DK0893450T3 - Chromatografisk fremgangsmåde til rensning af IgG med höjt udbytte og virusinaktivering - Google Patents

Chromatografisk fremgangsmåde til rensning af IgG med höjt udbytte og virusinaktivering

Info

Publication number
DK0893450T3
DK0893450T3 DK98110526T DK98110526T DK0893450T3 DK 0893450 T3 DK0893450 T3 DK 0893450T3 DK 98110526 T DK98110526 T DK 98110526T DK 98110526 T DK98110526 T DK 98110526T DK 0893450 T3 DK0893450 T3 DK 0893450T3
Authority
DK
Denmark
Prior art keywords
antibodies
caprylate
solution
precipitate
high yield
Prior art date
Application number
DK98110526T
Other languages
English (en)
Inventor
Wytold R Lebing
Patricia Alred
Doug C Lee
Hanns-Ingolf Paul
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25374006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0893450(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0893450T3 publication Critical patent/DK0893450T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/23—Solid materials, e.g. granules, powders, blocks or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A61L2103/09—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK98110526T 1997-06-20 1998-06-09 Chromatografisk fremgangsmåde til rensning af IgG med höjt udbytte og virusinaktivering DK0893450T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/879,362 US5886154A (en) 1997-06-20 1997-06-20 Chromatographic method for high yield purification and viral inactivation of antibodies

Publications (1)

Publication Number Publication Date
DK0893450T3 true DK0893450T3 (da) 2004-09-13

Family

ID=25374006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98110526T DK0893450T3 (da) 1997-06-20 1998-06-09 Chromatografisk fremgangsmåde til rensning af IgG med höjt udbytte og virusinaktivering

Country Status (10)

Country Link
US (5) US5886154A (da)
EP (1) EP0893450B1 (da)
JP (1) JP4359347B2 (da)
AT (1) ATE267214T1 (da)
AU (1) AU749336B2 (da)
CA (2) CA2239237C (da)
DE (1) DE69823931T2 (da)
DK (1) DK0893450T3 (da)
ES (1) ES2221096T3 (da)
PT (1) PT893450E (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111991571A (zh) * 2020-08-12 2020-11-27 湖州师范学院 一种柱上低pH病毒灭活的方法

