EE03877B1 - Tropaan-2-aldoksiimi derivaadid neurotransmitteritagasihaarde inhibiitoritena - Google Patents

Tropaan-2-aldoksiimi derivaadid neurotransmitteritagasihaarde inhibiitoritena

Info

Publication number
EE03877B1
EE03877B1 EE9600132A EE9600132A EE03877B1 EE 03877 B1 EE03877 B1 EE 03877B1 EE 9600132 A EE9600132 A EE 9600132A EE 9600132 A EE9600132 A EE 9600132A EE 03877 B1 EE03877 B1 EE 03877B1
Authority
EE
Estonia
Prior art keywords
pct
reuptake inhibitors
tropane
date oct
neurotransmitter reuptake
Prior art date
Application number
EE9600132A
Other languages
English (en)
Other versions
EE9600132A (et
Inventor
Moldt Peter
W�tjen Frank
Scheel-Kr�ger J�rgen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of EE9600132A publication Critical patent/EE9600132A/et
Publication of EE03877B1 publication Critical patent/EE03877B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EE9600132A 1994-04-19 1995-04-12 Tropaan-2-aldoksiimi derivaadid neurotransmitteritagasihaarde inhibiitoritena EE03877B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK44794 1994-04-19
DK133894 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en) 1994-04-19 1995-04-12 Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
EE9600132A EE9600132A (et) 1997-04-15
EE03877B1 true EE03877B1 (et) 2002-10-15

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9600132A EE03877B1 (et) 1994-04-19 1995-04-12 Tropaan-2-aldoksiimi derivaadid neurotransmitteritagasihaarde inhibiitoritena

Country Status (25)

Country Link
US (1) US5736556A (et)
EP (1) EP0756596B1 (et)
JP (1) JP2899418B2 (et)
KR (1) KR100210417B1 (et)
CN (1) CN1043763C (et)
AT (1) ATE222587T1 (et)
AU (1) AU690257B2 (et)
BG (1) BG63259B1 (et)
BR (1) BR9507489A (et)
CA (1) CA2187309C (et)
CZ (1) CZ284379B6 (et)
DE (1) DE69527839T2 (et)
DK (1) DK0756596T3 (et)
EE (1) EE03877B1 (et)
FI (1) FI965074A7 (et)
GE (1) GEP19991749B (et)
HU (1) HU215830B (et)
LV (1) LV11738B (et)
NO (1) NO964180L (et)
NZ (1) NZ284075A (et)
PL (1) PL183025B1 (et)
RU (1) RU2134264C1 (et)
SK (1) SK280875B6 (et)
UA (1) UA49801C2 (et)
WO (1) WO1995028401A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE362931T1 (de) * 1995-10-13 2007-06-15 Neurosearch As 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
EE03566B1 (et) * 1995-11-02 2001-12-17 Neurosearch A/S Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
JP3238414B2 (ja) * 1996-02-22 2001-12-17 ニューロサーチ・アクティーゼルスカブ トロパン―誘導体、その製造方法及びその使用方法
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
ATE431141T1 (de) 1999-07-13 2009-05-15 Alpha Res Group Llc Zusammensetzungen und verfahren zur behandlung der parkinson-krankheit
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
RS50904B (sr) * 2000-05-26 2010-08-31 Pfizer Inc. Derivati tropana i njihova primena
EP1397358A1 (en) * 2001-05-23 2004-03-17 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
WO2003045388A1 (en) * 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
WO2003099783A2 (en) * 2002-03-28 2003-12-04 President And Fellows Of Harvard College Tropane compounds
EP1682545B1 (en) 2003-10-03 2007-12-12 Pfizer Limited Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
WO2005070427A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
WO2006075976A1 (fr) * 2005-01-14 2006-07-20 Private Enterprise 'slavyanskaya Klinika' Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
SU941369A1 (ru) * 1978-12-29 1982-07-07 Научно-исследовательский институт фармакологии АМН СССР Хлоргидраты W-аминоацильных эфиров тропан-3-ола как стимул торы центральной нервной системы
AT397962B (de) * 1985-12-27 1994-08-25 Madaus & Co Dr Verfahren zur herstellung von azoniaspironortropanolestern
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds

Also Published As

Publication number Publication date
FI965074A0 (fi) 1996-12-17
HU215830B (hu) 2001-05-28
RU2134264C1 (ru) 1999-08-10
CZ298296A3 (en) 1997-06-11
FI965074A7 (fi) 1996-12-17
JP2899418B2 (ja) 1999-06-02
BG100883A (en) 1998-03-31
NO964180L (no) 1996-12-16
UA49801C2 (uk) 2002-10-15
WO1995028401A1 (en) 1995-10-26
DE69527839T2 (de) 2003-01-02
BG63259B1 (bg) 2001-07-31
HU9602707D0 (en) 1996-11-28
ATE222587T1 (de) 2002-09-15
HUT75865A (en) 1997-05-28
CN1043763C (zh) 1999-06-23
PL183025B1 (pl) 2002-05-31
CA2187309C (en) 2000-11-21
DK0756596T3 (da) 2002-12-23
CA2187309A1 (en) 1995-10-26
LV11738B (en) 1997-12-20
EE9600132A (et) 1997-04-15
EP0756596B1 (en) 2002-08-21
US5736556A (en) 1998-04-07
MX9604966A (es) 1998-05-31
LV11738A (lv) 1997-04-20
JPH09505607A (ja) 1997-06-03
NZ284075A (en) 1998-01-26
DE69527839D1 (en) 2002-09-26
PL316876A1 (en) 1997-02-17
NO964180D0 (no) 1996-10-02
GEP19991749B (en) 1999-09-10
AU690257B2 (en) 1998-04-23
KR100210417B1 (ko) 1999-07-15
SK280875B6 (sk) 2000-08-14
SK128896A3 (en) 1997-04-09
CN1148854A (zh) 1997-04-30
BR9507489A (pt) 1997-08-12
EP0756596A1 (en) 1997-02-05
AU2257595A (en) 1995-11-10
CZ284379B6 (cs) 1998-11-11

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

MM4A Lapsed by not paying the annual fees

Effective date: 20030412