DK0885220T3 - Tropanderivater, deres fresmtilling og anvendelse - Google Patents

Tropanderivater, deres fresmtilling og anvendelse

Info

Publication number: DK0885220T3
Authority: DK; Denmark
Prior art keywords: disorders; derivatives; fresmation; application; monoamine neurotransmitter
Prior art date: 1996-02-22

Application number

DK97903355T

Other languages

English (en)

Inventor

Joergen Scheel-Krueger

Peter Moldt

Frank Waetjen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-22

Filing date

1997-02-21

Publication date

2001-10-15

1997-02-21 Application filed by Neurosearch As filed Critical Neurosearch As

2001-10-15 Application granted granted Critical

2001-10-15 Publication of DK0885220T3 publication Critical patent/DK0885220T3/da

Links

150000003813 tropane derivatives Chemical class 0.000 title abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK97903355T 1996-02-22 1997-02-21 Tropanderivater, deres fresmtilling og anvendelse DK0885220T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK19496		1996-02-22
PCT/EP1997/000850 WO1997030997A1 (en)	1996-02-22	1997-02-21	Tropane-derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
DK0885220T3 true DK0885220T3 (da)	2001-10-15

Family

ID=8090830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97903355T DK0885220T3 (da)	1996-02-22	1997-02-21	Tropanderivater, deres fresmtilling og anvendelse

Country Status (31)