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403989B (de) 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
ES2421736T3 (es) * 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
JP3096737B1 (ja) * 1999-07-19 2000-10-10 工業技術院長 ヒト・動物細胞培養液
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US7332289B2 (en) * 2001-03-09 2008-02-19 Chugai Seiyaku Kabushiki Kaisha Method of purifying protein
US6893639B2 (en) * 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
US20040022792A1 (en) * 2002-06-17 2004-02-05 Ralph Klinke Method of stabilizing proteins at low pH
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
DK1561756T3 (da) 2002-09-11 2016-02-15 Chugai Pharmaceutical Co Ltd Fremgangsmåde til rensning af protein.
US20040116676A1 (en) * 2002-09-30 2004-06-17 Hotta Joann Methods for removal of contaminants from blood product solutions
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
US6984492B2 (en) * 2003-09-05 2006-01-10 Talecris Biotherapeutics, Inc. Methods and compositions for treating herpes infections
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
BRPI0507298A (pt) * 2004-01-30 2007-07-03 Suomen Punainen Risti Veripalv processo para a produção de imunoglobulina segura a vìrus
RU2337109C2 (ru) * 2004-02-27 2008-10-27 Октафарма Аг ПРЕПАРАТ ИММУНОГЛОБУЛИНА IgG И СПОСОБ ЕГО ПОЛУЧЕНИЯ
EP1786827A4 (en) * 2004-05-14 2008-10-29 Kirin Holdings Kk PROCESS FOR IMMUNOGLOBULINE CLEANING
SG162788A1 (en) 2005-06-14 2010-07-29 Amgen Inc Self-buffering protein formulations
US8293242B2 (en) * 2005-09-01 2012-10-23 Plasma Technologies, Llc Ultra-high yield of alpha-1-anti-trypsin
US7879332B2 (en) * 2005-09-01 2011-02-01 Plasma Technologies, Llc Ultra-high yield intravenous immune globulin preparation
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
CN100339386C (zh) * 2005-09-12 2007-09-26 大连三仪动物药品有限公司 动物用复合型免疫球蛋白的生产方法
US20070128693A1 (en) * 2005-12-06 2007-06-07 Advantek Serum Laboratories Limited3/F Method for the inactivation and removal of dengue virus from biological samples
JP5697847B2 (ja) * 2006-01-30 2015-04-08 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ＩｇＭを使用する治療方法および予防方法
FR2899111B1 (fr) * 2006-03-31 2010-09-03 Lab Francais Du Fractionnement Concentre d'immunoglobulines specifiques du chikungunya en tant que medicament.
JP2010510963A (ja) * 2006-06-14 2010-04-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー セラミックヒドロキシアパタイトを使用する抗体の精製方法
US20080132688A1 (en) * 2006-09-22 2008-06-05 Amgen Inc. Methods for Removing Viral Contaminants During Protein Purification
AU2013204044B2 (en) * 2007-11-30 2017-08-31 Abbvie Biotechnology Ltd. Protein formulations and methods of making same
SG10201604258YA (en) * 2007-11-30 2016-07-28 Abbvie Biotechnology Ltd Anti-tnf antibody formulations
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
PT2271382E (pt) 2008-04-15 2013-05-07 Grifols Therapeutics Inc Ultrafiltração em dois andares/diafiltração
WO2009145722A1 (en) * 2008-05-30 2009-12-03 Ge Healthcare Bio-Sciences Ab Separation method utilizing polyallylamine ligands
KR101464032B1 (ko) 2009-05-27 2014-11-27 백스터 인터내셔널 인코포레이티드 피하 사용을 위한 고 농축 면역글로불린 제제의 제조 방법
US20120101262A1 (en) * 2009-06-25 2012-04-26 Bristol-Myers Squibb Company Protein purification by caprylic acid (octanoic acid) precipitation
IT1397061B1 (it) 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
EP2531218B1 (en) 2010-02-04 2018-12-12 CSL Behring AG Immunoglobulin preparation
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
GB201006753D0 (en) 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US8796430B2 (en) 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield
AU2011244947B2 (en) * 2010-05-26 2012-06-07 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US8772462B2 (en) 2010-05-26 2014-07-08 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
EP2598223B1 (en) 2010-07-30 2022-04-06 EMD Millipore Corporation Chromatography media and method
KR20130128382A (ko) 2010-10-13 2013-11-26 옥타파마 아게 보체 인자 ｈ의 정제 방법
EP2649016B1 (en) 2010-12-06 2020-06-10 Pall Corporation Continuous processing methods for biological products
DE102010054767B4 (de) 2010-12-16 2013-02-21 Previpharma Ag Verfahren zur Trennung, Aufkonzentration und/oder Reinigung von (Blut)Plasmaprotein, Viren oder Virenbestandteilen
DE102010054766B4 (de) 2010-12-16 2012-08-30 Previpharma Ag Verfahren zur Trennung, Aufkonzentration oder Reinigung eines (Blut)Plasmaproteins oder Virenbestandteils aus einer Mischung
WO2012104418A2 (en) 2011-02-04 2012-08-09 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
FR2974301B1 (fr) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes
CN102250240B (zh) * 2011-06-27 2013-07-31 山东泰邦生物制品有限公司 一种从血浆分离组分ⅰ+ⅲ中纯化人免疫球蛋白的方法
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
WO2013130826A2 (en) 2012-02-29 2013-09-06 Baxter International Inc. Igg stimulated remyelination of peripheral nerves
EP2636684A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Prevention of infection
EP2636681A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Process for enriching IgA
AU2013201393B2 (en) 2012-03-09 2015-08-27 Csl Behring Ag Compositions
ES2381828B1 (es) 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
