UA49007C2 - Таксани, спосіб їх одержання та лікарський препарат з цитотоксичною дією - Google Patents
Таксани, спосіб їх одержання та лікарський препарат з цитотоксичною дієюInfo
- Publication number
- UA49007C2 UA49007C2 UA98084638A UA98084638A UA49007C2 UA 49007 C2 UA49007 C2 UA 49007C2 UA 98084638 A UA98084638 A UA 98084638A UA 98084638 A UA98084638 A UA 98084638A UA 49007 C2 UA49007 C2 UA 49007C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- taxanes
- formula
- medicine
- preparation
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000029749 Microtubule Human genes 0.000 abstract 1
- 108091022875 Microtubule Proteins 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 210000004688 microtubule Anatomy 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Описані таксани загальної формули (І) , (І) де Sk може бути R1 може бути воднем або С1-С10ацилом, R2 може бути -ОН, R3 може бути С1-С10алкілом, Х- заміщеним фенілом, С1-З10алкокси, Х - може бути воднем, галогеном, -N3 або -CN, і вільні гидрокси групи в (І) можуть бути додатково функціонально модифіковані шляхом етерифікації, а також їхні - - та -ціклодекстринові клатрати, а також сполуки загальної формули (І), поміщені в ліпосоми, а також спосіб одержання сполук загальної формули (І). Ці сполуки мають поліпшену стабілізацію мікротрубочок, а також демонструють здатність додатково впливати на полімеризацію тубілину.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605024A DE19605024A1 (de) | 1996-01-31 | 1996-01-31 | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| PCT/EP1997/000440 WO1997028156A1 (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA49007C2 true UA49007C2 (uk) | 2002-09-16 |
Family
ID=7785142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98084638A UA49007C2 (uk) | 1996-01-31 | 1997-01-31 | Таксани, спосіб їх одержання та лікарський препарат з цитотоксичною дією |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6162920A (uk) |
| EP (1) | EP0896577B1 (uk) |
| JP (1) | JP2001505527A (uk) |
| KR (1) | KR19990082151A (uk) |
| CN (1) | CN1073108C (uk) |
| AT (1) | ATE233757T1 (uk) |
| AU (1) | AU714313B2 (uk) |
| BR (1) | BR9708295A (uk) |
| CA (1) | CA2244746A1 (uk) |
| CZ (1) | CZ292504B6 (uk) |
| DE (2) | DE19605024A1 (uk) |
| DK (1) | DK0896577T3 (uk) |
| ES (1) | ES2192261T3 (uk) |
| HU (1) | HUP9901027A3 (uk) |
| IL (1) | IL124951A (uk) |
| NO (1) | NO983509D0 (uk) |
| PL (1) | PL186796B1 (uk) |
| PT (1) | PT896577E (uk) |
| RU (1) | RU2163599C2 (uk) |
| SK (1) | SK101198A3 (uk) |
| TR (1) | TR199801415T2 (uk) |
| TW (1) | TW444015B (uk) |
| UA (1) | UA49007C2 (uk) |
| WO (1) | WO1997028156A1 (uk) |
| ZA (1) | ZA97847B (uk) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070512A1 (en) | 2001-03-07 | 2002-09-12 | Daiichi Pharmaceutical Co, Ltd. | Method for producing 2-azetidinone derivative |
| CN101134119A (zh) * | 2002-05-24 | 2008-03-05 | 血管技术国际股份公司 | 用于涂覆医用植入物的组合物和方法 |
| NZ538926A (en) * | 2002-08-24 | 2006-03-31 | Zentaris Gmbh | Medicament containing disorazoles and derivatives thereof for the treatment of benign and malignant tumoral diseases |
| WO2004078065A2 (en) | 2003-03-03 | 2004-09-16 | Sinus Rhythm Technologies, Inc. | Electrical conduction block implant device |