Country	Link
US (3)	US6288079B1 (da)
EP (2)	EP0885220B1 (da)
JP (1)	JP3238414B2 (da)
KR (1)	KR100446571B1 (da)
CN (1)	CN1077574C (da)
AT (1)	ATE203023T1 (da)
AU (1)	AU720358B2 (da)
BG (1)	BG63945B1 (da)
BR (1)	BR9707636A (da)
CA (1)	CA2244773C (da)
CZ (1)	CZ287007B6 (da)
DE (1)	DE69705608T2 (da)
DK (1)	DK0885220T3 (da)
EE (1)	EE04751B1 (da)
ES (1)	ES2159839T3 (da)
GR (1)	GR3036829T3 (da)
HU (1)	HU228356B1 (da)
IL (1)	IL125146A (da)
IS (1)	IS1824B (da)
NO (1)	NO318731B1 (da)
NZ (1)	NZ330886A (da)
PL (1)	PL185132B1 (da)
PT (1)	PT885220E (da)
RU (1)	RU2167876C2 (da)
SG (1)	SG99853A1 (da)
SI (1)	SI0885220T1 (da)
SK (1)	SK281813B6 (da)
TR (1)	TR199801641T2 (da)
UA (1)	UA49872C2 (da)
WO (1)	WO1997030997A1 (da)
ZA (1)	ZA971525B (da)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4386399B2 (ja) *	1998-09-30	2009-12-16	日本メジフィジックス株式会社	光学活性トロピノンモノカルボン酸エステル誘導体の製造法
AUPP627498A0 (en)	1998-10-02	1998-10-22	University Of Queensland, The	Novel peptides - i
JP2005508872A (ja) *	2001-05-23	2005-04-07	ニューロサーチ、アクティーゼルスカブ	トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法
CA2373559C (en) *	2001-10-11	2010-07-27	Organix, Inc.	Serotonin transport inhibitors
AU2002348135A1 (en) *	2001-10-31	2003-05-12	Recovery Pharmaceuticals, Inc.	Methods for the treatment of addiction
US7381733B2 (en)	2001-11-30	2008-06-03	Neurosearch A/S	Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
CA2484482C (en)	2002-05-30	2011-07-26	Neurosearch A/S	Triple monoamine reuptake inhibitors for the treatment of chronic pain
WO2004039778A1 (en)	2002-11-01	2004-05-13	Neurosearch A/S	Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP2412719A1 (en)	2002-12-02	2012-02-01	Xenome Ltd	Chi-conotoxin peptides
WO2004050690A1 (en)	2002-12-02	2004-06-17	Xenome Ltd	NOVEL χ-CONOTOXIN PEPTIDES (-I)
CN100551924C (zh) *	2003-02-12	2009-10-21	神经研究公司	8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途
WO2004072071A1 (en)	2003-02-12	2004-08-26	Neurosearch A/S	8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2515732A1 (en)	2003-02-12	2004-08-26	Neurosearch A/S	Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CN100372850C (zh) *	2003-02-12	2008-03-05	神经研究公司	新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途
BRPI0411608A (pt)	2003-06-24	2006-08-08	Neurosearch As	derivado de 8-aza-biciclo [3.2.1] octano, composição farmacêutica, uso do composto, e, método de tratamento, prevenção ou alìvio de uma doença, um distúrbio ou uma condição de um organismo animal vivo
AR045141A1 (es) *	2003-07-31	2005-10-19	Neurosearch As	Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas.
KR100777885B1 (ko)	2003-10-03	2007-11-28	화이자 인코포레이티드	Ｈｉｖ 및 염증 치료를 위한 ｃｃｒ5 수용체 길항제 활성을갖는 이미다조피리딘 치환된 트로판 유도체
EP1675591B1 (en)	2003-10-16	2011-08-10	NeuroSearch A/S	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
AU2004290520A1 (en) *	2003-11-18	2005-06-02	Boehringer Ingelheim International Gmbh	Solid pharmaceutical preparation form
CA2554616A1 (en) *	2004-01-22	2005-08-04	Boehringer Ingelheim International Gmbh	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist
CA2553649A1 (en) *	2004-01-22	2005-08-04	Neurosearch A/S	Compounds for the sustained reduction of body weight
EP1708707A1 (en) *	2004-01-22	2006-10-11	Neurosearch A/S	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
DE102004004965B4 (de) *	2004-01-31	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
EP1755602A1 (en) *	2004-06-04	2007-02-28	Neurosearch A/S	Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation
US7524958B2 (en)	2004-06-18	2009-04-28	Neurosearch A/S	Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MXPA06013917A (es)	2004-06-18	2007-03-07	Neurosearch As	Nuevos derivados de piperidina sustituidos con alquilo y su uso como inhibidores de la recaptacion del neurotransmisor monoamino.
JP2008502650A (ja) *	2004-06-18	2008-01-31	ノイロサーチアクティーゼルスカブ	新規な９−アザ−ビシクロ［３．３．１］ノナン誘導体及びこれらのモノアミン神経伝達物質再取り込み阻害剤としての使用
KR20070061846A (ko)	2004-09-30	2007-06-14	뉴로서치 에이/에스	신규한 크로멘-2-온 유도체 및 모노아민 신경전달물질재흡수 억제제로서의 이의 용도
BRPI0515261A (pt) *	2004-09-30	2008-07-15	Neurosearch As	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso do composto quìmico ou de qualquer um de seus isÈmeros ou de qualquer mistura de seus isÈmeros, ou um sal farmaceuticamente aceitável do mesmo, e, método para o tratamento, a prevenção ou o alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo de animal vivo
EP1851207B1 (en)	2005-02-10	2009-07-01	Neurosearch A/S	Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1869050A1 (en) *	2005-04-04	2007-12-26	Neurosearch A/S	Novel substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP2272847A1 (en)	2005-04-08	2011-01-12	NeuroSearch A/S	Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
ATE481386T1 (de) *	2005-06-28	2010-10-15	Neurosearch As	Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern
WO2007000463A1 (en) *	2005-06-28	2007-01-04	Neurosearch A/S	Novel 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2007000464A1 (en) *	2005-06-28	2007-01-04	Neurosearch A/S	Novel 3-aza-spiro[5.5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US8049012B2 (en)	2005-06-28	2011-11-01	Neurosearch A/S	3-aza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2614833A1 (en) *	2005-07-12	2007-01-18	Boehringer Ingelheim International Gmbh	Pharmaceutical composition comprising 2, 3-disubstituted tropanes for the treatment of disorders of sexual desire
