DK0888271T3 - Benzamidinderivater substitueret med aminosyre- og hydroxysyrederivater og deres anvendelse som antikoagulerende midler - Google Patents

Benzamidinderivater substitueret med aminosyre- og hydroxysyrederivater og deres anvendelse som antikoagulerende midler

Info

Publication number: DK0888271T3
Authority: DK; Denmark
Prior art keywords: derivatives; amino acid; anticoagulants; benzamidine; substituted
Prior art date: 1996-02-12

Application number

DK97901221T

Other languages

Danish (da)

English (en)

Inventor

Monica Kochanny

Raju Mohan

Michael M Morrissey

Howard P Ng

Weija Yun

Original Assignee

Berlex Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-12

Filing date

1997-02-07

Publication date

2004-08-16

1997-02-07 Application filed by Berlex Lab filed Critical Berlex Lab

2004-08-16 Application granted granted Critical

2004-08-16 Publication of DK0888271T3 publication Critical patent/DK0888271T3/da

Links

125000003275 alpha amino acid group Chemical class 0.000 title abstract 2
239000003146 anticoagulant agent Substances 0.000 title abstract 2
229940127219 anticoagulant drug Drugs 0.000 title abstract 2
PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title abstract 2
150000001261 hydroxy acids Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001732 thrombotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

DK97901221T 1996-02-12 1997-02-07 Benzamidinderivater substitueret med aminosyre- og hydroxysyrederivater og deres anvendelse som antikoagulerende midler DK0888271T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/599,834 US5994375A (en)	1996-02-12	1996-02-12	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
PCT/IB1997/000098 WO1997029067A1 (en)	1996-02-12	1997-02-07	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants

Publications (1)

Publication Number	Publication Date
DK0888271T3 true DK0888271T3 (da)	2004-08-16

Family

ID=24401285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97901221T DK0888271T3 (da)	1996-02-12	1997-02-07	Benzamidinderivater substitueret med aminosyre- og hydroxysyrederivater og deres anvendelse som antikoagulerende midler

Country Status (23)

Country	Link
US (4)	US5994375A (pl)
EP (1)	EP0888271B1 (pl)
JP (1)	JP3762790B2 (pl)
KR (1)	KR19990082480A (pl)
CN (1)	CN1211232A (pl)
AT (1)	ATE265409T1 (pl)
AU (1)	AU715992B2 (pl)
CA (1)	CA2245925A1 (pl)
CZ (1)	CZ255098A3 (pl)
DE (1)	DE69728869T2 (pl)
DK (1)	DK0888271T3 (pl)
ES (1)	ES2221032T3 (pl)
HU (1)	HU223604B1 (pl)
IL (1)	IL125285A (pl)
NO (1)	NO312834B1 (pl)
NZ (1)	NZ326452A (pl)
PL (1)	PL186474B1 (pl)
PT (1)	PT888271E (pl)
RU (1)	RU98117078A (pl)
SK (1)	SK283306B6 (pl)
UA (1)	UA51694C2 (pl)
WO (1)	WO1997029067A1 (pl)
ZA (1)	ZA971183B (pl)

