DK0888341T3 - Hidtil ukendte svovlderivater indeholdende en amidbinding, fremgangsmåde for fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse - Google Patents
Hidtil ukendte svovlderivater indeholdende en amidbinding, fremgangsmåde for fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disseInfo
- Publication number
- DK0888341T3 DK0888341T3 DK97907157T DK97907157T DK0888341T3 DK 0888341 T3 DK0888341 T3 DK 0888341T3 DK 97907157 T DK97907157 T DK 97907157T DK 97907157 T DK97907157 T DK 97907157T DK 0888341 T3 DK0888341 T3 DK 0888341T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pharmaceuticals
- preparation
- pharmaceutical compositions
- amide bond
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003463 sulfur Chemical class 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- TXKZHJBAHJTASL-UHFFFAOYSA-N 2-phenylmethoxy-1,3-dioxole Chemical compound C(C1=CC=CC=C1)OC1OC=CO1 TXKZHJBAHJTASL-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- -1 carboxy, tetrazolyl Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9602672A FR2745571B1 (fr) | 1996-03-04 | 1996-03-04 | Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0888341T3 true DK0888341T3 (da) | 2006-04-10 |
Family
ID=9489805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97907157T DK0888341T3 (da) | 1996-03-04 | 1997-03-03 | Hidtil ukendte svovlderivater indeholdende en amidbinding, fremgangsmåde for fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6136842A (da) |
| EP (1) | EP0888341B1 (da) |
| JP (1) | JP2000507220A (da) |
| KR (1) | KR19990087484A (da) |
| CN (1) | CN1218467A (da) |
| AT (1) | ATE311384T1 (da) |
| AU (1) | AU724686B2 (da) |
| BR (1) | BR9707931A (da) |
| CA (1) | CA2248187A1 (da) |
| DE (1) | DE69734764T2 (da) |
| DK (1) | DK0888341T3 (da) |
| ES (1) | ES2253771T3 (da) |
| FR (1) | FR2745571B1 (da) |
| IL (1) | IL125960A0 (da) |
| NO (1) | NO984047L (da) |
| PL (1) | PL328699A1 (da) |
| RU (1) | RU2203661C2 (da) |
| TR (1) | TR199801756T2 (da) |
| WO (1) | WO1997032874A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| ATE288922T1 (de) * | 1998-04-23 | 2005-02-15 | Novartis Pharma Gmbh | Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen |
| US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
| EP1073674A1 (en) * | 1998-04-23 | 2001-02-07 | Novartis AG | Thiol inhibitors of endothelin-converting enzyme |
| US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| FR2805259B1 (fr) * | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2823212B1 (fr) * | 2001-04-10 | 2005-12-02 | Inst Nat Sante Rech Med | Inhibiteurs de la toxine botulique de type b |
| DE10147672A1 (de) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
| JP4705756B2 (ja) * | 2002-02-07 | 2011-06-22 | 仁 遠藤 | 芳香族アミノ酸誘導体及び医薬組成物 |
| MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| JP2006511562A (ja) * | 2002-12-20 | 2006-04-06 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 泌尿器系疾患の処置のための置換２，５−ジアミドインドール類の使用 |
| FR2931151A1 (fr) * | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1009252A (en) * | 1972-10-03 | 1977-04-26 | Santen Pharmaceutical Co. | N-(mercaptoacyl) aminoacids |
| US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
| GB2092574A (en) * | 1981-02-10 | 1982-08-18 | Ici Plc | Amide derivatives |
| US5262436A (en) * | 1987-03-27 | 1993-11-16 | Schering Corporation | Acylamino acid antihypertensives in the treatment of congestive heart failure |
| CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
| US5599951A (en) * | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| RU2083567C1 (ru) * | 1991-04-25 | 1997-07-10 | Ф.Хоффманн-Ля Рош Аг | Производные арилсульфонамида или их соли и фармацевтическая композиция, проявляющая ангиопротекторное, антигипертензивное и вазоспазмолитическое, в частности противоишемическое, действие |
-
1996
- 1996-03-04 FR FR9602672A patent/FR2745571B1/fr not_active Expired - Fee Related
-
1997
- 1997-03-03 US US09/142,286 patent/US6136842A/en not_active Expired - Fee Related
- 1997-03-03 TR TR1998/01756T patent/TR199801756T2/xx unknown
- 1997-03-03 EP EP97907157A patent/EP0888341B1/fr not_active Expired - Lifetime
- 1997-03-03 AU AU19306/97A patent/AU724686B2/en not_active Ceased
- 1997-03-03 WO PCT/FR1997/000367 patent/WO1997032874A1/fr not_active Ceased
- 1997-03-03 CN CN97194380A patent/CN1218467A/zh active Pending
- 1997-03-03 RU RU98118049/14A patent/RU2203661C2/ru not_active IP Right Cessation
- 1997-03-03 CA CA002248187A patent/CA2248187A1/fr not_active Abandoned
- 1997-03-03 KR KR1019980706912A patent/KR19990087484A/ko not_active Abandoned
- 1997-03-03 DK DK97907157T patent/DK0888341T3/da active
- 1997-03-03 ES ES97907157T patent/ES2253771T3/es not_active Expired - Lifetime
- 1997-03-03 BR BR9707931A patent/BR9707931A/pt not_active Application Discontinuation
- 1997-03-03 IL IL12596097A patent/IL125960A0/xx unknown
- 1997-03-03 DE DE69734764T patent/DE69734764T2/de not_active Expired - Fee Related
- 1997-03-03 JP JP9531511A patent/JP2000507220A/ja not_active Ceased
- 1997-03-03 AT AT97907157T patent/ATE311384T1/de not_active IP Right Cessation
- 1997-03-03 PL PL97328699A patent/PL328699A1/xx unknown
-
1998
- 1998-09-03 NO NO984047A patent/NO984047L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990087484A (ko) | 1999-12-27 |
| PL328699A1 (en) | 1999-02-15 |
| RU2203661C2 (ru) | 2003-05-10 |
| ATE311384T1 (de) | 2005-12-15 |
| CA2248187A1 (fr) | 1997-09-12 |
| AU1930697A (en) | 1997-09-22 |
| NO984047D0 (no) | 1998-09-03 |
| TR199801756T2 (xx) | 1998-12-21 |
| CN1218467A (zh) | 1999-06-02 |
| JP2000507220A (ja) | 2000-06-13 |
| DE69734764T2 (de) | 2006-09-21 |
| US6136842A (en) | 2000-10-24 |
| DE69734764D1 (de) | 2006-01-05 |
| NO984047L (no) | 1998-11-03 |
| FR2745571A1 (fr) | 1997-09-05 |
| EP0888341B1 (fr) | 2005-11-30 |
| AU724686B2 (en) | 2000-09-28 |
| EP0888341A1 (fr) | 1999-01-07 |
| ES2253771T3 (es) | 2006-06-01 |
| WO1997032874A1 (fr) | 1997-09-12 |
| FR2745571B1 (fr) | 1998-06-19 |
| BR9707931A (pt) | 1999-07-27 |
| IL125960A0 (en) | 1999-04-11 |
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