KR101594898B1 (ko)	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
EP1919476A2 (en)	2005-08-24	2008-05-14	Government of the United States of America, Represented by the Secretary, Department of Health and Human Services	Benztropine compounds and uses thereof as dopamine uptake inhibitors
WO2007028770A1 (en) *	2005-09-05	2007-03-15	Neurosearch A/S	Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease
WO2007028769A1 (en) *	2005-09-05	2007-03-15	Neurosearch A/S	Monoamine neurotransmitter re-uptake inhibitor for neuroprotection
EP1779851A1 (en)	2005-10-31	2007-05-02	Boehringer Ingelheim Pharma GmbH & Co.KG	Treatment of diabetes
TW200804367A (en)	2005-11-11	2008-01-16	Neurosearch As	Novel compounds
CN101379063A (zh)	2006-02-10	2009-03-04	神经研究公司	3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途
TW200800980A (en)	2006-02-17	2008-01-01	Neurosearch As	Novel compounds
WO2008028903A2 (en)	2006-09-04	2008-03-13	Neurosearch A/S	Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
WO2008031772A1 (en) *	2006-09-11	2008-03-20	Glaxo Group Limited	Azabicyclic compounds as inhibitors of monoamines reuptake
GB0703998D0 (en) *	2007-03-01	2007-04-11	Glaxo Group Ltd	Novel salt
TW200904815A (en)	2007-05-09	2009-02-01	Neurosearch As	Novel compounds
EP2201004A1 (en) *	2007-09-10	2010-06-30	Neurosearch A/S	Novel benzooxazol- and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2009034043A1 (en) *	2007-09-10	2009-03-19	Neurosearch A/S	Novel phenoxazin-3-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20110118304A1 (en) *	2007-11-20	2011-05-19	Neurosearch A/S	Method for treating over-eating disorders
EP2222303A1 (en) *	2007-11-20	2010-09-01	NeuroSearch A/S	A method for treating addiction
AU2010247763B2 (en)	2009-05-12	2015-12-24	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
AU2010247735B2 (en)	2009-05-12	2015-07-16	Albany Molecular Research, Inc.	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
AU2010247514A1 (en)	2009-05-15	2011-11-17	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011032903A1 (en)	2009-09-21	2011-03-24	Neurosearch A/S	Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20130040985A1 (en)	2010-01-29	2013-02-14	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en)	2010-03-25	2011-09-29	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
US8153653B2 (en) *	2010-06-22	2012-04-10	Hoffmann-La Roche Inc.	Amido-tropane derivatives
WO2012000881A1 (en)	2010-07-02	2012-01-05	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2012024397A2 (en)	2010-08-17	2012-02-23	Albany Molecular Research, Inc.	2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
BR112013008420A2 (pt)	2010-10-07	2016-06-28	Takeda Pharmaceutical	composto, medicamento, e, uso do composito
ES2704987T3 (es)	2012-02-16	2019-03-21	Saniona As	Composiciones farmacéuticas para terapia de combinación
US9579288B2 (en)	2015-03-03	2017-02-28	Saniona A/S	Tesofensine and beta blocker combination formulations
EA026727B1 (ru) *	2015-09-10	2017-05-31	Замертон Холдингс Лимитед	Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением
WO2017121432A1 (en)	2016-01-15	2017-07-20	Saniona A/S	Tesofensine and metoprolol for treatment of hypertension
EA028995B1 (ru) *	2016-02-25	2018-01-31	Замертон Холдингс Лимитед	Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением
MX381130B (es) *	2016-09-07	2025-03-12	Saniona As	Composiciones de tesofensina.
DE102017210141A1 (de)	2017-06-16	2018-12-20	Henkel Ag & Co. Kgaa	Portion zur Bereitstellung tensidhaltiger Flotten
MX2021008208A (es)	2019-01-07	2021-11-17	Saniona As	Tesofensina para la reduccion del peso corporal para pacientes con sindrome de prader-willi.
CA3176183A1 (en)	2020-04-22	2021-10-28	Jorgen Drejer	Treatment of hypothalamic obesity
TWI772928B (zh) *	2020-10-21	2022-08-01	行政院原子能委員會核能研究所	非放射性標準品β-CFT之製備方法
JP2025522944A (ja)	2022-07-08	2025-07-17	イニシエーターファーマエー／エス	女性性機能不全の治療用化合物
CN115572289A (zh) *	2022-10-24	2023-01-06	龙曦宁（上海）医药科技有限公司	一种特索芬辛的合成方法
EP4608400A1 (en)	2022-10-28	2025-09-03	Initiator Pharma A/S	Compound for treatment of pain
EP4646204A1 (en)	2023-01-03	2025-11-12	Initiator Pharma A/S	Compound for treatment of erectile dysfunction
WO2025051846A1 (en)	2023-09-05	2025-03-13	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4281130A (en) *	1979-05-24	1981-07-28	Sterling Drug Inc.	Lower-alkyl 4,6,7,8,8a-9-hexahydro-6,9-ethanothieno[3,2-f]indolizine-10-carboxylate
US5496953A (en) *	1990-08-09	1996-03-05	Research Triangle Institute	Cocaine receptor binding ligands
US5380848A (en) *	1990-08-09	1995-01-10	Research Triangle Institute	Cocaine receptor binding ligands
US5128118A (en) *	1990-08-09	1992-07-07	Research Triangle Institute	Cocaine receptor binding ligands
DE69233656D1 (de) *	1991-11-15	2006-10-19	Res Triangle Inst	Kokain-Rezeptor Bindungsliganden
AU671163B2 (en) *	1992-12-23	1996-08-15	Neurosearch A/S	Alkyl substituted heterocyclic compounds
AU672052B2 (en)	1992-12-23	1996-09-19	Neurosearch A/S	Antidepressant and antiparkinsonian compounds
AU672644B2 (en) *	1992-12-23	1996-10-10	Neurosearch A/S	Aryl substituted heterocyclic compounds
DE69527839T2 (de) *	1994-04-19	2003-01-02	Neurosearch A/S, Ballerup	Tropan-2-aldoximderivate als neurotransmitter "reuptake" inhibitoren
GB9626611D0 (en) *	1996-12-20	1997-02-05	Unilever Plc	Agglomerated silicas