ES2895173T3 (es) * 2012-06-29 2022-02-17 Emd Millipore Corp Métodos para inactivar virus durante un proceso de purificación de proteínas
AU2013205138B2 (en) * 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
EA201791717A1 (ru) 2012-09-07 2018-03-30 Кохерус Байосайенсис, Инк. Стабильные водные составы адалимумаба
KR20150118103A (ko) * 2013-02-06 2015-10-21 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 정제 방법
JP6608705B2 (ja) 2013-03-08 2019-11-20 ジェンザイム・コーポレーション 治療用タンパク質の連続的な精製
DK3016976T3 (da) * 2013-07-01 2020-12-07 Csl Behring Ag Proces
KR102356757B1 (ko) 2013-10-18 2022-02-03 노바셉 이큅먼트 솔루션즈 단백질 정제
CA2930634C (en) 2013-11-15 2023-05-09 Novartis Ag Removal of influenza nuclear protein (np) from influenza virus preparations
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
WO2015137531A1 (ko) * 2014-03-11 2015-09-17 주식회사 녹십자홀딩스 면역글로불린의 정제방법
CN106456813B (zh) * 2014-04-15 2020-06-30 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
JP6700197B2 (ja) * 2014-04-30 2020-05-27 ノヴォ ノルディスク アー／エス カプリル酸を用いてタンパク質を精製する方法
US10550148B2 (en) 2014-06-16 2020-02-04 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
KR101938948B1 (ko) 2014-06-25 2019-01-15 이엠디 밀리포어 코포레이션 밀집한 나권형 필터 엘리먼트, 모듈 및 시스템
ES2935333T3 (es) 2014-08-29 2023-03-06 Emd Millipore Corp Procesos para filtrar líquidos utilizando sistemas de filtración de flujo tangencial de paso único y sistemas de filtración de flujo tangencial con recirculación de retenido
SG10201901555UA (en) 2014-08-29 2019-03-28 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
CN106794389A (zh) 2014-09-02 2017-05-31 Emd密理博公司 具有纳米原纤化表面特征的高表面积纤维介质
WO2016073401A1 (en) 2014-11-03 2016-05-12 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
US9556253B2 (en) 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
CA2968915A1 (en) 2014-12-03 2016-06-09 Csl Behring Ag Pharmaceutical product with increased stability comprising immunoglobulins
CN107001410A (zh) 2014-12-08 2017-08-01 Emd密理博公司 混合床离子交换吸附剂
US9913903B2 (en) 2015-08-06 2018-03-13 Grifols Worldwide Operations Limited Method for the treatment or prevention of infection-related immune conditions using a composition comprising IgM
US10570194B2 (en) 2015-08-06 2020-02-25 Grifols Worldwide Operations Limited Method for treating infectious diseases using a composition comprising plasma-derived immunoglobulin M (IgM)
EP3135687B1 (en) 2015-08-31 2019-04-10 Instituto Grifols, S.A. Method for the preparation of immunoglobulins
CN105126100B (zh) * 2015-09-23 2021-01-26 成都蓉生药业有限责任公司 一种富含IgM的人免疫球蛋白制剂及其制备方法
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
KR102550844B1 (ko) * 2016-03-11 2023-07-05 베링거 인겔하임 인터내셔날 게엠베하 단백질의 제조 동안 바이러스를 연속적으로 불활성화시키는 방법
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
CA3077712C (en) 2016-06-09 2022-03-22 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
JP6370853B2 (ja) * 2016-09-26 2018-08-08 インスティトゥト グリフォルス，ソシエダ アノニマ 免疫グロブリンの調製方法
MX2019004580A (es) 2016-10-21 2019-08-12 Amgen Inc Formulaciones farmaceuticas y metodos para prepararlas.
BE1025090B1 (fr) * 2017-03-30 2018-10-29 Univercells Sa Procede et kit de purification de proteines
ES2977655T3 (es) 2018-05-17 2024-08-28 Csl Behring Ag Método y sistema de extracción de proteínas
HK40046210A (en) 2018-08-31 2021-10-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
GB201818811D0 (en) * 2018-11-19 2019-01-02 Smith & Nephew Method of immobilising a protein on a substrate
JP2023502412A (ja) 2019-11-20 2023-01-24 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 沈殿物からタンパク質を抽出する方法および不純物を沈殿させる方法
WO2021202373A1 (en) 2020-03-31 2021-10-07 Baxalta Incorporated A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma
TW202200204A (zh) 2020-05-27 2022-01-01 愛爾蘭商格里佛全球營運有限公司 用ｉｖｉｇ和恢復期血漿治療病毒感染的方法
CN115697408A (zh) * 2020-06-03 2023-02-03 基立福环球运营有限公司 超免疫igg和/或igm组合物及其制备方法及自捐献者获得超免疫人血浆的方法
AU2021303496A1 (en) 2020-07-10 2023-02-02 Grifols Worldwide Operations Limited Method for obtaining a composition comprising human plasma-derived immunoglobulin M
CN112500477B (zh) * 2020-12-05 2023-06-06 贵州泰邦生物制品有限公司 一种快速从血浆提取人免疫球蛋白的方法
KR20240013787A (ko) * 2021-05-26 2024-01-30 체에스엘 베링 아게 연속 추출에 의한 혈장 분획화
KR20240040107A (ko) 2021-07-29 2024-03-27 체에스엘 베링 아게 면역글로불린 g를 정제하는 방법 및 이의 용도
JP2025512990A (ja) 2022-04-08 2025-04-22 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト クロマトグラフィー培地を消毒及び／又は再生する方法
BE1029863B1 (nl) * 2022-05-10 2023-05-12 Prothya Biosolutions Belgium WERKWIJZEN VOOR HET PRODUCEREN VAN IMMUNOGLOBULINE G (IgG) PREPARATEN EN/OF OPLOSSINGEN
US20250297954A1 (en) 2022-06-28 2025-09-25 Csl Behring Ag Method of monitoring parameters in turbid solutions
WO2024105235A1 (en) 2022-11-18 2024-05-23 Grifols Worldwide Operations Limited Hyperimmune globulin compositions for use in the treatment of covid-19
KR20250161658A (ko) 2023-03-29 2025-11-17 체에스엘 베링 아게 부작용과 관련된 면역글로불린을 식별하는 방법
WO2025008781A1 (en) 2023-07-04 2025-01-09 Csl Behring Ag Method of purification
AU2024336754A1 (en) 2023-09-04 2026-03-05 Csl Behring Gmbh Spectroscopy methods
AU2024351533A1 (en) 2023-09-26 2026-03-19 Takeda Pharmaceutical Company Limited IMMUNOGLOBULIN FORMULATIONS DEPLETED IN IgA
WO2025126144A1 (en) 2023-12-13 2025-06-19 Csl Behring Ag Methods of monitoring parameters in solution

