lynetta J.	Collagen matrix for soft tissue augmentation
BRPI0513370A (pt) *	2004-07-14	2008-05-06	Novartis Ag	uso de uma combinação de ciclosporina e interferonas peguilados para tratamento de hepatite c (hcv)
KR100597309B1 (ko)	2004-09-17	2006-07-05	주식회사 핸슨바이오텍	세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법
EP1804823A4 (en)	2004-09-29	2010-06-09	Amr Technology Inc	NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
JP5139065B2 (ja) *	2004-10-01	2013-02-06	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
US7691812B2 (en) *	2004-11-04	2010-04-06	Trustees Of The University Of Pennsylvania	Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine A or other cyclophilin inhibitors
CA2587793A1 (en) *	2004-12-23	2006-07-06	Novartis Ag	Compositions for hcv treatment
WO2006071618A1 (en) *	2004-12-23	2006-07-06	Novartis Ag	Compounds for flaviviridae treatment
US8329658B2 (en)	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt) *	2005-09-30	2011-06-21	Scynexis Inc	uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
CN101316606B (zh) *	2005-09-30	2015-05-27	西尼克斯公司	治疗和预防丙型肝炎感染的方法和药物组合物
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
ATE502633T1 (de)	2006-05-19	2011-04-15	Scynexis Inc	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (fr) *	2006-06-02	2009-02-25	Claude Annie Perrichon	Gestion des electrons actifs
BRPI0719189A2 (pt) *	2006-10-12	2018-08-14	Univ Kyushu Nat Univ Corp	uso de ciclosporinas modificadas
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
US20080255038A1 (en) *	2007-04-11	2008-10-16	Samuel Earl Hopkins	Pharmaceutical compositions
WO2009042892A1 (en)	2007-09-26	2009-04-02	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
US9090671B2 (en)	2008-06-06	2015-07-28	Scynexis, Inc.	Macrocyclic peptides
AU2009268549B2 (en) *	2008-07-10	2015-07-16	Allergan, Inc.	Cyclosporin derivatives for treating ocular and dermal diseases and conditions
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (en) *	2008-12-31	2017-03-15	Cypralis Limited	Derivatives of cyclosporin a
WO2010080874A1 (en) *	2009-01-07	2010-07-15	Scynexis, Inc.	Cyclosporine derivative for use in the treatment of hcv and hiv infection
AU2010254316A1 (en)	2009-05-27	2011-12-22	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
AU2010339460A1 (en)	2009-12-30	2012-07-19	Scynexis Inc.	Cyclosporine analogues
WO2012009715A2 (en)	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en)	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9175042B2 (en) *	2010-10-12	2015-11-03	Allergan, Inc.	Cyclosporin analogs
RU2013119869A (ru)	2010-10-12	2014-11-20	Аллерган, Инк.	Аналоги циклоспорина
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
JP6144627B2 (ja)	2010-12-15	2017-06-07	コントラヴィアファーマシューティカルズ、インク．	アミノ酸１および３で修飾されたシクロスポリン類似体分子
EP2705856A1 (en)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Compounds for the treatment of neurodegenerative disorders
WO2020037530A1 (en) *	2018-08-22	2020-02-27	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Crystalline form of compound and uses thereof in medicine
WO2020118714A1 (en) *	2018-12-14	2020-06-18	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Maleate of scy-635 and uses thereof in medicine
WO2020118715A1 (en) *	2018-12-14	2020-06-18	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Salts of scy-635 and uses thereof in medicine
JP7764612B2 (ja) *	2021-12-09	2025-11-05	中美華世通生物医薬科技（武漢）股▲ふん▼有限公司	医薬におけるｗｓ６３５の使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
ATE148469T1 (de) *	1990-11-02	1997-02-15	Sandoz Ag	Zyklosporine
PL324531A1 (en) *	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus

1996
- 1996-12-24 FR FR9615955A patent/FR2757521B1/fr not_active Expired - Fee Related
1997
- 1997-12-19 MA MA24907A patent/MA26458A1/fr unknown
- 1997-12-23 ZA ZA9711607A patent/ZA9711607B/xx unknown
- 1997-12-23 DE DE69713152T patent/DE69713152D1/de not_active Expired - Lifetime
- 1997-12-23 DK DK97952999T patent/DK0951474T3/da active
- 1997-12-23 EP EP97952999A patent/EP0951474B1/fr not_active Expired - Lifetime
- 1997-12-23 WO PCT/FR1997/002406 patent/WO1998028330A1/fr not_active Ceased
- 1997-12-23 JP JP52849098A patent/JP4146518B2/ja not_active Expired - Lifetime
- 1997-12-23 TN TNTNSN97212A patent/TNSN97212A1/fr unknown
- 1997-12-23 PT PT97952999T patent/PT951474E/pt unknown
- 1997-12-23 AT AT97952999T patent/ATE218582T1/de not_active IP Right Cessation
- 1997-12-23 US US08/997,612 patent/US5994299A/en not_active Expired - Lifetime
- 1997-12-23 ES ES97952999T patent/ES2178038T3/es not_active Expired - Lifetime
- 1997-12-23 AU AU56693/98A patent/AU5669398A/en not_active Abandoned

Also Published As

Publication number	Publication date
US5994299A (en)	1999-11-30
DE69713152D1 (de)	2002-07-11
FR2757521B1 (fr)	1999-01-29
ZA9711607B (en)	1998-06-24
AU5669398A (en)	1998-07-17
ES2178038T3 (es)	2002-12-16
EP0951474A1 (fr)	1999-10-27
PT951474E (pt)	2002-11-29
ATE218582T1 (de)	2002-06-15
JP2001507347A (ja)	2001-06-05
JP4146518B2 (ja)	2008-09-10
TNSN97212A1 (fr)	2005-03-15
EP0951474B1 (fr)	2002-06-05
WO1998028330A1 (fr)	1998-07-02
FR2757521A1 (fr)	1998-06-26
MA26458A1 (fr)	2004-12-20

Publication	Publication Date	Title
ZA9711607B (en)	1998-06-24	Novel cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
ZA9711606B (en)	1998-06-25	Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
DK0951473T3 (da)	2002-09-16	Cyclosporinderivat, fremstilling af dette og farmaceutiske præparater indeholdende dette
ATE290015T1 (de)	2005-03-15	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
BG103945A (bg)	2000-07-31	Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
RU95101048A (ru)	1996-10-27	Производные пролинамида, фармкомпозиция на их основе
DK0750618T3 (da)	2003-06-10	Oxazolidinonderivater og farmaceutiske præparater indeholdende dem
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
RU95106362A (ru)	1996-12-27	Производные липопептида, способ их получения, содержащая их фармацевтическая композиция и способ ее получения
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
ES2196331T3 (es)	2003-12-16	Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.
BG100016A (bg)	1996-04-30	Нiv протеазни инхибитори във фармацевтични комбинации за лечение на спин
ATE254630T1 (de)	2003-12-15	Cyclosporine
NO971625L (no)	1997-05-30	Nye peptider med immunomodulatoriske effekter
DE69430385D1 (de)	2002-05-16	Hiv-proteaseinhibitoren
TR199900732T2 (xx)	1999-08-23	PDE IV inhibe eden 2-siyanoiminoimidazol t�revleri.
DK72289A (da)	1989-08-18	Cephemcarboxylsyreestere, deres fremstilling og anvendelse
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
NO20020914D0 (no)	2002-02-25	Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
DK0989994T3 (da)	2005-08-22	Streptograminderivater, deres fremstilling og præparater, der indeholder dem
NO20001846L (no)	2000-04-10	Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
ATE243219T1 (de)	2003-07-15	9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
MX9605312A (es)	1998-02-28	Dipsipeptidos ciclicos antifungales.
WO2003004019A8 (en)	2003-08-14	Use of heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin a for the treatment of beta-thalassaemia
ECSP900707A (es)	1992-03-18	Derivados de aminoacidos