1997
- 1997-02-21 JP JP52981097A patent/JP3238414B2/ja not_active Expired - Fee Related
- 1997-02-21 EP EP97903355A patent/EP0885220B1/en not_active Expired - Lifetime
- 1997-02-21 DE DE69705608T patent/DE69705608T2/de not_active Expired - Lifetime
- 1997-02-21 SG SG9903902A patent/SG99853A1/en unknown
- 1997-02-21 ES ES97903355T patent/ES2159839T3/es not_active Expired - Lifetime
- 1997-02-21 EP EP01108256A patent/EP1130020A1/en not_active Withdrawn
- 1997-02-21 IL IL12514697A patent/IL125146A/en not_active IP Right Cessation
- 1997-02-21 CZ CZ19982520A patent/CZ287007B6/cs not_active IP Right Cessation
- 1997-02-21 SK SK929-98A patent/SK281813B6/sk not_active IP Right Cessation
- 1997-02-21 AU AU17940/97A patent/AU720358B2/en not_active Ceased
- 1997-02-21 ZA ZA9701525A patent/ZA971525B/xx unknown
- 1997-02-21 NZ NZ330886A patent/NZ330886A/xx not_active IP Right Cessation
- 1997-02-21 CA CA002244773A patent/CA2244773C/en not_active Expired - Lifetime
- 1997-02-21 BR BR9707636A patent/BR9707636A/pt not_active IP Right Cessation
- 1997-02-21 HU HU9901199A patent/HU228356B1/hu not_active IP Right Cessation
- 1997-02-21 PT PT97903355T patent/PT885220E/pt unknown
- 1997-02-21 RU RU98117314/04A patent/RU2167876C2/ru active
- 1997-02-21 DK DK97903355T patent/DK0885220T3/da active
- 1997-02-21 PL PL97328503A patent/PL185132B1/pl not_active IP Right Cessation
- 1997-02-21 KR KR10-1998-0706518A patent/KR100446571B1/ko not_active Expired - Fee Related
- 1997-02-21 TR TR1998/01641T patent/TR199801641T2/xx unknown
- 1997-02-21 WO PCT/EP1997/000850 patent/WO1997030997A1/en not_active Ceased
- 1997-02-21 SI SI9730163T patent/SI0885220T1/xx unknown
- 1997-02-21 UA UA98073814A patent/UA49872C2/uk unknown
- 1997-02-21 AT AT97903355T patent/ATE203023T1/de active
- 1997-02-21 EE EE9800254A patent/EE04751B1/xx not_active IP Right Cessation
- 1997-02-21 US US09/101,524 patent/US6288079B1/en not_active Expired - Lifetime
- 1997-02-21 CN CN97192505A patent/CN1077574C/zh not_active Expired - Fee Related
1998
- 1998-07-15 BG BG102637A patent/BG63945B1/bg unknown
- 1998-08-17 IS IS4825A patent/IS1824B/is unknown
- 1998-08-21 NO NO19983877A patent/NO318731B1/no not_active IP Right Cessation
2001
- 2001-03-21 US US09/814,413 patent/US6395748B2/en not_active Expired - Fee Related
- 2001-10-08 GR GR20010401690T patent/GR3036829T3/el unknown
2002
- 2002-03-15 US US10/099,642 patent/US20020128284A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SK281813B6 (sk)	2001-08-06
PL185132B1 (pl)	2003-02-28
BG102637A (en)	1999-06-30
US6395748B2 (en)	2002-05-28
JP3238414B2 (ja)	2001-12-17
EP0885220A1 (en)	1998-12-23
HU228356B1 (en)	2013-03-28
HK1018957A1 (en)	2000-01-14
WO1997030997A1 (en)	1997-08-28
AU1794097A (en)	1997-09-10
TR199801641T2 (xx)	1998-11-23
KR100446571B1 (ko)	2004-11-03
CN1077574C (zh)	2002-01-09
EE9800254A (et)	1999-02-15
BG63945B1 (bg)	2003-07-31
DE69705608D1 (de)	2001-08-16
CA2244773A1 (en)	1997-08-28
CA2244773C (en)	2006-01-03
NO318731B1 (no)	2005-05-02
RU2167876C2 (ru)	2001-05-27
NO983877D0 (no)	1998-08-21
AU720358B2 (en)	2000-06-01
US20020128284A1 (en)	2002-09-12
HUP9901199A3 (en)	2001-02-28
CN1211982A (zh)	1999-03-24
SG99853A1 (en)	2003-11-27
GR3036829T3 (en)	2002-01-31
ES2159839T3 (es)	2001-10-16
CZ252098A3 (cs)	1998-11-11
DE69705608T2 (de)	2002-05-16
JP2000504739A (ja)	2000-04-18
IS1824B (is)	2002-10-01
EP1130020A1 (en)	2001-09-05
IL125146A (en)	2002-03-10
EE04751B1 (et)	2006-12-15
EP0885220B1 (en)	2001-07-11
SK92998A3 (en)	1998-11-04
SI0885220T1 (en)	2001-12-31
NO983877L (no)	1998-08-21
HUP9901199A2 (hu)	1999-08-30
IL125146A0 (en)	1999-01-26
KR19990087127A (ko)	1999-12-15
BR9707636A (pt)	1999-07-27
PT885220E (pt)	2001-11-30
CZ287007B6 (en)	2000-08-16
US6288079B1 (en)	2001-09-11
US20010018444A1 (en)	2001-08-30
IS4825A (is)	1998-08-17
PL328503A1 (en)	1999-02-01
NZ330886A (en)	1999-02-25
UA49872C2 (uk)	2002-10-15
ZA971525B (en)	1997-10-21
ATE203023T1 (de)	2001-07-15