| CN1296391C (zh) * | 2004-03-04 | 2007-01-24 | 中国人民解放军第二军医大学 | 氟代羧烷基环糊精醚类化合物及其制备方法和应用 |
| LT3173073T (lt) | 2004-05-03 | 2025-01-10 | Ipsen Biopharm Ltd. | Liposomos, skirtos vaistų pristatymui |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| JP7042739B2 (ja) | 2015-08-20 | 2022-03-28 | イプセン バイオファーム リミティド | 癌処置のためのリポソーム型イリノテカン及びｐａｒｐ阻害薬を使用する併用療法 |
| TW202400181A (zh) | 2015-08-21 | 2024-01-01 | 英商益普生生物製藥有限公司 | 使用包含微脂伊立替康(irinotecan)及奧沙利鉑(oxaliplatin)之組合療法治療轉移性胰臟癌的方法 |
| EP4647126A3 (en) | 2015-10-16 | 2026-02-11 | Ipsen Biopharm Ltd. | Stabilizing camptothecin pharmaceutical compositions |
| CN110402163A (zh) | 2016-11-02 | 2019-11-01 | 易普森生物制药有限公司 | 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017744C1 (ru) * | 1987-09-21 | 1994-08-15 | Фудзисава Фармасьютикал Ко., Лтд. | Способ получения соединений цефема или их кислотно-аддитивных солей |
| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| EP0690712B1 (en) * | 1993-03-22 | 2001-11-28 | Florida State University | Taxanes having a pyridyl substituted side-chain |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| FR2715307B1 (fr) * | 1994-01-25 | 1996-04-05 | Commissariat Energie Atomique | Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation. |
| DE69504843T2 (de) * | 1994-06-28 | 1999-02-11 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
-
1996
- 1996-01-31 DE DE19605024A patent/DE19605024A1/de not_active Withdrawn
-
1997
- 1997-01-31 KR KR1019980705874A patent/KR19990082151A/ko not_active Ceased
- 1997-01-31 PL PL97328055A patent/PL186796B1/pl not_active IP Right Cessation
- 1997-01-31 DK DK97902286T patent/DK0896577T3/da active
- 1997-01-31 CA CA002244746A patent/CA2244746A1/en not_active Abandoned
- 1997-01-31 TR TR1998/01415T patent/TR199801415T2/xx unknown
- 1997-01-31 CN CN97192006A patent/CN1073108C/zh not_active Expired - Fee Related
- 1997-01-31 PT PT97902286T patent/PT896577E/pt unknown
- 1997-01-31 AU AU15984/97A patent/AU714313B2/en not_active Ceased
- 1997-01-31 UA UA98084638A patent/UA49007C2/uk unknown
- 1997-01-31 SK SK1011-98A patent/SK101198A3/sk unknown
- 1997-01-31 DE DE69719502T patent/DE69719502T2/de not_active Expired - Lifetime
- 1997-01-31 JP JP52730897A patent/JP2001505527A/ja active Pending
- 1997-01-31 BR BR9708295A patent/BR9708295A/pt not_active Application Discontinuation
- 1997-01-31 TW TW086101169A patent/TW444015B/zh active
- 1997-01-31 IL IL12495197A patent/IL124951A/xx not_active IP Right Cessation
- 1997-01-31 CZ CZ19982426A patent/CZ292504B6/cs not_active IP Right Cessation
- 1997-01-31 AT AT97902286T patent/ATE233757T1/de not_active IP Right Cessation
- 1997-01-31 HU HU9901027A patent/HUP9901027A3/hu unknown
- 1997-01-31 RU RU98116122/04A patent/RU2163599C2/ru not_active IP Right Cessation
- 1997-01-31 ES ES97902286T patent/ES2192261T3/es not_active Expired - Lifetime
- 1997-01-31 US US09/117,506 patent/US6162920A/en not_active Expired - Fee Related
- 1997-01-31 WO PCT/EP1997/000440 patent/WO1997028156A1/en not_active Ceased
- 1997-01-31 ZA ZA9700847A patent/ZA97847B/xx unknown
- 1997-01-31 EP EP97902286A patent/EP0896577B1/en not_active Expired - Lifetime
-
1998
- 1998-07-30 NO NO983509A patent/NO983509D0/no unknown
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