ATE267214T1 - Chromatographieverfahren für reinigung von igg mit hoher ausbeute und virusinaktivierung - Google Patents

Chromatographieverfahren für reinigung von igg mit hoher ausbeute und virusinaktivierung

Info

Publication number
ATE267214T1
ATE267214T1 AT98110526T AT98110526T ATE267214T1 AT E267214 T1 ATE267214 T1 AT E267214T1 AT 98110526 T AT98110526 T AT 98110526T AT 98110526 T AT98110526 T AT 98110526T AT E267214 T1 ATE267214 T1 AT E267214T1
Authority
AT
Austria
Prior art keywords
antibodies
caprylate
solution
precipitate
igg
Prior art date
Application number
AT98110526T
Other languages
English (en)
Inventor
Wytold R Lebing
Patricia Alred
Doug C Lee
Hanns-Ingolf Paul
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25374006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE267214(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE267214T1 publication Critical patent/ATE267214T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/23—Solid materials, e.g. granules, powders, blocks or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A61L2103/09—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98110526T 1997-06-20 1998-06-09 Chromatographieverfahren für reinigung von igg mit hoher ausbeute und virusinaktivierung ATE267214T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/879,362 US5886154A (en) 1997-06-20 1997-06-20 Chromatographic method for high yield purification and viral inactivation of antibodies

Publications (1)

Publication Number Publication Date
ATE267214T1 true ATE267214T1 (de) 2004-06-15

Family

ID=25374006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98110526T ATE267214T1 (de) 1997-06-20 1998-06-09 Chromatographieverfahren für reinigung von igg mit hoher ausbeute und virusinaktivierung

Country Status (10)

