NO991206L - Benzamidinderivater substituert med sykliske aminosyre- eller sykliske hydroksysyrederivater, og deres anvendelse som antikoagulanter - Google Patents

Benzamidinderivater substituert med sykliske aminosyre- eller sykliske hydroksysyrederivater, og deres anvendelse som antikoagulanter

Info

Publication number
NO991206L
NO991206L NO991206A NO991206A NO991206L NO 991206 L NO991206 L NO 991206L NO 991206 A NO991206 A NO 991206A NO 991206 A NO991206 A NO 991206A NO 991206 L NO991206 L NO 991206L
Authority
NO
Norway
Prior art keywords
cyclic
derivatives
amino acid
anticoagulants
benzamidine
Prior art date
Application number
NO991206A
Other languages
English (en)
Other versions
NO991206D0 (no
Inventor
Monica Kochanny
Michael M Morrissey
Howard P Ng
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/920,319 external-priority patent/US6008234A/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO991206D0 publication Critical patent/NO991206D0/no
Publication of NO991206L publication Critical patent/NO991206L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Oppfinnelsen er rettet mot benzamidinderivater substituert med sykliske aminosyre- og sykliske hydrok- sysyrederivater som er anvendbare som antikoagulanter som representert ved formel (I), (II), (III), (IV), (V), (VI), (VII) hvori: A er -C(R8)= eller -N=; Zl og Z2 er uavhengig -O-, -N(R9)-, -S-, -S(O)-, -S(0)2- eller -OCH2-; R2 er -C(NH)NH2, -C(NH)N(H)OR9, -C(NH)N(H)C(0)OR12, -C(NH)N(H)C(0)R9, -C(NH)N(H)S(0)2R12 eller -C(NH)N(H)C(0)N(H)R9; R7 er -N(R9)-(C(R')(R10))n-R13 (hvor n er O til 4), -0-(C(R9)(R10))n-R13 (hvor n er O til 4), eller -N(R14)R15; R1 og R3 - R6 er som definert i beskrivelsen. Oppfinnelsen er også rettet mot farmasøytiske pre- parater inneholdende forbindelsene ifølge oppfinnelsen, og metoder for anvendelse av forbindelsene for å behandle sykdomstilstander karakteris- ert ved trombotisk aktivitet.
NO991206A 1996-09-12 1999-03-11 Benzamidinderivater substituert med sykliske aminosyre- eller sykliske hydroksysyrederivater, og deres anvendelse som antikoagulanter NO991206L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71306696A 1996-09-12 1996-09-12
US08/920,319 US6008234A (en) 1996-09-12 1997-08-27 Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
PCT/EP1997/004961 WO1998011094A1 (en) 1996-09-12 1997-09-11 Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants

Publications (2)

Publication Number Publication Date
NO991206D0 NO991206D0 (no) 1999-03-11
NO991206L true NO991206L (no) 1999-05-11

Family

ID=27108932

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991206A NO991206L (no) 1996-09-12 1999-03-11 Benzamidinderivater substituert med sykliske aminosyre- eller sykliske hydroksysyrederivater, og deres anvendelse som antikoagulanter

Country Status (18)

Country Link
US (3) US6265404B1 (no)
EP (1) EP0929547B1 (no)
JP (1) JP3565864B2 (no)
KR (1) KR20000036017A (no)
CN (2) CN1234798A (no)
AT (1) ATE228513T1 (no)
AU (1) AU723999B2 (no)
CA (1) CA2264521A1 (no)
CZ (1) CZ86199A3 (no)
DE (1) DE69717474T2 (no)
DK (1) DK0929547T3 (no)
ES (1) ES2188979T3 (no)
IL (1) IL128691A (no)
NO (1) NO991206L (no)
NZ (1) NZ334264A (no)
PT (1) PT929547E (no)
SK (1) SK29599A3 (no)
WO (1) WO1998011094A1 (no)

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US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
WO1998057934A1 (en) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (en) 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
BR0015120A (pt) * 1999-10-28 2002-06-25 Sankyo Co Derivado de benzamidina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um derivado de benzamidina ou de um sal deste farmaceuticamente aceitável
AU2004203154B2 (en) * 1999-10-28 2006-06-01 Sankyo Company, Limited Benzamidine derivatives
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AR040456A1 (es) 2002-06-27 2005-04-06 Bristol Myers Squibb Co Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
ZA200505523B (en) 2002-12-20 2006-09-27 Amgen Inc Asthma and allergic inflammation modulators
MXPA05007485A (es) 2003-01-14 2006-01-30 Arena Pharm Inc Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
ES2471919T3 (es) 2007-12-19 2014-06-27 Amgen, Inc Derivados de ácido fenilac�tico como moduladores de inflamación
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
MX2010011463A (es) 2008-04-16 2011-06-03 Portola Pharm Inc 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
PH12013500547A1 (en) 2010-09-22 2013-06-10 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
US9834518B2 (en) 2011-05-04 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers
CA3094793A1 (en) 2011-11-23 2013-05-30 Portola Pharmaceuticals, Inc. Pyrazine kinase inhibitors
US20150166591A1 (en) 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
MX386419B (es) 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
EP3939965A1 (en) 2015-06-22 2022-01-19 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders
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EP1040108B1 (en) 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants

Also Published As

Publication number Publication date
ATE228513T1 (de) 2002-12-15
US6232325B1 (en) 2001-05-15
CZ86199A3 (cs) 1999-08-11
DE69717474T2 (de) 2003-06-26
US6177473B1 (en) 2001-01-23
JP3565864B2 (ja) 2004-09-15
ES2188979T3 (es) 2003-07-01
SK29599A3 (en) 1999-08-06
DE69717474D1 (de) 2003-01-09
EP0929547A1 (en) 1999-07-21
KR20000036017A (ko) 2000-06-26
NZ334264A (en) 2000-08-25
CN1338454A (zh) 2002-03-06
JP2001500147A (ja) 2001-01-09
CN1234798A (zh) 1999-11-10
US6265404B1 (en) 2001-07-24
AU4384397A (en) 1998-04-02
IL128691A0 (en) 2000-01-31
EP0929547B1 (en) 2002-11-27
PT929547E (pt) 2003-03-31
IL128691A (en) 2007-07-24
CA2264521A1 (en) 1998-03-19
NO991206D0 (no) 1999-03-11
DK0929547T3 (da) 2003-03-10
WO1998011094A1 (en) 1998-03-19
AU723999B2 (en) 2000-09-07

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