Publication	Publication Date	Title
DK0885220T3 (da)	2001-10-15	Tropanderivater, deres fresmtilling og anvendelse
CY1117619T1 (el)	2017-04-26	Υδροχλωριδιο 8-χλωρο-1-μεθυλο-2,3,4,5-τετραϋδρο-1η-3βενζαζεπινης
IS2164B (is)	2006-11-15	ß2-adrenvirk viðtaka gerandefni
ATE446286T1 (de)	2009-11-15	Piperidin mch antagonisten und ihre verwendung in der behandlung von obesität und störungen des zentralnervensystems
BRPI0908738A8 (pt)	2017-10-10	Composto, medicamento, uso de um composto, e, processo para preparar os compostos
MX2009005509A (es)	2009-06-03	2-aminoquinolina como los antagonistas de los receptores 5-hidroxitriptamina 5a (5-ht5a).
MXPA05003734A (es)	2005-09-30	Inhibidores de acetilcolinesterasa en el sitio de enlace dual para el tratamiento de la enfermedad de alzheimer.
DE69926254D1 (de)	2005-08-25	Verwendung von radioliganden zum screening von inhibitoren der herstellung von beta-amyloid peptiden
DE502004011551D1 (de)	2010-09-30	1,3,4-substituierte pyrazole als 5-ht rezeptor-antagonisten zur behandlung von psychosen und neurologischen störungen
WO2007028083A3 (en)	2007-05-18	6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
DOP2011000130A (es)	2017-04-30	1-(arilsulfonil)-4-(pepirazin-1-il)-1h-benzimidazol como ligando de 5-hidroxitriptamina-6
TW200621245A (en)	2006-07-01	Thienopyridinone compounds and methods of treatment
PL1635828T3 (pl)	2008-10-31	Pochodne 4-(2-fenyloksyfenylo)-piperydyny lub 1,2,3,6-tetrahydropirydyny jako inhibitory wychwytu zwrotnego serotoniny
ATE334989T1 (de)	2006-08-15	Antidepressive azaheterocyclylmethyl-derivate von 2,3-dihydro-1,4-dioxino 2,3-föchinoxalin
WO2007058805A3 (en)	2007-10-04	Compositions and methods for treating cns disorders
UA81469C2 (en)	2008-01-10	4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
WO2005004867A3 (en)	2005-04-21	Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor
MX2010008239A (es)	2010-08-18	2-aminoquinolinas.
CA2521030A1 (en)	2004-10-14	4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
WO2000071533A3 (en)	2001-04-12	1,4-dithiin and 1,4-dithiepin- 1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor
AU2003215529A1 (en)	2003-10-08	The use of 3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl)-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition
MY128351A (en)	2007-01-31	ß2-ADRENERGIC RECEPTOR AGONISTS