Country Link
US (5) US5886154A (de)
EP (1) EP0893450B1 (de)
JP (1) JP4359347B2 (de)
AT (1) ATE267214T1 (de)
AU (1) AU749336B2 (de)
CA (2) CA2239237C (de)
DE (1) DE69823931T2 (de)
DK (1) DK0893450T3 (de)
ES (1) ES2221096T3 (de)
PT (1) PT893450E (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403989B (de) 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
JP3096737B1 (ja) * 1999-07-19 2000-10-10 工業技術院長 ヒト・動物細胞培養液
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
EP3088412B1 (de) * 2001-03-09 2021-05-05 Chugai Seiyaku Kabushiki Kaisha Proteinaufreinigungsverfahren
US6893639B2 (en) * 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
US20040022792A1 (en) * 2002-06-17 2004-02-05 Ralph Klinke Method of stabilizing proteins at low pH
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
ES2558303T3 (es) 2002-09-11 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
US20040116676A1 (en) * 2002-09-30 2004-06-17 Hotta Joann Methods for removal of contaminants from blood product solutions
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
US6984492B2 (en) * 2003-09-05 2006-01-10 Talecris Biotherapeutics, Inc. Methods and compositions for treating herpes infections
EP1532983A1 (de) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulinpräparationen mit erhöhter Stabilität
JP2008500959A (ja) * 2004-01-30 2008-01-17 スオメン プナイネン リスティ ヴェリパルヴェル ウイルスについて安全な免疫グロブリンの製造方法
CN1922207B (zh) * 2004-02-27 2012-06-06 奥克特珐玛股份有限公司 提供纯化的、病毒安全的抗体制剂的方法
EP1786827A4 (de) * 2004-05-14 2008-10-29 Kirin Holdings Kk Verfahren zur immunoglobulinaufreinigung
MX2007015476A (es) 2005-06-14 2008-02-25 Amgen Inc Formulaciones de proteina autoamortiguadoras.
US8293242B2 (en) * 2005-09-01 2012-10-23 Plasma Technologies, Llc Ultra-high yield of alpha-1-anti-trypsin
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
US7879332B2 (en) * 2005-09-01 2011-02-01 Plasma Technologies, Llc Ultra-high yield intravenous immune globulin preparation
CN100339386C (zh) * 2005-09-12 2007-09-26 大连三仪动物药品有限公司 动物用复合型免疫球蛋白的生产方法
US20070128693A1 (en) * 2005-12-06 2007-06-07 Advantek Serum Laboratories Limited3/F Method for the inactivation and removal of dengue virus from biological samples
WO2007106617A2 (en) * 2006-01-30 2007-09-20 Talecris Biotherapeutics, Inc. Method of treatment and prophylaxis of diseases related to amyloid deposition using igm
FR2899111B1 (fr) * 2006-03-31 2010-09-03 Lab Francais Du Fractionnement Concentre d'immunoglobulines specifiques du chikungunya en tant que medicament.
US20100234577A1 (en) * 2006-06-14 2010-09-16 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
WO2008036899A2 (en) * 2006-09-22 2008-03-27 Amgen Inc. Methods for removing viral contaminants during protein purification
AU2013204044B2 (en) * 2007-11-30 2017-08-31 Abbvie Biotechnology Ltd. Protein formulations and methods of making same
TWI543768B (zh) * 2007-11-30 2016-08-01 艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
ES2406029T3 (es) * 2008-04-15 2013-06-05 Grifols Therapeutics Inc. Ultrafiltración/diafiltración en dos fases
WO2009145722A1 (en) * 2008-05-30 2009-12-03 Ge Healthcare Bio-Sciences Ab Separation method utilizing polyallylamine ligands
MX2011012576A (es) 2009-05-27 2012-05-08 Baxter Int Metodo para producir una preparacion altamente concentrada de inmunoglobulina de uso subcutaneo.
WO2010151632A1 (en) * 2009-06-25 2010-12-29 Bristol-Myers Squibb Company Protein purifacation by caprylic acid (octanoic acid ) precipitation
IT1397061B1 (it) 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
DK2531218T3 (en) 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
EP2361636A1 (de) 2010-02-26 2011-08-31 CSL Behring AG Immunglobulinpräparat und Aufbewahrungssystem für ein Immunglobulinpräparat
GB201006753D0 (en) 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
US8796430B2 (en) 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield
AU2011244947B2 (en) * 2010-05-26 2012-06-07 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
KR101997543B1 (ko) 2010-07-30 2019-07-09 이엠디 밀리포어 코포레이션 크로마토그래피 매질 및 방법
RU2013121589A (ru) 2010-10-13 2014-11-20 Октафарма Аг Способ очистки фактора комплемента н
KR102027596B1 (ko) 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
DE102010054767B4 (de) 2010-12-16 2013-02-21 Previpharma Ag Verfahren zur Trennung, Aufkonzentration und/oder Reinigung von (Blut)Plasmaprotein, Viren oder Virenbestandteilen
DE102010054766B4 (de) 2010-12-16 2012-08-30 Previpharma Ag Verfahren zur Trennung, Aufkonzentration oder Reinigung eines (Blut)Plasmaproteins oder Virenbestandteils aus einer Mischung
ES2675353T3 (es) 2011-02-04 2018-07-10 Octapharma Ag Procedimiento para inactivación/eliminación de factores de coagulación por precipitación
FR2974301B1 (fr) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes
CN102250240B (zh) * 2011-06-27 2013-07-31 山东泰邦生物制品有限公司 一种从血浆分离组分ⅰ+ⅲ中纯化人免疫球蛋白的方法
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
DK2820042T3 (da) 2012-02-29 2019-10-28 Baxalta GmbH Igg-stimuleret remyelinisering af perifere nerver
EP2636681A1 (de) 2012-03-09 2013-09-11 CSL Behring AG Verfahren zur Anreicherung von IgA
ES2751976T3 (es) 2012-03-09 2020-04-02 Csl Behring Ag Composiciones que comprenden inmunoglobulinas de tipo secretor
EP2636684A1 (de) 2012-03-09 2013-09-11 CSL Behring AG Vorbeugung von Infektionen
ES2381828B1 (es) 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
CN104411820B (zh) * 2012-06-29 2017-05-03 Emd密理博公司 在蛋白纯化过程中灭活病毒的方法
AU2013205138B2 (en) * 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
WO2014039903A2 (en) 2012-09-07 2014-03-13 Coherus Biosciences, Inc. Stable aqueous formulations of adalimumab