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190437B1 (da) 1972-07-05 1975-08-08 Merieux Inst
US4156681A (en) 1974-03-28 1979-05-29 Plasmesco Ag Process for isolating albumin from blood
US4136094A (en) 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
JPS5855432A (ja) 1981-09-29 1983-04-01 Fujirebio Inc 静脈注射用免疫グロブリンの製法
CA1201063A (en) * 1982-07-20 1986-02-25 Winnipeg Rh Institute Inc., (The) Process for preparing purified immune globulin (igg)
US4434093A (en) 1982-07-26 1984-02-28 Ortho Diagnostic Systems Inc. Methods for preparation of HBs Ag free gamma globulins
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4534972A (en) 1983-03-29 1985-08-13 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4983722A (en) * 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
DE3821295A1 (de) * 1988-06-24 1989-12-28 Kernforschungsz Karlsruhe Verfahren zur abtrennung von technetium, ruthenium und palladium aus kernbrennstoff-loesungen
US4939176A (en) * 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
DE3927111C3 (de) 1989-08-17 1994-09-01 Biotest Pharma Gmbh Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate
DE3927112C1 (da) 1989-08-17 1990-10-25 Biotest Pharma Gmbh, 6072 Dreieich, De
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
JPH0778025B2 (ja) 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
DK0447585T4 (da) * 1990-03-22 2003-09-01 Biotest Pharma Gmbh Fremgangsmåde til fremstilling af et intravenøst tolerant immunglobulin-G-præparat
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
US5164587A (en) 1991-09-09 1992-11-17 Harbor Branch Oceanographic Institution, Inc. Polarimetric parameter measurement systems and methods for measuring a plurality of parameters
US5258177A (en) * 1991-12-10 1993-11-02 Alpha Therapeutic Corporation IgA preparation and process of making the same
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111991571A (zh) * 2020-08-12 2020-11-27 湖州师范学院 一种柱上低pH病毒灭活的方法

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AU749336B2 (en) 2002-06-27
US20020177693A1 (en) 2002-11-28
DE69823931D1 (de) 2004-06-24
US6307028B1 (en) 2001-10-23
AU7009998A (en) 1998-12-24
EP0893450A1 (en) 1999-01-27
JP4359347B2 (ja) 2009-11-04
PT893450E (pt) 2004-09-30
JPH1129494A (ja) 1999-02-02
DE69823931T2 (de) 2005-06-16
ES2221096T3 (es) 2004-12-16
EP0893450B1 (en) 2004-05-19
USRE43655E1 (en) 2012-09-11
US5886154A (en) 1999-03-23
CA2676074A1 (en) 1998-12-20
ATE267214T1 (de) 2004-06-15
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CA2239237A1 (en) 1998-12-20
CA2676074C (en) 2015-10-06

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