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DE69630214T2 (de) *	1995-03-10	2004-07-15	Berlex Laboratories, Inc., Richmond	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
ES2188979T3 (es)	1996-09-12	2003-07-01	Schering Ag	Derivados de benzamidina sustituidos con derivados de aminoacidos ciclicos e hidroxiacidos ciclicos, y su uso como anti-coagulantes.
US6004985A (en) *	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en)	1997-12-08	2004-02-03	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) *	1997-12-19	2000-10-31	Berlex Laboratories, Inc.	Ortho-anthranilamide derivatives as anti-coagulants
NZ503809A (en) *	1997-12-19	2002-04-26	Schering Ag	Ortho-anthranilamide derivatives as anti-coagulants
US6262088B1 (en) *	1998-11-19	2001-07-17	Berlex Laboratories, Inc.	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) *	1998-12-04	2000-10-03	Berlex Laboratories, Inc.	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
CA2348740A1 (en)	1998-12-23	2000-07-06	Ruth R. Wexler	Thrombin or factor xa inhibitors
US6350761B1 (en)	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
US6844367B1 (en)	1999-09-17	2005-01-18	Millennium Pharmaceuticals, Inc.	Benzamides and related inhibitors of factor Xa
ES2254385T3 (es)	2000-02-29	2006-06-16	Millennium Pharmaceuticals, Inc.	Benzamidas e inhibidores relacionados del factor xa.
EP1323189A2 (en) *	2000-09-13	2003-07-02	Shipley Company LLC	Electronic device manufacture
JP4087577B2 (ja)	2001-03-30	2008-05-21	富士フイルム株式会社	ヘテロ環連結体を含有する写真処理組成物及び画像形成方法
AU2002351412B2 (en)	2001-12-21	2010-05-20	Exelixis Patent Company Llc	Modulators of LXR
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
EP1569912B1 (en)	2002-12-03	2015-04-29	Pharmacyclics, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
AR040456A1 (es) *	2002-06-27	2005-04-06	Bristol Myers Squibb Co	Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
PT2077995E (pt)	2006-11-02	2012-05-10	Millennium Pharm Inc	Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
US7989465B2 (en)	2007-10-19	2011-08-02	Avila Therapeutics, Inc.	4,6-disubstituted pyrimidines useful as kinase inhibitors
US7982036B2 (en)	2007-10-19	2011-07-19	Avila Therapeutics, Inc.	4,6-disubstitued pyrimidines useful as kinase inhibitors
US12595251B2 (en)	2018-06-14	2026-04-07	Georgia State University Research Foundation, Inc.	Amidines and amidine analogs for the treatment of bacterial infections and potentiation antibiotics
CN119837855A (zh)	2019-12-19	2025-04-18	乔治亚州大学研究基金会	用于治疗细菌感染和增强抗生素的化合物

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GB824908A (en) *	1958-06-03	1959-12-09	May & Baker Ltd	Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) *	1976-01-13	1984-05-28	エーザイ株式会社	ビス−（メタ−アミジノフエノキシ）−化合物
JPH0813834B2 (ja) *	1990-08-01	1996-02-14	日東紡績株式会社	トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
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ZA928276B (en) *	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.
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ATE171709T1 (de) *	1992-02-14	1998-10-15	Corvas Int Inc	Inhibitoren der thrombose
DE4213919A1 (de)	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW234077B (pl)	1992-07-17	1994-11-11	Shell Internat Res Schappej B V
AU675981B2 (en) *	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
CA2151044A1 (en) *	1992-12-15	1994-06-23	Terence K. Brunck	Novel inhibitors for factor xa
US5332822A (en) *	1992-12-24	1994-07-26	Bristol-Myers Squibb Company	Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
US5633381A (en) *	1994-07-05	1997-05-27	Berlex Laboratories, Inc.	(Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
DE69630214T2 (de) *	1995-03-10	2004-07-15	Berlex Laboratories, Inc., Richmond	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US5612363A (en) *	1995-06-02	1997-03-18	Berlex Laboratories, Inc.	N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en)	1995-12-08	1998-12-15	Berlex Laboratories, Inc.	Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5693641A (en)	1996-08-16	1997-12-02	Berlex Laboratories Inc.	Bicyclic pyrimidine derivatives and their use as anti-coagulants
US5753635A (en)	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
ES2188979T3 (es) *	1996-09-12	2003-07-01	Schering Ag	Derivados de benzamidina sustituidos con derivados de aminoacidos ciclicos e hidroxiacidos ciclicos, y su uso como anti-coagulantes.
US6004985A (en) *	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants

1996
- 1996-02-12 US US08/599,834 patent/US5994375A/en not_active Expired - Fee Related
1997
- 1997-02-07 SK SK1092-98A patent/SK283306B6/sk unknown
- 1997-02-07 ES ES97901221T patent/ES2221032T3/es not_active Expired - Lifetime
- 1997-02-07 DK DK97901221T patent/DK0888271T3/da active
- 1997-02-07 CZ CZ982550A patent/CZ255098A3/cs unknown
- 1997-02-07 PT PT97901221T patent/PT888271E/pt unknown
- 1997-02-07 WO PCT/IB1997/000098 patent/WO1997029067A1/en not_active Ceased
- 1997-02-07 DE DE69728869T patent/DE69728869T2/de not_active Expired - Fee Related
- 1997-02-07 HU HU9902017A patent/HU223604B1/hu not_active IP Right Cessation
- 1997-02-07 NZ NZ326452A patent/NZ326452A/en unknown
- 1997-02-07 EP EP97901221A patent/EP0888271B1/en not_active Expired - Lifetime
- 1997-02-07 JP JP52833697A patent/JP3762790B2/ja not_active Expired - Fee Related
- 1997-02-07 CA CA002245925A patent/CA2245925A1/en not_active Abandoned
- 1997-02-07 CN CN97192215A patent/CN1211232A/zh active Pending
- 1997-02-07 AT AT97901221T patent/ATE265409T1/de not_active IP Right Cessation
- 1997-02-07 KR KR1019980706213A patent/KR19990082480A/ko not_active Abandoned
- 1997-02-07 PL PL97328412A patent/PL186474B1/pl not_active IP Right Cessation
- 1997-02-07 RU RU98117078/04A patent/RU98117078A/ru not_active Application Discontinuation
- 1997-02-07 AU AU14548/97A patent/AU715992B2/en not_active Ceased
- 1997-02-07 IL IL12528597A patent/IL125285A/en not_active IP Right Cessation
- 1997-02-12 ZA ZA9701183A patent/ZA971183B/xx unknown
- 1997-07-02 UA UA98094782A patent/UA51694C2/uk unknown
1998
- 1998-08-11 NO NO19983671A patent/NO312834B1/no not_active IP Right Cessation
1999
- 1999-09-09 US US09/393,180 patent/US6166088A/en not_active Expired - Fee Related
- 1999-09-09 US US09/394,458 patent/US6071912A/en not_active Expired - Fee Related
- 1999-09-09 US US09/393,198 patent/US6242454B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1997029067A1 (en)	1997-08-14
NO983671D0 (no)	1998-08-11
PL328412A1 (en)	1999-01-18
SK283306B6 (sk)	2003-05-02
AU1454897A (en)	1997-08-28
UA51694C2 (uk)	2002-12-16
EP0888271A1 (en)	1999-01-07
CA2245925A1 (en)	1997-08-14
PL186474B1 (pl)	2004-01-30
US5994375A (en)	1999-11-30
JP2000505431A (ja)	2000-05-09
ZA971183B (en)	1997-09-18
RU98117078A (ru)	2000-06-10
AU715992B2 (en)	2000-02-17
DE69728869T2 (de)	2005-01-05
KR19990082480A (ko)	1999-11-25
NZ326452A (en)	2000-02-28
NO983671L (no)	1998-09-11
CN1211232A (zh)	1999-03-17
EP0888271A4 (en)	2000-03-15
ATE265409T1 (de)	2004-05-15
HUP9902017A2 (hu)	1999-09-28
ES2221032T3 (es)	2004-12-16
IL125285A (en)	2002-11-10
NO312834B1 (no)	2002-07-08
HUP9902017A3 (en)	2000-06-28
CZ255098A3 (cs)	1999-01-13
IL125285A0 (en)	1999-03-12
HU223604B1 (hu)	2004-10-28
PT888271E (pt)	2004-09-30
EP0888271B1 (en)	2004-04-28
US6071912A (en)	2000-06-06
SK109298A3 (en)	1999-02-11
US6242454B1 (en)	2001-06-05
JP3762790B2 (ja)	2006-04-05
US6166088A (en)	2000-12-26
DE69728869D1 (de)	2004-06-03

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