KR20150118103A (ko) * 2013-02-06 2015-10-21 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 정제 방법
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
CN105358571B (zh) * 2013-07-01 2019-03-05 瑞士杰特贝林生物制品有限公司 方法
SG11201603028SA (en) 2013-10-18 2016-05-30 Universität Für Bodenkultur Wien Purification of proteins
AU2014350370B2 (en) 2013-11-15 2017-04-13 Novartis Ag Removal of residual cell culture impurities
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
CA2941232C (en) 2014-03-11 2020-08-25 Green Cross Holdings Corporation Method for purifying immunoglobulin
CN114225072B (zh) * 2014-04-15 2024-01-02 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
ES2975172T1 (es) * 2014-04-30 2024-07-03 Novo Nordisk As Métodos para la purificación de proteínas usando ácido caprílico
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
US10550148B2 (en) 2014-06-16 2020-02-04 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
JP6339674B2 (ja) 2014-06-25 2018-06-06 イー・エム・デイー・ミリポア・コーポレイシヨン 小型スパイラル型フィルターエレメント、モジュール、およびシステム
US10350518B2 (en) 2014-08-29 2019-07-16 Emd Millipore Corporation Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
KR102079585B1 (ko) 2014-08-29 2020-02-21 이엠디 밀리포어 코포레이션 잔류물의 재순환을 이용한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템
ES2877563T3 (es) 2014-09-02 2021-11-17 Emd Millipore Corp Medios de cromotografía que comprenden conjuntos porosos discretos de nanofibrillas
WO2016073401A1 (en) 2014-11-03 2016-05-12 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
US9556253B2 (en) 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
ES2825704T3 (es) 2014-12-03 2021-05-17 Csl Behring Ag Producto farmacéutico con mayor estabilidad que comprende inmunoglobulinas
US20170298091A1 (en) 2014-12-08 2017-10-19 Emd Millipore Corporation Mixed Bed Ion Exchange Adsorber
US9913903B2 (en) 2015-08-06 2018-03-13 Grifols Worldwide Operations Limited Method for the treatment or prevention of infection-related immune conditions using a composition comprising IgM
US10570194B2 (en) 2015-08-06 2020-02-25 Grifols Worldwide Operations Limited Method for treating infectious diseases using a composition comprising plasma-derived immunoglobulin M (IgM)
TR201905974T4 (tr) 2015-08-31 2019-05-21 Inst Grifols S A İmmünoglobuli̇nleri̇n hazirlanmasi i̇çi̇n yöntem
CN105126100B (zh) * 2015-09-23 2021-01-26 成都蓉生药业有限责任公司 一种富含IgM的人免疫球蛋白制剂及其制备方法
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
US11407981B2 (en) * 2016-03-11 2022-08-09 Boehringer Ingelheim International Gmbh Methods for continuously inactivating a virus during manufacture of a protein
WO2017184880A1 (en) 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
ES2925059T3 (es) 2016-06-09 2022-10-13 Emd Millipore Corp Elementos de filtro de trayectoria radial, sistemas y métodos de uso de los mismos
JP6370853B2 (ja) * 2016-09-26 2018-08-08 インスティトゥト グリフォルス，ソシエダ アノニマ 免疫グロブリンの調製方法
AU2017345490B2 (en) 2016-10-21 2022-07-07 Amgen Inc. Pharmaceutical formulations and methods of making the same
BE1025090B1 (fr) 2017-03-30 2018-10-29 Univercells Sa Procede et kit de purification de proteines
EP3794013B1 (de) 2018-05-17 2024-02-21 CSL Behring AG Verfahren und system zur proteinextraktion
HK40046210A (en) 2018-08-31 2021-10-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
GB201818811D0 (en) * 2018-11-19 2019-01-02 Smith & Nephew Method of immobilising a protein on a substrate
EP4061826A1 (de) 2019-11-20 2022-09-28 CSL Behring AG Verfahren zum extrahieren eines proteins aus einer ausfällung und verfahren zum ausfällen von verunreinigungen
EP4126930A1 (de) 2020-03-31 2023-02-08 Takeda Pharmaceutical Company Limited Verfahren zur herstellung einer immunglobulinzubereitung aus an einem c-1-inhibitor abgereichertem plasma
US20230235025A1 (en) 2020-05-27 2023-07-27 Grifols Worldwide Operations Limited Method for the treatment of virus infection with ivig and convalescent plasma
JP2023527864A (ja) * 2020-06-03 2023-06-30 グリフォルス・ワールドワイド・オペレーションズ・リミテッド 過免疫ｉｇｇ及び／又はｉｇｍ組成物及びその調製方法及び過免疫ヒト血漿をドナーから得る方法
AU2021303496A1 (en) 2020-07-10 2023-02-02 Grifols Worldwide Operations Limited Method for obtaining a composition comprising human plasma-derived immunoglobulin M
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法
CN112500477B (zh) * 2020-12-05 2023-06-06 贵州泰邦生物制品有限公司 一种快速从血浆提取人免疫球蛋白的方法
KR20240013787A (ko) * 2021-05-26 2024-01-30 체에스엘 베링 아게 연속 추출에 의한 혈장 분획화
JP2024527980A (ja) 2021-07-29 2024-07-26 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 免疫グロブリンｇを精製する方法およびその使用
CA3247416A1 (en) 2022-04-08 2023-10-12 Csl Behring Ag Methods of sanitizing and/or regenerating a chromatography medium
BE1029863B1 (nl) * 2022-05-10 2023-05-12 Prothya Biosolutions Belgium WERKWIJZEN VOOR HET PRODUCEREN VAN IMMUNOGLOBULINE G (IgG) PREPARATEN EN/OF OPLOSSINGEN
AU2023301415A1 (en) 2022-06-28 2025-02-06 Csl Behring Ag Method of monitoring parameters in turbid solutions
WO2024105235A1 (en) 2022-11-18 2024-05-23 Grifols Worldwide Operations Limited Hyperimmune globulin compositions for use in the treatment of covid-19
KR20250161658A (ko) 2023-03-29 2025-11-17 체에스엘 베링 아게 부작용과 관련된 면역글로불린을 식별하는 방법
CN121712573A (zh) 2023-07-04 2026-03-20 瑞士杰特贝林生物制品有限公司 纯化方法
WO2025051772A1 (en) 2023-09-04 2025-03-13 Csl Behring Gmbh Spectroscopy methods
WO2025068923A2 (en) 2023-09-26 2025-04-03 Takeda Pharmaceutical Company Limited IMMUNOGLOBULIN FORMULATIONS DEPLETED IN IgA
WO2025126144A1 (en) 2023-12-13 2025-06-19 Csl Behring Ag Methods of monitoring parameters in solution
WO2026074476A1 (en) 2024-10-02 2026-04-09 Csl Behring Ag Method of detecting autoantibodies against fc epsilon receptor i

