DK0896577T3 - Texanderivater med en pyridylsubstitueret C 13-sidekæde og deres anvendelse som midler mod tumorer - Google Patents

Texanderivater med en pyridylsubstitueret C 13-sidekæde og deres anvendelse som midler mod tumorer

Info

Publication number
DK0896577T3
DK0896577T3 DK97902286T DK97902286T DK0896577T3 DK 0896577 T3 DK0896577 T3 DK 0896577T3 DK 97902286 T DK97902286 T DK 97902286T DK 97902286 T DK97902286 T DK 97902286T DK 0896577 T3 DK0896577 T3 DK 0896577T3
Authority
DK
Denmark
Prior art keywords
microtubules
pct
taxol
depolymerisation
mitosis
Prior art date
Application number
DK97902286T
Other languages
Danish (da)
English (en)
Inventor
Guenter Neef
Hermann Graf
Ulrich Klar
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0896577T3 publication Critical patent/DK0896577T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK97902286T 1996-01-31 1997-01-31 Texanderivater med en pyridylsubstitueret C 13-sidekæde og deres anvendelse som midler mod tumorer DK0896577T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19605024A DE19605024A1 (de) 1996-01-31 1996-01-31 Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
PCT/EP1997/000440 WO1997028156A1 (en) 1996-01-31 1997-01-31 Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents

Publications (1)

Publication Number Publication Date
DK0896577T3 true DK0896577T3 (da) 2003-05-19

Family

ID=7785142

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97902286T DK0896577T3 (da) 1996-01-31 1997-01-31 Texanderivater med en pyridylsubstitueret C 13-sidekæde og deres anvendelse som midler mod tumorer

Country Status (25)

Country Link
US (1) US6162920A (uk)
EP (1) EP0896577B1 (uk)
JP (1) JP2001505527A (uk)
KR (1) KR19990082151A (uk)
CN (1) CN1073108C (uk)
AT (1) ATE233757T1 (uk)
AU (1) AU714313B2 (uk)
BR (1) BR9708295A (uk)
CA (1) CA2244746A1 (uk)
CZ (1) CZ292504B6 (uk)
DE (2) DE19605024A1 (uk)
DK (1) DK0896577T3 (uk)
ES (1) ES2192261T3 (uk)
HU (1) HUP9901027A3 (uk)
IL (1) IL124951A (uk)
NO (1) NO983509L (uk)
PL (1) PL186796B1 (uk)
PT (1) PT896577E (uk)
RU (1) RU2163599C2 (uk)
SK (1) SK101198A3 (uk)
TR (1) TR199801415T2 (uk)
TW (1) TW444015B (uk)
UA (1) UA49007C2 (uk)
WO (1) WO1997028156A1 (uk)
ZA (1) ZA97847B (uk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1375495B1 (en) 2001-03-07 2008-09-03 Daiichi Sankyo Company, Limited Method for producing a 2-azetidinone derivative
CA2484761C (en) * 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
BR0313789A (pt) * 2002-08-24 2005-07-05 Zentaris Gmbh Medicamento contendo disorazóis e seus derivados para o tratamento de doenças tumorais malignas e benignas
EP1605866B1 (en) 2003-03-03 2016-07-06 Syntach AG Electrical conduction block implant device
CN1296391C (zh) * 2004-03-04 2007-01-24 中国人民解放军第二军医大学 氟代羧烷基环糊精醚类化合物及其制备方法和应用
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
CA2821167C (en) * 2004-05-03 2016-06-28 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
PL3337467T3 (pl) 2015-08-20 2021-06-14 Ipsen Biopharm Ltd. Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu
PL3337478T5 (pl) 2015-08-21 2026-05-04 Ipsen Biopharm Ltd. Kombinacja leków obejmująca liposomalny irynotekan, oksaliplatynę, 5-fluorouracyl i leukoworynę do leczenia nowotworu trzustki z przerzutami
AU2016340153B2 (en) 2015-10-16 2022-06-02 Ipsen Biopharm Ltd. Stabilizing camptothecin pharmaceutical compositions
EP3535026A1 (en) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017744C1 (ru) * 1987-09-21 1994-08-15 Фудзисава Фармасьютикал Ко., Лтд. Способ получения соединений цефема или их кислотно-аддитивных солей
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
JPH08508471A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー ピリジル置換側鎖を有するタキサン
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
FR2715307B1 (fr) * 1994-01-25 1996-04-05 Commissariat Energie Atomique Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation.
WO1996000724A1 (en) * 1994-06-28 1996-01-11 Pharmacia & Upjohn Company 7-ether-taxol analogs, antineoplastic use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0896577B1 (en) 2003-03-05
BR9708295A (pt) 1999-08-03
RU2163599C2 (ru) 2001-02-27
ES2192261T3 (es) 2003-10-01
TR199801415T2 (xx) 1998-10-21
KR19990082151A (ko) 1999-11-15
US6162920A (en) 2000-12-19
HUP9901027A2 (hu) 2001-05-28
EP0896577A1 (en) 1999-02-17
AU1598497A (en) 1997-08-22
PL186796B1 (pl) 2004-02-27
IL124951A (en) 2003-12-10
PT896577E (pt) 2003-06-30
WO1997028156A1 (en) 1997-08-07
DE69719502T2 (de) 2004-02-19
UA49007C2 (uk) 2002-09-16
DE69719502D1 (de) 2003-04-10
CN1210535A (zh) 1999-03-10
JP2001505527A (ja) 2001-04-24
CA2244746A1 (en) 1997-08-07
SK101198A3 (en) 1998-12-02
HK1018778A1 (en) 2000-01-07
AU714313B2 (en) 1999-12-23
HUP9901027A3 (en) 2001-08-28
TW444015B (en) 2001-07-01
IL124951A0 (en) 1999-01-26
CZ292504B6 (cs) 2003-10-15
NO983509D0 (no) 1998-07-30
PL328055A1 (en) 1999-01-04
NO983509L (no) 1998-07-30
ZA97847B (en) 1997-08-04
DE19605024A1 (de) 1997-08-07
ATE233757T1 (de) 2003-03-15
CN1073108C (zh) 2001-10-17
CZ242698A3 (cs) 1999-07-14

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