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190437B1 (de) 1972-07-05 1975-08-08 Merieux Inst
US4156681A (en) 1974-03-28 1979-05-29 Plasmesco Ag Process for isolating albumin from blood
US4136094A (en) 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
JPS5855432A (ja) 1981-09-29 1983-04-01 Fujirebio Inc 静脈注射用免疫グロブリンの製法
CA1201063A (en) * 1982-07-20 1986-02-25 Winnipeg Rh Institute Inc., (The) Process for preparing purified immune globulin (igg)
US4434093A (en) 1982-07-26 1984-02-28 Ortho Diagnostic Systems Inc. Methods for preparation of HBs Ag free gamma globulins
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4534972A (en) 1983-03-29 1985-08-13 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4983722A (en) * 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
DE3821295A1 (de) * 1988-06-24 1989-12-28 Kernforschungsz Karlsruhe Verfahren zur abtrennung von technetium, ruthenium und palladium aus kernbrennstoff-loesungen
US4939176A (en) * 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
DE3927111C3 (de) 1989-08-17 1994-09-01 Biotest Pharma Gmbh Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate
DE3927112C1 (de) * 1989-08-17 1990-10-25 Biotest Pharma Gmbh, 6072 Dreieich, De
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
JPH0778025B2 (ja) 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
DE59009020D1 (de) * 1990-03-22 1995-06-08 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates.
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
US5164587A (en) 1991-09-09 1992-11-17 Harbor Branch Oceanographic Institution, Inc. Polarimetric parameter measurement systems and methods for measuring a plurality of parameters
US5258177A (en) * 1991-12-10 1993-11-02 Alpha Therapeutic Corporation IgA preparation and process of making the same
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies

Also Published As

Publication number Publication date
DE69823931D1 (de) 2004-06-24
EP0893450B1 (de) 2004-05-19
EP0893450A1 (de) 1999-01-27
DK0893450T3 (da) 2004-09-13
CA2239237C (en) 2010-02-02
PT893450E (pt) 2004-09-30
US5886154A (en) 1999-03-23
JP4359347B2 (ja) 2009-11-04
AU7009998A (en) 1998-12-24
CA2676074C (en) 2015-10-06
DE69823931T2 (de) 2005-06-16
USRE43655E1 (en) 2012-09-11
USRE44558E1 (en) 2013-10-22
US6307028B1 (en) 2001-10-23
JPH1129494A (ja) 1999-02-02
ES2221096T3 (es) 2004-12-16
CA2239237A1 (en) 1998-12-20
AU749336B2 (en) 2002-06-27
CA2676074A1 (en) 1998-12-20
US20020177693A1 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
ATE267214T1 (de) Chromatographieverfahren für reinigung von igg mit hoher ausbeute und virusinaktivierung
DK450785A (da) Fremgangsmaade til fremstilling af et koncentrat af antihaemofilisk faktor med hoej renhed
JP2644946B2 (ja) ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法
DE3778086D1 (de) Herstellungsverfahren von quaternaeren ammoniumhydroxiden von hoher reinheit.
LV10053A (lv) Kompleksa "Faktors-YIII + fon Villebranda faktors" koncentrata iegusanas metode
NZ226651A (en) Ion exchange protein separation method characterised by adjusting ph so that the pure protein and the impurity are oppositely charged
DK1268399T3 (da) Fremgangsmåde til separering af en basisk aminosyre fra fermenteringsvæske
ES2216181T5 (es) Procedimiento para preparar dimero purificado de factor derivado de hueso.
EP0309787A3 (en) Process for producing a highly purified, virus-free and biologically active transferrin preparation
DE3062792D1 (en) A process in purification and concentration of the factor viii-complex
DE69631229D1 (de) Herstellung von virusinaktivierten Intravenös injektierbaren Globulin aus Immunserum
ATE283864T1 (de) Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor
DE69303941D1 (de) Verfahren zur Herstellung von hochreinem Fibrinogen
ATE398171T1 (de) Hyaluronidase enthaltendes präparat und pharmazeutische verwendung davon
JPS62111953A (ja) グリシンとｌ−セリンの分離方法
KR100369582B1 (ko) 재조합알파-인터페론의정제방법
DE3170868D1 (en) Process for the preparation of highly purified antihemophilic factor
SE435787B (sv) Forfarande for framstellning av immunoglobulinderivat
JPS61234792A (ja) マウスインタ−フエロンの精製法
KR930006151A (ko) 지렁이로부터 프로테아제를 분리 정제하는 방법
FR2623506B1 (fr) Procede de preparation de synthons peptidiques
JPS61181395A (ja) マウスインタ−フエロンの精製法
KR910016926A (ko) 인간 β-인터페론의 정제방법
RO85360B1 (ro) Procedeu de obtinere a fosfatazei alcaline

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0893450

Country of ref document: EP